Noel Rose

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Adhesion molecules as susceptibility factors in spontaneous autoimmune thyroiditis in the NOD-H2h4 mouse
    Raphael E Bonita
    Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Exp Mol Pathol 73:155-63. 2002
  2. ncbi request reprint Kinetics of mononuclear cell infiltration and cytokine expression in iodine-induced thyroiditis in the NOD-H2h4 mouse
    Raphael E Bonita
    MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Exp Mol Pathol 74:1-12. 2003
  3. ncbi request reprint Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease
    Sylvia Frisancho-Kiss
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health and School of Medicine, Baltimore, MD 21205, USA
    J Immunol 178:6710-4. 2007
  4. pmc Mercury exposure, malaria, and serum antinuclear/antinucleolar antibodies in Amazon populations in Brazil: a cross-sectional study
    Ines A Silva
    The Johns Hopkins University Bloomberg School of Public Health, 615 N, Wolfe Street, Room E6642, Baltimore, Maryland 21201, USA
    Environ Health 3:11. 2004
  5. pmc Linking iodine with autoimmune thyroiditis
    N R Rose
    Department of Molecular Microbiology and Immunology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Environ Health Perspect 107:749-52. 1999
  6. ncbi request reprint Iodine: an environmental trigger of thyroiditis
    Noel R Rose
    MCP Hahnemann University School of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Autoimmun Rev 1:97-103. 2002
  7. pmc Critical cytokine pathways to cardiac inflammation
    Noel R Rose
    Departments of Pathology and of Molecular Microbiology and Immunology, The Johns Hopkins Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
    J Interferon Cytokine Res 31:705-10. 2011
  8. ncbi request reprint Autoimmune disease 2002: an overview
    Noel R Rose
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Investig Dermatol Symp Proc 9:1-4. 2004
  9. doi request reprint The adjuvant effect in infection and autoimmunity
    Noel R Rose
    Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, 615 N Wolfe St, MMI, E5009, Baltimore, MD 21205, USA
    Clin Rev Allergy Immunol 34:279-82. 2008
  10. ncbi request reprint Prediction and prevention of autoimmune disease: a personal perspective
    Noel R Rose
    Department of Pathology, Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 1109:117-28. 2007

Research Grants

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Adhesion molecules as susceptibility factors in spontaneous autoimmune thyroiditis in the NOD-H2h4 mouse
    Raphael E Bonita
    Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Exp Mol Pathol 73:155-63. 2002
    ..ICAM-1 was not detected on the thyrocytes of other untreated strains of mice, implicating expression of this adhesion molecule as a critical event in the recruitment of inflammatory mononuclear cells to the thyroid...
  2. ncbi request reprint Kinetics of mononuclear cell infiltration and cytokine expression in iodine-induced thyroiditis in the NOD-H2h4 mouse
    Raphael E Bonita
    MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Exp Mol Pathol 74:1-12. 2003
    ..Thyrocytes clearly expressed I-Ak after 4 weeks of iodine treatment near the location of mononuclear cell infiltration...
  3. ncbi request reprint Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease
    Sylvia Frisancho-Kiss
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health and School of Medicine, Baltimore, MD 21205, USA
    J Immunol 178:6710-4. 2007
    ..Cross-regulation of TLR4 and Tim-3 occurs during the innate and adaptive immune response. This novel mechanism may help explain why inflammatory heart disease is more severe in males...
  4. pmc Mercury exposure, malaria, and serum antinuclear/antinucleolar antibodies in Amazon populations in Brazil: a cross-sectional study
    Ines A Silva
    The Johns Hopkins University Bloomberg School of Public Health, 615 N, Wolfe Street, Room E6642, Baltimore, Maryland 21201, USA
    Environ Health 3:11. 2004
    ..A few studies have examined relationships between mercury exposures and adverse immunological reactions in humans, but there is little evidence of mercury-associated autoimmunity in humans...
  5. pmc Linking iodine with autoimmune thyroiditis
    N R Rose
    Department of Molecular Microbiology and Immunology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Environ Health Perspect 107:749-52. 1999
    ..This animal model provides a unique opportunity for investigating in detail the mechanisms by which an environmental agent can trigger a pathogenic autoimmune response in a susceptible host...
  6. ncbi request reprint Iodine: an environmental trigger of thyroiditis
    Noel R Rose
    MCP Hahnemann University School of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Autoimmun Rev 1:97-103. 2002
    ....
  7. pmc Critical cytokine pathways to cardiac inflammation
    Noel R Rose
    Departments of Pathology and of Molecular Microbiology and Immunology, The Johns Hopkins Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
    J Interferon Cytokine Res 31:705-10. 2011
    ..Rather, IL-17A is needed for progression to dilated cardiomyopathy. These findings may provide useful markers to identify individuals prone to develop an autoimmune sequel after infection and suggest future early interventions...
  8. ncbi request reprint Autoimmune disease 2002: an overview
    Noel R Rose
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Investig Dermatol Symp Proc 9:1-4. 2004
    ..Such basic studies may suggest improved treatment or preventive measures for this group of diseases...
  9. doi request reprint The adjuvant effect in infection and autoimmunity
    Noel R Rose
    Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, 615 N Wolfe St, MMI, E5009, Baltimore, MD 21205, USA
    Clin Rev Allergy Immunol 34:279-82. 2008
    ..The adjuvant effect is usually exerted early after infection during the innate immune response, operating at least in part through toll-like receptors and mast cells to direct the subsequent pathogenic adaptive immune response...
  10. ncbi request reprint Prediction and prevention of autoimmune disease: a personal perspective
    Noel R Rose
    Department of Pathology, Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 1109:117-28. 2007
    ..Thus, predictive biomarkers aid in identifying individuals with inordinate risk of disease and provide opportunities for earlier interventions to arrest the disease process...
  11. ncbi request reprint Life amidst the contrivances
    Noel R Rose
    Department of Pathology, Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Nat Immunol 7:1009-11. 2006
    ..b>Noel Rose recounts the events that led to the establishment of autoimmunity as a cause of disease.
  12. ncbi request reprint Cardiomyopathies
    Noel R Rose
    Departments of Pathology and of Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Autoimmunity 37:347-50. 2004
  13. doi request reprint Predictors of autoimmune disease: autoantibodies and beyond
    Noel R Rose
    Departments of Pathology and of Molecular Microbiology and Immunology, Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, Baltimore, MD 21205, USA
    Autoimmunity 41:419-28. 2008
    ..The new tools of multiplex testing and information handling open opportunities to identify early signposts of disease...
  14. ncbi request reprint Immunologic hazards associated with vaccination of humans
    N R Rose
    Department of Pathology, The Johns Hopkins Medical Institutions and World Health Organization Collaborating Center for Autoimmune Diseases, USA
    J Autoimmun 14:11-3. 2000
    ..We propose an algorithm for systematic study of possible immunologic hazards of vaccines in animals and human subjects...
  15. ncbi request reprint Autoantibodies to thyroglobulin in health and disease
    N R Rose
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Appl Biochem Biotechnol 83:245-51; discussion 251-4, 297-313. 2000
    ..Finally, thyroglobulin-reactive autoantibodies exhibit proteolytic activity on thyroglobulin...
  16. doi request reprint Myocarditis: infection versus autoimmunity
    Noel R Rose
    Departments of Pathology and of Molecular Microbiology and Immunology, Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, Room 659, Baltimore, MD 21205, USA
    J Clin Immunol 29:730-7. 2009
    ..Many cases are associated with viral infection, and appropriate treatment may depend upon whether the disease is primarily infectious, immune-mediated, or both...
  17. ncbi request reprint Molecular mimicry: a critical look at exemplary instances in human diseases
    N R Rose
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cell Mol Life Sci 57:542-51. 2000
    ..Based on analogous sequences of amino acids or on cross-reactions of monoclonal antibodies, numerous examples of such mimicry have been reported. There are, however, no clear examples of a human disease caused by molecular mimicry...
  18. pmc The genetics of autoimmune thyroiditis: the first decade
    Noel R Rose
    Johns Hopkins University, Bloomberg School of Public Health, Feinstone Department of Molecular, Microbiology and Immunology, 615 North Wolfe Street, Suite E5014, Baltimore, MD 21205, USA
    J Autoimmun 37:88-94. 2011
    ..The first evidence of modulatory genes on the sex-related X chromosome emerged. All of these genetic findings were concurrently translated to the human disease, Hashimoto's thyroiditis, where thyroglobulin is also the initiating antigen...
  19. ncbi request reprint Mechanisms of autoimmunity
    Noel R Rose
    Department of Pathology and W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Semin Liver Dis 22:387-94. 2002
    ..The diseases present differently depending on the site of pathology but share many fundamental mechanisms...
  20. doi request reprint America's first department of immunology: an informal history
    Noel R Rose
    Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins University, MMI E5009, Baltimore, MD 21205, USA
    Immunol Res 47:240-7. 2010
    ..A review of its history may foretell future developments and directions of immunology in this and other institutions...
  21. ncbi request reprint Animal models for autoimmune myocarditis and autoimmune thyroiditis
    Daniela Cihakova
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Methods Mol Med 102:175-93. 2004
    ..H2h4 mice. These mice express the H-2A(k) allele on an NOD genetic background and develop spontaneous thyroiditis, which is exacerbated with dietary iodine...
  22. doi request reprint Pathogenesis of myocarditis and dilated cardiomyopathy
    Daniela Cihakova
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Adv Immunol 99:95-114. 2008
    ..The most abundant cells in heart infiltrate in human giant cell myocarditis or EAM are monocyte/macrophages, and there is now evidence that macrophages play a decisive role in the course of EAM...
  23. pmc Quantitative analysis of myocardial inflammation by flow cytometry in murine autoimmune myocarditis: correlation with cardiac function
    Marina Afanasyeva
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Pathol 164:807-15. 2004
    ....
  24. pmc Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation
    Daniela Cihakova
    Johns Hopkins University, Department of Pathology, Division of Immunology, Ross 648, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 172:1195-208. 2008
    ..IL-13 KO mice had increased caspase-1 activation, leading to increased production of both IL-1beta and IL-18. Therefore, IL-13 protects against myocarditis by modulating monocyte/macrophage populations and by regulating their function...
  25. doi request reprint Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy
    G Christian Baldeviano
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 106:1646-55. 2010
    ..CD4(+) T helper (Th)17 cells have been implicated in the pathogenesis of autoimmune diseases, but the role of Th17-produced cytokines during inflammation-induced cardiac remodeling has not been previously studied...
  26. ncbi request reprint Two autoimmune diabetes loci influencing T cell apoptosis control susceptibility to experimental autoimmune myocarditis
    Mehmet L Guler
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 174:2167-73. 2005
    ..SW mice demonstrate the same characteristics in apoptosis. These results suggest that common pathogenetic mechanisms involving apoptosis of both thymic and peripheral T cells are shared by multiple autoimmune diseases...
  27. ncbi request reprint Iodine and IFN-gamma synergistically enhance intercellular adhesion molecule 1 expression on NOD.H2h4 mouse thyrocytes
    Rajni B Sharma
    Department of Pathology, School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 174:7740-5. 2005
    ..These findings suggest that iodine and IFN-gamma cooperate to promote thyroidal expression of ICAM-1 in this mouse model of thyroiditis, highlighting the complex interplay present in the pathogenesis of Hashimoto's thyroiditis...
  28. doi request reprint Sex differences in a murine model of Sjögren's syndrome
    Daniela Cihakova
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1173:378-83. 2009
    ..Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation...
  29. ncbi request reprint Sex differences in coxsackievirus B3-induced myocarditis: IL-12Rbeta1 signaling and IFN-gamma increase inflammation in males independent from STAT4
    Sylvia Frisancho-Kiss
    Department of Pathology, Johns Hopkins University, School of Medicine, 728 Rutland Avenue, Baltimore, MD 21205, USA
    Brain Res 1126:139-47. 2006
    ..Thus, IFN-gamma increases inflammation in males independent from STAT4. These results demonstrate that sex differences greatly influence viral replication and the severity of acute CVB3-induced myocarditis...
  30. pmc Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury
    Dolores B Njoku
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Eur J Immunol 39:1652-63. 2009
    ..This is the first demonstration of dual roles for IL-4 in the pathogenesis of immune-mediated DILI by suppressing auto-antigen-induced regulatory responses while promoting hapten-induced pro-inflammatory responses...
  31. pmc L.E.A.P.S. heteroconjugate is able to prevent and treat experimental autoimmune myocarditis by altering trafficking of autoaggressive cells to the heart
    Daniela Cihakova
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int Immunopharmacol 8:624-33. 2008
    ..J-My-1 injections resulted in decreased levels of chemokines MIP-1alpha and IP-10 in hearts. We propose that J-My-1 treatment interferes with trafficking of autoaggressive immune cells to the heart...
  32. pmc The prevalence of 30 ICD-10 autoimmune diseases in Denmark
    William W Eaton
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Immunol Res 47:228-31. 2010
    ..The prevalences vary from 0.06/1,000 for Pemphigus to 8.94/1,000 for Type 1 diabetes. Nearly 4% of the population had one or more autoimmune disease. The general conclusion is that autoimmune diseases as an aggregate are common...
  33. pmc Epidemiology of autoimmune diseases in Denmark
    William W Eaton
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, USA
    J Autoimmun 29:1-9. 2007
    ..Within families, aggregation is strongest for individual diseases and weak across diseases. These data confirm the importance of the autoimmune diseases as a group and suggest that common etiopathologies exist among them...
  34. pmc Sex differences in autoimmune disease from a pathological perspective
    Delisa Fairweather
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe St, Room E7628, Baltimore, MD 21205, USA
    Am J Pathol 173:600-9. 2008
    ..Th17 responses increase neutrophil inflammation and chronic fibrosis. This distinction between acute and chronic pathology has primarily been overlooked, but greatly impacts our understanding of sex differences in autoimmune disease...
  35. ncbi request reprint Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart
    Delisa Fairweather
    Department of Environmental Health Sciences, Johns Hopkins University and Bloomberg School of Public Health, 615 North Wolfe Street, Rm E7628, Baltimore, MD 21205, USA
    J Immunol 176:3516-24. 2006
    ..These results show that expression of CR1/2 is not necessary for effective clearance of CVB3 infection, but prevents immune-mediated damage to the heart...
  36. ncbi request reprint IL-12 receptor beta 1 and Toll-like receptor 4 increase IL-1 beta- and IL-18-associated myocarditis and coxsackievirus replication
    Delisa Fairweather
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 170:4731-7. 2003
    ..These findings have important implications not only for the pathogenesis of myocarditis, but for other autoimmune diseases triggered by viral infections...
  37. ncbi request reprint Novel model of constrictive pericarditis associated with autoimmune heart disease in interferon-gamma-knockout mice
    Marina Afanasyeva
    Department of Pathology, Johns Hopkins Medical Intitutions, Baltimore, MD, USA
    Circulation 110:2910-7. 2004
    ..Constrictive pericarditis represents a serious hemodynamic syndrome that may lead to heart failure. Studies of its pathophysiological mechanisms have been impeded by the lack of an animal model...
  38. pmc Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart
    Delisa Fairweather
    Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 165:1883-94. 2004
    ....
  39. pmc Regenerative potentials of the murine thyroid in experimental autoimmune thyroiditis: role of CD24
    Cindy Y Chen
    Department of Pathology, The Johns Hopkins Medical Institutions, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Endocrinology 150:492-9. 2009
    ..Regeneration was faster in the absence of CD24, likely a consequence of the effect of CD24 on the infiltrating lymphocytes. The study suggests that the EAT model can also be used as a tool to investigate adult thyroid stem cells...
  40. ncbi request reprint Thyroid-specific expression of IFN-gamma limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes
    Jobert G Barin
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 170:5523-9. 2003
    ..The study supports a disease-limiting role of IFN-gamma in autoimmune thyroiditis. Furthermore, it provides the first evidence that local IFN-gamma activity in the thyroid is sufficient for disease suppression...
  41. ncbi request reprint Early chemokine expression induced by interferon-gamma in a murine model of Hashimoto's thyroiditis
    Hiroaki Kimura
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Exp Mol Pathol 77:161-7. 2004
    ..Our findings indicate that the isolated expression of IFNgamma is capable of recruiting mononuclear cells but they do not progress to full lymphoid transformation of the thyroid...
  42. ncbi request reprint Studies on murine thyroiditis: new insights from organ flow cytometry
    Patrizio Caturegli
    The Johns Hopkins Medical Institutions, Department of Pathology, Baltimore, Maryland, USA
    Thyroid 13:419-26. 2003
    ..These methods should also be applicable to other organ systems targeted by autoimmune attack, such as heart, exocrine, and other endocrine glands...
  43. ncbi request reprint NKT cell regulation of autoimmune thyroiditis
    C Lynne Burek
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Autoimmunity 36:405-8. 2003
  44. ncbi request reprint Mast cells and innate cytokines are associated with susceptibility to autoimmune heart disease following coxsackievirus B3 infection
    Delisa Fairweather
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Autoimmunity 37:131-45. 2004
    ..Thus, susceptibility to autoimmune heart disease can be determined as early as 6 h following viral infection in susceptible strains of mice...
  45. pmc IP-10 protects while MIP-2 promotes experimental anesthetic hapten - induced hepatitis
    Dolores B Njoku
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Autoimmun 32:52-9. 2009
    ..05) confirmed that IP-10 reduced T cell priming to CYP2E1 and TFA. We propose that MIP-2 promotes and IP-10 protects against the development of hepatitis and T cell priming in this murine model...
  46. pmc Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older women
    George C Wang
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 95:1161-8. 2010
    ..These trends were not observed with antinuclear antibodies. Conclusion: Independent of thyroid function status, community-dwelling older women who are seropositive for TgAbs and TPOAbs are less likely to be frail than seronegative women...
  47. ncbi request reprint Cutting edge: a critical role for IL-10 in induction of nasal tolerance in experimental autoimmune myocarditis
    Ziya Kaya
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 168:1552-6. 2002
    ..This study implicates IL-10 in the induction of nasal tolerance and in limiting inflammation later during the disease process...
  48. pmc Increased thyroidal fat and goitrous hypothyroidism induced by interferon-gamma
    Hiroaki Kimura
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Int J Exp Pathol 86:97-106. 2005
    ....
  49. ncbi request reprint A novel model of drug hapten-induced hepatitis with increased mast cells in the BALB/c mouse
    Dolores B Njoku
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Blalock 906A, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Exp Mol Pathol 78:87-100. 2005
    ..This is the first report, to our knowledge, of a hapten-induced model of hepatitis with immune and autoimmune features...
  50. ncbi request reprint Questions and answers about autoimmunity and the smallpox vaccine
    Neal Halsey
    Department of International Health, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Isr Med Assoc J 5:40-1. 2003
  51. doi request reprint Mechanisms of IFNγ regulation of autoimmune myocarditis
    Jobert G Barin
    Training Program in Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Mol Pathol 89:83-91. 2010
    ..Together, these data indicate multiple mechanisms of autonomous and non-autonomous CD4(+) T cell regulation mediated by IFNγ in the control of autoimmune heart disease...
  52. pmc Genetic complexity of autoimmune myocarditis
    Haiyan S Li
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Autoimmun Rev 7:168-73. 2008
    ..Identification of genetic polymorphisms controlling autoimmune myocarditis will help us understand the mechanisms underlying autoimmune diseases in general, thereby improving potential therapies in patients...
  53. pmc Influence of signal transducer and activator of transcription-1 signaling on thyroid morphology and function
    Hiroaki J Kimura
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 150:3409-16. 2009
    ..These results indicate that STAT1 is required to mediate some but not all of the phenotypic changes induced by IFN gamma and that it also regulates iodine accumulation via TGFbeta signaling...
  54. pmc Autoimmune hypophysitis of SJL mice: clinical insights from a new animal model
    Shey Cherng Tzou
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Endocrinology 149:3461-9. 2008
    ..These findings provide new insights into the pathogenesis of AH, and establish a platform for developing novel diagnostic biomarkers and therapeutics...
  55. doi request reprint Autoimmune thyroiditis and ROS
    C Lynne Burek
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, United States
    Autoimmun Rev 7:530-7. 2008
    ..H2(h4) mouse thyrocytes. These results suggest that antioxidants may have therapeutic value in preventing autoimmune thyroiditis...
  56. pmc A locus on chromosome 1 promotes susceptibility of experimental autoimmune myocarditis and lymphocyte cell death
    Davinna L Ligons
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Clin Immunol 130:74-82. 2009
    ..SW than B10.S mice whereas B10.A-Eam1 congenic mice exhibited an intermediate phenotype. Our results show that Eam1 reduces lymphocyte apoptosis and increases susceptibility to EAM...
  57. ncbi request reprint Maternal thyroid autoantibodies during the third trimester and hearing deficits in children: an epidemiologic assessment
    Ellen E Wasserman
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
    Am J Epidemiol 167:701-10. 2008
    ..These data suggest that antenatal exposure to maternal TPOaAb during the third trimester of pregnancy is associated with impaired auditory development...
  58. ncbi request reprint Viruses as adjuvants for autoimmunity: evidence from Coxsackievirus-induced myocarditis
    Delisa Fairweather
    The Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Rev Med Virol 15:17-27. 2005
    ..Recent findings suggest that mast cell activation by viruses or adjuvants may be important in initiating autoimmune disease...
  59. pmc Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity
    Delisa Fairweather
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Methods 41:118-22. 2007
    ..An improved understanding of the interaction between environmental exposures and the development of heart disease represents a clear challenge for immunotoxicologists...
  60. ncbi request reprint IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart
    Delisa Fairweather
    Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Immunol 174:261-9. 2005
    ....
  61. ncbi request reprint IL-12 overexpression in mice as a model for Sjögren lung disease
    Sharon McGrath-Morrow
    Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Am J Physiol Lung Cell Mol Physiol 291:L837-46. 2006
    ..This new mouse model highlights the role of IL-12 in the initiation of Sjögren syndrome...
  62. pmc Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice
    Hiroaki J Kimura
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 4:e7857. 2009
    ..They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown...
  63. ncbi request reprint Expression of class II major histocompatibility complex molecules on thyrocytes does not cause spontaneous thyroiditis but mildly increases its severity after immunization
    Hiroaki Kimura
    Department of Pathology, Johns Hopkins Medical Institutions, Ross Building, Room 656, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Endocrinology 146:1154-62. 2005
    ..These findings suggest that expression of class II MHC molecules on epithelial cells is not sufficient to initiate autoimmunity but mildly modulates an already established autoimmune attack against the target organ...
  64. ncbi request reprint Autoimmune hypophysitis
    Patrizio Caturegli
    Johns Hopkins Pathology, Ross 656, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Endocr Rev 26:599-614. 2005
    ..The present review synthesizes the clinical and research data reported in this body of scientific literature...
  65. ncbi request reprint Infection and thyroid autoimmunity: A seroepidemiologic study of TPOaAb
    Ellen E Wasserman
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Autoimmunity 42:439-46. 2009
    ..These findings require further investigation. We believe that if T. gondii is in fact confirmed to trigger or enhance a TPOaAb response, the most likely mechanism involved is the bystander effect...
  66. pmc Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis
    Dolores B Njoku
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe St Blalock 906A, Baltimore, MD 21287, USA
    Clin Vaccine Immunol 13:258-65. 2006
    ..Persons susceptible to anesthetic-induced IDDIH develop CYP2E1-specific IgG4 autoantibodies which form small, nonprecipitating immune complexes that escape clearance because of their size or by direct inhibition of complement activation...
  67. pmc Women and autoimmune diseases
    Delisa Fairweather
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Emerg Infect Dis 10:2005-11. 2004
    ..Sex hormones may further amplify this hyperimmune response to infection in susceptible persons, which leads to an increased prevalence of autoimmune diseases in women...
  68. pmc Gonadectomy of male BALB/c mice increases Tim-3(+) alternatively activated M2 macrophages, Tim-3(+) T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis
    Sylvia Frisancho-Kiss
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Brain Behav Immun 23:649-57. 2009
    ....
  69. pmc Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure
    Marina Afanasyeva
    Department of Pathology, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:180-5. 2005
    ..An exaggerated inflammatory response in IFN-gamma KO mice causes cardiac dysfunction, leading to dilated cardiomyopathy and heart failure...
  70. ncbi request reprint Genetic differences in bone marrow-derived lymphoid lineages control susceptibility to experimental autoimmune myocarditis
    Haiyan S Li
    Department of Pathology, The John Hopkins University, Baltimore, MD 21205, USA
    J Immunol 180:7480-4. 2008
    ..Our findings significantly narrow the cellular expression of genetic polymorphisms controlling the EAM phenotype...
  71. ncbi request reprint Autoimmune myocarditis: cellular mediators of cardiac dysfunction
    Marina Afanasyeva
    Cardiovascular Research Group, Faculty of Medicine, University of Calgary, Canada
    Autoimmun Rev 3:476-86. 2004
    ..EAM provides insights into the role of the immune system in the development of dilated cardiomyopathy (DCM) and heart failure and may serve as a general paradigm for autoimmune organ-specific tissue damage...
  72. ncbi request reprint Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium
    Stefan Göser
    Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany
    Circulation 114:1693-702. 2006
    ..Thus, the cardiac troponins are paramount for disease classification and risk stratification. However, little is known about the long-term effects of the released troponins on cardiac function...
  73. ncbi request reprint Heritability of levels of autoantibodies to thyroid antigens using the method of plotting regression of offspring on midparent (ROMP)
    Ingrid M Outschoorn
    Unidad de Respuesta Inmune, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Autoimmunity 40:366-71. 2007
    ..The method may be extended to study epitope spreading and other measures of disease progression...
  74. pmc Cell damage and autoimmunity: a critical appraisal
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Autoimmun 30:5-11. 2008
    ..Finally an essential genetic foundation underlies all these hazards for autoimmunity in the form of risk-associated polymorphisms in immunoregulatory genes. They may be predictive of future or impending disease...
  75. pmc Complement receptors regulate lipopolysaccharide-induced T-cell stimulation
    Ziya Kaya
    Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany
    Immunology 114:493-8. 2005
    ..These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS...
  76. ncbi request reprint Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy
    Stefan Göser
    Department of Internal Medicine III, University of Heidelberg, Germany
    Circulation 112:3400-7. 2005
    ..To determine their critical role in the pathogenesis of myocarditis, we inhibited mononuclear cell activation and migration to see if it would affect disease severity and disease prevalence in experimental autoimmune myocarditis (EAM)...
  77. pmc Cardiomyopathy is linked to complement activation
    Marina Afanasyeva
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Pathol 161:351-7. 2002
  78. ncbi request reprint Type 1 diabetes: virus infection or autoimmune disease?
    Delisa Fairweather
    Nat Immunol 3:338-40. 2002
  79. pmc Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies
    James S Anderson
    Anesthesia Consultants Associated, El Paso, Texas, USA
    Anesth Analg 104:1452-3, table of contents. 2007
    ..Three cases of drug-induced liver injury (DILI) have been reported after desflurane anesthesia. However, no previous reports have detected serum autoantibodies such as that reported with DILI from halothane or isoflurane...
  80. pmc Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness
    Roberto Rocchi
    Department of Pathology and Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:6019-24. 2007
    ..The study demonstrates a link between Toll-like and Fc receptor signaling and thyroid gland function, uncovering a role of mast cells in murine NTI...
  81. pmc Reproducibility of immunological tests used to assess multiple chemical sensitivity syndrome
    Donald R Hoover
    Department of Statistics and Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, New Jersey, USA
    Clin Diagn Lab Immunol 10:1029-36. 2003
    ..When comparing markers that are not well standardized, it may be important to distribute samples from different study groups evenly over time...
  82. ncbi request reprint Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)
    Ingrid M Outschoorn
    Department of Biochemistry and Molecular Biology, Monash University Clayton, 3800 Victoria, Australia
    Autoimmunity 38:325-6. 2005
    ..569, p = 0.001), consistent with the reported Gm association, but not in chronic lymphocytic thyroiditis or type 1 diabetes. Extension of the procedure to other autoantibody disorders could be informative...
  83. ncbi request reprint Autoimmune thyroid diseases
    Patrizio Caturegli
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Rheumatol 19:44-8. 2007
    ..The review is organized into four main areas: genetics, environment, adaptive immune system, and innate immune system...
  84. ncbi request reprint On the implications of polyclonal B cell activation
    Arthur M Silverstein
    Nat Immunol 4:931-2; author reply 932. 2003
  85. ncbi request reprint The pathogenic role of anti-thyroglobulin antibody on pregnancy: evidence from an active immunization model in mice
    Shelly Tartakover Matalon
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv, Israel
    Hum Reprod 18:1094-9. 2003
    ..The aim of this study was to examine whether active immunization with Tg could elicit anti-Tg autoantibodies and reproductive failure without interfering with thyroid function...
  86. ncbi request reprint Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity
    Sylvia Frisancho-Kiss
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 176:6411-5. 2006
    ..These results indicate that regulation of inflammation in the heart begins during innate immunity and that Tim-3 signaling on cells of the innate immune system critically influences regulation of the adaptive immune response...
  87. pmc Trifluoroacetylated IgG4 antibodies in a child with idiosyncratic acute liver failure after first exposure to halothane
    Christine Nguyen
    Department of Pediatric Gastroenterology, Lucille Packard Children s Hospital, Stanford University Medical Center, Palo Alto, CA, USA
    J Pediatr Gastroenterol Nutr 47:199-202. 2008

Research Grants24

  1. Genetic mechanisms of autoimmune myocarditis
    Noel Rose; Fiscal Year: 2007
    ..We build on our preliminary data to propose hypothesis-driven aims to identify host genes that control susceptibility and characterize their mechanisms of action in a murine model of autoimmune myocarditis. ..
  2. Role of innate immunity in autoimmune myocarditis
    Noel Rose; Fiscal Year: 2005
    ..The findings generated by these studies will aid in understanding the development of autoimmune disease initiated by infection. ..
  3. Cell/Tissue Damage and Autoimmune Response
    Noel Rose; Fiscal Year: 2006
    ..The program will feature presentations by eminent researchers including Noel Rose, Betty Diamond and Eric Gershwin...
  4. Pathogenesis of Autoimmune Myocarditis
    Noel Rose; Fiscal Year: 2007
    ..We propose to broaden our knowledge of the pathogenesis of myocarditis, in order to rationalize new biologic approaches to treatment. ..
  5. Sex differences in Coxsackievirus-induced myocarditis
    Noel Rose; Fiscal Year: 2004
    ..The findings generated by these studies will aid in understanding the sex- based differences in severity in this model of infection-induced autoimmune disease. ..
  6. Pathogenesis of Autoimmune Myocarditis
    Noel Rose; Fiscal Year: 2005
    ..It will also provide us with a basis for designing new therapeutic interventions in patients with myocarditis. ..
  7. Pathogenesis of Autoimmune Myocarditis
    Noel Rose; Fiscal Year: 2009
    ..We propose to broaden our knowledge of the pathogenesis of myocarditis, in order to rationalize new biologic approaches to treatment. ..