William J Savage

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Allergic agonists in apheresis platelet products are associated with allergic transfusion reactions
    William J Savage
    Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Transfusion 52:575-81. 2012
  2. ncbi request reprint New insights into paroxysmal nocturnal hemoglobinuria
    William J Savage
    The Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hematology 12:371-6. 2007
  3. pmc Atopic predisposition of recipients in allergic transfusion reactions to apheresis platelets
    William J Savage
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Transfusion 51:2337-42. 2011
  4. pmc Plasma glial fibrillary acidic protein levels in children with sickle cell disease
    William J Savage
    Divisions of Transfusion Medicine and Pediatric Hematology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Hematol 86:427-9. 2011
  5. pmc Allergic transfusion reactions to platelets are associated more with recipient and donor factors than with product attributes
    William J Savage
    Department of Pathology, Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Transfusion 51:1716-22. 2011
  6. doi request reprint Biomarkers in pediatrics: children as biomarker orphans
    William J Savage
    Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Proteomics Clin Appl 4:915-21. 2010
  7. pmc Plasma glial fibrillary acidic protein levels in a child with sickle cell disease and stroke
    William J Savage
    Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Acta Haematol 125:103-6. 2011
  8. pmc Scratching the surface of allergic transfusion reactions
    William J Savage
    Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Transfusion 53:1361-71. 2013
  9. pmc The cost-effectiveness of platelet additive solution to prevent allergic transfusion reactions
    Seema Kacker
    Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Pathology, Johns Hopkins University, Baltimore, Maryland Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota
    Transfusion 53:2609-18. 2013
  10. pmc ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusions
    Matthew S Karafin
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    Transfusion 52:2087-93. 2012

Detail Information

Publications22

  1. pmc Allergic agonists in apheresis platelet products are associated with allergic transfusion reactions
    William J Savage
    Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Transfusion 52:575-81. 2012
    ..To assess product factors associated with ATRs, we investigated candidate mediators in apheresis platelet (PLT) products associated with ATRs and controls...
  2. ncbi request reprint New insights into paroxysmal nocturnal hemoglobinuria
    William J Savage
    The Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hematology 12:371-6. 2007
    ..The recently FDA approved complement inhibitor eculizumab has been shown to decrease hemolysis, decrease erythrocyte transfusion requirements, and improve quality of life for PNH patients...
  3. pmc Atopic predisposition of recipients in allergic transfusion reactions to apheresis platelets
    William J Savage
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Transfusion 51:2337-42. 2011
    ..The biologic mechanisms of allergic transfusion reactions (ATRs) are largely unknown. We sought to compare the atopic predisposition of platelet (PLT) recipients who experienced an ATR to nonreactive control recipients...
  4. pmc Plasma glial fibrillary acidic protein levels in children with sickle cell disease
    William J Savage
    Divisions of Transfusion Medicine and Pediatric Hematology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Hematol 86:427-9. 2011
    ..Plasma GFAP is elevated among children with SCD and may be associated with subclinical brain injury...
  5. pmc Allergic transfusion reactions to platelets are associated more with recipient and donor factors than with product attributes
    William J Savage
    Department of Pathology, Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Transfusion 51:1716-22. 2011
    ..Mechanisms of allergic transfusion reactions (ATRs) are not well understood. The aim of this study was to distinguish recipient-, donor-, and product-specific factors associated with ATRs...
  6. doi request reprint Biomarkers in pediatrics: children as biomarker orphans
    William J Savage
    Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Proteomics Clin Appl 4:915-21. 2010
    ..This review focuses on the fundamentals of biomarkers, the additional considerations needed for applying biomarker research to children, and recommendations for advancing pediatric biomarker research...
  7. pmc Plasma glial fibrillary acidic protein levels in a child with sickle cell disease and stroke
    William J Savage
    Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Acta Haematol 125:103-6. 2011
    ..Stroke in SCD can occur in the setting of acute illness, and a biomarker that could predict the onset and triage ill children to therapeutic intervention more quickly would be useful...
  8. pmc Scratching the surface of allergic transfusion reactions
    William J Savage
    Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Transfusion 53:1361-71. 2013
    ..Further understanding of the mechanisms of ATRs is necessary so that rationally designed and cost-effective prevention measures can be developed...
  9. pmc The cost-effectiveness of platelet additive solution to prevent allergic transfusion reactions
    Seema Kacker
    Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Pathology, Johns Hopkins University, Baltimore, Maryland Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota
    Transfusion 53:2609-18. 2013
    ..Storage in platelet additive solution (PAS) has been shown to reduce ATRs from apheresis platelets (APs). This study evaluated the cost-effectiveness of using PAS storage as an alternative method to reduce ATRs...
  10. pmc ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusions
    Matthew S Karafin
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    Transfusion 52:2087-93. 2012
    ....
  11. ncbi request reprint Prevention of allergic transfusion reactions to platelets and red blood cells through plasma reduction
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
    Transfusion 51:1676-83. 2011
    ..This study evaluated whether removing plasma from apheresis platelets (APs) or red blood cells (RBCs) by concentrating or washing transfusion products can decrease the incidence of ATRs...
  12. pmc Cost-effectiveness of prospective red blood cell antigen matching to prevent alloimmunization among sickle cell patients
    Seema Kacker
    Department of Pathology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts
    Transfusion 54:86-97. 2014
    ..Prospective antigen matching can prevent alloimmunization, but is costly and may not benefit most patients...
  13. pmc The impact of apheresis platelet manipulation on corrected count increment
    Matthew Karafin
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Transfusion 52:1221-7. 2012
    ..However, these processes may damage platelets (PLTs). This study evaluated whether concentrating or washing APs decrease the corrected count increment (CCI)...
  14. pmc Bacterial culture reduces but does not eliminate the risk of septic transfusion reactions to single-donor platelets
    Alice K Fuller
    Department of Pathology, Hemapheresis and Transfusion Services Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Transfusion 49:2588-93. 2009
    ..6 per 100,000; 95% confidence interval [CI], 0.17-36.9 per 100,000) transfusions. The goal of this study was to determine if bacterial testing of SDPs reduced the rate of SPTRs in our hospital...
  15. ncbi request reprint Odds of transfusion for older adults compared to younger adults undergoing surgery
    Charles H Brown
    From the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Transfusion Medicine, Brigham and Women s Hospital, Boston, Massachusetts and Division of Geriatric Medicine and Gerontology, Johns Hopkins Medical Institutions, Baltimore, Maryland and Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, Maryland
    Anesth Analg 118:1168-78. 2014
    ..Our objective in this study was to determine whether the odds of transfusion are higher in older patients than in younger patients in the perioperative period...
  16. pmc Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling
    Christopher S Ennen
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 205:251.e1-7. 2011
    ..Glial fibrillary acidic protein (GFAP) is specific to astrocytes in the central nervous system. We hypothesized that serum GFAP would be increased in neonates with hypoxic-ischemic encephalopathy (HIE) treated with whole-body cooling...
  17. doi request reprint Congenital T cell deficiency in a patient with CHARGE syndrome
    Julie Hoover-Fong
    McKusick Nathans Institute of Genetic Medicine, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA
    J Pediatr 154:140-2. 2009
    ..We report a patient with molecularly confirmed CHARGE syndrome, which included a congenital T cell deficiency, who was treated with peripheral blood mononuclear cell transplantation...
  18. pmc Partial manual exchange reduces iron accumulation during chronic red cell transfusions for sickle cell disease
    William J Savage
    Division of Transfusion Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pediatr Hematol Oncol 35:434-6. 2013
    ..02). A reduction in LIC from pretransfusion phlebotomy could not be established (P=0.4). Partial manual exchanges appear to be an effective strategy for slowing the pace of iron loading in the setting of chronic transfusion for SCD. ..
  19. pmc Hemoglobin drift after cardiac surgery
    Timothy J George
    Division of Cardiac Surgery, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 94:703-9. 2012
    ..The purpose of this study was to define the natural progression of hemoglobin levels in postoperative cardiac surgery patients...
  20. doi request reprint Multiplex assays for biomarker research and clinical application: translational science coming of age
    Qin Fu
    The Johns Hopkins Bayview Proteomics Center, Johns Hopkins University, Baltimore, MD 21224, USA
    Proteomics Clin Appl 4:271-84. 2010
    ..We also discuss choosing an appropriate platform, judging the performance of assays, obtaining reliable, quantitative results for translational research and clinical applications in the biomarker field...
  21. pmc Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH
    William J Savage
    Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Exp Hematol 37:42-51. 2009
    ..Investigate the contribution of PIG-A mutations to clonal expansion in paroxysmal nocturnal hemoglobinuria (PNH)...
  22. pmc Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia
    Jeffrey J Pu
    Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Eur J Haematol 87:37-45. 2011
    ..To investigate the natural history of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients with acquired aplastic anemia (AA)...