R Salvatori

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Lanreotide extended-release aqueous-gel formulation, injected by patient, partner or healthcare provider in patients with acromegaly in the United States: 1-year data from the SODA registry
    Roberto Salvatori
    Division of Endocrinology, Johns Hopkins University, 1830 East Monument Street 333, Baltimore, MD, 21287, USA
    Pituitary 17:13-21. 2014
  2. doi request reprint Isolated GH deficiency due to a GHRH receptor mutation causes hip joint problems and genu valgum, and reduces size but not density of trabecular and mixed bone
    Carlos C Epitácio-Pereira
    MD, Division of Endocrinology, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, MD 21287
    J Clin Endocrinol Metab 98:E1710-5. 2013
  3. doi request reprint Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency
    Carla R P Oliveira
    Federal University of Sergipe, Aracaju, SE, Brazil
    J Clin Endocrinol Metab 97:1013-9. 2012
  4. pmc Prognostic value of exercise echocardiography in diabetic patients
    Joselina L M Oliveira
    Department of Internal Medicine, Cardiology and Endocrinology Division, Federal University of Sergipe, Aracaju, Sergipe, Brazil
    Cardiovasc Ultrasound 7:24. 2009
  5. ncbi request reprint GH response to hypoglycemia and clonidine in the GH-releasing hormone resistance syndrome
    R Salvatori
    Division of Endocrinology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Endocrinol Invest 29:805-8. 2006
  6. ncbi request reprint Adrenal insufficiency
    Roberto Salvatori
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    JAMA 294:2481-8. 2005
  7. ncbi request reprint Pituitary tumors
    Nestoras Mathioudakis
    Roberto Salvatori, MD Johns Hopkins School of Endocrinology and Metabolism, 1830 East Monument Street, Suite 333, Baltimore, MD 21287, USA
    Curr Treat Options Neurol 11:287-96. 2009
  8. pmc Effectiveness of self- or partner-administration of an extended-release aqueous-gel formulation of lanreotide in lanreotide-naïve patients with acromegaly
    Roberto Salvatori
    Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Pituitary 13:115-22. 2010
  9. doi request reprint A novel frame shift mutation in the GHRH receptor gene in familial isolated GH deficiency: early occurrence of anterior pituitary hypoplasia
    Rugia Shohreh
    Department of Medicine, Division of Endocrinology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 96:2982-6. 2011
  10. ncbi request reprint Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene
    R Salvatori
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 84:917-23. 1999

Research Grants

  1. Molecular analysis of GHRH receptor missense mutations
    Roberto Salvatori; Fiscal Year: 2004
  2. Consequences of generalized lack of GHRH
    Roberto Salvatori; Fiscal Year: 2005
  3. Consequences of lifetime isolated Growth Hormone deficiency
    Roberto Salvatori; Fiscal Year: 2007
  4. Creation of a mouse model of isolated GH deficiency
    Roberto Salvatori; Fiscal Year: 2007

Collaborators

Detail Information

Publications52

  1. doi request reprint Lanreotide extended-release aqueous-gel formulation, injected by patient, partner or healthcare provider in patients with acromegaly in the United States: 1-year data from the SODA registry
    Roberto Salvatori
    Division of Endocrinology, Johns Hopkins University, 1830 East Monument Street 333, Baltimore, MD, 21287, USA
    Pituitary 17:13-21. 2014
    ..Acromegaly symptoms remained stable. Biochemical, safety and convenience data support the clinical validity of injecting LD at home. ..
  2. doi request reprint Isolated GH deficiency due to a GHRH receptor mutation causes hip joint problems and genu valgum, and reduces size but not density of trabecular and mixed bone
    Carlos C Epitácio-Pereira
    MD, Division of Endocrinology, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, MD 21287
    J Clin Endocrinol Metab 98:E1710-5. 2013
    ..We have shown that adult IGHD individuals from the Itabaianinha, homozygous for the c.57+1G>A GHRHR mutation, have reduced bone stiffness, but BMD and joint status in this cohort are unknown...
  3. doi request reprint Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency
    Carla R P Oliveira
    Federal University of Sergipe, Aracaju, SE, Brazil
    J Clin Endocrinol Metab 97:1013-9. 2012
    ..GH reduces insulin sensitivity (IS), whereas IGF-I increases it. IGF-I seems to be critical for the development of the β-cells, and impaired IS has been reported in GH deficiency (GHD)...
  4. pmc Prognostic value of exercise echocardiography in diabetic patients
    Joselina L M Oliveira
    Department of Internal Medicine, Cardiology and Endocrinology Division, Federal University of Sergipe, Aracaju, Sergipe, Brazil
    Cardiovasc Ultrasound 7:24. 2009
    ..The purpose of this investigation was to evaluate the value of EE in predicting cardiac events in diabetics...
  5. ncbi request reprint GH response to hypoglycemia and clonidine in the GH-releasing hormone resistance syndrome
    R Salvatori
    Division of Endocrinology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Endocrinol Invest 29:805-8. 2006
    ..There was a small but significant GH increase during ITT, but not during CL test. These results indicate that a minimal albeit significant GH response to ITT can occur despite complete lack of GHRH-R function...
  6. ncbi request reprint Adrenal insufficiency
    Roberto Salvatori
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    JAMA 294:2481-8. 2005
    ..Important differences exist between primary and secondary AI, and the diagnosis of secondary AI may be challenging. The therapy of AI should be carefully tailored to the requirements of the individual patient...
  7. ncbi request reprint Pituitary tumors
    Nestoras Mathioudakis
    Roberto Salvatori, MD Johns Hopkins School of Endocrinology and Metabolism, 1830 East Monument Street, Suite 333, Baltimore, MD 21287, USA
    Curr Treat Options Neurol 11:287-96. 2009
    ..In the hands of an experienced pituitary neurosurgeon, the prognosis for endocrinologic recovery and visual improvement is good...
  8. pmc Effectiveness of self- or partner-administration of an extended-release aqueous-gel formulation of lanreotide in lanreotide-naïve patients with acromegaly
    Roberto Salvatori
    Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Pituitary 13:115-22. 2010
    ..0001). Self- or partner-administration of lanreotide is generally well tolerated and associated with IGF-1 and GH control in many lanreotide-naïve patients with acromegaly...
  9. doi request reprint A novel frame shift mutation in the GHRH receptor gene in familial isolated GH deficiency: early occurrence of anterior pituitary hypoplasia
    Rugia Shohreh
    Department of Medicine, Division of Endocrinology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 96:2982-6. 2011
    ..We analyzed the GHRHR and measured pituitary size in a consanguineous family with the father and three of the five siblings with IGHD...
  10. ncbi request reprint Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene
    R Salvatori
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 84:917-23. 1999
    ..We describe a novel mutation in the GHRHR gene as cause of dwarfism in the largest kindred with familial IGHD described to date...
  11. ncbi request reprint Growth hormone and IGF-1
    Roberto Salvatori
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA
    Rev Endocr Metab Disord 5:15-23. 2004
  12. ncbi request reprint Serum GH response to pharmacological stimuli and physical exercise in two siblings with two new inactivating mutations in the GH-releasing hormone receptor gene
    Roberto Salvatori
    Division of Endocrinology, Department of Medicine and The Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Eur J Endocrinol 147:591-6. 2002
    ..The GH response to physical exercise (PE) in patients lacking GHRHR has never been studied. We hypothesized that subjects lacking functional GHRHR may be a model to study GH response to PE...
  13. ncbi request reprint Detection of a recurring mutation in the human growth hormone-releasing hormone receptor gene
    Roberto Salvatori
    Department of Medicine and The Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Clin Endocrinol (Oxf) 57:77-80. 2002
    ..This mutation was described in two families with different ethnic background residing in two different continents (Europe and North America)...
  14. ncbi request reprint Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site
    Roberto Salvatori
    Division of Endocrinology, and the Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Mol Endocrinol 16:450-8. 2002
    ..These results demonstrate that mutations in the GHRHR are not limited to the coding sequence and that promoter mutations that impair Pit-1 binding can reduce expression of the GHRHR gene...
  15. ncbi request reprint Isolated growth hormone (GH) deficiency due to compound heterozygosity for two new mutations in the GH-releasing hormone receptor gene
    R Salvatori
    Division of Endocrinology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Clin Endocrinol (Oxf) 54:681-7. 2001
    ..We searched for mutations in the GHRH-R gene in a family in which two of three siblings were affected by IGHD...
  16. ncbi request reprint Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib
    R Salvatori
    Division of Endocrinology, Department of Medicine, Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 86:273-9. 2001
    ..These results demonstrate that missense mutations in the GHRHR gene are a cause of IGHD IB, and that defects in the GHRHR gene may be a more common cause of GH deficiency than previously suspected...
  17. ncbi request reprint Absence of mutations in the growth hormone (GH)-releasing hormone receptor gene in GH-secreting pituitary adenomas
    R Salvatori
    Division of Endocrinology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Clin Endocrinol (Oxf) 54:301-7. 2001
    ....
  18. ncbi request reprint A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency
    Mauri Carakushansky
    Divisions of Pediatric Endocrinology and Endocrinology and The Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Eur J Endocrinol 148:25-30. 2003
    ..We searched for GHRHR mutations in two siblings with IGHD type IB and a history of parental consanguinity...
  19. ncbi request reprint Heterozygosity for a mutation in the growth hormone-releasing hormone receptor gene does not influence adult stature, but affects body composition
    Rossana M C Pereira
    Division of Endocrinology, Johns Hopkins University, Baltimore, MD 21287, USA
    J Clin Endocrinol Metab 92:2353-7. 2007
    ..Although heterozygous carriers of these mutations appear normal, we hypothesized that heterozygosity for a GHRHR mutation might be associated with a subclinical phenotype...
  20. ncbi request reprint Naturally-occurring missense mutations in the human growth hormone-releasing hormone receptor alter ligand binding
    Maria Alba
    Division of Endocrinology and The Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Endocrinol 186:515-21. 2005
    ..These studies demonstrate that abnormal ligand binding is a common mechanism by which naturally occurring missense mutation alter GHRH-R function...
  21. pmc Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene
    Manuel H Aguiar-Oliveira
    Division of Endocrinology, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 95:714-21. 2010
    ..The prevalence of heterozygosity did not differ in young and old groups, suggesting no survival advantage or disadvantage. Conclusions: In a selected genetic background, lifelong untreated IGHD does not affect longevity...
  22. pmc Mpl Baltimore: a thrombopoietin receptor polymorphism associated with thrombocytosis
    Alison R Moliterno
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:11444-7. 2004
    ..K39N represents an identified functional Mpl polymorphism and is associated with altered protein expression of Mpl and a clinical phenotype of thrombocytosis...
  23. ncbi request reprint A mouse with targeted ablation of the growth hormone-releasing hormone gene: a new model of isolated growth hormone deficiency
    Maria Alba
    Division of Endocrinology, Johns Hopkins University School of Medicine, 1830 East Monument Street 333, Baltimore, Maryland 21287, USA
    Endocrinology 145:4134-43. 2004
    ..In conclusion, we demonstrate that ablation of the GHRH gene causes IGHD in mice. The GHRHKO mouse will be the new useful model of IGHD...
  24. ncbi request reprint Variability in anterior pituitary size within members of a family with GH deficiency due to a new splice mutation in the GHRH receptor gene
    Maria Alba
    Division of Endocrinology, and the Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Clin Endocrinol (Oxf) 60:470-5. 2004
    ..We searched for GHRHR mutations and studied pituitary morphology in three prepubertal sibs with severe IGHD, who were born from consanguineous parents...
  25. ncbi request reprint Lack of evidence of premature atherosclerosis in untreated severe isolated growth hormone (GH) deficiency due to a GH-releasing hormone receptor mutation
    Joselina Luzia Menezes Oliveira
    Division of Endocrinology, Johns Hopkins University, 1830 East Monument Street, 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 91:2093-9. 2006
    ..However, several confounding factors exist, such as associated pituitary deficits and replacement of other hormones or surgical or radiological therapies used to treat the underlying pituitary of hypothalamic pathologies...
  26. ncbi request reprint Partial reversibility of growth hormone (GH) deficiency in the GH-releasing hormone (GHRH) knockout mouse by postnatal treatment with a GHRH analog
    Maria Alba
    Division of Endocrinology and Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, 1830 East Monument Street 333, Baltimore, Maryland 21287, USA
    Endocrinology 146:1506-13. 2005
    ....
  27. pmc Mutation analysis of the muscarinic cholinergic receptor genes in isolated growth hormone deficiency type IB
    Ali Mohamadi
    Division of Endocrinology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 94:2565-70. 2009
    ..Five types of mAchR (M(1)-M(5)) exist. A transgenic mouse in which the function of the M(3) receptor was selectively ablated in the central nervous system has isolated GH deficiency similar to animals with defective GHRH or GHRHR gene...
  28. ncbi request reprint Effects of combined long-term treatment with a growth hormone-releasing hormone analogue and a growth hormone secretagogue in the growth hormone-releasing hormone knock out mouse
    Danilo Fintini
    Department of Medicine, Division of Endocrinology, and the Ilyssa Center for Molecular and Cellular Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroendocrinology 82:198-207. 2005
    ..These data demonstrate that in GHRHKO mice, GHRP-2 has a growth-stimulating effect that augments the response induced by JI-38. In addition, the presence of GHRH seems necessary for the stimulation of GH secretion by GHRP-2...
  29. ncbi request reprint Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
    Maria Alba
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Physiol Endocrinol Metab 291:E1290-4. 2006
    ..These findings demonstrate that treatment with once-daily administration of CJC-1295 is able to maintain normal body composition and growth in GHRHKO mice. The same dose is less effective when administered every 48 or 72 h...
  30. pmc Partial rescue of growth failure in growth hormone (GH)-deficient mice by a single injection of a double-stranded adeno-associated viral vector expressing the GH gene driven by a muscle-specific regulatory cassette
    Marco Martari
    Division of Endocrinology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Gene Ther 20:759-66. 2009
    ..The present study shows that systemic GH delivery to GHD animals is possible via a single intramuscular injection of dsAAV carrying a muscle-specific GH-expressing regulatory cassette...
  31. ncbi request reprint Autosomal-dominant isolated growth hormone deficiency (IGHD type II) with normal GH-1 gene
    Danilo Fintini
    Division of Endocrinology, Department of Medicine and Ilyssa Center for Molecular and Cellular Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Horm Res 65:76-82. 2006
    ..Rarely, heterozygous mutations in the gene encoding for HESX-1 gene (HESX-1) may cause autosomal-dominant IGHD, with penetrance that has been shown to be variable in both humans and mice...
  32. pmc Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency
    Carla R P Oliveira
    Division of Endocrinology, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 95:693-8. 2010
    ..6 (13.8) vs. 8.5 (11.1) microg/min]. Conclusions: Subjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium...
  33. ncbi request reprint Effects of long-term treatment with growth hormone-releasing peptide-2 in the GHRH knockout mouse
    Maria Alba
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Physiol Endocrinol Metab 289:E762-7. 2005
    ..These data demonstrate that GHRP-2 failed to reverse the severe GHD caused by lack of GHRH...
  34. doi request reprint A single injection of double-stranded adeno-associated viral vector expressing GH normalizes growth in GH-deficient mice
    Alessia Sagazio
    Division of Endocrinology, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street 333, Baltimore, Maryland 21287, USA
    J Endocrinol 196:79-88. 2008
    ..These data show that normalization of longitudinal growth can be reached in GHD mice using a single injection of a double-stranded adeno-associated virus expressing GH...
  35. ncbi request reprint Influence of estrogen administration on the growth response to growth hormone (GH) in GH-deficient mice
    Danilo Fintini
    Department of Medicine, Division of Endocrinology, Ilyssa Center for Molecular and Cellular Endocrinology, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Biol Med (Maywood) 230:715-20. 2005
    ..These results show that subcutaneous or oral EE does not reduce the growth response to GH in female GHD mice...
  36. ncbi request reprint Effects of recombinant mouse growth hormone treatment on growth and body composition in GHRH knock out mice
    Maria Alba
    Department of Medicine, Division of Endocrinology, and the Ilyssa Center for Molecular and Cellular Endocrinology, Johns Hopkins University School of Medicine, 1830 East Monument Street 333, Baltimore, MD 21287, USA
    Growth Horm IGF Res 15:275-82. 2005
    ..To determine the optimal GH replacement schedule in GHD mice, and to study its effect on body composition, we treated mice with targeted ablation of the GHRH gene (GHRH knock out-GHRHKO) with recombinant mouse GH (rmGH)...
  37. ncbi request reprint Vitamin A deficiency does not influence longitudinal growth in mice
    Alessia Sagazio
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nutrition 23:483-8. 2007
    ..Accordingly, epidemiologic studies have shown that short children have lower VA intake than do children with normal stature...
  38. ncbi request reprint Thyroid morphology and function in adults with untreated isolated growth hormone deficiency
    Marta Regina Silva Alcântara
    Division of Endocrinology, Johns Hopkins University, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 91:860-4. 2006
    ..Although goiter is frequent in acromegalic patients, the effects of GH deficiency (GHD) are difficult to assess, because hypopituitaric subjects who lack GH often also have a partial or complete deficit of TSH...
  39. ncbi request reprint Giant somatotrophinoma without acromegalic features: more "quiet" than "silent": case report
    Aniket Sidhaye
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neurosurgery 56:E1154; discussion E1154. 2005
    ..Because of this, they may be amenable to treatment with somatostatin analogues...
  40. ncbi request reprint Cushing's Syndrome attributable to ectopic secretion of corticotropin in a patient with two neuroendocrine tumors
    Roberto Salvatori
    Department of Medicine Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Endocr Pract 12:656-9. 2006
    ..To report a case of ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) in a patient with two distinct neuroendocrine tumors and to highlight the difficulties of establishing the differential diagnosis of EAS...
  41. ncbi request reprint Metastatic renal cell carcinoma to the pituitary presenting with hyperprolactinemia
    S Basaria
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Endocrinol Invest 27:471-4. 2004
    ..Mild-to-moderate degree of hyperprolactinemia is a rare presentation of pituitary metastases. We report the case of a woman with metastatic RCC to the pituitary presenting an unusually high degree of hyperprolactinemia...
  42. pmc Recurrence of hyperprolactinemia after withdrawal of long-term cabergoline therapy
    J Kharlip
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 94:2428-36. 2009
    ..Recurrence of hyperprolactinemia after cabergoline withdrawal ranges widely from 36 to 80%. The Pituitary Society recommends withdrawal of cabergoline in selected patients...
  43. doi request reprint GH, but not GHRH, plays a role in the development of experimental autoimmune encephalomyelitis
    Rugia Shohreh
    Division of Endocrinology, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Endocrinology 152:3803-10. 2011
    ..GH treatment was also associated with a markedly increase in spleen size and T-cell proliferation specific to myelin oligodendrocyte glycoprotein peptide. GH (but not GHRH) plays an important role in the development of EAE...
  44. doi request reprint Adult-onset growth hormone deficiency: causes, complications and treatment options
    Nestoras Mathioudakis
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 USA
    Curr Opin Endocrinol Diabetes Obes 15:352-8. 2008
    ..Description of the progresses related to the complications and treatment of adult-onset growth hormone deficiency...
  45. ncbi request reprint Familial Growth Hormone Deficiency and Mutations in the GHRH Receptor Gene
    Maria Alba
    Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Vitam Horm 69:209-20. 2004
    ..Magnetic resonance imaging shows hypoplasia of the anterior pituitary. In this chapter, we describe the GHRHR mutations reported to date and the phenotype of affected individuals...
  46. ncbi request reprint Clinical management of growth hormone therapy in adults
    Roberto Salvatori
    Division of Endocrinology, The Johns Hopkins University School of Medicine, Baltimore, USA
    Manag Care 18:10-6. 2009
    ..When used in an approved and ethical fashion for the defined population, this treatment can enhance the health and well-being of the many patients who suffer from the complications of GHD...
  47. ncbi request reprint Magnetic resonance imaging study of pituitary morphology in subjects homozygous and heterozygous for a null mutation of the GHRH receptor gene
    Helio A Oliveira
    Endocrinology and Radiology Divisions, Federal University of Sergipe, Aracaju, SE 49060 100, Brazil
    Eur J Endocrinol 148:427-32. 2003
    ..We tested if APH was present in a large cohort of patients homozygous and heterozygous for a GHRHR mutation...
  48. ncbi request reprint [Growth or somatotrophic hormone: new perspectives in isolated GH deficiency after description of the mutation in the GHRH receptor gene in individuals of Itabaianinha County, Brazil]
    Anita Hermínia O Souza
    Servico de Endocrinologia, Hospital Universitario, Universidade Federal de Sergipe, Aracaju, SE
    Arq Bras Endocrinol Metabol 48:406-13. 2004
    ....
  49. ncbi request reprint Metabolic effects of growth hormone (GH) replacement in children and adolescents with severe isolated GH deficiency due to a GHRH receptor mutation
    Helena Gleeson
    Christie Hospital, Department of Endocrinology, Manchester, UK
    Clin Endocrinol (Oxf) 66:466-74. 2007
    ..The interpretation of the true effect of GH replacement therapy (GHRT) on metabolic status in GH deficiency (GHD) is often complicated by differing aetiologies of GHD and by the presence of additional hormone deficits...
  50. ncbi request reprint Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naive adults
    Joselina L M Oliveira
    Department of Endocrinology, Federal University of Sergipe, Aracaju, SE Brazil 49060 100
    J Clin Endocrinol Metab 92:4664-70. 2007
    ..GH deficiency (GHD) in adults is associated with increased abdominal adiposity and systolic blood pressure, total and low-density lipoprotein cholesterol, and C-reactive protein...
  51. ncbi request reprint Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia
    José Augusto Soares Barreto-Filho
    Endocrinology Division of the Federal University of Sergipe, 49060 100 Aracaju, Brazil
    J Clin Endocrinol Metab 87:2018-23. 2002
    ..In conclusion, this genetically homogeneous isolated GHD population presents a syndrome characterized by central obesity, dyslipidemia, and elevated SBP but reduced cardiac dimensions compared with controls...
  52. pmc Climacteric in untreated isolated growth hormone deficiency
    Menilson Menezes
    Division of Endocrinology, Federal University of Sergipe, Aracaju, Sergipe, Brasil
    Menopause 15:743-7. 2008
    ..To study the time, intensity of symptoms, hormonal profile, and related morbidity of climacteric in women with untreated isolated growth hormone (GH) deficiency (IGHD)...

Research Grants7

  1. Molecular analysis of GHRH receptor missense mutations
    Roberto Salvatori; Fiscal Year: 2004
    ..Altogether, these experiments will teach us new information about the pathophysiology of GHRHR signaling in health and disease. ..
  2. Consequences of generalized lack of GHRH
    Roberto Salvatori; Fiscal Year: 2005
    ..By recombinase technique, we will generate KO lines with no Neor, avoiding any interference with distant or neighboring genes. In addition, results obtained in the GHRHKO1 line will be confirmed or disproved. ..
  3. Consequences of lifetime isolated Growth Hormone deficiency
    Roberto Salvatori; Fiscal Year: 2007
    ....
  4. Creation of a mouse model of isolated GH deficiency
    Roberto Salvatori; Fiscal Year: 2007
    ..In addition, it will mimic the clinical scenario that occurs in most children with IGHD, and it will be an important tool to study the effects of therapies aimed to increase the secretion of endogenous GH. ..