Research Topics
Genomes and Genes | Edward M SchaefferSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Pre-processing Agilent microarray dataMarianna Zahurak
Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA
BMC Bioinformatics 8:142. 2007..The larger goal is to define best study design and pre-processing practices for Agilent arrays, and we offer some suggestions...
Renal medullary carcinoma: molecular, pathological and clinical evidence for treatment with topoisomerase-inhibiting therapyEdward M Schaeffer
The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
BJU Int 106:62-5. 2010..Aetiology (case series) Level of Evidence 4...- Cystoscopic management of an extruded coil from arteriovenous fistula embolization using arthroscopic instrumentsEdward M Schaeffer
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Endourol 22:1527-9. 2008..We describe one potential complication of transcatheter embolization that involves necrosis of the bladder wall with a novel technique for endoscopic management of an extruded coil in the bladder... 
Duplex ultrasonography detects clinically significant anomalies of penile arterial vasculature affecting surgical approach to penile straighteningEdward M Schaeffer
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Urology 67:166-9. 2006..To determine the frequency of aberrant penile arterial anatomy in men with Peyronie's disease (PD) and the potential impact on the surgical approach to penile straightening...- Incidence of local recurrence and port site metastasis after laparoscopic radical nephroureterectomyMichael Muntener
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
Urology 70:864-8. 2007..To address the incidence of local recurrence and port site metastasis in patients who underwent laparoscopic radical nephroureterectomy (RNU) for upper tract transitional cell carcinoma (TCC)... - A contemporary analysis of outcomes of adenocarcinoma of the prostate with seminal vesicle invasion (pT3b) after radical prostatectomyPhillip M Pierorazio
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Urol 185:1691-7. 2011..We investigated outcomes in men with pT3b disease in the contemporary era... - Effect of treatment with 5-α reductase inhibitors on progression in monitored men with favourable-risk prostate cancerAshley E Ross
James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medicinal Institutions, Baltimore, MD, USA
BJU Int 110:651-7. 2012.... - Preoperative characteristics of high-Gleason disease predictive of favourable pathological and clinical outcomes at radical prostatectomyPhillip M Pierorazio
James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA
BJU Int 110:1122-8. 2012.... - Wnt signaling though beta-catenin is required for prostate lineage specificationBrian W Simons
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Biol 371:246-55. 2012..Deletion of beta-catenin in the adult prostate did not significantly affect organ homeostasis. Collectively, these data establish that beta-catenin and Wnt signaling play key roles in prostate lineage specification and bud outgrowth... - Oncologic outcomes of extravesical stapling of distal ureter in laparoscopic nephroureterectomyFrederico R Romero
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Endourol 21:1025-7. 2007..To evaluate the safety and oncologic efficacy of extravesical laparoscopic stapling of the distal ureter and bladder cuff during nephroureterectomy for pelvicaliceal transitional-cell carcinoma (TCC)... - The accuracy of multidetector computerized tomography for evaluating tumor thrombus in patients with renal cell carcinomaThomas J Guzzo
The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Urol 181:486-90; discussion 491. 2009..We assessed the accuracy of multidetector computerized tomography for predicting tumor thrombus and the level of venous involvement in patients with renal cell carcinoma... - Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcomePaula J Hurley
Department of Urology, The Johns Hopkins University, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 109:14977-82. 2012..Thus, SPARCL1 is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence... - Bone mineral content and prostate cancer risk: data from the Baltimore Longitudinal Study of AgingStacy Loeb
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, and the National Institute on Ageing, National Institutes of Health Clinical Research Branch, Baltimore, MD, USA
BJU Int 106:28-31. 2010..Aetiology (inception cohort) Level of Evidence 2b... - Laparoscopic radical nephrectomy for patients with pathologic T3b renal-cell carcinoma: the Johns Hopkins experienceThomas J Guzzo
The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
J Endourol 23:63-7. 2009..The goal of our study was to evaluate the safety and short-tem oncologic efficacy of laparoscopic radical nephrectomy in patients with renal vein involvement... - Perioperative outcomes of elderly patients undergoing laparoscopic renal proceduresThomas J Guzzo
James Buchanan Brady Urologic Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 73:572-6. 2009..S. population. The outcomes of elderly patients undergoing laparoscopic renal procedures are less well defined than those of younger patients... - Long-term survival after radical prostatectomy for men with high Gleason sum in pathologic specimenPhillip M Pierorazio
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 76:715-21. 2010..To evaluate the long-term outcomes of patients with high Gleason sum 8-10 at radical prostatectomy (RP) and to identify the predictors of prostate cancer-specific survival (CSS) in this cohort... - Should prostate specific antigen be adjusted for body mass index? Data from the Baltimore Longitudinal Study of AgingStacy Loeb
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Urol 182:2646-51. 2009..We examined the relationship between body mass index and prostate specific antigen by age in men without prostate cancer in a longitudinal aging study to determine whether prostate specific antigen must be adjusted for body mass index... - Sox9 is required for prostate development and prostate cancer initiationZhenhua Huang
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Oncotarget 3:651-63. 2012..Due to its essential role in cancer initiation, manipulation of Sox9 targets in at-risk men may prove useful in the chemoprevention of prostate cancer... - Evolution of the clinical presentation of men undergoing radical prostatectomy for high-risk prostate cancerPhillip M Pierorazio
Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA
BJU Int 109:988-93. 2012.... - What are the outcomes of radical prostatectomy for high-risk prostate cancer?Stacy Loeb
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
Urology 76:710-4. 2010..These patients are often treated with combined radiation and androgen deprivation therapy, and less is known about the long-term survival in this population after radical prostatectomy (RP)... - Prostate specific antigen at the initial diagnosis of metastasis to bone in patients after radical prostatectomyStacy Loeb
Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Urol 184:157-61. 2010..This information would be useful in determining when to initiate androgen deprivation therapy... - Xanthogranulomatous pyelonephritis: presentation and management in the era of laparoscopyThomas J Guzzo
Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
BJU Int 104:1265-8. 2009.... - Distribution of PSA velocity by total PSA levels: data from the Baltimore Longitudinal Study of AgingStacy Loeb
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Urology 77:143-7. 2011..35 and >2.0 ng/mL/y have been associated with an increased risk of prostate cancer (CaP) death more than 10 years and 1 year before diagnosis, respectively. It is unknown how frequently PSAVs of this magnitude occur in community men... - Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicityAshley E Ross
Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
BJU Int 108:447-54. 2011..To evaluate the cytotoxicity of dimeric naphthoquinones (BiQs) in prostate cancer cells. • To assess the interaction of dimeric naphthoquinones with common therapies including radiation and docetaxel... - Intraperitoneal effects of extraperitoneal laparoscopic radical prostatectomyTrinity J Bivalacqua
The Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
Urology 72:273-7. 2008..To compare routine radiologic and laboratory findings after extraperitoneal and transperitoneal laparoscopic radical prostatectomy (eLRP, tLRP) and assess relevant clinical correlations... - Laparoscopic radical nephroureterectomy with en-bloc distal ureteral and bladder cuff excision using a single position pneumovesicum methodThomas J Guzzo
The James Buchanan Brady Urologic Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 72:850-2. 2008..This technique is efficient, technically feasible and adheres to the oncologic principles of radical nephroureterectomy... - Long-term oncologic outcome after laparoscopic radical nephroureterectomy for upper tract transitional cell carcinomaMichael Muntener
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
Eur Urol 51:1639-44. 2007..To assess the long-term oncologic efficacy of laparoscopic radical nephroureterectomy (RNU)... - Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapyRoula Albadine
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
J Urol 182:735-40. 2009.... - Is repeat prostate biopsy associated with a greater risk of hospitalization? Data from SEER-MedicareStacy Loeb
Department of Urology, New York University, New York, New York 10016, USA
J Urol 189:867-70. 2013..We determined whether repeat biopsies are associated with an increased risk of hospitalization compared to the initial biopsy... - The case for open radical prostatectomyEdward M Schaeffer
Johns Hopkins Medical Institution, Brady Urological Institute, 600 North Wolfe Street, Marburg 145, Baltimore, MD 21287, USA
Urol Clin North Am 37:49-55, Table of Contents. 2010..Although there are many differences between the 2 approaches, the common goal is to optimize oncologic and functional outcomes. This article highlights the background, techniques, and outcomes of open and robotic prostatectomy... - Urothelial carcinoma: stem cells on the edgeWilliam D Brandt
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Cancer Metastasis Rev 28:291-304. 2009..In this review, we discuss the implications of these findings in understanding CSCs and in better understanding how UroCas form, progress, and should be treated... - Application of Evicel to cavernous nerves of the rat does not influence erectile function in vivoTrinity J Bivalacqua
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 72:1169-73. 2008..To evaluate the effect of the fibrin sealant, Evicel, on the neuroregulatory control of penile erections in an experimental rat model... - Amyloidosis of the seminal vesicle and hematospermiaEdward M Schaeffer
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-2101, USA
J Urol 171:2382. 2004 - Urinary markers in the detection of bladder cancer: what's new?Matthew E Nielsen
Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2101, USA
Curr Opin Urol 16:350-5. 2006..In the context of relative limitations of the current standard of cystoscopy and cytology, there has been burgeoning activity in the development of novel molecular urine-based markers for bladder cancer detection... - Prophylactic use of antimicrobials in commonly performed outpatient urologic proceduresEdward M Schaeffer
James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
Nat Clin Pract Urol 3:24-31. 2006..Special consideration for the type and duration of prophylaxis should be given to patients with moderate to severe cardiac valvular conditions and recently inserted prosthetic joints... - A critical analysis of the long-term impact of radical prostatectomy on cancer control and function outcomesStephen A Boorjian
Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, MN 55905, USA
Eur Urol 61:664-75. 2012..Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP)... - Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injuryGiulia Calenda
Albert Einstein College of Medicine, Bronx, NY, USA
BJU Int 109:1552-64. 2012.... - Oncologic efficacy of laparoscopic RPLND in treatment of clinical stage I nonseminomatous germ cell testicular cancerMatthew E Nielsen
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
Urology 70:1168-72. 2007..LRPLND is emerging as a less-invasive alternative in the adjuvant surgical treatment of patients with testicular cancer... - Prostate specific antigen testing among the elderly--when to stop?Edward M Schaeffer
Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland, USA
J Urol 181:1606-14; discussion 1613-4. 2009..We evaluated the relationship between prostate specific antigen and the risk of aggressive prostate cancer developing in men of various ages... - Pyeloduodenal fistula due to advanced upper tract malignancyDavid J Hernandez
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 69:1206-7. 2007 - Can ischemic preconditioning ameliorate renal ischemia-reperfusion injury in a single-kidney porcine model?David J Hernandez
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Endourol 22:2531-6. 2008..We sought to determine the effect of a specific preconditioning regimen on ischemia-reperfusion renal injury in a single-kidney porcine model... - High anterior release of the levator fascia improves sexual function following open radical retropubic prostatectomyMatthew E Nielsen
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
J Urol 180:2557-64; discussion 2564. 2008..We prospectively evaluated the effect of high anterior release on oncological and sexual function outcomes following open radical retropubic prostatectomy... - Clinical sequelae of radiographic iceball involvement of collecting system during computed tomography-guided percutaneous renal tumor cryoablationChristopher A Warlick
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 67:918-22. 2006.... - Complications after prostate biopsy: data from SEER-MedicareStacy Loeb
Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Urol 186:1830-4. 2011..We determined the risk of serious complications requiring hospitalization. We hypothesized that with emerging multidrug resistant organisms there may be an increasing risk of infectious complications... - Laparoscopic retroperitoneal lymph node dissection: duplication of open techniqueMohamad E Allaf
Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21237, USA
Urology 65:575-7. 2005..A modified template dissection that fully duplicates the open technique is now routinely performed at our institution. We describe and show in the accompanying video segments a laparoscopic modified template dissection... - Molecular effects of genistein on male urethral developmentAshley E Ross
Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
J Urol 185:1894-8. 2011..We investigated the effects of genistein, the primary phytoestrogen in soy, on the molecular program of male urethral development... - Paraneoplastic polyarthritis from non-small-cell lung cancer metastatic to the bladderTrinity J Bivalacqua
Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
J Clin Oncol 25:2621-3. 2007 - Urological radiographic manifestations of the Ehlers-Danlos syndromeJonathan Berger
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Urol 178:1490. 2007 - Genetic regulation of prostate developmentJoshua J Meeks
Department of Urology, Northwestern University School of Medicine, Chicago, Illinois, USA
J Androl 32:210-7. 2011..These molecules and pathways are critical for prostate development with both known and postulated roles in prostatic pathology... - Risk factors, prevention and early detection of prostate cancerStacy Loeb
Brady Urological Institute, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Marburg 1, Baltimore, MD 21287, USA
Prim Care 36:603-21. 2009..The current screening strategies using prostate-specific antigen and digital rectal examination are also discussed, as well as the limitations of these protocols and potential methods for improving early detection... - Adrenal myelolipomaEdward M Schaeffer
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA
J Urol 173:1760. 2005 - Rebuttal from authors re: Peter Albers. Quality criteria of laparoscopic nephroureterectomy. Eur Urol. 2007;51:1481-2Michael Muntener
Eur Urol 51:1482-4. 2007