A V Savonenko

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Retardation of cognitive aging by life-long diet restriction: implications for genetic variance
    Alicja L Markowska
    Neuromnemonics Laboratory, Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Aging 23:75-86. 2002
  2. ncbi request reprint The cognitive effects of ovariectomy and estrogen replacement are modulated by aging
    A V Savonenko
    Neuromnemonics Laboratory, Department of Psychology, The Johns Hopkins University, 558 Ross Research Building, 720 Rutland Avenue, 21218, Baltimore, MD, USA
    Neuroscience 119:821-30. 2003
  3. pmc Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
    Katherine D Laclair
    Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA
    Mol Neurodegener 8:18. 2013
  4. pmc Alzheimer's therapeutics: translation of preclinical science to clinical drug development
    Alena V Savonenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 37:261-77. 2012
  5. ncbi request reprint Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities
    Alena Savonenko
    Department of Pathology, Johns Hopkins School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neurobiol Dis 18:602-17. 2005
  6. pmc Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory
    Alena Savonenko
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Learn Mem 10:293-303. 2003
  7. pmc Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor
    A Savonenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Neurol 217:63-73. 2009
  8. pmc Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice
    A V Savonenko
    Departments of Pathology, Neurology, and Neuroscience, Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:5585-90. 2008
  9. ncbi request reprint Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development
    Joanna L Jankowsky
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building Room 558, Baltimore, MD 21205, USA
    Curr Neurol Neurosci Rep 2:457-64. 2002
  10. doi request reprint Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease
    Ying Liu
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 28:13805-14. 2008

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Retardation of cognitive aging by life-long diet restriction: implications for genetic variance
    Alicja L Markowska
    Neuromnemonics Laboratory, Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Aging 23:75-86. 2002
    ..Thus, a more diverse genetic milieu, such as in hybrid rats, relative to inbred rats, may increase the susceptibility to an effect of DR on age-related cognitive decline...
  2. ncbi request reprint The cognitive effects of ovariectomy and estrogen replacement are modulated by aging
    A V Savonenko
    Neuromnemonics Laboratory, Department of Psychology, The Johns Hopkins University, 558 Ross Research Building, 720 Rutland Avenue, 21218, Baltimore, MD, USA
    Neuroscience 119:821-30. 2003
    ....
  3. pmc Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
    Katherine D Laclair
    Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205, USA
    Mol Neurodegener 8:18. 2013
    ..Although recent bexarotene studies failed to replicate the rapid clearance of Aβ from brains, behavioral and cognitive effects of this compound remain controversial...
  4. pmc Alzheimer's therapeutics: translation of preclinical science to clinical drug development
    Alena V Savonenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 37:261-77. 2012
    ..We discuss ways to improve both the predictive validity of mouse models and the translation of knowledge between preclinical and clinical stages of drug development...
  5. ncbi request reprint Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities
    Alena Savonenko
    Department of Pathology, Johns Hopkins School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neurobiol Dis 18:602-17. 2005
    ....
  6. pmc Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory
    Alena Savonenko
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Learn Mem 10:293-303. 2003
    ....
  7. pmc Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor
    A Savonenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Neurol 217:63-73. 2009
    ..Our findings suggest that PGE(2) signaling via the EP2 receptors plays an important role in cognitive and emotional behaviors that recapitulate some aspects of human psychopathology related to schizophrenia...
  8. pmc Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice
    A V Savonenko
    Departments of Pathology, Neurology, and Neuroscience, Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:5585-90. 2008
    ..Collectively, our findings suggest that alterations in BACE1-dependent NRG1/ErbB4 signaling may participate in the pathogenesis of schizophrenia and related psychiatric disorders...
  9. ncbi request reprint Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development
    Joanna L Jankowsky
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building Room 558, Baltimore, MD 21205, USA
    Curr Neurol Neurosci Rep 2:457-64. 2002
    ....
  10. doi request reprint Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease
    Ying Liu
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 28:13805-14. 2008
    ..Our results show that a transgenic mouse model of Abeta pathology develops progressive MAergic neurodegeneration occurring in AD cases...
  11. pmc Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice
    Nino Tabatadze
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci Res 88:2940-51. 2010
    ..Our study identifies nSMase2 as an important component for efficient memory formation and underscores the importance of ceramide in regulating synaptic events related to learning and memory...
  12. ncbi request reprint Increased estrogen receptor beta expression correlates with decreased spine formation in the rat hippocampus
    Sylwia Szymczak
    Nencki Institute, Pasteura 3, 02 093 Warsaw, Poland
    Hippocampus 16:453-63. 2006
    ..In summary, our results suggest that ERbeta inhibits synapse formation in hippocampal neurons...
  13. ncbi request reprint Long-lasting cognitive injury in rats with apparent full gross neurological recovery after short-term cardiac arrest
    Matthew Schreckinger
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Resuscitation 75:105-13. 2007
    ..We used short (5 min) asphyxic-cardiac arrest that resulted in no apparent gross neurological deficits to study the long-term effects of mild hypoxic ischemia on the neurobehavioral status of rats...