Kathleen B Schwarz

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Children with Chronic Hepatitis B in the United States and Canada
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, Md Electronic address
    J Pediatr 167:1287-1294.e2. 2015
  2. pmc Metaprotein expression modeling for label-free quantitative proteomics
    Joseph E Lucas
    Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    BMC Bioinformatics 13:74. 2012
  3. doi request reprint Percutaneous liver biopsy in hemophiliac children with chronic hepatitis C virus infection
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pediatr Gastroenterol Nutr 46:423-8. 2008
  4. ncbi request reprint Safety, efficacy and pharmacokinetics of peginterferon alpha2a (40 kd) in children with chronic hepatitis C
    Kathleen B Schwarz
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Pediatr Gastroenterol Nutr 43:499-505. 2006
  5. doi request reprint Seroprevalence of HCV infection in homeless Baltimore families
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins Medical Institutions, Johns Hopkins Children s Center, Baltimore, MD 21287, USA
    J Health Care Poor Underserved 19:580-7. 2008
  6. ncbi request reprint Hepatitis B vaccination rate of homeless children in Baltimore
    K Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, and Baltimore City Health Department, Baltimore, Maryland 21287, USA
    J Pediatr Gastroenterol Nutr 41:225-9. 2005
  7. pmc The combination of ribavirin and peginterferon is superior to peginterferon and placebo for children and adolescents with chronic hepatitis C
    Kathleen B Schwarz
    Department of Pediatrics, Division of Gastroenterology and Nutrition, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 140:450-458.e1. 2011
  8. ncbi request reprint Plasma markers of platelet activation in cystic fibrosis liver and lung disease
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pediatr Gastroenterol Nutr 37:187-91. 2003
  9. ncbi request reprint Pediatric issues in new therapies for hepatitis B and C
    Kathleen B Schwarz
    Department of Pediatric Gastroenterology and Nutrition, Johns Hopkins Children s Center, 600 North Wolfe Street, Brady 320, Baltimore, MD 21287, USA
    Curr Gastroenterol Rep 5:233-9. 2003
  10. pmc Positive impact of a shelter-based hepatitis B vaccine program in homeless Baltimore children and adolescents
    Kathleen Schwarz
    Johns Hopkins University School of Medicine, 600 N Wolfe Street Brady 320, Baltimore, MD 21287, USA
    J Urban Health 85:228-38. 2008

Research Grants

Detail Information

Publications39

  1. doi request reprint Children with Chronic Hepatitis B in the United States and Canada
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, Md Electronic address
    J Pediatr 167:1287-1294.e2. 2015
    ..To test the hypothesis that children with chronic hepatitis B living in the US and Canada would have international origins and characteristic hepatitis B virus (HBV) genotypes and laboratory profiles...
  2. pmc Metaprotein expression modeling for label-free quantitative proteomics
    Joseph E Lucas
    Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    BMC Bioinformatics 13:74. 2012
    ..Additionally, there may be systematic shifts in the sensitivity of the machine between experiments or even through time within the duration of a single experiment...
  3. doi request reprint Percutaneous liver biopsy in hemophiliac children with chronic hepatitis C virus infection
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pediatr Gastroenterol Nutr 46:423-8. 2008
    ..To develop a protocol for safe performance of percutaneous liver biopsies in children with deficiency of factor VIII (n = 12) or IX (n = 2) and chronic hepatitis C virus infection...
  4. ncbi request reprint Safety, efficacy and pharmacokinetics of peginterferon alpha2a (40 kd) in children with chronic hepatitis C
    Kathleen B Schwarz
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Pediatr Gastroenterol Nutr 43:499-505. 2006
    ..In conclusion, our findings provide a basis for larger studies evaluating the efficacy and safety of pegINF-alpha2a as monotherapy as well as in combination with ribavirin in pediatric patients with chronic hepatitis C...
  5. doi request reprint Seroprevalence of HCV infection in homeless Baltimore families
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins Medical Institutions, Johns Hopkins Children s Center, Baltimore, MD 21287, USA
    J Health Care Poor Underserved 19:580-7. 2008
    ..Conclusion. The homeless families were very receptive to our HCV seroprevalence study and are likely also to be receptive to shelter-based HCV prevention programs for young children and adolescents as well as for adults...
  6. ncbi request reprint Hepatitis B vaccination rate of homeless children in Baltimore
    K Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, and Baltimore City Health Department, Baltimore, Maryland 21287, USA
    J Pediatr Gastroenterol Nutr 41:225-9. 2005
    ..To investigate the hepatitis B vaccination rate in homeless children 2 to 18 years old living in Baltimore City...
  7. pmc The combination of ribavirin and peginterferon is superior to peginterferon and placebo for children and adolescents with chronic hepatitis C
    Kathleen B Schwarz
    Department of Pediatrics, Division of Gastroenterology and Nutrition, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 140:450-458.e1. 2011
    ..We conducted a randomized controlled trial of PEG and ribavirin, compared with PEG and placebo, in children 5 to 17 years old with chronic hepatitis C...
  8. ncbi request reprint Plasma markers of platelet activation in cystic fibrosis liver and lung disease
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pediatr Gastroenterol Nutr 37:187-91. 2003
    ....
  9. ncbi request reprint Pediatric issues in new therapies for hepatitis B and C
    Kathleen B Schwarz
    Department of Pediatric Gastroenterology and Nutrition, Johns Hopkins Children s Center, 600 North Wolfe Street, Brady 320, Baltimore, MD 21287, USA
    Curr Gastroenterol Rep 5:233-9. 2003
    ..Given the lack of data regarding treatment of HCV in children, it is generally agreed among pediatric hepatologists that the optimal treatment is within the context of randomized, controlled trials...
  10. pmc Positive impact of a shelter-based hepatitis B vaccine program in homeless Baltimore children and adolescents
    Kathleen Schwarz
    Johns Hopkins University School of Medicine, 600 N Wolfe Street Brady 320, Baltimore, MD 21287, USA
    J Urban Health 85:228-38. 2008
    ..A brief exposure to a culturally appropriate HBV video improves HBV knowledge and may improve return rates for vaccine...
  11. pmc Design of the PEDS-C trial: pegylated interferon +/- ribavirin for children with chronic hepatitis C viral infection
    Karen F Murray
    Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Washington, Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
    Clin Trials 4:661-73. 2007
    ..Establishment of the research team, protocol, administrative infrastructure, and ancillary contributors for the pediatric trial took years of planning...
  12. ncbi request reprint Modulation of the IL-12/IFN-gamma axis by IFN-alpha therapy for hepatitis C
    Adriana A Byrnes
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Leukoc Biol 81:825-34. 2007
    ..No differences in pretreatment IL-12 productive capacity were seen between patient groups. However, therapy with IFN-alpha led to suppression of inducible IL-12 production throughout the course of therapy in both groups of patients...
  13. doi request reprint Recommendations for screening, monitoring, and referral of pediatric chronic hepatitis B
    Barbara A Haber
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:e1007-13. 2009
    ....
  14. pmc Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado Denver School of Medicine and The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 51:183-6. 2010
    ..Our purpose is to describe the ophthalmologic complications of pegylated interferon-alpha2a with either placebo or ribavirin in children with chronic HCV (the PEDS-C trial)...
  15. doi request reprint Children Treated With Pegylated Interferon alfa-2a ± Ribavirin for Chronic Hepatitis C
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD Department of Pediatrics, Indiana University School of Medicine, Indianapolis Department of Medicine, Boston Children s Hospital, Boston, MA Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia Department of Pediatrics, Seattle Children s Hospital, Seattle, WA Department of Pediatrics, University of California, San Francisco, San Francisco Department of Pediatrics, University of Florida College of Medicine, Gainesville Department of Pediatrics, Columbia University Medical Center, New York, NY Roche Products Limited, Welwyn Garden City, UK Clinical Trials and Surveys Corporation, Owings Mills, MD
    J Pediatr Gastroenterol Nutr 62:93-6. 2016
    ....
  16. pmc High prevalence of overweight and obesity in homeless Baltimore children and their caregivers: a pilot study
    Kathleen B Schwarz
    Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    MedGenMed 9:48. 2007
    ..Because obesity is currently a major public health issue in the United States, it is possible that obesity has supplanted nutritional deficiencies as the "new malnutrition" of the homeless...
  17. ncbi request reprint An analysis of published trials of interferon monotherapy in children with chronic hepatitis C
    Karen R Jacobson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pediatr Gastroenterol Nutr 34:52-8. 2002
    ....
  18. pmc Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study
    Kathleen B Schwarz
    Johns Hopkins Medical Institutions, Baltimore, MD
    Hepatology 58:1724-31. 2013
    ..Group 2 subjects also frequently displayed cardiovascular (71%) and gastrointestinal (24%) anomalies; interestingly, this group had genitourinary anomalies more frequently (47%) compared to Group 3 subjects (10%)...
  19. pmc Recruitment and retention strategies in a clinical trial for children with chronic hepatitis C infection
    Aparna Roy
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Pediatr Nurs 28:243-8. 2013
    ..The overall retention rate was 84% at 2 years. Lessons learned will be valuable in designing future pediatric trials...
  20. pmc Growth failure and outcomes in infants with biliary atresia: a report from the Biliary Atresia Research Consortium
    Patricia A DeRusso
    Johns Hopkins School of Medicine and The Johns Hopkins Children s Center, Baltimore, Maryland, USA
    Hepatology 46:1632-8. 2007
    ..The combination of intermediate bilirubin concentrations and poor mean weight z-scores 3 months after HPE was also associated with poor clinical outcome...
  21. ncbi request reprint Primary liver carcinoma arising in people younger than 30 years
    Walter M Klein
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Clin Pathol 124:512-8. 2005
    ..HCCs are the most common primary liver carcinoma in children and young adults followed by FLCs. They are morphologically similar to adult HCC, but more likely to be CK7(+)...
  22. ncbi request reprint Long-term complete remission and immune tolerance after intensive chemotherapy for lymphoproliferative disorders complicating liver transplant
    W Leung
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Transplantation 67:1487-9. 1999
    ..B cell lymphoproliferative disorders (LPD) and liver rejection are major lethal complications after hepatic transplantation. Reduction in immunosuppression is the treatment for the former, but is a risk factor for the latter...
  23. doi request reprint Rotavirus Infects Human Biliary Epithelial Cells and Stimulates Secretion of Cytokines IL-6 and IL-8 via MAPK Pathway
    Maria Grazia Clemente
    Pediatric Liver Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Pediatric Clinic, Department of Surgery, Microsurgery and Medical Sciences, University of Sassari, 07100 Sassari, Italy
    Biomed Res Int 2015:697238. 2015
    ..RRV can infect human cholangiocytes resulting in the production of proinflammatory and profibrotic cytokines via the MAPK pathway. RRV-infected H69 cells could be a useful model system for investigating the viral hypothesis of BA...
  24. ncbi request reprint Viral hepatitis
    Kathleen B Schwarz
    The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pediatr Gastroenterol Nutr 35:S29-32. 2002
  25. doi request reprint New-onset autoimmune hepatitis in young patients with preexisting liver disease
    Aglaia Zellos
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Dig Liver Dis 42:657-60. 2010
    ..The occurrence of AIH in these patients may be due to a complex interaction between the underlying liver disease, chronic medication use and genetic predisposition resulting in altered immunoregulatory mechanisms...
  26. doi request reprint Outcome after percutaneous endoscopic gastrostomy in children and young adults
    John E Fortunato
    Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pediatr Gastroenterol Nutr 50:390-3. 2010
    ..We hypothesized that definable preoperative clinical factors predict the need for further intervention to provide enteral access after PEG. Our aim was to identify factors associated with PEG outcome...
  27. pmc The use of Yes-associated protein expression in the diagnosis of persistent neonatal cholestatic liver disease
    Grzegorz T Gurda
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287
    Hum Pathol 45:1057-64. 2014
    ..In summary, we show that YAP expression modulates both bile duct proliferation and liver damage/fibrosis while acting as a sensitive and specific marker in the differential diagnosis of persistent neonatal cholestasis. ..
  28. ncbi request reprint Epidemiology of primary hepatic malignancies in U.S. children
    Anil Darbari
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hepatology 38:560-6. 2003
    ..Hepatocellular carcinoma has worse survival rates than hepatoblastoma, and its incidence has not increased. Better maintenance of databases may provide information about associated factors behind this unexpected occurrence...
  29. doi request reprint Analysis of viral testing in nonacetaminophen pediatric acute liver failure
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, Division of Gastroenterology and Nutrition, Charlotte R Bloomberg Johns Hopkins Children s Center, Baltimore, MD Liver Unit, Birmingham Children s Hospital, Birmingham, UK Department of Pediatrics, Columbia University School of Medicine, Division of Gastroenterology, New York, NY Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, Division of Pediatric Gastroenterology, Ann Arbor Department of Pediatrics, University of Texas Southwestern Medical Center, Division of Gastroenterology, Dallas Department of Pediatrics, University of Cincinnati College of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH Department of Epidemiology Department of Pediatrics, University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA
    J Pediatr Gastroenterol Nutr 59:616-23. 2014
    ..Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large-scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants...
  30. doi request reprint Prevalence of groups A and C rotavirus antibodies in infants with biliary atresia and cholestatic controls
    Maria Grazia Clemente
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD
    J Pediatr 166:79-84. 2015
    ..To analyze the prevalence of acute asymptomatic group A and C rotavirus (RV-A and RV-C) infection in neonates with cholestasis...
  31. ncbi request reprint Immunopathogenesis of chronic hepatitis C virus infection
    Ding You Li
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Pediatr Gastroenterol Nutr 35:260-7. 2002
  32. ncbi request reprint Fractures in biliary atresia misinterpreted as child abuse
    Patricia A DeRusso
    Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Pediatrics 112:185-8. 2003
    ..Pediatricians should be aware of an increased incidence of fractures and overall prevalence of bone disease in this population...
  33. ncbi request reprint Autoimmune hepatitis
    Ding You Li
    Department of Pediatrics, Children s Mercy Hospital and University of Missouri, Kansas City School of Medicine, 64108, USA
    Adolesc Med Clin 15:131-43, x. 2004
    ....
  34. doi request reprint Alagille syndrome and liver transplantation
    Binita M Kamath
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 50:11-5. 2010
    ....
  35. pmc Cross-sectional analysis of health-related quality of life in pediatric liver transplant recipients
    Estella M Alonso
    Department of Pediatrics, Children s Memorial Hospital, 2300 Children s Plaza, Box 65, Chicago, IL 60614, USA
    J Pediatr 156:270-6.e1. 2010
    ..To investigate the distribution of health-related quality of life in pediatric liver transplant recipients compared with a normative population...
  36. ncbi request reprint Clinical trial of lamivudine in children with chronic hepatitis B
    Maureen M Jonas
    of Gastroenterology, Children s Hospital, Boston, MA 02115, USA
    N Engl J Med 346:1706-13. 2002
    ..Lamivudine therapy is effective for chronic hepatitis B infection in adults. We evaluated the efficacy and tolerability of lamivudine as a treatment for chronic infection with hepatitis B virus (HBV) in children...
  37. pmc Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C Trial
    Zachary D Goodman
    Armed Forces Institute of Pathology and Veterans Administration Special Reference Laboratory for Pathology, Washington, DC, USA
    Hepatology 47:836-43. 2008
    ....
  38. ncbi request reprint Long-term lamivudine therapy for children with HBeAg-positive chronic hepatitis B
    Etienne M Sokal
    Departement de Pediatrie, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Hepatology 43:225-32. 2006
    ..However, the incidence of YMMD mutations increased over time and resulted in lower response rates. VR was maintained in most patients who had initially responded to lamivudine in the first 12 months...
  39. ncbi request reprint Treatment options for chronic hepatitis B and C infection in children
    Winita Hardikar
    Royal Children s Hospital, Department of Gastroenterology and Nutrition, Melbourne, Australia
    Expert Rev Anti Infect Ther 4:583-91. 2006
    ..By contrast, treatment indication for CHC in children remains controversial. If used, combination therapy with pegylated interferon and ribavirin is likely to produce the highest rates of sustained viral response...

Research Grants2

  1. VIRAL HEPATITIS IN CHILDREN OF INJECTION DRUG USERS
    Kathleen Schwarz; Fiscal Year: 2003
    ....
  2. Pegylated Interferon +/- Ribavirin for Children with HCV
    Kathleen Schwarz; Fiscal Year: 2008
    ..Other endpoints include biochemical and clinical safety assessments. This trial would thus provide critically needed data to guide safe and effective treatment of CHC, a major cause of liver disease in children [unreadable] [unreadable]..