Research Topics
Species | B M RonnettSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
p16 expression in primary ovarian mucinous and endometrioid tumors and metastatic adenocarcinomas in the ovary: utility for identification of metastatic HPV-related endocervical adenocarcinomasRussell Vang
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Surg Pathol 31:653-63. 2007....
Identification and characterization of a spontaneous ovarian carcinoma in Lewis ratsAllison C Sharrow
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Ovarian Res 3:9. 2010..Limited progress has been made toward improving the survival rate of patients with this disease in part because of the lack of a good animal model. We present here a model of spontaneous ovarian carcinoma arising in a normal Lewis rat...- HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapyJessica N McAlpine
Department of Gynaecology and Obstetrics, University of British Columbia, Vancouver, BC, Canada
BMC Cancer 9:433. 2009..We investigated HER2 expression and amplification, and the potential for trastuzumab therapy in this histologic subtype of ovarian cancer... 
Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasmsBrigitte M Ronnett
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 32:1835-53. 2008....- Mucinous tumors arising in ovarian mature cystic teratomas: relationship to the clinical syndrome of pseudomyxoma peritoneiBrigitte M Ronnett
Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 1231, USA
Am J Surg Pathol 27:650-7. 2003..Such tumors probably represent the only cases of ovarian origin of PMP... - Hydatidiform moles: ancillary techniques to refine diagnosisBrigitte M Ronnett
Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland, USA
Int J Gynecol Pathol 30:101-16. 2011.... - Patients with pseudomyxoma peritonei associated with disseminated peritoneal adenomucinosis have a significantly more favorable prognosis than patients with peritoneal mucinous carcinomatosisB M Ronnett
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
Cancer 92:85-91. 2001..A recent study reported a pathologic classification that separated patients into prognostically distinct groups, but the follow-up was relatively short... - Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomasHongxiu Ji
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore 21231, USA
Int J Gynecol Pathol 21:391-400. 2002..Loss of Dpc4 expression is useful for distinguishing metastatic pancreatic carcinomas in the ovary from both primary ovarian mucinous tumors and metastatic mucinous carcinomas derived from other sites... - Synchronous and metachronous endocervical and ovarian neoplasms: evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasmsEsther Elishaev
Department of Pathology, Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 29:281-94. 2005..The presence of HPV DNA in these ovarian tumors confirms that they are metastatic endocervical adenocarcinomas... - Hormone receptor immunohistochemistry and human papillomavirus in situ hybridization are useful for distinguishing endocervical and endometrial adenocarcinomasAnnette Staebler
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A
Am J Surg Pathol 26:998-1006. 2002..The clinical utility of these techniques should be evaluated in studies that include curettage and biopsy specimens... - Women with undiagnosed colorectal adenocarcinomas presenting with ovarian metastases: clinicopathologic features and comparison with women having known colorectal adenocarcinomas and ovarian involvementKara Judson
Department of Pathology, School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
Int J Gynecol Pathol 27:182-90. 2008.... - Molecular genetic analysis of appendiceal mucinous adenomas in identical twins, including one with pseudomyxoma peritoneiI M Shih
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Surg Pathol 25:1095-9. 2001.... - Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas in the ovaryDengfeng Cao
Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
Int J Gynecol Pathol 24:67-72. 2005.... - Distinction of endocervical and endometrial adenocarcinomas: immunohistochemical p16 expression correlated with human papillomavirus (HPV) DNA detectionM Ali Ansari-Lari
Department of Pathology Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Surg Pathol 28:160-7. 2004.... - Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomasHeidi W Shappell
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
Am J Surg Pathol 26:1529-41. 2002..We therefore recommend the term "seromucinous" for these tumors, which acknowledges both their serous and mucinous features... - Uterine myxoid leiomyosarcoma with widespread metastases in a catT K Cooper
Department of Comparative Medicine, Johns Hopkins University School of Medicine, Broadway Research Building, Suite 863, 733 North Broadway, Baltimore, MD 21205 2196 USA
Vet Pathol 43:552-6. 2006..The clinical behavior and gross, microscopic, and immunohistochemical findings established a diagnosis of myxoid leiomyosarcoma... - Endocervical adenocarcinomas with prominent endometrial or endomyometrial involvement simulating primary endometrial carcinomas: utility of HPV DNA detection and immunohistochemical expression of p16 and hormone receptors to confirm the cervical origin ofAnna Yemelyanova
Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 33:914-24. 2009..A subset of misclassified endocervical adenocarcinomas may account for some HPV-positive uterine carcinomas reported as primary endometrial carcinomas... - Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 casesRussell Vang
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Surg Pathol 30:1130-9. 2006.... - Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 casesAnna Yemelyanova
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Surg Pathol 33:1504-14. 2009.... - Immunohistochemistry for estrogen and progesterone receptors in the distinction of primary and metastatic mucinous tumors in the ovary: an analysis of 124 casesRussell Vang
Department of Pathology, Division of Gynecologic Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Mod Pathol 19:97-105. 2006.... - Pseudoinfiltrative tubal metaplasia of the endocervix: a potential form of in utero diethylstilbestrol exposure-related adenosis simulating minimal deviation adenocarcinomaRussell Vang
Division of Gynecologic Pathology, Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland 21231, USA
Int J Gynecol Pathol 24:391-8. 2005..The clinicopathologic findings suggest the lesions are benign, and the association with in utero DES exposure raises the possibility that these could be a form of DES-related adenosis... - Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7Russell Vang
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Mod Pathol 19:1421-8. 2006..Cytokeratin 7 provides the predominant discriminatory value among these markers yet is limited to distinction of primary ovarian tumors from metastases of lower gastrointestinal tract origin... - Ovarian mucinous tumors associated with mature cystic teratomas: morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encounterRussell Vang
Department of Pathology and Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Surg Pathol 31:854-69. 2007..Those tumors having CK7 expression with or without CK20 expression may be derived from upper gastrointestinal tract-type or sinonasal-type teratomatous elements but could be independent tumors of surface epithelial-stromal origin... - Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: clinicopathologic features, human papillomavirus DNA detection, and P16 expressionAnil V Parwani
Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
Hum Pathol 36:82-90. 2005..The invasive component is usually evident in the excisional biopsy specimen, allowing for recognition of a tumor that needs further management... - Molecular genotyping of hydatidiform moles: analytic validation of a multiplex short tandem repeat assayKathleen M Murphy
Department of Pathology, Johns Hopkins Medical Institutions, Park Bldg Room SB202, 600 North Wolfe St, Baltimore, MD 21287, USA
J Mol Diagn 11:598-605. 2009..To avoid these pitfalls, we have developed an algorithm with quantitative guidelines for the interpretation of short tandem repeat genotyping data... - Ovarian metastases of appendiceal tumors with goblet cell carcinoidlike and signet ring cell patterns: a report of 30 casesAlexandra C Hristov
Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, 401 N Broadway, Baltimore, MD 21231, USA
Am J Surg Pathol 31:1502-11. 2007..In cases in which the primary tumor is not already evident, their "goblet cell carcinoidlike" patterns should direct attention to the appendix as a possible source... - The role of cytoreductive surgery for colon cancer metastatic to the ovaryColleen C McCormick
Department of Gynecology and Obstetrics, Kelly Gynecologic Oncology Service, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
Gynecol Oncol 105:791-5. 2007..We sought to further elucidate the survival impact of cytoreductive surgery among patients with colon cancer metastatic to the ovary... - Glial implants in gliomatosis peritonei arise from normal tissue, not from the associated teratomaA W Ferguson
Department of Pathology, University of Michigan Hospital, Ann Arbor 48109, USA
Am J Pathol 159:51-5. 2001..This finding has important implications for more common gynecological entities with debatable pathogenesis, such as endometriosis, by definitively demonstrating the metaplastic potential of stem cells within the peritoneal cavity... - Suitability of self-collected vaginal samples for cervical cancer screening in periurban villages in Andhra Pradesh, IndiaA Pavani Sowjanya
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 18:1373-8. 2009.... - Ovarian atypical proliferative (borderline) mucinous tumors: gastrointestinal and seromucinous (endocervical-like) types are immunophenotypically distinctiveRussell Vang
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Int J Gynecol Pathol 25:83-9. 2006..quot;.. - Diagnosis and subclassification of hydatidiform moles using p57 immunohistochemistry and molecular genotyping: validation and prospective analysis in routine and consultation practice settings with development of an algorithmic approachThomas G McConnell
Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 33:805-17. 2009.... - Complete hydatidiform mole with retained maternal chromosomes 6 and 11Thomas G McConnell
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Am J Surg Pathol 33:1409-15. 2009..Genome-wide analysis has the potential to assist in localizing imprinted genes critical for determining the morphologic and behavioral phenotypes of hydatidiform moles... - Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumorsMaryam A Farinola
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Int J Gynecol Pathol 26:375-82. 2007..These patterns of expression of ERalpha and PR may aid our understanding of the biologic differences between granulosa and Sertoli cell tumors... - Atypical squamous cells of undetermined significance in liquid-based cytologic specimens: results of reflex human papillomavirus testing and histologic follow-up in routine practice with comparison of interpretive and probabilistic reporting methodsAngelique W Levi
Division of Cytopathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Cancer 99:191-7. 2003..This observation, the similar yield of lesions in both groups, and the significant risk of high-grade lesions argue against application of the interpretive model to HPV-tested ASCUS cases... - Metastatic HPV-related cervical adenocarcinomas presenting with thromboembolic events (Trousseau Syndrome): clinicopathologic characteristics of 2 casesEmanuela Veras
Departments of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland 21231, USA
Int J Gynecol Pathol 28:134-9. 2009..These features more commonly suggest metastatic adenocarcinoma of upper gastrointestinal tract origin but the presence of HPV DNA within the tumors establishes them as cervical in origin... - Are all pelvic (nonuterine) serous carcinomas of tubal origin?Christopher G Przybycin
Departments of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Surg Pathol 34:1407-16. 2010.... - Telomere length abnormalities occur early in the initiation of epithelial carcinogenesisAlan K Meeker
Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Clin Cancer Res 10:3317-26. 2004..6%. The implications of these findings include the potential that telomere length assessment in situ may be a widely useful biomarker for monitoring disease prevention strategies and for improved early diagnosis... - Primary and metastatic mucinous adenocarcinomas in the ovaries: incidence in routine practice with a new approach to improve intraoperative diagnosisJeffrey D Seidman
Department of Pathology, Washington Hospital Center, Washington, DC 20010, USA
Am J Surg Pathol 27:985-93. 2003..After careful exclusion of noninvasive, microinvasive, and metastatic tumors, pure mucinous adenocarcinoma primary in the ovary appears to be substantially less common than previously reported... - Clear cell papillary cystadenoma of the epididymis and mesosalpinx: immunohistochemical differentiation from metastatic clear cell renal cell carcinomaHakan Aydin
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 29:520-3. 2005..Our findings indicate that, in cases where there is uncertainty about the histologic diagnosis of clear cell papillary cystadenoma, the above immunohistochemical panel helps to rule out metastatic renal cell carcinoma... - PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinomaJames V Lacey
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Cancer Res 68:6014-20. 2008..Loss of PTEN expression in endometrial biopsies was neither associated with nor a sensitive and specific marker of subsequent progression to endometrial carcinoma... - Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classificationAnna V Yemelyanova
Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 32:128-38. 2008..Use of the algorithm is intended as an adjunct to the complete clinicopathologic evaluation that ideally should occur when problematic mucinous tumors in the ovary are encountered... - Atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion: diagnostic performance, human papillomavirus testing, and follow-up resultsMonica Srodon
Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland 21231, USA
Cancer 108:32-8. 2006.... - Pathology of borderline (low malignant potential) ovarian tumoursJeffrey D Seidman
Department of Pathology, Washington Hospital Center, Washington, DC 20010, USA
Best Pract Res Clin Obstet Gynaecol 16:499-512. 2002..The remaining mucinous borderline tumours are always confined to the ovaries and have a benign behaviour. Since borderline tumours can now be classified into benign and malignant types, the category has no further utility... - Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap testsSteven L Kahn
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Cancer 114:57-64. 2008.... - The histologic type and stage distribution of ovarian carcinomas of surface epithelial originJeffrey D Seidman
Department of Pathology, Washington Hospital Center, Washington, DC 20010, USA
Int J Gynecol Pathol 23:41-4. 2004.... - Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2Zhenhua Lin
Department of Pathology, Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA
Am J Pathol 174:136-43. 2009..In contrast, L2 was primarily diffuse within the nucleus and distinct from ND-10 as defined by PML immunofluorescent staining in CIN lesions, condylomata, and HPV16-transduced organotypic cultures... - Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenograftsFrancescopaolo Di Cello
Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Cancer Ther 7:2090-5. 2008..Importantly, these drugs have lower toxicity than chemotherapeutic agents used to treat advanced-stage uterine cancers... - Borderline ovarian tumors: key points and workshop summarySteven G Silverberg
Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
Hum Pathol 35:910-7. 2004.... - Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behaviorBrigitte M Ronnett
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Hum Pathol 35:949-60. 2004..Improved classification of these mucinous tumors has clarifed the behavior of true M-BOTs by excluding these simulators from the M-BOT category... - The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesisAbeba Tesfaye
Hematology Division, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 67:3998-4004. 2007..Although a larger study is needed to confirm these results, HMGA1a may be a useful marker for aggressive human uterine cancers... - Abnormal villous morphology associated with triple trisomy of paternal originAlexis Norris-Kirby
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Mol Diagn 12:525-9. 2010..The three trisomies may have originated from paternal meiosis II errors, or from mitotic nondisjunction. We believe this to be the first report of triple trisomy in a SAB confirmed to be of paternal origin... - Metastatic endocervical adenocarcinoma presenting as a virilizing ovarian mass during pregnancyJohn L Powell
Department of Obstetrics and Gynecology, New Hanover Regional Medical Center, Coastal Area Health Education Center, Wilmington, North Carolina 28402 9025, USA
Obstet Gynecol 100:1129-33. 2002..We report a case of metastatic endocervical adenocarcinoma that presented as a virilizing ovarian mass in a young pregnant woman and simulated a primary ovarian endometrioid tumor... - Pseudomyxoma peritonei: A rose by any other nameBrigitte M Ronnett
Am J Surg Pathol 30:1483-4; author reply 1484-5. 2006