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Species | A RosenblattSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Age, CAG repeat length, and clinical progression in Huntington's diseaseAdam Rosenblatt
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Mov Disord 27:272-6. 2012..This suggests that the aging process itself influences clinical outcomes in Huntington's disease. Inconsistent results in prior studies examining CAG repeat length and progression may indeed reflect a lack of age adjustment...
Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS studyJian Liang Li
Department of Neurology, Boston University School of Medicine, Boston, MA, USA
BMC Med Genet 7:71. 2006....
The art of managing dementia in the elderlyAdam Rosenblatt
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287 7131, USA
Cleve Clin J Med 72:S3-13. 2005..Even when treatments prove ineffective, providing information and support is of great value to patients and their families and caregivers...- Predictors of neuropathological severity in 100 patients with Huntington's diseaseAdam Rosenblatt
Department of Psychiatry, Johns Hopkins University School of Medicine, Meyer 2 181, 600 North Wolfe Street, Baltimore, MD 21287, USA
Ann Neurol 54:488-93. 2003..Motor impairment appears to be a good clinical measure of neuronal cell loss, at least late in the course of HD and therefore may prove useful in observational and treatment studies... - The association of CAG repeat length with clinical progression in Huntington diseaseA Rosenblatt
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 66:1016-20. 2006..To determine whether the rate of clinical progression in Huntington disease (HD) is influenced by the size of the CAG expansion... - The Maryland Assisted Living Study: prevalence, recognition, and treatment of dementia and other psychiatric disorders in the assisted living population of central MarylandAdam Rosenblatt
Division of Geriatric Psychiatry and Neuropsychiatry, John Hopkins School of Medicine, Baltimore, Maryland 21287, USA
J Am Geriatr Soc 52:1618-25. 2004..To obtain a direct estimate of the prevalence of dementia and other psychiatric disorders in residents of assisted living (AL) in Central Maryland, and their rates of recognition and treatment... - Factors contributing to institutionalization in patients with Huntington's diseaseAdam Rosenblatt
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mov Disord 26:1711-6. 2011..This may illustrate the especially debilitating nature of the movement disorder of Huntington's disease in comparison with the other dementias... - Acetylcholinesterase inhibitors in assisted living: patterns of use and association with retentionAdam Rosenblatt
Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Int J Geriatr Psychiatry 23:178-84. 2008..To describe patterns of Acetylcholinesterase inhibitor (ACI) use in an Assisted Living (AL) population, and the association of ACIs with retention in AL... - Familial influence on age of onset among siblings with Huntington diseaseA Rosenblatt
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland USA
Am J Med Genet 105:399-403. 2001..A linkage study is feasible with the cooperation of a number of major centers and may be made more efficient by concentrating on sibling pairs that are highly discordant for age of onset... - A disorder similar to Huntington's disease is associated with a novel CAG repeat expansionR L Margolis
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Neurol 50:373-80. 2001..Cloning the causative CAG expansion mutation for this new disease, which we have termed Huntington's disease-like 2, may yield valuable insight into the pathogenesis of HD and related disorders... - A disorder similar to Huntington's disease is associated with a novel CAG repeat expansionR L Margolis
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Neurol 50:373-80. 2001..Cloning the causative CAG expansion mutation for this new disease, which we have termed Huntington's disease-like 2, may yield valuable insight into the pathogenesis of HD and related disorders... - Physical aggression in dementia patients and its relationship to depressionC G Lyketsos
Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
Am J Psychiatry 156:66-71. 1999..The goal of this study was to determine the frequency of physically aggressive behavior in community-residing patients with dementia and its relationship to depression... - A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2S E Holmes
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Nat Genet 29:377-8. 2001..We now report the cloning of this expansion and its localization to a variably spliced exon of JPH3 (encoding junctophilin-3), a gene involved in the formation of junctional membrane structures... - Unstable expansion of the CAG trinucleotide repeat in MAB21L1: report of a second pedigree and effect on protein expressionR L Margolis
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Med Genet 36:62-4. 1999..This raises the possibility that longer expansions in the MAB21L1 repeat may also be associated with a clinical phenotype... - Neuropsychiatry of Huntington's disease and other basal ganglia disordersA Rosenblatt
Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287, USA
Psychosomatics 41:24-30. 2000.... - Differential impairment of spatial location memory in Huntington's diseaseJ Brandt
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
J Neurol Neurosurg Psychiatry 76:1516-9. 2005..To determine whether a differential impairment of spatial memory exists in Huntington's disease (HD)... - An open-label study of escitalopram (Lexapro) for the treatment of 'Depression of Alzheimer's disease' (dAD)V Rao
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD, USA
Int J Geriatr Psychiatry 21:273-4. 2006..Depression is a frequent neuropsychiatric complication of Alzheimer's Disease... - Managing what you measure: creating outcome-driven systems of care for youth with serious emotional disturbancesA Rosenblatt
Department of Psychiatry, University of California, San Francisco 94104, USA
J Behav Health Serv Res 25:177-93. 1998..The resulting specific plan for measuring system- and client-level outcomes deriving from this process, along with challenges to the implementation of the outcome management plan, is described... - Functional brain changes in presymptomatic Huntington's diseaseSarah A J Reading
Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287, USA
Ann Neurol 55:879-83. 2004..In the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifically less activation in the left anterior cingulate cortex (BA 24, 32) compared with matched controls... - Psychopathology in patients with degenerative cerebellar diseases: a comparison to Huntington's diseaseIracema Leroi
Program in Cellular and Molecular Medicine, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Psychiatry 159:1306-14. 2002..These results also support previous findings that the cerebellum may have a role in modulating emotion and cognition... - The relationship between delusions and depression in Alzheimer's diseaseMedhat M Bassiony
Department of Psychiatry, Faculty of Medicine, Zagazig University, Egypt
Int J Geriatr Psychiatry 17:549-56. 2002..This finding has implications for our understanding of the etio-pathogenesis and management of delusions and depression in AD... - A four-year prospective study of cognitive functioning in Huntington's diseaseJulianna Ward
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Int Neuropsychol Soc 12:445-54. 2006..g., QNE and Trail Making Test, Part A) but not in dysfunction on tasks requiring higher-order processing... - Depression in assisted living is common and related to physical burdenLea C Watson
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Am J Geriatr Psychiatry 14:876-83. 2006..AL is a rapidly growing segment of long-term care and represents an important setting in which to find and treat serious depression... - A comparison of small and large assisted living facilities for the diagnosis and care of dementia: the Maryland Assisted Living StudyIracema Leroi
Manchester Mental Health and Social Care Trust, University of Manchester, Department of Psychiatry and Behavioural Sciences, Mancheter, UK
Int J Geriatr Psychiatry 22:224-32. 2007..To compare the demographic, clinical, and psychiatric characteristics of residents living in small (< or = 15 beds) and large assisted living (AL) facilities in the United States... - Effect of dementia and treatment of dementia on time to discharge from assisted living facilities: the Maryland assisted living studyConstantine G Lyketsos
Department of Psychiatry Johns Hopkins Bayview, Johns Hopkins Medicine, Maryland 21224, USA
J Am Geriatr Soc 55:1031-7. 2007..To estimate the association between dementia and time to discharge from individual assisted living (AL) facilities and examine, in residents with dementia, factors associated with shorter duration of residence in individual AL facilities... - Insomnia and daytime sleepiness in people with dementia residing in assisted living: findings from the Maryland Assisted Living StudyVani Rao
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
Int J Geriatr Psychiatry 23:199-206. 2008..To estimate the frequency and correlates of insomnia and daytime sleepiness among people with dementia in AL facilities... - Predictors of functional impairment in residents of assisted-living facilities: the Maryland Assisted Living studyDaniel J Burdick
Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Gerontol A Biol Sci Med Sci 60:258-64. 2005..These results may be instrumental in developing a more efficient model of care for residents of assisted living facilities, one based on having accurate predictive models of degree of impairment... - Understanding the psychiatric prodrome of Huntington diseaseAdam Rosenblatt
J Neurol Neurosurg Psychiatry 78:913. 2007 - Neuropsychiatry of Huntington's diseaseAdam Rosenblatt
Department of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Dialogues Clin Neurosci 9:191-7. 2007..Further study of the neuropsychiatry of HD may help to reveal the underpinnings of psychiatric conditions found in the general population... - Predictors of providing informed consent or assent for research participation in assisted living residentsBetty S Black
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, 600 North Wolfe Street, Baltimore, MD 21287, USA
Am J Geriatr Psychiatry 16:83-91. 2008..This study's goal was to identify factors associated with providing either informed consent or assent for research in individuals at high risk for cognitive impairment... - Characteristics and outcomes for assisted living residents with dementia: comparing dementia-specific care units with non-dementia-specific care unitsQuincy M Samus
J Am Geriatr Soc 56:1361-3. 2008 - Isolated hallucinosis in Alzheimer's disease is associated with African-American raceMedhat M Bassiony
Neuropsychiatry Service, Department of Psychiatry and Behavioral Science, School of Medicine, The Johns Hopkins University, USA
Int J Geriatr Psychiatry 17:205-10. 2002..This finding has implications for our understanding of the etio-pathogenesis of hallucinations in Alzheimer's disease and for meeting health service needs of African-American patients... - Predictors of caregiver unawareness and nontreatment of dementia among residents of assisted living facilities: the Maryland Assisted Living StudyDonovan T Maust
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Geriatr Psychiatry 14:668-75. 2006..These observations suggest that systematic educational interventions for caregivers and families may improve detection and hence treatment in the AL setting... - Neuropsychological manifestations of the genetic mutation for Huntington's disease in presymptomatic individualsJason Brandt
Baltimore Huntington s Disease Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, MD, USA
J Int Neuropsychol Soc 8:918-24. 2002..Conceptual and methodological problems associated with the search for presymptomatic cognitive and behavioral indicators of dementing illness are discussed... - Cognitive impairments in cerebellar degeneration: a comparison with Huntington's diseaseJason Brandt
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287-7218, USA
J Neuropsychiatry Clin Neurosci 16:176-84. 2004..These differences may reflect the involvement of the cerebellar dentate nucleus and the striatal nuclei in separate "loops" or closed circuits, linking them with specific areas of cerebral neocortex... - Prevalence of major depression one year after predictive testing for Huntington's diseaseAnn Marie Codori
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21287, USA
Genet Test 8:114-9. 2004..Clinical testing programs should assess patients for depressive symptoms after testing, and patients with clinically significant complaints should be referred to a mental health professional... - Falls and age in patients with Alzheimer's diseaseMedhat M Bassiony
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Science, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Nerv Ment Dis 192:570-2. 2004..The authors conclude that falls in community-residing patients with AD are significantly associated with old age. Population-based prospective studies are needed to investigate further the risk factors for falls in AD... - Forgotten frontal lobe syndrome or "Executive Dysfunction Syndrome"Constantine G Lyketsos
Division of Geriatric Psychiatry and Neuropsychiatry, Psychiatry and Behavioral Sciences, Johns Hopkins Medicine, Baltimore, MD 21287, USA
Psychosomatics 45:247-55. 2004 - Huntington's Disease-like 2 (HDL2) in North America and JapanRussell L Margolis
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann Neurol 56:670-4. 2004..0098). The results further support the evidence that the repeat expansion at the chromosome 16q24.3 locus is the direct cause of HDL2 and provide preliminary guidelines for the genetic testing of patients with an HD-like phenotype... - Amantadine for executive dysfunction syndrome in patients with dementiaShannon J Drayton
Department of Pharmacy, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Psychosomatics 45:205-9. 2004..Despite its limitations, this study offers preliminary data to support a controlled trial of amantadine in patients with executive dysfunction syndrome... - Sleep disturbances in the elderly residing in assisted living: findings from the Maryland Assisted Living StudyVani Rao
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
Int J Geriatr Psychiatry 20:956-66. 2005..Common sleep disturbances are insomnia and excessive daytime sleepiness. There are no published studies on the prevalence of sleep disturbance in the assisted living (AL) setting... - Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging studySarah A J Reading
Division of Psychiatric Neuroimaging, Department of Psychiatry, The Johns Hopkins University, Phipps 313, Baltimore, MD 21287, USA
Psychiatry Res 140:55-62. 2005..Our results indicate that, before the onset of manifest HD, there are regional decreases in fractional anisotropy, indicating early white matter disorganization... - Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16Luc Djousse
Evans Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA
Neurogenetics 5:109-14. 2004..Furthermore, the modifier may be present on both HD and normal chromosomes bearing the 3 allele of the MSX1 marker... - The association of neuropsychiatric symptoms and environment with quality of life in assisted living residents with dementiaQuincy M Samus
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
Gerontologist 45:19-26. 2005..We conducted this study to determine whether neuropsychiatric symptoms and environmental characteristics are associated with quality of life in assisted living residents with dementia... - Major depression and cognitive decline after 11.5 years: findings from the ECA studyAdam Rosenblatt
Department of Psychiatry, Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
J Nerv Ment Dis 191:827-30. 2003 - Transition to nursing home from assisted living is not associated with dementia or dementia-related problem behaviorsPaul B Rosenberg
Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins School of Medicine, Osler 320, 600 North Wolfe Street, Baltimore, MD, USA
J Am Med Dir Assoc 7:73-8. 2006..To examine risk factors for transition from assisted living (AL) care to skilled nursing facility (SNF) care in a random sample of adults residing in AL... - A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS studyJian-Liang Li
Department of Neurology, Boston University School of Medicine, and Bioinformatics Program, School of Public Health, Boston University, Boston, MA, USA
Am J Hum Genet 73:682-7. 2003..Suggestive evidence for linkage was found at 4p16 (LOD=1.93), 6p21-23 (LOD=2.29), and 6q24-26 (LOD=2.28), which may be useful for investigation of genes that modify age at onset of HD... - Correlates of caregiver-rated quality of life in assisted living: the Maryland Assisted Living studyQuincy M Samus
The Johns Hopkins School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA
J Gerontol B Psychol Sci Soc Sci 61:P311-4. 2006..Because of the strong association of neuropsychiatric symptoms with QOL, special attention should be given to their recognition and amelioration...