Steven P Schulman
Affiliation: Johns Hopkins University
- Effects of acute hormone therapy on recurrent ischemia in postmenopausal women with unstable anginaSteven P Schulman
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Am Coll Cardiol 39:231-7. 2002..We tested whether acute hormone therapy reduces ambulatory electrocardiographic ischemia in postmenopausal (PMP) women with unstable angina (UA)...
- L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trialSteven P Schulman
Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, USA
JAMA 295:58-64. 2006..The amino acid L-arginine is a substrate for nitric oxide synthase and is increasingly used as a health supplement. Prior studies suggest that L-arginine has the potential to reduce vascular stiffness...
- Abnormalities in arterial-ventricular coupling in older healthy persons are attenuated by sodium nitroprussidePaul D Chantler
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Am J Physiol Heart Circ Physiol 300:H1914-22. 2011..This is relevant to common conditions in older subjects associated with a significant impairment of exercise performance such as frailty or heart failure with preserved ejection fraction...
- Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial loadPaul D Chantler
Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21225, USA
Am J Physiol Heart Circ Physiol 302:H349-58. 2012..These findings provide interesting insights into the dynamic cardiovascular alterations during exercise...
- The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercisePaul D Chantler
Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21225, USA
Am J Physiol Heart Circ Physiol 295:H145-53. 2008..Whether a smaller E(a)I/E(LV)I reserve leads to functional limitations warrants further examination...
- Response to catecholamine stimulation of polymorphisms of the beta-1 and beta-2 adrenergic receptorsRhondalyn C McLean
Division of Cardiology, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
Am J Cardiol 110:1001-7. 2012..In conclusion, β-receptor gene variants significantly influence inotropic and chronotropic responses to β-agonist exposure in patients on β-blocker therapy...
- Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy studyPaul A Bottomley
Division of MR Research, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Circulation 119:1918-24. 2009..CK flux is defined as the product of [PCr] and k. CK flux and k have never been measured in human MI...
- Antiplatelet therapy in non-ST-segment elevation acute coronary syndromesSteven P Schulman
Coronary Care Unit, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
JAMA 292:1875-82. 2004..Recognition that there is a great deal of interpatient variability in response to these antiplatelet therapies highlights the need for future research in this area...
- Neurohumoral features of myocardial stunning due to sudden emotional stressIlan S Wittstein
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
N Engl J Med 352:539-48. 2005..Reversible left ventricular dysfunction precipitated by emotional stress has been reported, but the mechanism remains unknown...
- Effects of aspirin responsiveness and platelet reactivity on early vein graft thrombosis after coronary artery bypass graft surgeryTyler J Gluckman
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Am Coll Cardiol 57:1069-77. 2011..The purpose of this study was to determine if an incomplete response to or inadequate antiplatelet effect of aspirin, or both, contribute to saphenous vein graft (SVG) occlusion after coronary artery bypass graft (CABG) surgery...
- Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromesNauder Faraday
Division of Cardiac Surgical Intensive Care, Department of Anesthesiology adn Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Platelets 15:9-14. 2004..84, P < 0.05). TRAP induced platelet-neutrophil conjugate formation is related to in vivo ischemic risk in ACS patients...
- Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardiumCraig S Smith
Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Baltimore, MD 21287 6568, USA
Circulation 114:1151-8. 2006..The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery...
- A simplified approach to the management of non-ST-segment elevation acute coronary syndromesTy J Gluckman
Division of Cardiology, The Johns Hopkins Hospital, Baltimore, MD, USA
JAMA 293:349-57. 2005..While current practice guidelines provide an evidence-based approach to management of acute coronary syndromes (ACS), application of the evidence by individual physicians has been suboptimal...
- Effect of short-term estrogen with and without progesterone therapy on circulating markers of endothelial activation and injury in postmenopausal women with unstable angina pectorisEric T Chou
Division of Cardiology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Am J Cardiol 91:1240-2. 2003
- Effects of a pharmacologically-induced shift of hemoglobin-oxygen dissociation on myocardial energetics during ischemia in patients with coronary artery diseaseSamer S Najjar
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
J Cardiovasc Magn Reson 7:657-66. 2005..We evaluated whether exercise-induced myocardial ischemia can be alleviated in subjects with coronary artery disease (CAD) by enhancing oxygen release with an allosteric modifier of hemoglobin's affinity for oxygen (RSR13)...
- Polymorphisms of the beta adrenergic receptor predict left ventricular remodeling following acute myocardial infarctionRhondalyn C McLean
Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Cardiovasc Drugs Ther 25:251-8. 2011..This study was undertaken to explore the relationship between LV remodeling after myocardial infarction and polymorphisms in the cardiac β1-AR and β2-AR genes...
- Pathogenesis and early management of non-ST-segment elevation acute coronary syndromesTomas H Ayala
Division of Cardiology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
Cardiol Clin 24:19-35. 2006....
- Incidence of antiplatelet factor 4/heparin antibody induction in patients undergoing percutaneous coronary revascularizationTyler J Gluckman
Department of Medicine Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Am J Cardiol 95:744-7. 2005..Correlations were then made across antibody induction, heparin exposure, and clinical outcome at 6 months...
- Age and gender affect ventricular-vascular coupling during aerobic exerciseSamer S Najjar
Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
J Am Coll Cardiol 44:611-7. 2004....
- Postoperative ventricular function and cardiac enzymes after on-pump versus off-pump CABG surgeryPatricia P Chang
Department of From the Departments of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 89:1107-10. 2002
- Age-related vascular stiffness and left ventricular size after myocardial infarctionGlenn A Hirsch
Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Geriatr Cardiol 16:222-8. 2007..02) were significant predictors of end-systolic volume index. Older patients have increased LV size after MI compared with younger patients, possibly related to age-related decreases in aortic distensibility affecting LV remodeling...
- Troponin-I elevation in a young man with arrhythmogenic right ventricular dysplasia/cardiomyopathyWilliam J Kostis
Department of Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Interv Card Electrophysiol 22:49-53. 2008..The patient was successfully treated with radiofrequency ablation. This case illustrates that ARVD/C may result in elevated cardiac enzymes in the absence of coronary artery disease...
- Intensive care after resuscitation from cardiac arrest: a focus on heart and brain injurySteven P Schulman
Department of Medicine Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neurol Clin 24:41-59, vi. 2006..This article addresses the acute care, with emphasis on the cardiac and neurologic aspects,that patients who have post cardiac arrest are provided in the cardiac ICU...
- Images in cardiovascular medicine. ST-segment elevation in an unresponsive patientGlenn A Hirsch
Division of Cardiology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA
Circulation 108:e165-6. 2003
- Familial hypertrophic cardiomyopathy associated with cardiac beta-myosin heavy chain and troponin I mutationsAisha Frazier
Department of Pediatrics, Cardiology Division, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
Pediatr Cardiol 29:846-50. 2008....
- Interaction of hemostatic genetics with hormone therapy: new insights to explain arterial thrombosis in postmenopausal womenJoel B Braunstein
The Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Divsion of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Chest 121:906-20. 2002..Genetic profiling has great potential to improve the safety and efficacy of individualized pharmacotherapy in postmenopausal women and other at-risk populations for the prevention of cardiovascular disease...
- Cardiac Stem Cell Therapy. Need for Optimization of Efficacy and Safety MonitoringPeter Oettgen
Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Circulation 114:353-8. 2006
- Race, medical researcher distrust, perceived harm, and willingness to participate in cardiovascular prevention trialsJoel B Braunstein
Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, Connecticut, USA
Medicine (Baltimore) 87:1-9. 2008..These factors, in turn, appear to explain much of the resistance among African American persons to participate in clinical trials compared to white persons...
- The value of clopidogrel administered postoperatively following a non-ST-segment elevation acute coronary syndromeTy J Gluckman
Chest 127:2297. 2005
- A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation in patients with systolic heart failure: rationale, design, and baseline patient characteristicsWilliam T Abraham
The Ohio State University Heart Center, Division of Cardiovascular Medicine, Columbus, OH 43210 1252, USA
Am Heart J 156:641-648.e1. 2008..Baseline characteristics for patients randomized in this trial are also presented...