Diana G Scorpio

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Restricted changes in major surface protein-2 (msp2) transcription after prolonged in vitro passage of Anaplasma phagocytophilum
    Diana G Scorpio
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    BMC Microbiol 4:1. 2004
  2. pmc Retrospective clinical and molecular analysis of conditioned laboratory dogs (Canis familiaris) with serologic reactions to Ehrlichia canis, Borrelia burgdorferi, and Rickettsia rickettsii
    Diana G Scorpio
    Department of Molecular and Comparative Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Assoc Lab Anim Sci 47:23-8. 2008
  3. doi request reprint Cervicovaginal evaluation in macaques used as a model for topical microbicide safety studies
    Diana G Scorpio
    Department of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Med Primatol 37:65-73. 2008
  4. pmc Sequential analysis of Anaplasma phagocytophilum msp2 transcription in murine and equine models of human granulocytic anaplasmosis
    Diana G Scorpio
    Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Vaccine Immunol 15:418-24. 2008
  5. ncbi request reprint Comparative strain analysis of Anaplasma phagocytophilum infection and clinical outcomes in a canine model of granulocytic anaplasmosis
    Diana G Scorpio
    Department of Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Vector Borne Zoonotic Dis 11:223-9. 2011
  6. pmc Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury
    Diana G Scorpio
    Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, 720 Rutland Avenue, Ross 459, Baltimore, Maryland 21205, USA
    Clin Vaccine Immunol 13:806-9. 2006
  7. ncbi request reprint Innate immune tissue injury and murine HGA: tissue injury in the murine model of granulocytic anaplasmosis relates to host innate immune response and not pathogen load
    Diana G Scorpio
    Department of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Ann N Y Acad Sci 1063:425-8. 2005
  8. ncbi request reprint Msp2 variation in Anaplasma phagocytophilum in vivo does not stimulate T cell immune responses or interferon-gamma production
    Kyoung Seong Choi
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEMS Immunol Med Microbiol 49:374-86. 2007
  9. pmc CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis
    Diana G Scorpio
    Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Diagn Lab Immunol 11:963-8. 2004
  10. ncbi request reprint Role of reactive nitrogen species in development of hepatic injury in a C57bl/6 mouse model of human granulocytic anaplasmosis
    Michelle D Browning
    Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Comp Med 56:55-62. 2006

Collaborators

Detail Information

Publications20

  1. pmc Restricted changes in major surface protein-2 (msp2) transcription after prolonged in vitro passage of Anaplasma phagocytophilum
    Diana G Scorpio
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    BMC Microbiol 4:1. 2004
    ..Thus, Msp2 profiles and msp2 transcripts of low passage A. phagocytophilum Webster strain, initially comprised of a single abundant msp2 transcript, were re-examined after > or = 20 in vitro passages without immune selection...
  2. pmc Retrospective clinical and molecular analysis of conditioned laboratory dogs (Canis familiaris) with serologic reactions to Ehrlichia canis, Borrelia burgdorferi, and Rickettsia rickettsii
    Diana G Scorpio
    Department of Molecular and Comparative Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Assoc Lab Anim Sci 47:23-8. 2008
    ..Exposure to and potential for infection with these bacteria and other pathogens may contribute to blood and tissue alterations that could confound experiments and lead to misinterpretation of data in canine models...
  3. doi request reprint Cervicovaginal evaluation in macaques used as a model for topical microbicide safety studies
    Diana G Scorpio
    Department of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Med Primatol 37:65-73. 2008
    ..Cervicovaginal evaluation for topical microbicide safety studies requires proper technique, equipment, supplies, and sequence of sample collection...
  4. pmc Sequential analysis of Anaplasma phagocytophilum msp2 transcription in murine and equine models of human granulocytic anaplasmosis
    Diana G Scorpio
    Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Vaccine Immunol 15:418-24. 2008
    ..Alteration in transcription of msp2 has no bearing on clinical disease in horses, suggesting the existence of a separate proinflammatory component differentially expressed with changing in vitro passage...
  5. ncbi request reprint Comparative strain analysis of Anaplasma phagocytophilum infection and clinical outcomes in a canine model of granulocytic anaplasmosis
    Diana G Scorpio
    Department of Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Vector Borne Zoonotic Dis 11:223-9. 2011
    ..Therefore, this strain should be considered for use in future studies of A. phagocytophilum canine infection models...
  6. pmc Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury
    Diana G Scorpio
    Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, 720 Rutland Avenue, Ross 459, Baltimore, Maryland 21205, USA
    Clin Vaccine Immunol 13:806-9. 2006
    ..We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more than A. phagocytophilum itself...
  7. ncbi request reprint Innate immune tissue injury and murine HGA: tissue injury in the murine model of granulocytic anaplasmosis relates to host innate immune response and not pathogen load
    Diana G Scorpio
    Department of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Ann N Y Acad Sci 1063:425-8. 2005
    ..Our hypothesis is that the innate immune response to A. phagocytophilum results in inflammatory histopathology, but does not control the pathogen...
  8. ncbi request reprint Msp2 variation in Anaplasma phagocytophilum in vivo does not stimulate T cell immune responses or interferon-gamma production
    Kyoung Seong Choi
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEMS Immunol Med Microbiol 49:374-86. 2007
    ..Differential A. phagocytophilum Msp2 expression is unrelated to T-cell response and unlikely to induce the cellular immunopathology underlying disease manifestations...
  9. pmc CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis
    Diana G Scorpio
    Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Diagn Lab Immunol 11:963-8. 2004
    ..The results support the hypothesis of bacterial propagation through chemokine induction and confirm that tissue injury is unrelated to A. phagocytophilum tissue load...
  10. ncbi request reprint Role of reactive nitrogen species in development of hepatic injury in a C57bl/6 mouse model of human granulocytic anaplasmosis
    Michelle D Browning
    Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Comp Med 56:55-62. 2006
    ..Therefore, human and animal patients with HGA likely would benefit from therapy targeting reduced inflammation to supplement anti-infective modalities...
  11. pmc Differential innate immune cell activation and proinflammatory response in Anaplasma phagocytophilum infection
    Kyoung Seong Choi
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 624, Baltimore, MD 21205, USA
    Infect Immun 75:3124-30. 2007
    ..This result supports the concept that NK1.1(+) cells, including NK and NKT cells, are major components in the early pathogenesis of A. phagocytophilum infection...
  12. pmc Human granulocytic anaplasmosis and Anaplasma phagocytophilum
    J Stephen Dumler
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Emerg Infect Dis 11:1828-34. 2005
    ..More study is needed to define the immunology and pathogenetic mechanisms and to understand why severe disease develops in some persons and why some animals become long-term permissive reservoir hosts...
  13. ncbi request reprint Anaplasma phagocytophilum ligation to toll-like receptor (TLR) 2, but not to TLR4, activates macrophages for nuclear factor-kappa B nuclear translocation
    Kyoung Seong Choi
    Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 189:1921-5. 2004
    ..NF- kappa B was activated only through TLR2, which suggests its role in innate immune induction with A. phagocytophilum infections. The role of innate immunity in human anaplasmosis immunopathology requires more study...
  14. pmc Refinement of canine pancreatitis model: inducing pancreatitis by using endoscopic retrograde cholangiopancreatography
    Dawn S Ruben
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Comp Med 59:78-82. 2009
    ..This method is presented as a refinement of a canine model and presents an alternative method of inducing pancreatitis, with decreased risk of developing associated clinical signs...
  15. pmc Comparison of side effects between buprenorphine and meloxicam used postoperatively in Dutch belted rabbits (Oryctolagus cuniculus)
    Coreen S Cooper
    Molecular and Comparative Pathobiology, Johns Hopkins University SOM, Baltimore, Maryland, USA
    J Am Assoc Lab Anim Sci 48:279-85. 2009
    ..On the basis of these results, meloxicam appears to be a suitable alternative or adjunct to buprenorphine for alleviating postoperative pain with minimal risk of anorexia and gastrointestinal ileus...
  16. pmc The adult Göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA
    Comp Med 58:568-79. 2008
    ..New heart failure therapies and devices can be tested preclinically in this adult animal model of chronic heart failure...
  17. ncbi request reprint Peroral transgastric endoscopic ligation of fallopian tubes with long-term survival in a porcine model
    Sanjay B Jagannath
    Division of Gastroenterology, Johns Hopkins University School of Medicine, 1830 Monument Street, Baltimore, MD 21205, USA
    Gastrointest Endosc 61:449-53. 2005
    ..We now report successful performance of peroral endoscopic transgastric ligation of Fallopian tubes with long-term survival in a porcine model...
  18. ncbi request reprint Frontline: control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88
    Friederike D von Loewenich
    Institute of Clinical Microbiology, Immunology, and Hygiene, University of Erlangen, Erlangen, Germany
    Eur J Immunol 34:1789-97. 2004
    ..phagocytophilum. From these data we conclude that effector mechanisms that are crucial to the defense against numerous other intracellular pathogens are dispensable for the control of A. phagocytophilum...
  19. ncbi request reprint A case of Sweet syndrome associated with human granulocytic anaplasmosis
    Charles L G Halasz
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Arch Dermatol 141:887-9. 2005
    ..We report a case of SS associated with human granulocytic anaplasmosis (HGA), which is of interest because Anaplasma phagocytophilum infects, multiplies in, and disrupts the function of neutrophils, the key infiltrating cell in SS...
  20. pmc Neorickettsia helminthoeca in dog, Brazil
    Selwyn A Headley
    Emerg Infect Dis 12:1303-4. 2006