William J Savage
Affiliation: Johns Hopkins University
- Allergic agonists in apheresis platelet products are associated with allergic transfusion reactionsWilliam J Savage
Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Transfusion 52:575-81. 2012..To assess product factors associated with ATRs, we investigated candidate mediators in apheresis platelet (PLT) products associated with ATRs and controls...
- New insights into paroxysmal nocturnal hemoglobinuriaWilliam J Savage
The Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Hematology 12:371-6. 2007..The recently FDA approved complement inhibitor eculizumab has been shown to decrease hemolysis, decrease erythrocyte transfusion requirements, and improve quality of life for PNH patients...
- Atopic predisposition of recipients in allergic transfusion reactions to apheresis plateletsWilliam J Savage
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Transfusion 51:2337-42. 2011..The biologic mechanisms of allergic transfusion reactions (ATRs) are largely unknown. We sought to compare the atopic predisposition of platelet (PLT) recipients who experienced an ATR to nonreactive control recipients...
- Plasma glial fibrillary acidic protein levels in children with sickle cell diseaseWilliam J Savage
Divisions of Transfusion Medicine and Pediatric Hematology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Am J Hematol 86:427-9. 2011..Plasma GFAP is elevated among children with SCD and may be associated with subclinical brain injury...
- Allergic transfusion reactions to platelets are associated more with recipient and donor factors than with product attributesWilliam J Savage
Department of Pathology, Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Transfusion 51:1716-22. 2011..Mechanisms of allergic transfusion reactions (ATRs) are not well understood. The aim of this study was to distinguish recipient-, donor-, and product-specific factors associated with ATRs...
- Biomarkers in pediatrics: children as biomarker orphansWilliam J Savage
Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Proteomics Clin Appl 4:915-21. 2010..This review focuses on the fundamentals of biomarkers, the additional considerations needed for applying biomarker research to children, and recommendations for advancing pediatric biomarker research...
- Plasma glial fibrillary acidic protein levels in a child with sickle cell disease and strokeWilliam J Savage
Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
Acta Haematol 125:103-6. 2011..Stroke in SCD can occur in the setting of acute illness, and a biomarker that could predict the onset and triage ill children to therapeutic intervention more quickly would be useful...
- ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusionsMatthew S Karafin
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
Transfusion 52:2087-93. 2012....
- Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reductionAaron A R Tobian
Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
Transfusion 51:1676-83. 2011..This study evaluated whether removing plasma from apheresis platelets (APs) or red blood cells (RBCs) by concentrating or washing transfusion products can decrease the incidence of ATRs...
- The impact of apheresis platelet manipulation on corrected count incrementMatthew Karafin
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Transfusion 52:1221-7. 2012..However, these processes may damage platelets (PLTs). This study evaluated whether concentrating or washing APs decrease the corrected count increment (CCI)...
- Bacterial culture reduces but does not eliminate the risk of septic transfusion reactions to single-donor plateletsAlice K Fuller
Department of Pathology, Hemapheresis and Transfusion Services Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Transfusion 49:2588-93. 2009..6 per 100,000; 95% confidence interval [CI], 0.17-36.9 per 100,000) transfusions. The goal of this study was to determine if bacterial testing of SDPs reduced the rate of SPTRs in our hospital...
- Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body coolingChristopher S Ennen
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Obstet Gynecol 205:251.e1-7. 2011..Glial fibrillary acidic protein (GFAP) is specific to astrocytes in the central nervous system. We hypothesized that serum GFAP would be increased in neonates with hypoxic-ischemic encephalopathy (HIE) treated with whole-body cooling...
- Congenital T cell deficiency in a patient with CHARGE syndromeJulie Hoover-Fong
McKusick Nathans Institute of Genetic Medicine, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA
J Pediatr 154:140-2. 2009..We report a patient with molecularly confirmed CHARGE syndrome, which included a congenital T cell deficiency, who was treated with peripheral blood mononuclear cell transplantation...
- Hemoglobin drift after cardiac surgeryTimothy J George
Division of Cardiac Surgery, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Ann Thorac Surg 94:703-9. 2012..The purpose of this study was to define the natural progression of hemoglobin levels in postoperative cardiac surgery patients...
- Multiplex assays for biomarker research and clinical application: translational science coming of ageQin Fu
The Johns Hopkins Bayview Proteomics Center, Johns Hopkins University, Baltimore, MD 21224, USA
Proteomics Clin Appl 4:271-84. 2010..We also discuss choosing an appropriate platform, judging the performance of assays, obtaining reliable, quantitative results for translational research and clinical applications in the biomarker field...
- Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNHWilliam J Savage
Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
Exp Hematol 37:42-51. 2009..Investigate the contribution of PIG-A mutations to clonal expansion in paroxysmal nocturnal hemoglobinuria (PNH)...
- Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemiaJeffrey J Pu
Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Eur J Haematol 87:37-45. 2011..To investigate the natural history of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients with acquired aplastic anemia (AA)...