Scheherazade Sadegh-Nasseri

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint How HLA-DM works: recognition of MHC II conformational heterogeneity
    Scheherazade Sadegh-Nasseri
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Front Biosci (Schol Ed) 4:1325-32. 2012
  2. pmc Anergy in peripheral memory CD4(+) T cells induced by low avidity engagement of T cell receptor
    S Mirshahidi
    Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 194:719-31. 2001
  3. pmc Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection
    Scheherazade Sadegh-Nasseri
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunol Res 47:56-64. 2010
  4. pmc The convergent roles of tapasin and HLA-DM in antigen presentation
    Scheherazade Sadegh-Nasseri
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Trends Immunol 29:141-7. 2008
  5. pmc Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy
    Scheherazade Sadegh-Nasseri
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunology 129:1-7. 2010
  6. pmc HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes
    Kedar Narayan
    Graduate Program in Immunology, Johns Hopkins University Baltimore, Maryland 21205, USA
    Nat Immunol 8:92-100. 2007
  7. pmc A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes
    Isamu Z Hartman
    Graduate Program in Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:1333-40. 2010
  8. pmc Anergy in memory CD4+ T cells is induced by B cells
    Sarat K Dalai
    Department of Pathology, Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore MD 21205, USA
    J Immunol 181:3221-31. 2008
  9. doi request reprint Studying MHC class II peptide loading and editing in vitro
    AeRyon Kim
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Methods Mol Biol 960:447-59. 2013
  10. pmc Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells
    Sarat K Dalai
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Immunol Cell Biol 89:870-81. 2011

Research Grants

  1. Role of DM in Generation of Immunodominant Epitope(s)
    Scheherazade Sadegh Nasseri; Fiscal Year: 2010
  2. Structure/biology of short-lived MHC II-ligand complexes
    Scheherazade Sadegh Nasseri; Fiscal Year: 2007
  3. STRUCTURE/BIOLOGY OF SHORT LIVED MHC II LIGAND COMPLEXES
    Scheherazade Sadegh Nasseri; Fiscal Year: 2002
  4. Role of DM in Generation of Immunodominant Epitope(s)
    Scheherazade Sadegh Nasseri; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. ncbi request reprint How HLA-DM works: recognition of MHC II conformational heterogeneity
    Scheherazade Sadegh-Nasseri
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Front Biosci (Schol Ed) 4:1325-32. 2012
    ..In this review, we discuss our current understanding of HLA-DM function in peptide exchange and selection and its relevance to epitope immunodominance...
  2. pmc Anergy in peripheral memory CD4(+) T cells induced by low avidity engagement of T cell receptor
    S Mirshahidi
    Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 194:719-31. 2001
    ....
  3. pmc Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection
    Scheherazade Sadegh-Nasseri
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunol Res 47:56-64. 2010
    ....
  4. pmc The convergent roles of tapasin and HLA-DM in antigen presentation
    Scheherazade Sadegh-Nasseri
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Trends Immunol 29:141-7. 2008
    ..Utilization of a common mode of peptide selection by two different, but related, biological systems argue for its mechanistic validity...
  5. pmc Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy
    Scheherazade Sadegh-Nasseri
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunology 129:1-7. 2010
    ..We suggest that altered peptide ligand (APL) and low densities of agonist ligands induce anergy by engaging less than optimal numbers of TCRs. The physiological impacts of anergy in memory CD4(+) T cells are discussed...
  6. pmc HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes
    Kedar Narayan
    Graduate Program in Immunology, Johns Hopkins University Baltimore, Maryland 21205, USA
    Nat Immunol 8:92-100. 2007
    ..We suggest that DM may mediate peptide dissociation by a 'hit-and-run' mechanism that results in conformational changes in MHC class II molecules and disruption of hydrogen bonds between betaHis81 and bound peptide...
  7. pmc A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes
    Isamu Z Hartman
    Graduate Program in Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:1333-40. 2010
    ..Thus, we provide a new tool for the identification of physiologically relevant helper T cell epitopes from antigens...
  8. pmc Anergy in memory CD4+ T cells is induced by B cells
    Sarat K Dalai
    Department of Pathology, Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore MD 21205, USA
    J Immunol 181:3221-31. 2008
    ..Furthermore, we present data showing that anergy in this system is mediated by CTLA-4 up-regulation on T cells. This is the first study to demonstrate formally that B cells are the APCs that induce anergy in memory CD4(+) T cells...
  9. doi request reprint Studying MHC class II peptide loading and editing in vitro
    AeRyon Kim
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Methods Mol Biol 960:447-59. 2013
    ..We also have described an Intrinsic Tryptophan Fluorescence Assay for studying transient interactions of DM and MHC class II molecules...
  10. pmc Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells
    Sarat K Dalai
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Immunol Cell Biol 89:870-81. 2011
    ..We propose that quiescence might be a mechanism necessary to regulate long-term survival of CD4 memory T cells and to prevent cross-reactivity to self, hence autoimmunity...
  11. pmc HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1
    Kedar Narayan
    Graduate Program in Immunology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Mol Immunol 46:3157-62. 2009
    ..The simultaneous presence of peptide and DM in the milieu is thus crucial for the efficient generation of specific peptide-MHC class II complexes over time...
  12. ncbi request reprint The magnitude of TCR engagement is a critical predictor of T cell anergy or activation
    Saied Mirshahidi
    Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Immunol 172:5346-55. 2004
    ..The use of short-lived peptides to induce T cells anergy is a potential strategy for the prevention or treatment of autoimmune diseases...
  13. pmc Staphylococcal enterotoxin A induces small clusters of HLA-DR1 on B cells
    Kedar Narayan
    Graduate Program in Immunology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    PLoS ONE 4:e6188. 2009
    ..These results present direct visual evidence of SEA-mediated clustering of MHC class II molecules on treated antigen presenting cells, and provide a new structural approach to addressing problems of this nature...
  14. ncbi request reprint Synaptic PDZ domain-mediated protein interactions are disrupted by inhalational anesthetics
    Ming Fang
    Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 278:36669-75. 2003
    ..These findings reveal the PDZ domain as a new molecular target for inhalational anesthetics...
  15. ncbi request reprint Short peptide sequences mimic HLA-DM functions
    Chih Ling Chou
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85715, USA
    Mol Immunol 45:1935-43. 2008
    ..We suggest that helper peptides might interact with the same critical residues on MHC class II that is targeted by DM...

Research Grants15

  1. Role of DM in Generation of Immunodominant Epitope(s)
    Scheherazade Sadegh Nasseri; Fiscal Year: 2010
    ..This research has great impacts on discovering immunodominant epitopes of infectious agents relevant to biodefense. ..
  2. Structure/biology of short-lived MHC II-ligand complexes
    Scheherazade Sadegh Nasseri; Fiscal Year: 2007
    ..Compare peptide repertoires of DO-/-, DM-/- and WT thymic stromal cells 3b. Generate mice expressing a DR1 mutant (DRbG86Y) that participates in short-lived complexes and study thymocyte selection. ..
  3. STRUCTURE/BIOLOGY OF SHORT LIVED MHC II LIGAND COMPLEXES
    Scheherazade Sadegh Nasseri; Fiscal Year: 2002
    ..In addition, the structure of unstable peptide/DR1 will be determined by X-ray crystallography to investigate the structural basis of unstable binding. The physiological consequences of short-lived complexes will be examined. ..
  4. Role of DM in Generation of Immunodominant Epitope(s)
    Scheherazade Sadegh Nasseri; Fiscal Year: 2010
    ..This research has great impacts on discovering immunodominant epitopes of infectious agents relevant to biodefense. ..