Karl H Schuleri

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc The adult Göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA
    Comp Med 58:568-79. 2008
  2. pmc CT for evaluation of myocardial cell therapy in heart failure: a comparison with CMR imaging
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
    JACC Cardiovasc Imaging 4:1284-93. 2011
  3. pmc Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice
    Roberto M Saraiva
    Cardiology Division, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Nitric Oxide 16:331-8. 2007
  4. ncbi request reprint Multimodality noninvasive imaging demonstrates in vivo cardiac regeneration after mesenchymal stem cell therapy
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 48:2116-24. 2006
  5. doi request reprint Prospective electrocardiogram-gated delayed enhanced multidetector computed tomography accurately quantifies infarct size and reduces radiation exposure
    Hyuk Jae Chang
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JACC Cardiovasc Imaging 2:412-20. 2009
  6. doi request reprint Early improvement in cardiac tissue perfusion due to mesenchymal stem cells
    Karl H Schuleri
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 294:H2002-11. 2008
  7. doi request reprint Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve
    Mehnaz Khan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Medicine, Tower 711, 600 N Wolfe St, Baltimore, MD 21287, USA
    Eur J Appl Physiol 112:2933-41. 2012
  8. ncbi request reprint [Stem cell therapy for myocardial regeneration: mechanisms and current clinical applications]
    Marco Centola
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    G Ital Cardiol (Rome) 9:234-50. 2008
  9. pmc Characterization of peri-infarct zone heterogeneity by contrast-enhanced multidetector computed tomography: a comparison with magnetic resonance imaging
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Coll Cardiol 53:1699-707. 2009
  10. pmc Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar
    Albert C Lardo
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circulation 113:394-404. 2006

Collaborators

Detail Information

Publications25

  1. pmc The adult Göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA
    Comp Med 58:568-79. 2008
    ..New heart failure therapies and devices can be tested preclinically in this adult animal model of chronic heart failure...
  2. pmc CT for evaluation of myocardial cell therapy in heart failure: a comparison with CMR imaging
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
    JACC Cardiovasc Imaging 4:1284-93. 2011
    ..The aim of this study was to use multidetector computed tomography (MDCT) to assess therapeutic effects of myocardial regenerative cell therapies...
  3. pmc Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice
    Roberto M Saraiva
    Cardiology Division, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Nitric Oxide 16:331-8. 2007
    ..These data offer novel insights into potential mechanisms of myocardial dysfunction in obesity...
  4. ncbi request reprint Multimodality noninvasive imaging demonstrates in vivo cardiac regeneration after mesenchymal stem cell therapy
    Luciano C Amado
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 48:2116-24. 2006
    ..The purpose of this study was to test the hypothesis, with noninvasive multimodality imaging, that allogeneic mesenchymal stem cells (MSCs) produce and/or stimulate active cardiac regeneration in vivo after myocardial infarction (MI)...
  5. doi request reprint Prospective electrocardiogram-gated delayed enhanced multidetector computed tomography accurately quantifies infarct size and reduces radiation exposure
    Hyuk Jae Chang
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JACC Cardiovasc Imaging 2:412-20. 2009
    ....
  6. doi request reprint Early improvement in cardiac tissue perfusion due to mesenchymal stem cells
    Karl H Schuleri
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 294:H2002-11. 2008
    ..Cardiac MRI-based measures of blood flow may be a useful tool to predict a successful myocardial regenerative process after MSC treatment...
  7. doi request reprint Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve
    Mehnaz Khan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Medicine, Tower 711, 600 N Wolfe St, Baltimore, MD 21287, USA
    Eur J Appl Physiol 112:2933-41. 2012
    ..4,014 ± 314 RFU/min/mg protein, p = 0.005). Arg-II upregulation in aging rat hearts contributes to age-related decreased contractile function...
  8. ncbi request reprint [Stem cell therapy for myocardial regeneration: mechanisms and current clinical applications]
    Marco Centola
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    G Ital Cardiol (Rome) 9:234-50. 2008
    ....
  9. pmc Characterization of peri-infarct zone heterogeneity by contrast-enhanced multidetector computed tomography: a comparison with magnetic resonance imaging
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Coll Cardiol 53:1699-707. 2009
    ..This study examined whether multidetector computed tomography (MDCT) improves the ability to define peri-infarct zone (PIZ) heterogeneity relative to magnetic resonance imaging (MRI)...
  10. pmc Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar
    Albert C Lardo
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circulation 113:394-404. 2006
    ....
  11. ncbi request reprint Aging impairs the beneficial effect of granulocyte colony-stimulating factor and stem cell factor on post-myocardial infarction remodeling
    Stephanie Lehrke
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 99:553-60. 2006
    ....
  12. pmc Cardiovascular magnetic resonance characterization of peri-infarct zone remodeling following myocardial infarction
    Karl H Schuleri
    Johns Hopkins School of Medicine, Division of Cardiology, 1042 Ross Building, Baltimore, MD 21205, USA
    J Cardiovasc Magn Reson 14:24. 2012
    ..However, CMR data assessing the temporal formation and functional remodeling characteristics of this complex region are limited. We intended to characterize early temporal changes in scar morphology and regional function in the PIZ...
  13. ncbi request reprint Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy
    Khalid M Minhas
    Cardiology Division, Department of Medicine, Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21212, USA
    Circ Res 98:271-9. 2006
    ....
  14. pmc Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy
    Karl H Schuleri
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Eur Heart J 30:2722-32. 2009
    ..Here we tested the hypothesis that autologous MSCs can be safely injected into a chronic myocardial infarct scar, reduce its size, and improve ventricular function...
  15. doi request reprint Quantitative automated assessment of myocardial perfusion at cardiac catheterization
    Andrew J Boyle
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 102:980-7. 2008
    ..Further studies to assess the prognostic value of this technique are warranted...
  16. doi request reprint Integration of infarct size, tissue perfusion, and metabolism by hybrid cardiac positron emission tomography/computed tomography: evaluation in a porcine model of myocardial infarction
    Riikka Lautamaki
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21210, USA
    Circ Cardiovasc Imaging 2:299-305. 2009
    ..We used this technique to obtain biomorphological insights into the interrelation between tissue damage, inflammation, and microvascular obstruction early after myocardial infarction...
  17. doi request reprint Applications of cardiac multidetector CT beyond coronary angiography
    Karl H Schuleri
    Department of Medicine, Division of Cardiology, Johns Hopkins University Baltimore, MD 21205, USA
    Nat Rev Cardiol 6:699-710. 2009
    ..In this Review, we discuss recent technical developments in cardiac MDCT and outline newly enabled noncoronary cardiac applications including viability assessment, myocardial perfusion and molecular imaging...
  18. doi request reprint A new method for cardiac computed tomography regional function assessment: stretch quantifier for endocardial engraved zones (SQUEEZ)
    Amir Pourmorteza
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Cardiovasc Imaging 5:243-50. 2012
    ..We developed a method to detect and track such features on the endocardium to extract a metric that reflects local myocardial contraction...
  19. doi request reprint Recent developments in wide-detector cardiac computed tomography
    Sang Il Choi
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave 1042 Ross Building, Baltimore, MD 21205, USA
    Int J Cardiovasc Imaging 25:23-9. 2009
    ..We will also review examples of wide detector coronary angiography imaging and discuss emerging complementary non-coronary applications that have been enabled by wide-detector MDCT imaging...
  20. doi request reprint CT-based myocardial perfusion imaging-practical considerations: acquisition, image analysis, interpretation, and challenges
    Vishal C Mehra
    Department of Medicine, Division of Cardiology, Johns Hopkins University, 600 N Wolfe Street, Carnegie Building 565C, Baltimore, MD 21287, USA
    J Cardiovasc Transl Res 4:437-48. 2011
    ....
  21. pmc Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity
    Shubha V Y Raju
    Division of Cardiology and Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:4222-7. 2006
    ....
  22. pmc Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism
    Jochen Steppan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 103:4759-64. 2006
    ..These findings have implications for therapy in pathophysiologic states such as aging and heart failure in which myocardial NO signaling is disrupted...
  23. pmc Molecular hybrid positron emission tomography/computed tomography imaging of cardiac angiotensin II type 1 receptors
    Kenji Fukushima
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Coll Cardiol 60:2527-34. 2012
    ..The goal of this study was to explore the feasibility of targeted imaging of the angiotensin II type 1 receptor (AT1R) in cardiac tissue, using clinical hybrid positron emission tomography/computed tomography (PET/CT)...
  24. pmc Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction
    Luciano C Amado
    Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, Blalock 618, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:11474-9. 2005
    ....
  25. ncbi request reprint Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibrium
    Roberto M Saraiva
    Cardiology Division, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Circulation 112:3415-22. 2005
    ..Counter to this idea, we tested the hypothesis that NOS1 has a protective effect after MI...