Research Topics
| Diana G ScorpioSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
Restricted changes in major surface protein-2 (msp2) transcription after prolonged in vitro passage of Anaplasma phagocytophilumDiana G Scorpio
Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
BMC Microbiol 4:1. 2004..Thus, Msp2 profiles and msp2 transcripts of low passage A. phagocytophilum Webster strain, initially comprised of a single abundant msp2 transcript, were re-examined after > or = 20 in vitro passages without immune selection...- Retrospective clinical and molecular analysis of conditioned laboratory dogs (Canis familiaris) with serologic reactions to Ehrlichia canis, Borrelia burgdorferi, and Rickettsia rickettsiiDiana G Scorpio
Department of Molecular and Comparative Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Am Assoc Lab Anim Sci 47:23-8. 2008..Exposure to and potential for infection with these bacteria and other pathogens may contribute to blood and tissue alterations that could confound experiments and lead to misinterpretation of data in canine models... 
Cervicovaginal evaluation in macaques used as a model for topical microbicide safety studiesDiana G Scorpio
Department of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Med Primatol 37:65-73. 2008..Cervicovaginal evaluation for topical microbicide safety studies requires proper technique, equipment, supplies, and sequence of sample collection...- Sequential analysis of Anaplasma phagocytophilum msp2 transcription in murine and equine models of human granulocytic anaplasmosisDiana G Scorpio
Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Clin Vaccine Immunol 15:418-24. 2008..Alteration in transcription of msp2 has no bearing on clinical disease in horses, suggesting the existence of a separate proinflammatory component differentially expressed with changing in vitro passage... - Comparative strain analysis of Anaplasma phagocytophilum infection and clinical outcomes in a canine model of granulocytic anaplasmosisDiana G Scorpio
Department of Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Vector Borne Zoonotic Dis 11:223-9. 2011..Therefore, this strain should be considered for use in future studies of A. phagocytophilum canine infection models... - Innate immune response to Anaplasma phagocytophilum contributes to hepatic injuryDiana G Scorpio
Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, 720 Rutland Avenue, Ross 459, Baltimore, Maryland 21205, USA
Clin Vaccine Immunol 13:806-9. 2006..We show that despite evasion of these host responses, phox, NOS2, TNF, and MyD88 are activated and contribute to inflammation and hepatic injury more than A. phagocytophilum itself... 
Innate immune tissue injury and murine HGA: tissue injury in the murine model of granulocytic anaplasmosis relates to host innate immune response and not pathogen loadDiana G Scorpio
Department of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Ann N Y Acad Sci 1063:425-8. 2005..Our hypothesis is that the innate immune response to A. phagocytophilum results in inflammatory histopathology, but does not control the pathogen...- Msp2 variation in Anaplasma phagocytophilum in vivo does not stimulate T cell immune responses or interferon-gamma productionKyoung Seong Choi
Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
FEMS Immunol Med Microbiol 49:374-86. 2007..Differential A. phagocytophilum Msp2 expression is unrelated to T-cell response and unlikely to induce the cellular immunopathology underlying disease manifestations... - Role of reactive nitrogen species in development of hepatic injury in a C57bl/6 mouse model of human granulocytic anaplasmosisMichelle D Browning
Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Comp Med 56:55-62. 2006..Therefore, human and animal patients with HGA likely would benefit from therapy targeting reduced inflammation to supplement anti-infective modalities... - Differential innate immune cell activation and proinflammatory response in Anaplasma phagocytophilum infectionKyoung Seong Choi
Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 624, Baltimore, MD 21205, USA
Infect Immun 75:3124-30. 2007..This result supports the concept that NK1.1(+) cells, including NK and NKT cells, are major components in the early pathogenesis of A. phagocytophilum infection... - Human granulocytic anaplasmosis and Anaplasma phagocytophilumJ Stephen Dumler
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Emerg Infect Dis 11:1828-34. 2005..More study is needed to define the immunology and pathogenetic mechanisms and to understand why severe disease develops in some persons and why some animals become long-term permissive reservoir hosts... - CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosisDiana G Scorpio
Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin Diagn Lab Immunol 11:963-8. 2004..The results support the hypothesis of bacterial propagation through chemokine induction and confirm that tissue injury is unrelated to A. phagocytophilum tissue load... - Anaplasma phagocytophilum ligation to toll-like receptor (TLR) 2, but not to TLR4, activates macrophages for nuclear factor-kappa B nuclear translocationKyoung-seong Choi
Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Infect Dis 189:1921-5. 2004..NF- kappa B was activated only through TLR2, which suggests its role in innate immune induction with A. phagocytophilum infections. The role of innate immunity in human anaplasmosis immunopathology requires more study... - Refinement of canine pancreatitis model: inducing pancreatitis by using endoscopic retrograde cholangiopancreatographyDawn S Ruben
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Comp Med 59:78-82. 2009..This method is presented as a refinement of a canine model and presents an alternative method of inducing pancreatitis, with decreased risk of developing associated clinical signs... - Comparison of side effects between buprenorphine and meloxicam used postoperatively in Dutch belted rabbits (Oryctolagus cuniculus)Coreen S Cooper
Molecular and Comparative Pathobiology, Johns Hopkins University SOM, Baltimore, Maryland, USA
J Am Assoc Lab Anim Sci 48:279-85. 2009..On the basis of these results, meloxicam appears to be a suitable alternative or adjunct to buprenorphine for alleviating postoperative pain with minimal risk of anorexia and gastrointestinal ileus... - The adult Göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapiesKarl H Schuleri
Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA
Comp Med 58:568-79. 2008..New heart failure therapies and devices can be tested preclinically in this adult animal model of chronic heart failure... - Peroral transgastric endoscopic ligation of fallopian tubes with long-term survival in a porcine modelSanjay B Jagannath
Division of Gastroenterology, Johns Hopkins University School of Medicine, 1830 Monument Street, Baltimore, MD 21205, USA
Gastrointest Endosc 61:449-53. 2005..The endoscopic transgastric approach to the peritoneal cavity has potential for a wide array of diagnostic and therapeutic procedures... - Frontline: control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88Friederike D von Loewenich
Institute of Clinical Microbiology, Immunology, and Hygiene, University of Erlangen, Erlangen, Germany
Eur J Immunol 34:1789-97. 2004..phagocytophilum. From these data we conclude that effector mechanisms that are crucial to the defense against numerous other intracellular pathogens are dispensable for the control of A. phagocytophilum... - A case of Sweet syndrome associated with human granulocytic anaplasmosisCharles L G Halasz
Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, NY, USA
Arch Dermatol 141:887-9. 2005..CONCLUSION: The significant involvement of neutrophils with both SS and HGA warrants a broader search for additional cases that may further define whether pathogenetic linkages could exist... - Neorickettsia helminthoeca in dog, BrazilSelwyn A Headley
Emerg Infect Dis 12:1303-4. 2006