T E Schläpfer

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Distinctive neurocognitive effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in major depression
    Svenja C Schulze-Rauschenbach
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Br J Psychiatry 186:410-6. 2005
  2. doi request reprint Vagus nerve stimulation for depression: efficacy and safety in a European study
    T E Schlaepfer
    Departments of Psychiatry, University Hospital, Bern, Switzerland
    Psychol Med 38:651-61. 2008
  3. doi request reprint Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression
    Bettina H Bewernick
    Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
    Biol Psychiatry 67:110-6. 2010
  4. pmc Chronic depression as a model disease for cerebral aging
    Bettina H Bewernick
    Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
    Dialogues Clin Neurosci 15:77-85. 2013
  5. pmc Modulating affect, cognition, and behavior - prospects of deep brain stimulation for treatment-resistant psychiatric disorders
    Thomas E Schlaepfer
    Brain Stimulation Group, Department of Psychiatry and Psychotherapy, University of Bonn Bonn, Germany
    Front Integr Neurosci 5:29. 2011
  6. doi request reprint [Deep brain stimulation as possible alternative for therapy resistant depression]
    T E Schläpfer
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105, Bonn, Deutschland
    Nervenarzt 85:156-61. 2014
  7. doi request reprint Neuromodulation for treatment resistant depression: state of the art and recommendations for clinical and scientific conduct
    Thomas E Schlaepfer
    Department of Psychiatry and Psychotherapy, University Hospital, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Brain Topogr 27:12-9. 2014
  8. doi request reprint Deep brain stimulation for major depression
    T E Schlaepfer
    Brain Stimulation Group, Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany Departments of Psychiatry and Mental Health, Johns Hopkins University, Baltimore, MD, USA Electronic address
    Handb Clin Neurol 116:235-43. 2013
  9. ncbi request reprint Deep brain stimulation for treatment of refractory depression
    Thomas E Schlaepfer
    Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
    Lancet 366:1420-2. 2005
  10. ncbi request reprint Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression
    Thomas E Schlaepfer
    Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
    Neuropsychopharmacology 33:368-77. 2008

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Distinctive neurocognitive effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in major depression
    Svenja C Schulze-Rauschenbach
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Br J Psychiatry 186:410-6. 2005
    ....
  2. doi request reprint Vagus nerve stimulation for depression: efficacy and safety in a European study
    T E Schlaepfer
    Departments of Psychiatry, University Hospital, Bern, Switzerland
    Psychol Med 38:651-61. 2008
    ..Vagus nerve stimulation (VNS) therapy is associated with a decrease in seizure frequency in partial-onset seizure patients. Initial trials suggest that it may be an effective treatment, with few side-effects, for intractable depression...
  3. doi request reprint Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression
    Bettina H Bewernick
    Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
    Biol Psychiatry 67:110-6. 2010
    ..Since anhedonia is a feature of depression and there is evidence of dysfunction of the reward system, DBS to the nucleus accumbens (NAcc) might be promising...
  4. pmc Chronic depression as a model disease for cerebral aging
    Bettina H Bewernick
    Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
    Dialogues Clin Neurosci 15:77-85. 2013
    ..A common pathological mechanism in depression and cerebral aging-a dysfunction of neuroprotection and neurogenesis-is discussed. This has implications for new treatment methods...
  5. pmc Modulating affect, cognition, and behavior - prospects of deep brain stimulation for treatment-resistant psychiatric disorders
    Thomas E Schlaepfer
    Brain Stimulation Group, Department of Psychiatry and Psychotherapy, University of Bonn Bonn, Germany
    Front Integr Neurosci 5:29. 2011
    ..DBS is a unique and very promising method for the treatment of therapy-resistant psychiatric patients. The method allows manipulating pathological neuronal networks in a very precise way...
  6. doi request reprint [Deep brain stimulation as possible alternative for therapy resistant depression]
    T E Schläpfer
    Klinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105, Bonn, Deutschland
    Nervenarzt 85:156-61. 2014
    ..More than 100,000 patients have already been treated worldwide using DBS which is a procedure in which electrodes are placed bilaterally in certain brain regions where they can modulate disease-related dysfunctions. ..
  7. doi request reprint Neuromodulation for treatment resistant depression: state of the art and recommendations for clinical and scientific conduct
    Thomas E Schlaepfer
    Department of Psychiatry and Psychotherapy, University Hospital, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Brain Topogr 27:12-9. 2014
    ....
  8. doi request reprint Deep brain stimulation for major depression
    T E Schlaepfer
    Brain Stimulation Group, Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany Departments of Psychiatry and Mental Health, Johns Hopkins University, Baltimore, MD, USA Electronic address
    Handb Clin Neurol 116:235-43. 2013
    ..Standards are needed for study registration, target selection, patient inclusion and monitoring, and publication of results to guarantee safety for the patients and scientific exchange. ..
  9. ncbi request reprint Deep brain stimulation for treatment of refractory depression
    Thomas E Schlaepfer
    Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
    Lancet 366:1420-2. 2005
  10. ncbi request reprint Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression
    Thomas E Schlaepfer
    Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
    Neuropsychopharmacology 33:368-77. 2008
    ..These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression...
  11. ncbi request reprint [Brain stimulation methods for resistance to therapy]
    T E Schläpfer
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Uniklinikum, Sigmund Freud Strasse 25, 53121, Bonn
    Nervenarzt 78:575-81; quiz 582-3. 2007
    ..Their clinical effects and effectivity require further definition. This paper reports the current status of brain stimulation methods and describes possible further developments...
  12. ncbi request reprint [The development of deep brain stimulation as a putative treatment for resistant psychiatric disorders]
    T E Schläpfer
    Klinik fur Psychiatrie und Psychotherapie, Bonn, Uniklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Nervenarzt 81:696-701. 2010
    ..Only in this way can the potentially most interesting therapeutic development of clinical psychiatry of the last 20 years be continued uninterrupted...
  13. doi request reprint [Brain stimulation procedures. Transcranial magnetic stimulation, magnetic seizure therapy and deep brain stimulation]
    T E Schläpfer
    Klinik fur Psychiatrie und Psychotherapie, Uniklinikum Bonn
    Nervenarzt 83:95-103; quiz 104-5. 2012
    ..The effects in severe therapy-resistant obsessive-compulsive disorders and depressions are promising. However, the evaluation of ethical issues remains an important task...
  14. ncbi request reprint Decreased frontal white-matter volume in chronic substance abuse
    Thomas E Schlaepfer
    Department of Psychiatry, University Hospital, Bonn, Germany
    Int J Neuropsychopharmacol 9:147-53. 2006
    ....
  15. ncbi request reprint [Alcohol and the brain--morphological and functional brain changes]
    T E Schläpfer
    Psychiatrische Poliklinik am Universitätsspital Bern
    Ther Umsch 57:191-5. 2000
    ..Functional studies revealed that alcohol may lead to patterns of reduced activity in brain activation which correlate with the atrophy and take months to years to recover...
  16. ncbi request reprint Efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of affective disorders
    Thomas E Schlaepfer
    Department of Psychiatry, University Hospital, Bern, Switzerland
    Neuropsychopharmacology 28:201-5. 2003
    ..Most studies indicate that both low-frequency TMS and higher (20 Hz) frequency repetitive TMS may have some antidepressant properties. However, definite therapeutic effects of clinical significance still remain to be demonstrated...
  17. doi request reprint Neuroelectric signatures of reward learning and decision-making in the human nucleus accumbens
    Michael X Cohen
    Department of Epileptology and Center for Life and Brain, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 34:1649-58. 2009
    ....
  18. ncbi request reprint Deep brain stimulation for psychiatric disorders--state of the art
    T E Schläpfer
    Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany
    Adv Tech Stand Neurosurg 34:37-57. 2009
    ..Therefore, a distinct focus of this review lies on ethical aspects for DBS in neuropsychiatric disorders...
  19. ncbi request reprint Beyond the treatment of epilepsy: new applications of vagus nerve stimulation in psychiatry
    Markus Kosel
    Department of Psychiatry, University Hospital, Bern, Switzerland
    CNS Spectr 8:515-21. 2003
    ..Besides its clinical usefulness, VNS can be used as a research tool, allowing neurophysiologic investigations of the parasympathetic system and its interactions with other parts of the central nervous system...
  20. pmc Noradrenergic enhancement of amygdala responses to fear
    Oezguer A Onur
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Soc Cogn Affect Neurosci 4:119-26. 2009
    ....
  21. ncbi request reprint Mechanisms and state of the art of vagus nerve stimulation
    Markus Kosel
    Department of Psychiatry, University Hospital, Bern, Switzerland
    J ECT 18:189-92. 2002
    ....
  22. doi request reprint Intracranial EEG correlates of expectancy and memory formation in the human hippocampus and nucleus accumbens
    Nikolai Axmacher
    Department of Epileptology, University of Bonn, 53105 Bonn, Germany
    Neuron 65:541-9. 2010
    ..These results are consistent with the hypothesis that activity in a loop involving the hippocampus and the nucleus accumbens promotes encoding of unexpected events...
  23. ncbi request reprint Mood improvement after deep brain stimulation of the internal globus pallidus for tardive dyskinesia in a patient suffering from major depression
    Markus Kosel
    Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany
    J Psychiatr Res 41:801-3. 2007
    ....
  24. ncbi request reprint Magnetic seizure therapy improves mood in refractory major depression
    Markus Kosel
    Department of Psychiatry, University Hospital Bern, Switzerland
    Neuropsychopharmacology 28:2045-8. 2003
    ..Our preliminary data support the prospect of antidepressant efficacy of MST and point to a benign cognitive side-effect profile in a patient suffering from severe treatment-resistant major depression...
  25. doi request reprint Cerebral blood flow effects of acute intravenous heroin administration
    Markus Kosel
    Department of Psychiatry, University Hospital, Bonn, Germany
    Eur Neuropsychopharmacol 18:278-85. 2008
    ....
  26. pmc Nuclei accumbens phase synchrony predicts decision-making reversals following negative feedback
    Michael X Cohen
    Department of Epileptology and Center for Life and Brain and Department of Psychiatry and Psychotherapy, University of Bonn, 53105 Bonn, Germany
    J Neurosci 29:7591-8. 2009
    ..These findings suggest that a neural network including the nucleus accumbens bilaterally becomes functionally connected via theta phase synchrony to signal the need to adjust behavior...
  27. ncbi request reprint Diminished GABA(A) receptor-binding capacity and a DNA base substitution in a patient with treatment-resistant depression and anxiety
    Markus Kosel
    Psychiatric Neuroimaging Group of the Department of Psychiatry, University Hospital, Bern, Switzerland
    Neuropsychopharmacology 29:347-50. 2004
    ..No conclusion can, however, be made about casual links in this single case [corrected]...
  28. doi request reprint Magnetic seizure therapy of treatment-resistant depression in a patient with bipolar disorder
    Sarah Kayser
    Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
    J ECT 25:137-40. 2009
    ..Taken together, these results suggest that MST, compared with ECT, might have antidepressant effects and may have fewer clinical side effects...
  29. ncbi request reprint Incident mania during therapy with vagus nerve stimulation
    Caroline Frick
    J ECT 21:197. 2005
  30. ncbi request reprint Safety and feasibility of magnetic seizure therapy (MST) in major depression: randomized within-subject comparison with electroconvulsive therapy
    Sarah H Lisanby
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 28:1852-65. 2003
    ..Magnetic seizure induction in patients with depression is feasible, and appears to have a superior acute side effect profile than ECT. Future research will be needed to establish whether MST has antidepressant efficacy...
  31. ncbi request reprint Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patients
    Urs P Mosimann
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Psychiatry Res 126:123-33. 2004
    ..Therapeutic effects of rTMS in this clinically challenging patient group remain to be demonstrated...
  32. ncbi request reprint Repetitive transcranial magnetic stimulation for the treatment of depression. Systematic review and meta-analysis
    Jose Luis R Martin
    Iberoamerican Cochrane Centre, Hospital de la Santa Crue i Sant Pau, Barcelona, Spain
    Br J Psychiatry 182:480-91. 2003
    ..Repetitive transcranial magnetic stimulation (rTMS) may be useful in the treatment of depression but results from trials have been inconclusive to date...
  33. ncbi request reprint Learning from the history of neuroscience: dogma and patient interests: comment to Dr. Finks commentary
    Thomas E Schlaepfer
    Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany
    J ECT 20:137-8; discussion 138. 2004
  34. ncbi request reprint Deep-brain stimulation for Parkinson's disease
    Klaus Lieb
    N Engl J Med 355:2256; author reply 2256. 2006
  35. ncbi request reprint Antidepressant effects of repetitive transcranial magnetic stimulation in the elderly: correlation between effect size and coil-cortex distance
    Urs P Mosimann
    Arch Gen Psychiatry 59:560-1. 2002