Research Topics
Genomes and GenesSpecies | Adam RosenblattSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Efficacy and safety of donepezil in patients with Alzheimer's disease in assisted living facilitiesAdam Rosenblatt
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Am J Alzheimers Dis Other Demen 25:483-9. 2010..Donepezil improved cognition and behavior and was safe and well tolerated. The results suggest a need for proactive screening and diagnosis of AD and support the value of treatment and use of donepezil in participants residing in ALFs...
Neuropsychiatry of Huntington's diseaseAdam Rosenblatt
Department of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Dialogues Clin Neurosci 9:191-7. 2007..Further study of the neuropsychiatry of HD may help to reveal the underpinnings of psychiatric conditions found in the general population...
Correlates of caregiver-rated quality of life in assisted living: the Maryland Assisted Living studyQuincy M Samus
The Johns Hopkins School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA
J Gerontol B Psychol Sci Soc Sci 61:P311-4. 2006..Because of the strong association of neuropsychiatric symptoms with QOL, special attention should be given to their recognition and amelioration...- Acetylcholinesterase inhibitors in assisted living: patterns of use and association with retentionAdam Rosenblatt
Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Int J Geriatr Psychiatry 23:178-84. 2008..To describe patterns of Acetylcholinesterase inhibitor (ACI) use in an Assisted Living (AL) population, and the association of ACIs with retention in AL... - Insomnia and daytime sleepiness in people with dementia residing in assisted living: findings from the Maryland Assisted Living StudyVani Rao
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
Int J Geriatr Psychiatry 23:199-206. 2008..To estimate the frequency and correlates of insomnia and daytime sleepiness among people with dementia in AL facilities... - Transition to nursing home from assisted living is not associated with dementia or dementia-related problem behaviorsPaul B Rosenberg
Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Osler 320, 600 North Wolfe Street, Baltimore, MD, USA
J Am Med Dir Assoc 7:73-8. 2006..To examine risk factors for transition from assisted living (AL) care to skilled nursing facility (SNF) care in a random sample of adults residing in AL... - Correlates of functional dependence among recently admitted assisted living residents with and without dementiaQuincy M Samus
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA
J Am Med Dir Assoc 10:323-9. 2009.... - Sleep disturbances in the elderly residing in assisted living: findings from the Maryland Assisted Living StudyVani Rao
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
Int J Geriatr Psychiatry 20:956-66. 2005..Common sleep disturbances are insomnia and excessive daytime sleepiness. There are no published studies on the prevalence of sleep disturbance in the assisted living (AL) setting... - Age, CAG repeat length, and clinical progression in Huntington's diseaseAdam Rosenblatt
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Mov Disord 27:272-6. 2012..This suggests that the aging process itself influences clinical outcomes in Huntington's disease. Inconsistent results in prior studies examining CAG repeat length and progression may indeed reflect a lack of age adjustment... - The association of neuropsychiatric symptoms and environment with quality of life in assisted living residents with dementiaQuincy M Samus
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
Gerontologist 45:19-26. 2005..We conducted this study to determine whether neuropsychiatric symptoms and environmental characteristics are associated with quality of life in assisted living residents with dementia... - The physical environment influences neuropsychiatric symptoms and other outcomes in assisted living residentsMark C Bicket
Johns Hopkins School of Medicine, Johns Hopkins Medicine, MD, USA
Int J Geriatr Psychiatry 25:1044-54. 2010..We sought to quantify the relationship of AL physical environment with resident outcomes including neuropsychiatric symptoms (NPS), quality of life (QOL), and fall risk, and to compare the effects for demented and non-demented residents... - Depression in assisted living is common and related to physical burdenLea C Watson
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Am J Geriatr Psychiatry 14:876-83. 2006..AL is a rapidly growing segment of long-term care and represents an important setting in which to find and treat serious depression... - Predictors of functional impairment in residents of assisted-living facilities: the Maryland Assisted Living studyDaniel J Burdick
Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Gerontol A Biol Sci Med Sci 60:258-64. 2005..These results may be instrumental in developing a more efficient model of care for residents of assisted living facilities, one based on having accurate predictive models of degree of impairment... - Earliest functional declines in Huntington diseaseLeigh J Beglinger
Department of Psychiatry, The University of Iowa, Iowa City, IA, USA
Psychiatry Res 178:414-8. 2010..These are also important areas for clinical monitoring and treatment planning as up to 65% experienced loss in at least one area prior to diagnosis... - The association between activity participation and time to discharge in the assisted living settingSarah K Tighe
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA
Int J Geriatr Psychiatry 23:586-91. 2008..This study examines the relationship between participation in activities and the length of time residents remain in AL... - Neuropsychological deficits in Huntington's disease gene carriers and correlates of early "conversion"Jason Brandt
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neuropsychiatry Clin Neurosci 20:466-72. 2008..People with the Huntington's disease mutation who are carefully examined neurologically and found to be asymptomatic have, at most, very minimal problem-solving impairment, and only if they are within a few years of clinical onset... - Predictors of providing informed consent or assent for research participation in assisted living residentsBetty S Black
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, 600 North Wolfe Street, Baltimore, MD 21287, USA
Am J Geriatr Psychiatry 16:83-91. 2008..This study's goal was to identify factors associated with providing either informed consent or assent for research in individuals at high risk for cognitive impairment... - Factors contributing to institutionalization in patients with Huntington's diseaseAdam Rosenblatt
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mov Disord 26:1711-6. 2011..This may illustrate the especially debilitating nature of the movement disorder of Huntington's disease in comparison with the other dementias... - A four-year prospective study of cognitive functioning in Huntington's diseaseJulianna Ward
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Int Neuropsychol Soc 12:445-54. 2006..g., QNE and Trail Making Test, Part A) but not in dysfunction on tasks requiring higher-order processing... - Predictors of caregiver unawareness and nontreatment of dementia among residents of assisted living facilities: the Maryland Assisted Living StudyDonovan T Maust
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Geriatr Psychiatry 14:668-75. 2006..These observations suggest that systematic educational interventions for caregivers and families may improve detection and hence treatment in the AL setting... - Comorbidities of obsessive and compulsive symptoms in Huntington's diseaseKaren E Anderson
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
J Nerv Ment Dis 198:334-8. 2010..Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan... - Predictors of neuropathological severity in 100 patients with Huntington's diseaseAdam Rosenblatt
Department of Psychiatry, Johns Hopkins University School of Medicine, Meyer 2 181, 600 North Wolfe Street, Baltimore, MD 21287, USA
Ann Neurol 54:488-93. 2003..Motor impairment appears to be a good clinical measure of neuronal cell loss, at least late in the course of HD and therefore may prove useful in observational and treatment studies... - The spectrum of medical illness and medication use among residents of assisted living facilities in central MarylandMatthew K McNabney
Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD 21224, USA
J Am Med Dir Assoc 9:558-64. 2008..To better inform efforts to optimize care in this setting, we sought to quantify chronic medical illnesses and their treatment... - Functional brain changes in presymptomatic Huntington's diseaseSarah A J Reading
Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287, USA
Ann Neurol 55:879-83. 2004..In the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifically less activation in the left anterior cingulate cortex (BA 24, 32) compared with matched controls... - Cognitive impairments in cerebellar degeneration: a comparison with Huntington's diseaseJason Brandt
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287-7218, USA
J Neuropsychiatry Clin Neurosci 16:176-84. 2004..These differences may reflect the involvement of the cerebellar dentate nucleus and the striatal nuclei in separate "loops" or closed circuits, linking them with specific areas of cerebral neocortex... - Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging studySarah A J Reading
Division of Psychiatric Neuroimaging, Department of Psychiatry, The Johns Hopkins University, Phipps 313, Baltimore, MD 21287, USA
Psychiatry Res 140:55-62. 2005..Our results indicate that, before the onset of manifest HD, there are regional decreases in fractional anisotropy, indicating early white matter disorganization... - The Maryland Assisted Living Study: prevalence, recognition, and treatment of dementia and other psychiatric disorders in the assisted living population of central MarylandAdam Rosenblatt
Division of Geriatric Psychiatry and Neuropsychiatry, John Hopkins School of Medicine, Baltimore, Maryland 21287, USA
J Am Geriatr Soc 52:1618-25. 2004..To obtain a direct estimate of the prevalence of dementia and other psychiatric disorders in residents of assisted living (AL) in Central Maryland, and their rates of recognition and treatment... - Depressive symptoms in prodromal Huntington's Disease correlate with Stroop-interference related functional connectivity in the ventromedial prefrontal cortexPaul G Unschuld
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychiatry Res 203:166-74. 2012..These findings suggest that depressive symptoms in prodromal HD subjects may reflect altered functional brain network activity in the context of early HD-related brain alterations... - Forgotten frontal lobe syndrome or "Executive Dysfunction Syndrome"Constantine G Lyketsos
Division of Geriatric Psychiatry and Neuropsychiatry, Psychiatry and Behavioral Sciences, Johns Hopkins Medicine, Baltimore, MD 21287, USA
Psychosomatics 45:247-55. 2004 - Falls and age in patients with Alzheimer's diseaseMedhat M Bassiony
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Science, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Nerv Ment Dis 192:570-2. 2004..The authors conclude that falls in community-residing patients with AD are significantly associated with old age. Population-based prospective studies are needed to investigate further the risk factors for falls in AD... - Cerebral cortex structure in prodromal Huntington diseasePeggy C Nopoulos
Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA 52242, USA
Neurobiol Dis 40:544-54. 2010..Early in the course of HD, the cortex shows changes that are manifest as cortical thinning and are most robust in the posterior and superior regions of the cerebrum... - Neuropsychological manifestations of the genetic mutation for Huntington's disease in presymptomatic individualsJason Brandt
Baltimore Huntington s Disease Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, MD, USA
J Int Neuropsychol Soc 8:918-24. 2002..Conceptual and methodological problems associated with the search for presymptomatic cognitive and behavioral indicators of dementing illness are discussed... - Huntington's Disease-like 2 (HDL2) in North America and JapanRussell L Margolis
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann Neurol 56:670-4. 2004..0098). The results further support the evidence that the repeat expansion at the chromosome 16q24.3 locus is the direct cause of HDL2 and provide preliminary guidelines for the genetic testing of patients with an HD-like phenotype... - Prevalence of major depression one year after predictive testing for Huntington's diseaseAnn Marie Codori
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21287, USA
Genet Test 8:114-9. 2004..Clinical testing programs should assess patients for depressive symptoms after testing, and patients with clinically significant complaints should be referred to a mental health professional... - Effect of dementia and treatment of dementia on time to discharge from assisted living facilities: the Maryland assisted living studyConstantine G Lyketsos
Department of Psychiatry Johns Hopkins Bayview, Johns Hopkins Medicine, Maryland 21224, USA
J Am Geriatr Soc 55:1031-7. 2007..To estimate the association between dementia and time to discharge from individual assisted living (AL) facilities and examine, in residents with dementia, factors associated with shorter duration of residence in individual AL facilities... - Behavioral neurology and neuropsychiatry fellowship training: the Johns Hopkins modelSandeep Vaishnavi
Department of Psychiatry, Johns Hopkins School of Medicine, 5300 Alpha Commons Drive, Baltimore, MD 21224, USA
J Neuropsychiatry Clin Neurosci 21:335-41. 2009..The authors describe how the Johns Hopkins Behavioral Neurology & Neuropsychiatry Fellowship has approached the challenging job of providing training for an inherently multidisciplinary field... - Amantadine for executive dysfunction syndrome in patients with dementiaShannon J Drayton
Department of Pharmacy, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Psychosomatics 45:205-9. 2004..Despite its limitations, this study offers preliminary data to support a controlled trial of amantadine in patients with executive dysfunction syndrome... - Major depression and cognitive decline after 11.5 years: findings from the ECA studyAdam Rosenblatt
Department of Psychiatry, Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
J Nerv Ment Dis 191:827-30. 2003 - CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approachesDouglas R Langbehn
Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
Am J Med Genet B Neuropsychiatr Genet 153:397-408. 2010..The Langbehn et al. model appears accurate enough to have substantial utility in various research contexts. We also emphasize remaining caveats, many of which are relevant for any direct application to genetic counseling... - Striatal neuronal loss correlates with clinical motor impairment in Huntington's diseaseZhihong Guo
Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mov Disord 27:1379-86. 2012..Our findings suggest that neuronal loss and atrophy in striatum and neuronal loss in subthalamic nuclei contribute specifically to the motor impairment of HD, but not to chorea... - Psychopathology in patients with degenerative cerebellar diseases: a comparison to Huntington's diseaseIracema Leroi
Program in Cellular and Molecular Medicine, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Psychiatry 159:1306-14. 2002..These results also support previous findings that the cerebellum may have a role in modulating emotion and cognition... - Challenges assessing clinical endpoints in early Huntington diseaseJane S Paulsen
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
Mov Disord 25:2595-603. 2010..We conclude that future clinical trials designed for very early disease will require the development of new and more sensitive measures of real-life function... - The art of managing dementia in the elderlyAdam Rosenblatt
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287 7131, USA
Cleve Clin J Med 72:S3-13. 2005..Even when treatments prove ineffective, providing information and support is of great value to patients and their families and caregivers... - A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS studyJian-Liang Li
Department of Neurology, Boston University School of Medicine, and Bioinformatics Program, School of Public Health, Boston University, Boston, MA, USA
Am J Hum Genet 73:682-7. 2003..Suggestive evidence for linkage was found at 4p16 (LOD=1.93), 6p21-23 (LOD=2.29), and 6q24-26 (LOD=2.28), which may be useful for investigation of genes that modify age at onset of HD... - Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16Luc Djousse
Evans Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA
Neurogenetics 5:109-14. 2004..Furthermore, the modifier may be present on both HD and normal chromosomes bearing the 3 allele of the MSX1 marker... - Understanding the psychiatric prodrome of Huntington diseaseAdam Rosenblatt
J Neurol Neurosurg Psychiatry 78:913. 2007 - A comparison of small and large assisted living facilities for the diagnosis and care of dementia: the Maryland Assisted Living StudyIracema Leroi
Manchester Mental Health and Social Care Trust, University of Manchester, Department of Psychiatry and Behavioural Sciences, Mancheter, UK
Int J Geriatr Psychiatry 22:224-32. 2007..To compare the demographic, clinical, and psychiatric characteristics of residents living in small (< or = 15 beds) and large assisted living (AL) facilities in the United States... - The relationship between delusions and depression in Alzheimer's diseaseMedhat M Bassiony
Department of Psychiatry, Faculty of Medicine, Zagazig University, Egypt
Int J Geriatr Psychiatry 17:549-56. 2002..This finding has implications for our understanding of the etio-pathogenesis and management of delusions and depression in AD... - Isolated hallucinosis in Alzheimer's disease is associated with African-American raceMedhat M Bassiony
Neuropsychiatry Service, Department of Psychiatry and Behavioral Science, School of Medicine, The Johns Hopkins University, USA
Int J Geriatr Psychiatry 17:205-10. 2002..This finding has implications for our understanding of the etio-pathogenesis of hallucinations in Alzheimer's disease and for meeting health service needs of African-American patients... - Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS studyJian Liang Li
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
BMC Med Genet 7:71. 2006.... - Characteristics and outcomes for assisted living residents with dementia: comparing dementia-specific care units with non-dementia-specific care unitsQuincy M Samus
J Am Geriatr Soc 56:1361-3. 2008
Research Grants
- DEMENTIA AND PSYCHIATRIC DISORDERS IN ASSISTED LIVINGAdam Rosenblatt; Fiscal Year: 2007..abstract_text> ..