Adam Sapirstein

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Tele ICU: paradox or panacea?
    Adam Sapirstein
    Department of Anesthesia and Critical Care Medicine The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Best Pract Res Clin Anaesthesiol 23:115-26. 2009
  2. ncbi request reprint Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation
    Adam Sapirstein
    Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, 600 N Wolfe St Meyer 297 A, Baltimore, MD 21287 7294, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1774-82. 2005
  3. doi request reprint Inhibition of cytosolic phospholipase A(2) alpha protects against focal ischemic brain damage in mice
    Jian Zhang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 720 Rutland Ave, Ross 347, Baltimore, MD 21205, USA
    Brain Res 1471:129-37. 2012
  4. pmc Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice
    Koji Kishimoto
    the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 7:42. 2010
  5. pmc Cytosolic phospholipase A(2) alpha mediates electrophysiologic responses of hippocampal pyramidal neurons to neurotoxic NMDA treatment
    Ying Shen
    Department of Neuroscience, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:6078-83. 2007
  6. pmc Host cytosolic phospholipase A₂α contributes to group B Streptococcus penetration of the blood-brain barrier
    Ravi Maruvada
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Infect Immun 79:4088-93. 2011
  7. ncbi request reprint Cytosolic phospholipase A alpha modulates NMDA neurotoxicity in mouse hippocampal cultures
    Ken M Brady
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Eur J Neurosci 24:3381-6. 2006
  8. ncbi request reprint Effect of postoperative epidural analgesia on morbidity and mortality after lung resection in Medicare patients
    Christopher L Wu
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Clin Anesth 18:515-20. 2006
  9. doi request reprint Enhancing the quality of care in the intensive care unit: a systems engineering approach
    Steven P Tropello
    The Armstrong Institute for Patient Safety and Quality, Johns Hopkins University School of Medicine, Baltimore, MD 21202, USA
    Crit Care Clin 29:113-24. 2013
  10. ncbi request reprint 1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia
    Muzamil Ahmad
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Eur J Neurosci 23:35-42. 2006

Research Grants

  1. Cytosolic Phospholipase A2 Alpha in Stroke Injury
    Adam Sapirstein; Fiscal Year: 2007
  2. Cytosolic Phospholipase A2 Alpha in Stroke Injury
    Adam Sapirstein; Fiscal Year: 2009
  3. Cytosolic Phospholipase A2 Alpha in Stroke Injury
    Adam Sapirstein; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Tele ICU: paradox or panacea?
    Adam Sapirstein
    Department of Anesthesia and Critical Care Medicine The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Best Pract Res Clin Anaesthesiol 23:115-26. 2009
    ..Tele-ICU is expensive to deploy and use, it may add burdens to existing intensivists, and it requires organizational and culture changes that can be difficult to accomplish...
  2. ncbi request reprint Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation
    Adam Sapirstein
    Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, 600 N Wolfe St Meyer 297 A, Baltimore, MD 21287 7294, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1774-82. 2005
    ..These results indicate that cPLA(2)alpha inhibition is a novel anti-inflammatory strategy that modulates, but does not completely prevent, eicosanoid responses...
  3. doi request reprint Inhibition of cytosolic phospholipase A(2) alpha protects against focal ischemic brain damage in mice
    Jian Zhang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 720 Rutland Ave, Ross 347, Baltimore, MD 21205, USA
    Brain Res 1471:129-37. 2012
    ..cPLA(2)α activity augments injury in the acute and delayed phases of cerebral ischemia and reperfusion injury. We conclude that cPLA(2)α inhibition may be clinically useful if started before initiation of cerebral ischemia...
  4. pmc Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice
    Koji Kishimoto
    the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 7:42. 2010
    ..In this study we investigated the role of cPLA2alpha in early ischemic cerebral injury...
  5. pmc Cytosolic phospholipase A(2) alpha mediates electrophysiologic responses of hippocampal pyramidal neurons to neurotoxic NMDA treatment
    Ying Shen
    Department of Neuroscience, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:6078-83. 2007
    ..These results indicate that cPLA(2)alpha activity is required for development of aberrant electrophysiologic events triggered by NMDA receptor activation, in part through attenuation of K-channel function...
  6. pmc Host cytosolic phospholipase A₂α contributes to group B Streptococcus penetration of the blood-brain barrier
    Ravi Maruvada
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Infect Immun 79:4088-93. 2011
    ..These findings demonstrate that specific host factors involving cPLA₂α and cysteinyl LTs contribute to type III GBS penetration of the blood-brain barrier and their contribution involves PKCα...
  7. ncbi request reprint Cytosolic phospholipase A alpha modulates NMDA neurotoxicity in mouse hippocampal cultures
    Ken M Brady
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Eur J Neurosci 24:3381-6. 2006
    ....
  8. ncbi request reprint Effect of postoperative epidural analgesia on morbidity and mortality after lung resection in Medicare patients
    Christopher L Wu
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Clin Anesth 18:515-20. 2006
    ..To perform an analysis of the Medicare claims database in patients undergoing lung resection to determine whether there is an association between postoperative epidural analgesia and mortality...
  9. doi request reprint Enhancing the quality of care in the intensive care unit: a systems engineering approach
    Steven P Tropello
    The Armstrong Institute for Patient Safety and Quality, Johns Hopkins University School of Medicine, Baltimore, MD 21202, USA
    Crit Care Clin 29:113-24. 2013
    ..Specific examples of applying a systems engineering approach to the Patient Care Program Acute Care Initiative are presented...
  10. ncbi request reprint 1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia
    Muzamil Ahmad
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Eur J Neurosci 23:35-42. 2006
    ....
  11. pmc Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier
    Longkun Zhu
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Infect Immun 78:4302-10. 2010
    ..coli penetration of the blood-brain barrier, and studies are needed to further elucidate the mechanisms involved with metabolic products of arachidonic acid for their contribution to E. coli invasion of the blood-brain barrier...
  12. ncbi request reprint Stroke outcomes in mice lacking the genes for neuronal heme oxygenase-2 and nitric oxide synthase
    Khodadad Namiranian
    Johns Hopkins School of Medicine, Baltimore MD, USA
    Curr Neurovasc Res 2:23-7. 2005
    ..The results suggest that the deleterious action of nNOS would counteract the role of HO-2 in neuroprotection...
  13. doi request reprint Centralized triage for multiple intensive care units: the central intensivist physician
    Mark Romig
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Med Qual 25:343-5. 2010
    ..The authors conclude that the CIP program may improve overall critical care resource use while maintaining unit specialization within a large tertiary care hospital setting...
  14. ncbi request reprint Implications of the cytosolic phospholipase A2 knockout mouse on perioperative therapeutics
    Adam Sapirstein
    Anesthesiology and Critical Care Medicine, Johns Hopkins, Baltimore, MD 21287, USA
    Int Anesthesiol Clin 41:79-90. 2003
  15. ncbi request reprint Effect of duration of osmotherapy on blood-brain barrier disruption and regional cerebral edema after experimental stroke
    Chih Hung Chen
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 26:951-8. 2006
    ....
  16. ncbi request reprint Group IV cytosolic phospholipase A2 (PLA2) function: insights from the knockout mouse
    Joseph V Bonventre
    Department of Medicine, Harvard Medical School, Medical Service, Massachusetts General Hospital, Harvard Massachusetts Institute of Technology, Division of Health Sciences, Boston, MA, USA
    Adv Exp Med Biol 507:25-31. 2002
  17. ncbi request reprint Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets
    Tarek A Samad
    Neural Plasticity Research Group, Dept of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Trends Mol Med 8:390-6. 2002
    ....
  18. pmc Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction
    Fumito Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 109:1493-500. 2002
    ..These results indicate that cPLA(2) contributes to the murine pulmonary vasoconstrictor response to hypoxia. Augmenting pulmonary vascular tone restores HPV in the absence of cPLA(2) activity...
  19. ncbi request reprint Participation of cytosolic phospholipase A2 in eicosanoid generation by mouse bone marrow-derived mast cells
    Bruno L Diaz
    Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Adv Exp Med Biol 507:41-6. 2002
  20. ncbi request reprint Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachido
    Won K Han
    Medical Services, Massachusetts General Hospital, Department of Medicine and Anesthesia, Harvard Medical School, Massachusetts, USA
    J Biol Chem 278:24153-63. 2003
    ..Group IIa and V PLA2s are regulatory and cPLA2alpha is responsible for AA release...

Research Grants4

  1. Cytosolic Phospholipase A2 Alpha in Stroke Injury
    Adam Sapirstein; Fiscal Year: 2007
    ..The results of these studies will show if drugs aimed against the enzyme cPLA2a can be used to decrease injury following stroke and if the new protein, KIDS- cPLA2a has potential as a new brain-specific therapy for stroke. ..
  2. Cytosolic Phospholipase A2 Alpha in Stroke Injury
    Adam Sapirstein; Fiscal Year: 2009
    ..The results of these studies will show if drugs aimed against the enzyme cPLA2a can be used to decrease injury following stroke and if the new protein, KIDS- cPLA2a has potential as a new brain-specific therapy for stroke. ..
  3. Cytosolic Phospholipase A2 Alpha in Stroke Injury
    Adam Sapirstein; Fiscal Year: 2010
    ..The results of these studies will show if drugs aimed against the enzyme cPLA2a can be used to decrease injury following stroke and if the new protein, KIDS- cPLA2a has potential as a new brain-specific therapy for stroke. ..