Genomes and Genes
Ashley E Ross
Affiliation: Johns Hopkins University
- Prostate-specific antigen kinetics during follow-up are an unreliable trigger for intervention in a prostate cancer surveillance programAshley E Ross
Departments of Urology and Pathology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
J Clin Oncol 28:2810-6. 2010....
- Effect of treatment with 5-α reductase inhibitors on progression in monitored men with favourable-risk prostate cancerAshley E Ross
James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medicinal Institutions, Baltimore, MD, USA
BJU Int 110:651-7. 2012....
- Trends in immediate perioperative morbidity and delay in discharge after open and minimally invasive radical prostatectomy (RP): a 20-year institutional experiencePhillip M Pierorazio
The James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD, USA
BJU Int 112:45-53. 2013..Specifically, it addresses approach-specific morbidities and indicates that MIRP is associated with higher rates of 'off-pathway' discharge, most often due to ileus...
- Wnt signaling though beta-catenin is required for prostate lineage specificationBrian W Simons
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Biol 371:246-55. 2012..Deletion of beta-catenin in the adult prostate did not significantly affect organ homeostasis. Collectively, these data establish that beta-catenin and Wnt signaling play key roles in prostate lineage specification and bud outgrowth...
- Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcomePaula J Hurley
Department of Urology, The Johns Hopkins University, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 109:14977-82. 2012..Thus, SPARCL1 is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence...
- Preoperative characteristics of high-Gleason disease predictive of favourable pathological and clinical outcomes at radical prostatectomyPhillip M Pierorazio
James Buchanan Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA
BJU Int 110:1122-8. 2012....
- Evolution of the clinical presentation of men undergoing radical prostatectomy for high-risk prostate cancerPhillip M Pierorazio
Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA
BJU Int 109:988-93. 2012....
- Sox9 is required for prostate development and prostate cancer initiationZhenhua Huang
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Oncotarget 3:651-63. 2012..Due to its essential role in cancer initiation, manipulation of Sox9 targets in at-risk men may prove useful in the chemoprevention of prostate cancer...
- A contemporary analysis of outcomes of adenocarcinoma of the prostate with seminal vesicle invasion (pT3b) after radical prostatectomyPhillip M Pierorazio
The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Urol 185:1691-7. 2011..We investigated outcomes in men with pT3b disease in the contemporary era...
- Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicityAshley E Ross
Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
BJU Int 108:447-54. 2011..To evaluate the cytotoxicity of dimeric naphthoquinones (BiQs) in prostate cancer cells. • To assess the interaction of dimeric naphthoquinones with common therapies including radiation and docetaxel...
- African american men with very low-risk prostate cancer exhibit adverse oncologic outcomes after radical prostatectomy: should active surveillance still be an option for them?Debasish Sundi
All authors Johns Hopkins University, Baltimore, MD
J Clin Oncol 31:2991-7. 2013..To explore whether race-based health disparities exist among men with very low-risk PCa, we evaluated oncologic outcomes of AA men with very low-risk PCa who were candidates for AS but elected to undergo radical prostatectomy (RP)...
- Metabolic and electrochemical mechanisms of dimeric naphthoquinones cytotoxicity in breast cancer cellsAshkan Emadi
Johns Hopkins University, School of Medicine, Department of Internal Medicine, Division of Hematology, 720 Rutland Avenue, Baltimore, MD 21205, USA
Bioorg Med Chem 19:7057-62. 2011..These results also suggest that dimeric naphthoquinones may be used to selectively target cancer cells that depend on oxidative phosphorylation for energy production and macromolecular synthesis...
- Attenuated RhoA/Rho-kinase signaling in penis of transgenic sickle cell miceTrinity J Bivalacqua
James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 76:510.e7-12. 2010..Therefore, the objective of the present study was to evaluate the molecular changes in RhoA and ROCK in an established transgenic sickle cell mouse model of priapism...
- Benign prostate glands at the bladder neck margin in robotic vs open radical prostatectomyStacy Loeb
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
BJU Int 105:1446-9. 2010....
- Molecular effects of genistein on male urethral developmentAshley E Ross
Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
J Urol 185:1894-8. 2011..We investigated the effects of genistein, the primary phytoestrogen in soy, on the molecular program of male urethral development...
- Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase BlkTheresa Tretter
Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Exp Med 198:1863-73. 2003..Thus, sustained activation of Blk induces responses normally associated with the pre-BCR...
- Posttranslational modification of constitutive nitric oxide synthase in the penisBiljana Musicki
The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, 600 N Wolfe Avenue, Marburg 143, Baltimore, MD 21287, USA
J Androl 30:352-62. 2009..This communication reviews the role of eNOS and nNOS in erectile physiology and discusses the alterations in eNOS and nNOS via posttranslation modification in various vascular diseases of the penis...