Research Topics
| T E SchläpferSummaryAffiliation: Johns Hopkins University Country: USA Publications
| Collaborators
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Detail Information
Publications
Distinctive neurocognitive effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in major depressionSvenja C Schulze-Rauschenbach
Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, D 53105 Bonn, Germany
Br J Psychiatry 186:410-6. 2005..CONCLUSIONS: In contrast to unilateral ECT, rTMS has no adverse memory effects...
Vagus nerve stimulation for depression: efficacy and safety in a European studyT E Schlaepfer
Departments of Psychiatry, University Hospital, Bern, Switzerland
Psychol Med 38:651-61. 2008..Vagus nerve stimulation (VNS) therapy is associated with a decrease in seizure frequency in partial-onset seizure patients. Initial trials suggest that it may be an effective treatment, with few side-effects, for intractable depression...- Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depressionBettina H Bewernick
Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
Biol Psychiatry 67:110-6. 2010..Since anhedonia is a feature of depression and there is evidence of dysfunction of the reward system, DBS to the nucleus accumbens (NAcc) might be promising... - [Alcohol and the brain--morphological and functional brain changes]T E Schläpfer
Psychiatrische Poliklinik am Universitätsspital Bern
Ther Umsch 57:191-5. 2000..Functional studies revealed that alcohol may lead to patterns of reduced activity in brain activation which correlate with the atrophy and take months to years to recover... - [The development of deep brain stimulation as a putative treatment for resistant psychiatric disorders]T E Schläpfer
Klinik fur Psychiatrie und Psychotherapie, Bonn, Uniklinikum Bonn, Sigmund Freud Strasse 25, Bonn, Germany
Nervenarzt 81:696-701. 2010..Only in this way can the potentially most interesting therapeutic development of clinical psychiatry of the last 20 years be continued uninterrupted... - [Brain stimulation methods for resistance to therapy]T E Schläpfer
Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Uniklinikum, Sigmund Freud Strasse 25, 53121, Bonn
Nervenarzt 78:575-81; quiz 582-3. 2007..Their clinical effects and effectivity require further definition. This paper reports the current status of brain stimulation methods and describes possible further developments... - Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depressionThomas E Schlaepfer
Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
Neuropsychopharmacology 33:368-77. 2008..These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression... - [Brain stimulation procedures. Transcranial magnetic stimulation, magnetic seizure therapy and deep brain stimulation]T E Schläpfer
Klinik fur Psychiatrie und Psychotherapie, Uniklinikum Bonn
Nervenarzt 83:95-103; quiz 104-5. 2012..The effects in severe therapy-resistant obsessive-compulsive disorders and depressions are promising. However, the evaluation of ethical issues remains an important task... - Deep brain stimulation for treatment of refractory depressionThomas E Schlaepfer
Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
Lancet 366:1420-2. 2005 - Decreased frontal white-matter volume in chronic substance abuseThomas E Schlaepfer
Department of Psychiatry, University Hospital, Bonn, Germany
Int J Neuropsychopharmacol 9:147-53. 2006.... - Neuroelectric signatures of reward learning and decision-making in the human nucleus accumbensMichael X Cohen
Department of Epileptology and Center for Life and Brain, University of Bonn, Bonn, Germany
Neuropsychopharmacology 34:1649-58. 2009.... - Efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of affective disordersThomas E Schlaepfer
Department of Psychiatry, University Hospital, Bern, Switzerland
Neuropsychopharmacology 28:201-5. 2003..Most studies indicate that both low-frequency TMS and higher (20 Hz) frequency repetitive TMS may have some antidepressant properties. However, definite therapeutic effects of clinical significance still remain to be demonstrated... 
Noradrenergic enhancement of amygdala responses to fearOezguer A Onur
Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
Soc Cogn Affect Neurosci 4:119-26. 2009....- Beyond the treatment of epilepsy: new applications of vagus nerve stimulation in psychiatryMarkus Kosel
Department of Psychiatry, University Hospital, Bern, Switzerland
CNS Spectr 8:515-21. 2003..Besides its clinical usefulness, VNS can be used as a research tool, allowing neurophysiologic investigations of the parasympathetic system and its interactions with other parts of the central nervous system... - Deep brain stimulation for psychiatric disorders--state of the artT E Schläpfer
Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany
Adv Tech Stand Neurosurg 34:37-57. 2009..Therefore, a distinct focus of this review lies on ethical aspects for DBS in neuropsychiatric disorders... - Mood improvement after deep brain stimulation of the internal globus pallidus for tardive dyskinesia in a patient suffering from major depressionMarkus Kosel
Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany
J Psychiatr Res 41:801-3. 2007.... - Intracranial EEG correlates of expectancy and memory formation in the human hippocampus and nucleus accumbensNikolai Axmacher
Department of Epileptology, University of Bonn, 53105 Bonn, Germany
Neuron 65:541-9. 2010..These results are consistent with the hypothesis that activity in a loop involving the hippocampus and the nucleus accumbens promotes encoding of unexpected events... - Mechanisms and state of the art of vagus nerve stimulationMarkus Kosel
Department of Psychiatry, University Hospital, Bern, Switzerland
J ECT 18:189-92. 2002.... - Diminished GABA(A) receptor-binding capacity and a DNA base substitution in a patient with treatment-resistant depression and anxietyMarkus Kosel
Psychiatric Neuroimaging Group of the Department of Psychiatry, University Hospital, Bern, Switzerland
Neuropsychopharmacology 29:347-50. 2004..No conclusion can, however, be made about casual links in this single case [corrected]... - Nuclei accumbens phase synchrony predicts decision-making reversals following negative feedbackMichael X Cohen
Department of Epileptology and Center for Life and Brain and Department of Psychiatry and Psychotherapy, University of Bonn, 53105 Bonn, Germany
J Neurosci 29:7591-8. 2009..These findings suggest that a neural network including the nucleus accumbens bilaterally becomes functionally connected via theta phase synchrony to signal the need to adjust behavior... - Magnetic seizure therapy improves mood in refractory major depressionMarkus Kosel
Department of Psychiatry, University Hospital Bern, Switzerland
Neuropsychopharmacology 28:2045-8. 2003..Our preliminary data support the prospect of antidepressant efficacy of MST and point to a benign cognitive side-effect profile in a patient suffering from severe treatment-resistant major depression... - Magnetic seizure therapy of treatment-resistant depression in a patient with bipolar disorderSarah Kayser
Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
J ECT 25:137-40. 2009..Taken together, these results suggest that MST, compared with ECT, might have antidepressant effects and may have fewer clinical side effects... - Cerebral blood flow effects of acute intravenous heroin administrationMarkus Kosel
Department of Psychiatry, University Hospital, Bonn, Germany
Eur Neuropsychopharmacol 18:278-85. 2008.... - Incident mania during therapy with vagus nerve stimulationCaroline Frick
J ECT 21:197. 2005 - Safety and feasibility of magnetic seizure therapy (MST) in major depression: randomized within-subject comparison with electroconvulsive therapySarah H Lisanby
Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
Neuropsychopharmacology 28:1852-65. 2003..Magnetic seizure induction in patients with depression is feasible, and appears to have a superior acute side effect profile than ECT. Future research will be needed to establish whether MST has antidepressant efficacy... - Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patientsUrs P Mosimann
Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
Psychiatry Res 126:123-33. 2004..Therapeutic effects of rTMS in this clinically challenging patient group remain to be demonstrated... - Deep-brain stimulation for Parkinson's diseaseKlaus Lieb
N Engl J Med 355:2256; author reply 2256. 2006 - Learning from the history of neuroscience: dogma and patient interests: comment to Dr. Finks commentaryThomas E Schlaepfer
Department of Psychiatry and Psychotherapy, University Hospital Bonn, Germany
J ECT 20:137-8; discussion 138. 2004 - Antidepressant effects of repetitive transcranial magnetic stimulation in the elderly: correlation between effect size and coil-cortex distanceUrs P Mosimann
Arch Gen Psychiatry 59:560-1. 2002 - Repetitive transcranial magnetic stimulation for the treatment of depression. Systematic review and meta-analysisJose Luis R Martin
Iberoamerican Cochrane Centre, Hospital de la Santa Crue i Sant Pau, Barcelona, Spain
Br J Psychiatry 182:480-91. 2003..Repetitive transcranial magnetic stimulation (rTMS) may be useful in the treatment of depression but results from trials have been inconclusive to date...