Research Topics
| David SchretlenSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Frequency and bases of abnormal performance by healthy adults on neuropsychological testingDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, USA
J Int Neuropsychol Soc 14:436-45. 2008..However, it eliminated the contribution of these variables to rates of abnormal test performance. These findings raise fundamental questions about the nature and interpretation of abnormal test performance by normal, healthy adults...
Examining the range of normal intraindividual variability in neuropsychological test performanceDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Int Neuropsychol Soc 9:864-70. 2003..These data reveal that marked intraindividual variability is very common in normal adults, and underscore the need to base diagnostic inferences on clinically recognizable patterns rather than psychometric variability alone...- Demographic, clinical, and neurocognitive correlates of everyday functional impairment in severe mental illnessD Schretlen
Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Abnorm Psychol 109:134-8. 2000..These findings demonstrate the relevance of cognitive performance to everyday functioning in severe mental illness. They are discussed with respect to hypothesized determinants of psychiatric disability... 
Neuropsychological functioning in bipolar disorder and schizophreniaDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, and Olin Neuropsychiatric Research Center, Hartford Hospital Institute of Living, CT, USA
Biol Psychiatry 62:179-86. 2007..Some patients with bipolar disorder (BD) demonstrate neuropsychological deficits even when stable. However, it remains unclear whether these differ qualitatively from those seen in schizophrenia (SZ)...- Development, psychometric properties, and validity of the hopkins adult reading test (HART)David J Schretlen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, 600 N Wolfe St, Meyer 218, Baltimore, Maryland 21287 7218, USA
Clin Neuropsychol 23:926-43. 2009..Combined with demographic variables, these two brief word reading tests accurately predict a broader range of IQs than Blair and Spreen's (1989) longer version. Equivalent forms make it especially useful for longitudinal studies... - The use of word-reading to estimate "premorbid" ability in cognitive domains other than intelligenceDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Int Neuropsychol Soc 11:784-7. 2005.... - Behavioral aspects of Lesch-Nyhan disease and its variantsDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
Dev Med Child Neurol 47:673-7. 2005..Although patients with LNV typically do not self-injure or display severe aggression, attention problems are common and a few patients demonstrate other behavioral anomalies... - White matter abnormalities and cognition in a community sampleTracy D Vannorsdall
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Clin Neuropsychol 24:209-17. 2009..Results point to both age-related and age-independent effects of WMH on cognition in later life and suggest that the accumulation of WMH might partially explain normal age-related declines in cognition... - Serum uric acid and cognitive function in community-dwelling older adultsDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
Neuropsychology 21:136-40. 2007..05). Despite its antioxidant properties, these findings suggest that even mild elevations of UA might increase the risk of cognitive decline among older adults... - A quantitative review of the effects of traumatic brain injury on cognitive functioningDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Int Rev Psychiatry 15:341-9. 2003..Cognitive functioning also improves during the first two years after moderate-severe TBI, but remains markedly impaired even among patients tested > 2 years post-injury... - Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophreniaDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
Schizophr Res 118:224-31. 2010..In these outpatients with schizophrenia, HSV-1 seropositivity and performance on a cognitive test that is highly sensitive to it co-localize to closely overlapping brain regions... - Serum uric acid and brain ischemia in normal elderly adultsD J Schretlen
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 69:1418-23. 2007..Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke. Further, even high normal UA is associated with increased risk of mild cognitive dysfunction in elderly adults... - A neuropsychological study of personality: trait openness in relation to intelligence, fluency, and executive functioningDavid J Schretlen
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Clin Exp Neuropsychol 32:1068-73. 2010..These findings suggest that Openness is more closely associated with the acquisition of broad verbal intellectual skills and knowledge than with executive abilities localized to a specific brain region or neurotransmitter system... - Neurocognitive functioning in Lesch-Nyhan disease and partial hypoxanthine-guanine phosphoribosyltransferase deficiencyD J Schretlen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Int Neuropsychol Soc 7:805-12. 2001..The variants produced scores that were intermediate between those of patients with LND and normal participants on nearly every cognitive measure. We discuss these findings in terms of what is known about the neuropathology of LND... - Determinants of Benton Facial Recognition Test performance in normal adultsD J Schretlen
Department of Psychiatry and Behavior Sciences, Johns Hopkins University School of Medicine, Maryland, USA
Neuropsychology 15:405-10. 2001..VBR and processing speed alone accounted for nearly 34% of the variance. These findings suggest that both normal atrophic brain changes and decreases in processing speed contribute to individual differences in facial discrimination... - Elucidating the contributions of processing speed, executive ability, and frontal lobe volume to normal age-related differences in fluid intelligenceD Schretlen
Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Int Neuropsychol Soc 6:52-61. 2000..These findings suggest that both the processing speed and frontal-executive theory of cognitive aging are partially correct and complement one another... - Gray matter in amnestic mild cognitive impairment: voxel-based morphometryDavid Bonekamp
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA
Neuroreport 21:259-63. 2010..Voxel-based morphometry provides an operator-unbiased means to investigate volumetric differences, which may be related to impaired neuropsychological functioning... - A morphometric analysis of neuroanatomic abnormalities in traumatic brain injuryTracy D Vannorsdall
Johns Hopkins Hospital, 600 N Wolfe St, Meyer 218, Baltimore, MD 21287, USA
J Neuropsychiatry Clin Neurosci 22:173-81. 2010..Findings suggest that diffuse rather than focal aspects of TBI contribute most to cognitive outcome... - Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification testKoko Ishizuka
Department of Psychiatry, Johns Hopkins University School of Medicine, United States
Neurosci Res 66:106-10. 2010..Our study further reinforces a relation between olfactory identification deficit and negative symptoms in SZ and suggests that smell identification could be a candidate endophenotype relevant to negative symptoms of SZ... - Accounting for estimated IQ in neuropsychological test performance with regression-based techniquesS Marc Testa
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
J Int Neuropsychol Soc 15:1012-22. 2009..More broadly, we note that adjusting test scores for age and other characteristics might actually decrease the accuracy with which test performance predicts absolute criteria, such as the ability to drive or live independently... - Prevalence and types of sleep disturbances acutely after traumatic brain injuryVani Rao
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Baltimore, MD, USA
Brain Inj 22:381-6. 2008..To assess the prevalence of and risk factors for sleep disturbances in the acute post-traumatic brain injury (TBI) period... - Predictors of new-onset depression after mild traumatic brain injuryVani Rao
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
J Neuropsychiatry Clin Neurosci 22:100-4. 2010..Identifying risk factors for mild TBI depression can aid in early diagnosis and treatment... - Aggression after traumatic brain injury: prevalence and correlatesVani Rao
Division of Neuropsychiatry and Geriatric Psychiatry, Dept of Psychiatry, Johns Hopkins University, 5300 Alpha Commons Dr, 4th Floor, 444, Baltimore, MD 21224, USA
J Neuropsychiatry Clin Neurosci 21:420-9. 2009..Implications of the study include early screening for aggression, evaluation for depression, and consideration of psychosocial support in aggressive patients... - Cranial volume, mild cognitive deficits, and functional limitations associated with diabetes in a community sampleAndrea L Christman
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Arch Clin Neuropsychol 25:49-59. 2010..01). Nondemented adults with diabetes exhibit neuroanatomic and cognitive abnormalities. Their cognitive deficits correlate with everyday functional limitations... - Gray-matter abnormalities in deficit schizophreniaNicola G Cascella
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Schizophr Res 120:63-70. 2010..Further, the neuroanatomic differences between these two putative subtypes of schizophrenia involve brain regions that appear to be associated with the negative symptoms that define the deficit syndrome of schizophrenia... - Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot studyHeather C Strasser
Division of Psychiatric Neuroimaging, Johns Hopkins University, Baltimore, Catonsville, Maryland
Biol Psychiatry 57:633-9. 2005..CONCLUSIONS: These results suggest that PBP but not NPBP is associated with increased ventricle volumes and a trend toward smaller left hippocampal volumes, as observed in SZ... - Apathy syndrome after traumatic brain injury compared with deficits in schizophreniaVani Rao
Department of Psychiatry and Behavioral Sciences, Johns Hopkins Univ School of Medicine, Baltimore, MD 21287 7218, USA
Psychosomatics 48:217-22. 2007..Their differences may help to identify anatomical correlates of these apathy syndromes and aid in the design of more effective management strategies for both groups of patients... - Schizophrenia and epilepsy: is there a shared susceptibility?Nicola G Cascella
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neurosci Res 63:227-35. 2009.... - Delineation of the motor disorder of Lesch-Nyhan diseaseH A Jinnah
Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
Brain 129:1201-17. 2006..Explanations for the differing observations available in the literature are provided, along with a summary of how the motor disorder of LND relates to current understanding of its pathophysiology involving the basal ganglia... - Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine cravingDean F Wong
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
Neuropsychopharmacology 31:2716-27. 2006..These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine... - Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PETDean F Wong
Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
Neuropsychopharmacology 33:1239-51. 2008..The finding of decreased SERT BP, and the possible elevation in 5-HT2AR in individuals with TS who had increased DA rel, suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD... - Neuropsychological impairment in deficit vs. non-deficit schizophreniaNicola G Cascella
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 144, Baltimore, MD 21287, United States
J Psychiatr Res 42:930-7. 2008..Their impairment of verbal fluency is consistent with the observation that poverty of speech is a clinically significant feature of patients with SZ-D... - Interrater and test-retest reliability of a fixed condition design fluency testLisle R Kingery
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Clin Neuropsychol 20:729-40. 2006.... - How well does IQ predict neuropsychological test performance in normal adults?Catherine M Diaz-Asper
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Int Neuropsychol Soc 10:82-90. 2004..These findings confirm that IQ predicts concurrent neuropsychological performance across the entire spectrum of intelligence, but more so among persons of average IQ or less than among those with above average IQ... - Rapid cognitive screening of patients with substance use disordersMarc L Copersino
Department of Psychiatry, Harvard Medical School and Division of Alcohol and Drug Use, McLean Hospital, Belmont, MA 02478, USA
Exp Clin Psychopharmacol 17:337-44. 2009..These findings indicate that the MoCA provides a time-efficient and resource-conscious way to identify patients with SUDs and neuropsychological impairment, thus addressing a critical need in the addiction treatment research community... - Cerebral ischemia mediates the effect of serum uric acid on cognitive functionTracy D Vannorsdall
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 39:3418-20. 2008..We hypothesized that individual differences in white matter hyperintensities mediate the association between UA and mild cognitive dysfunction... - The relationship of recency discrimination to explicit memory and executive functioningKevin J Manning
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Int Neuropsychol Soc 13:710-5. 2007.... - A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometryShashwath A Meda
Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, CT 06106, USA
Schizophr Res 101:95-105. 2008..However, results from these studies vary widely, likely due to different methodological or statistical approaches... - Positron emission tomography of striatal serotonin transporters in Parkinson diseaseLevente Kerenyi
Department of Neurology, Medical School Debrecen, Hungary
Arch Neurol 60:1223-9. 2003..CONCLUSIONS: These results suggest that the density of serotonin transporters, like that of dopamine transporters, is reduced in the striatum of patients with PD and that these changes are related to disease stage... - Testing prospective memory: does the value of a borrowed item help people remember to get it back?Arnold Bakker
Department of Psychology, Tilburg University, The Netherlands
Clin Neuropsychol 16:64-6. 2002..The correlation was negligible (rho = -.001). Number of cues needed was better predicted by score on the Mini-Mental State Exam (r = -.541, p <.001) than by subject's age, sex, or education, or the value of the item taken... - Lesch-Nyhan disease in a female with a clinically normal monozygotic twinLaura De Gregorio
University of California San Diego, La Jolla, CA 92093, USA
Mol Genet Metab 85:70-7. 2005..As in many other reported cases of X-linked diseases, the discordant phenotype of the two monozygous twin sisters suggests that the process responsible for monozygotic twinning can trigger skewed X inactivation...
Research Grants
- Lesch-Nyhan Disease: Neuroanatomic and Biochemical Bases of the PhenotypeDavid J Schretlen; Fiscal Year: 2010..These studies will provide crucial information for future clinical trials. ..