David Schretlen

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Frequency and bases of abnormal performance by healthy adults on neuropsychological testing
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, USA
    J Int Neuropsychol Soc 14:436-45. 2008
  2. ncbi request reprint Examining the range of normal intraindividual variability in neuropsychological test performance
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 9:864-70. 2003
  3. ncbi request reprint Demographic, clinical, and neurocognitive correlates of everyday functional impairment in severe mental illness
    D Schretlen
    Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Abnorm Psychol 109:134-8. 2000
  4. ncbi request reprint Behavioral aspects of Lesch-Nyhan disease and its variants
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
    Dev Med Child Neurol 47:673-7. 2005
  5. ncbi request reprint The use of word-reading to estimate "premorbid" ability in cognitive domains other than intelligence
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Int Neuropsychol Soc 11:784-7. 2005
  6. pmc Neuropsychological functioning in bipolar disorder and schizophrenia
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, and Olin Neuropsychiatric Research Center, Hartford Hospital Institute of Living, CT, USA
    Biol Psychiatry 62:179-86. 2007
  7. ncbi request reprint Serum uric acid and cognitive function in community-dwelling older adults
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
    Neuropsychology 21:136-40. 2007
  8. ncbi request reprint Serum uric acid and brain ischemia in normal elderly adults
    D J Schretlen
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 69:1418-23. 2007
  9. doi request reprint Development, psychometric properties, and validity of the hopkins adult reading test (HART)
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, 600 N Wolfe St, Meyer 218, Baltimore, Maryland 21287 7218, USA
    Clin Neuropsychol 23:926-43. 2009
  10. pmc White matter abnormalities and cognition in a community sample
    Tracy D Vannorsdall
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Clin Neuropsychol 24:209-17. 2009

Research Grants

Detail Information

Publications42

  1. doi request reprint Frequency and bases of abnormal performance by healthy adults on neuropsychological testing
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, USA
    J Int Neuropsychol Soc 14:436-45. 2008
    ..However, it eliminated the contribution of these variables to rates of abnormal test performance. These findings raise fundamental questions about the nature and interpretation of abnormal test performance by normal, healthy adults...
  2. ncbi request reprint Examining the range of normal intraindividual variability in neuropsychological test performance
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 9:864-70. 2003
    ..These data reveal that marked intraindividual variability is very common in normal adults, and underscore the need to base diagnostic inferences on clinically recognizable patterns rather than psychometric variability alone...
  3. ncbi request reprint Demographic, clinical, and neurocognitive correlates of everyday functional impairment in severe mental illness
    D Schretlen
    Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Abnorm Psychol 109:134-8. 2000
    ..These findings demonstrate the relevance of cognitive performance to everyday functioning in severe mental illness. They are discussed with respect to hypothesized determinants of psychiatric disability...
  4. ncbi request reprint Behavioral aspects of Lesch-Nyhan disease and its variants
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
    Dev Med Child Neurol 47:673-7. 2005
    ..Although patients with LNV typically do not self-injure or display severe aggression, attention problems are common and a few patients demonstrate other behavioral anomalies...
  5. ncbi request reprint The use of word-reading to estimate "premorbid" ability in cognitive domains other than intelligence
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Int Neuropsychol Soc 11:784-7. 2005
    ....
  6. pmc Neuropsychological functioning in bipolar disorder and schizophrenia
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, and Olin Neuropsychiatric Research Center, Hartford Hospital Institute of Living, CT, USA
    Biol Psychiatry 62:179-86. 2007
    ..Some patients with bipolar disorder (BD) demonstrate neuropsychological deficits even when stable. However, it remains unclear whether these differ qualitatively from those seen in schizophrenia (SZ)...
  7. ncbi request reprint Serum uric acid and cognitive function in community-dwelling older adults
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
    Neuropsychology 21:136-40. 2007
    ..05). Despite its antioxidant properties, these findings suggest that even mild elevations of UA might increase the risk of cognitive decline among older adults...
  8. ncbi request reprint Serum uric acid and brain ischemia in normal elderly adults
    D J Schretlen
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 69:1418-23. 2007
    ..Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke. Further, even high normal UA is associated with increased risk of mild cognitive dysfunction in elderly adults...
  9. doi request reprint Development, psychometric properties, and validity of the hopkins adult reading test (HART)
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, 600 N Wolfe St, Meyer 218, Baltimore, Maryland 21287 7218, USA
    Clin Neuropsychol 23:926-43. 2009
    ..Combined with demographic variables, these two brief word reading tests accurately predict a broader range of IQs than Blair and Spreen's (1989) longer version. Equivalent forms make it especially useful for longitudinal studies...
  10. pmc White matter abnormalities and cognition in a community sample
    Tracy D Vannorsdall
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Clin Neuropsychol 24:209-17. 2009
    ..Results point to both age-related and age-independent effects of WMH on cognition in later life and suggest that the accumulation of WMH might partially explain normal age-related declines in cognition...
  11. pmc A neuropsychological study of personality: trait openness in relation to intelligence, fluency, and executive functioning
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Exp Neuropsychol 32:1068-73. 2010
    ..These findings suggest that Openness is more closely associated with the acquisition of broad verbal intellectual skills and knowledge than with executive abilities localized to a specific brain region or neurotransmitter system...
  12. doi request reprint Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
    Schizophr Res 118:224-31. 2010
    ..In these outpatients with schizophrenia, HSV-1 seropositivity and performance on a cognitive test that is highly sensitive to it co-localize to closely overlapping brain regions...
  13. ncbi request reprint Neurocognitive functioning in Lesch-Nyhan disease and partial hypoxanthine-guanine phosphoribosyltransferase deficiency
    D J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 7:805-12. 2001
    ..The variants produced scores that were intermediate between those of patients with LND and normal participants on nearly every cognitive measure. We discuss these findings in terms of what is known about the neuropathology of LND...
  14. ncbi request reprint Determinants of Benton Facial Recognition Test performance in normal adults
    D J Schretlen
    Department of Psychiatry and Behavior Sciences, Johns Hopkins University School of Medicine, Maryland, USA
    Neuropsychology 15:405-10. 2001
    ..VBR and processing speed alone accounted for nearly 34% of the variance. These findings suggest that both normal atrophic brain changes and decreases in processing speed contribute to individual differences in facial discrimination...
  15. ncbi request reprint Elucidating the contributions of processing speed, executive ability, and frontal lobe volume to normal age-related differences in fluid intelligence
    D Schretlen
    Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Int Neuropsychol Soc 6:52-61. 2000
    ..These findings suggest that both the processing speed and frontal-executive theory of cognitive aging are partially correct and complement one another...
  16. ncbi request reprint A quantitative review of the effects of traumatic brain injury on cognitive functioning
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Int Rev Psychiatry 15:341-9. 2003
    ..Cognitive functioning also improves during the first two years after moderate-severe TBI, but remains markedly impaired even among patients tested > 2 years post-injury...
  17. pmc Gray matter in amnestic mild cognitive impairment: voxel-based morphometry
    David Bonekamp
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA
    Neuroreport 21:259-63. 2010
    ..Voxel-based morphometry provides an operator-unbiased means to investigate volumetric differences, which may be related to impaired neuropsychological functioning...
  18. doi request reprint A morphometric analysis of neuroanatomic abnormalities in traumatic brain injury
    Tracy D Vannorsdall
    Johns Hopkins Hospital, 600 N Wolfe St, Meyer 218, Baltimore, MD 21287, USA
    J Neuropsychiatry Clin Neurosci 22:173-81. 2010
    ..Findings suggest that diffuse rather than focal aspects of TBI contribute most to cognitive outcome...
  19. doi request reprint Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test
    Koko Ishizuka
    Department of Psychiatry, Johns Hopkins University School of Medicine, United States
    Neurosci Res 66:106-10. 2010
    ..Our study further reinforces a relation between olfactory identification deficit and negative symptoms in SZ and suggests that smell identification could be a candidate endophenotype relevant to negative symptoms of SZ...
  20. doi request reprint Accounting for estimated IQ in neuropsychological test performance with regression-based techniques
    S Marc Testa
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
    J Int Neuropsychol Soc 15:1012-22. 2009
    ..More broadly, we note that adjusting test scores for age and other characteristics might actually decrease the accuracy with which test performance predicts absolute criteria, such as the ability to drive or live independently...
  21. pmc Prevalence and types of sleep disturbances acutely after traumatic brain injury
    Vani Rao
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Baltimore, MD, USA
    Brain Inj 22:381-6. 2008
    ..To assess the prevalence of and risk factors for sleep disturbances in the acute post-traumatic brain injury (TBI) period...
  22. pmc Schizophrenia and epilepsy: is there a shared susceptibility?
    Nicola G Cascella
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurosci Res 63:227-35. 2009
    ....
  23. pmc Cranial volume, mild cognitive deficits, and functional limitations associated with diabetes in a community sample
    Andrea L Christman
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Clin Neuropsychol 25:49-59. 2010
    ..01). Nondemented adults with diabetes exhibit neuroanatomic and cognitive abnormalities. Their cognitive deficits correlate with everyday functional limitations...
  24. ncbi request reprint Neuropsychological impairment in deficit vs. non-deficit schizophrenia
    Nicola G Cascella
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 144, Baltimore, MD 21287, United States
    J Psychiatr Res 42:930-7. 2008
    ..Their impairment of verbal fluency is consistent with the observation that poverty of speech is a clinically significant feature of patients with SZ-D...
  25. pmc Aggression after traumatic brain injury: prevalence and correlates
    Vani Rao
    Division of Neuropsychiatry and Geriatric Psychiatry, Dept of Psychiatry, Johns Hopkins University, 5300 Alpha Commons Dr, 4th Floor, 444, Baltimore, MD 21224, USA
    J Neuropsychiatry Clin Neurosci 21:420-9. 2009
    ..Implications of the study include early screening for aggression, evaluation for depression, and consideration of psychosocial support in aggressive patients...
  26. ncbi request reprint Apathy syndrome after traumatic brain injury compared with deficits in schizophrenia
    Vani Rao
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Univ School of Medicine, Baltimore, MD 21287 7218, USA
    Psychosomatics 48:217-22. 2007
    ..Their differences may help to identify anatomical correlates of these apathy syndromes and aid in the design of more effective management strategies for both groups of patients...
  27. pmc Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET
    Dean F Wong
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    Neuropsychopharmacology 33:1239-51. 2008
    ..The finding of decreased SERT BP, and the possible elevation in 5-HT2AR in individuals with TS who had increased DA rel, suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD...
  28. pmc Predictors of new-onset depression after mild traumatic brain injury
    Vani Rao
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 22:100-4. 2010
    ..Identifying risk factors for mild TBI depression can aid in early diagnosis and treatment...
  29. ncbi request reprint Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 31:2716-27. 2006
    ..These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine...
  30. pmc Delineation of the motor disorder of Lesch-Nyhan disease
    H A Jinnah
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
    Brain 129:1201-17. 2006
    ..Explanations for the differing observations available in the literature are provided, along with a summary of how the motor disorder of LND relates to current understanding of its pathophysiology involving the basal ganglia...
  31. doi request reprint Gray-matter abnormalities in deficit schizophrenia
    Nicola G Cascella
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Schizophr Res 120:63-70. 2010
    ..Further, the neuroanatomic differences between these two putative subtypes of schizophrenia involve brain regions that appear to be associated with the negative symptoms that define the deficit syndrome of schizophrenia...
  32. ncbi request reprint Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study
    Heather C Strasser
    Division of Psychiatric Neuroimaging, Johns Hopkins University, Baltimore, Catonsville, Maryland
    Biol Psychiatry 57:633-9. 2005
    ..One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests that psychotic (PBP) and nonpsychotic (NPBP) forms of BP are two subtypes that might differ in pathophysiology...
  33. pmc Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study
    Sabin Khadka
    Olin Neuropsychiatry Research Center, Hartford Hospital Institute of Living, Hartford, CT 06106, USA
    Biol Psychiatry 74:458-66. 2013
    ..Schizophrenia and bipolar disorder share overlapping symptoms and risk genes. Shared aberrant functional connectivity is hypothesized in both disorders and in relatives...
  34. ncbi request reprint Interrater and test-retest reliability of a fixed condition design fluency test
    Lisle R Kingery
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Clin Neuropsychol 20:729-40. 2006
    ....
  35. ncbi request reprint How well does IQ predict neuropsychological test performance in normal adults?
    Catherine M Diaz-Asper
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 10:82-90. 2004
    ..These findings confirm that IQ predicts concurrent neuropsychological performance across the entire spectrum of intelligence, but more so among persons of average IQ or less than among those with above average IQ...
  36. doi request reprint Cerebral ischemia mediates the effect of serum uric acid on cognitive function
    Tracy D Vannorsdall
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 39:3418-20. 2008
    ..We hypothesized that individual differences in white matter hyperintensities mediate the association between UA and mild cognitive dysfunction...
  37. ncbi request reprint The relationship of recency discrimination to explicit memory and executive functioning
    Kevin J Manning
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Int Neuropsychol Soc 13:710-5. 2007
    ....
  38. pmc Rapid cognitive screening of patients with substance use disorders
    Marc L Copersino
    Department of Psychiatry, Harvard Medical School and Division of Alcohol and Drug Use, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 17:337-44. 2009
    ..These findings indicate that the MoCA provides a time-efficient and resource-conscious way to identify patients with SUDs and neuropsychological impairment, thus addressing a critical need in the addiction treatment research community...
  39. ncbi request reprint Positron emission tomography of striatal serotonin transporters in Parkinson disease
    Levente Kerenyi
    Department of Neurology, Medical School Debrecen, Hungary
    Arch Neurol 60:1223-9. 2003
    ..Little is known about serotonin neurons in Parkinson disease (PD)...
  40. pmc A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, CT 06106, USA
    Schizophr Res 101:95-105. 2008
    ..However, results from these studies vary widely, likely due to different methodological or statistical approaches...
  41. ncbi request reprint Lesch-Nyhan disease in a female with a clinically normal monozygotic twin
    Laura De Gregorio
    University of California San Diego, La Jolla, CA 92093, USA
    Mol Genet Metab 85:70-7. 2005
    ..As in many other reported cases of X-linked diseases, the discordant phenotype of the two monozygous twin sisters suggests that the process responsible for monozygotic twinning can trigger skewed X inactivation...
  42. ncbi request reprint Testing prospective memory: does the value of a borrowed item help people remember to get it back?
    Arnold Bakker
    Department of Psychology, Tilburg University, The Netherlands
    Clin Neuropsychol 16:64-6. 2002
    ..The correlation was negligible (rho = -.001). Number of cues needed was better predicted by score on the Mini-Mental State Exam (r = -.541, p <.001) than by subject's age, sex, or education, or the value of the item taken...

Research Grants3

  1. Lesch-Nyhan Disease: Neuroanatomic and Biochemical Bases of the Phenotype
    David J Schretlen; Fiscal Year: 2010
    ..These studies will provide crucial information for future clinical trials. ..