Ahmad R Sedaghat

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
    Lin Shen
    Department of Medicine, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21205, USA
    Nat Med 14:762-6. 2008
  2. pmc Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Antivir Ther 14:263-71. 2009
  3. pmc Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland 21205, USA
    BMC Infect Dis 8:2. 2008
  4. pmc Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy
    Timothy P Brennan
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 83:8470-81. 2009
  5. pmc Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Pathog 3:e122. 2007
  6. pmc A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs
    Lin Shen
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci Transl Med 3:91ra63. 2011
  7. pmc Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle
    Ahmad R Sedaghat
    Department of Medicine and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:4832-7. 2008
  8. pmc T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 49:1763-6. 2009
  9. pmc Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes
    Yefei Han
    Department of Medicine, Ross 1049, School of Medicine, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Virol 78:6122-33. 2004
  10. pmc Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells
    Justin R Bailey
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Virol 80:6441-57. 2006

Collaborators

Detail Information

Publications13

  1. pmc Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
    Lin Shen
    Department of Medicine, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21205, USA
    Nat Med 14:762-6. 2008
    ..Only agents with slopes >1 achieve high-level inhibition of single-round infectivity, a finding with profound implications for drug and vaccine development...
  2. pmc Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Antivir Ther 14:263-71. 2009
    ..Alternative explanations for this phenomenon are also possible. For example, the stage in the viral life cycle at which raltegravir acts might explain the distinct viral dynamics produced by this drug...
  3. pmc Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland 21205, USA
    BMC Infect Dis 8:2. 2008
    ..However, the mechanism underlying the long half-life of the latent reservoir is unknown. The most likely potential mechanisms are low-level viral replication and the intrinsic stability of latently infected cells...
  4. pmc Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy
    Timothy P Brennan
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 83:8470-81. 2009
    ..The finding that some of the residual viremia in patients on HAART stems from an unidentified cellular source other than CD4(+) T cells has implications for eradication efforts...
  5. pmc Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Pathog 3:e122. 2007
    ..Thus, intensification of standard HAART regimens should have minimal effects on the decay of the latent reservoir...
  6. pmc A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs
    Lin Shen
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci Transl Med 3:91ra63. 2011
    ..This model explains the high antiviral activity of two drug classes important for successful HIV-1 treatment and defines a characteristic of good targets for antiviral drugs in general, namely, intermolecular cooperativity...
  7. pmc Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle
    Ahmad R Sedaghat
    Department of Medicine and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:4832-7. 2008
    ..We propose that clinically observed viral decay rates for HAART regimens should be evaluated in the context of the drug classes that are represented...
  8. pmc T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 49:1763-6. 2009
    ..Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation...
  9. pmc Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes
    Yefei Han
    Department of Medicine, Ross 1049, School of Medicine, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Virol 78:6122-33. 2004
    ..Taken together, these results demonstrate that HIV-1 genomes reside within actively transcribed host genes in resting CD4+ T cells in vivo...
  10. pmc Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells
    Justin R Bailey
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Virol 80:6441-57. 2006
    ..The sequences have been deposited in GenBank. The accession numbers are DQ 391282 to DQ 391351 (for env) and DQ 391352 to DQ 392955 (for RT)...
  11. pmc Short communication: dynamic constraints on the second phase compartment of HIV-infected cells
    Adam M Spivak
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA
    AIDS Res Hum Retroviruses 27:759-61. 2011
    ....
  12. pmc Chronic CD4+ T-cell activation and depletion in human immunodeficiency virus type 1 infection: type I interferon-mediated disruption of T-cell dynamics
    Ahmad R Sedaghat
    Johns Hopkins University School of Medicine, Department of Medicine, 879 BRB, 733 N Broadway, Baltimore, Maryland 21205, USA
    J Virol 82:1870-83. 2008
    ..From these results, we propose a new model for CD4(+) T-cell depletion during chronic HIV-1 infection...
  13. pmc Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection
    Amanda J Chase
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Virol 81:12748-57. 2007
    ..These results indicate that Tregs are rapidly depleted in the GALT of SIV-infected macaques, defining a role for the loss of Treg-mediated suppression in early events in the pathogenesis of the disease...