Research Topics
Genomes and Genes | John T SchroederSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Human basophils secrete IL-3: evidence of autocrine priming for phenotypic and functional responses in allergic diseaseJohn T Schroeder
Department of Medicine, Division of Allergy and Clinical Immunology at Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224, USA
J Immunol 182:2432-8. 2009....
Toll-like receptor 9 suppression in plasmacytoid dendritic cells after IgE-dependent activation is mediated by autocrine TNF-alphaJohn T Schroeder
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224, USA
J Allergy Clin Immunol 121:486-91. 2008..This mode of activation, however, reduces Toll-like receptor 9 (TLR9) expression in pDCs and their ability to mount an IFN-alpha response when subsequently activated with oligodeoxynucleotide containing CpG...
Basophils: emerging roles in the pathogenesis of allergic diseaseJohn T Schroeder
Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Immunol Rev 242:144-60. 2011..If confirmed and translated to humans, these provocative findings will give new meaning to the role basophils have in allergic disease, and in immunology overall...- Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralizationJohn T Schroeder
Division of Allergy and Clinical Immunology at the Johns Hopkins Asthma and Allergy Center, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Allergy Clin Immunol 125:896-901.e6. 2010.... - Pulmonary allergic responses augment interleukin-13 secretion by circulating basophils yet suppress interferon-alpha from plasmacytoid dendritic cellsJ T Schroeder
The Department of Medicine, Divisions of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Clin Exp Allergy 40:745-54. 2010..IFN-alpha secreted predominantly by plasmacytoid dendritic cells (pDCs), suppresses basophil priming for IL-13 production in vitro... - TLR9- and FcepsilonRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expressionJohn T Schroeder
Department of Medicine, Division of Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224, USA
J Immunol 175:5724-31. 2005.... - SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lungLi Zhang
Division of Allergy and Clinical Immunology, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Immunol 184:1180-90. 2010..These findings demonstrate that SHP-1 is a critical regulator of mast cell development and function and that SHP-1-deficient mast cells are able to produce increased Th2 cytokines and initiate allergic inflammatory responses in the lung... - Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cellsTrong Le
Department of Pediatrics, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Allergy Clin Immunol 123:217-23. 2009..Immature human blood monocytoid dendritic cells (mDCs) express high-affinity receptors for IgE (Fc epsilon RI), yet their exact function and regulation remain poorly understood... - IFN-alpha inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine releaseYi-Hsing Chen
The Johns Hopkins Asthma and Allergy Center, Department of Medicine, Division of Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA
J Allergy Clin Immunol 112:944-50. 2003..CONCLUSIONS: These results support the belief that early innate immune responses resulting in IFN-alpha production negatively regulate allergic responses by also inhibiting priming of basophil cytokine release... - Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretionAnja P Bieneman
Johns Hopkins Asthma and Allergy Center, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Allergy Clin Immunol 115:295-301. 2005.... - Cellular immune response parameters that influence IgE sensitizationPamela A Frischmeyer-Guerrerio
The Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins Children s Hospital, Johns Hopkins University, USA
J Immunol Methods 383:21-9. 2012.... - The safety and efficacy of sublingual and oral immunotherapy for milk allergyCorinne A Keet
Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 129:448-55, 455.e1-5. 2012..Oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) are potential therapies for food allergy, but the optimal method of administration, mechanism of action, and duration of response remain unknown... - Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodelingTao Zheng
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Invest Dermatol 129:742-51. 2009..IL-13 is a potent stimulator of dermal inflammation and remodeling and this transgenic model of AD is a good tool for investigating the underlying mechanisms in the pathogenesis of AD... - Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil modelsJacqueline M Langdon
The John Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Leukoc Biol 84:1151-8. 2008..Mast cells and basophils derived from CD34+ precursor cells represent suitable models for transfection studies. Reducing SHIP-1 protein in cultured mast cells and in cultured basophils increases releasability of the cells... - Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lungSun Young Oh
Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Allergy Clin Immunol 119:123-31. 2007..We hypothesized that SHIP-1 plays an important role as a regulator in pulmonary allergic inflammation and in maintaining lung homeostasis... - Expression of activation markers on basophils in a controlled model of anaphylaxisLaura M Gober
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Allergy Clin Immunol 119:1181-8. 2007..Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined in vivo in anaphylaxis... - Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitisPeter S Creticos
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, USA
N Engl J Med 355:1445-55. 2006..Conjugating immunostimulatory sequences of DNA to specific allergens offers a new approach to allergen immunotherapy that reduces acute allergic responses... - Human IgE+ and IgE- are not equivalent to mouse highly cytokinergic IgELiping Xie
Johns Hopkins Asthma and Allergy Center at Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 121:1027-33. 2008..Recently, there have been reports of monomeric highly cytokinergic IgEs causing mediator release, cytokine release, and phosphorylation events in cultured rodent and human mast cells in the absence of antigen... - Basophils beyond effector cells of allergic inflammationJohn T Schroeder
The Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
Adv Immunol 101:123-61. 2009..This novel concept combined with the fact that basophils selectively infiltrate allergic lesion sites has sparked greater interest in this once overlooked immune cell, both in adaptive as well as in innate immunity... - Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitorDonald MacGlashan
Johns Hopkins University, Asthma and Allergy Center, Baltimore, MD 21224, USA
Int Immunopharmacol 11:475-9. 2011..These results suggest that btk is specifically required for IgE-mediated activation of human basophils... - Allergic agonists in apheresis platelet products are associated with allergic transfusion reactionsWilliam J Savage
Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Transfusion 52:575-81. 2012..To assess product factors associated with ATRs, we investigated candidate mediators in apheresis platelet (PLT) products associated with ATRs and controls... - Selective expression of nuclear factor of activated T cells 2/c1 in human basophils: evidence for involvement in IgE-mediated IL-4 generationJohn T Schroeder
Johns Hopkins Asthma and Allergy Center, Division of Clinical Immunology, Baltimore, MD 21224, USA
J Allergy Clin Immunol 109:507-13. 2002..The nuclear factor of activated T cells (NFAT) family of transcription factors plays a key role in rapidly inducing IL4 gene expression in effector T cells... - Basophils in airway diseaseDonald MacGlashan
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Curr Allergy Asthma Rep 2:126-32. 2002..Coupled with new insights into cytokine secretion from these cells, a more accurate picture of the dynamics of this specialized form of inflammation is available for refining our hypotheses regarding its regulation... - New approaches in immunotherapy: allergen vaccination with immunostimulatory DNAPeter Socrates Creticos
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, 5501 Hopkins Bayview Circle, Room 2B, 71, Baltimore, MD 21224, USA
Immunol Allergy Clin North Am 24:569-81, v. 2004..This article addresses a specific adjuvant approach to immunotherapy in which highly active immunostimulatory phosphorothioate oligodeoxyribonucleotide moieties are linked to the principal allergenic moiety of a relevant aeroallergen... - Histone deacetylation inhibits IL4 gene expression in T cellsMaryam Valapour
Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Allergy Clin Immunol 109:238-45. 2002..In addition, alterations in chromatin structure are thought to play a role in regulating the expression of cytokines in the T(H)2 gene cluster, although the biochemical basis for these alterations in human T cells is not well understood... - Bacterial c-di-GMP is an immunostimulatory moleculeDavid K R Karaolis
Intragenics Research Institute, Havre de Grace, MD 21078, USA
J Immunol 178:2171-81. 2007..c-di-GMP is stable in human serum. We propose that cyclic dinucleotides like c-di-GMP can be used clinically in humans and animals as an immunomodulator, immune enhancer, immunotherapeutic, immunoprophylactic, or vaccine adjuvant...
Research Grants
- Differential Cytokine Secretion by Human BasophilsJohn Schroeder; Fiscal Year: 2007..Thus, these differential effects on basophil IL-4 and IL-13, mediated through TLR, may also help in delineating the mechanisms regulating cytokine production. ..