Fausto J Rodriguez

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes
    Fausto J Rodriguez
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, 720 Rutland Avenue, Ross Building, 512B, Baltimore, MD 21205, USA
    Acta Neuropathol 123:349-67. 2012
  2. ncbi request reprint Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma
    Sama Ahsan
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 1800 Orleans St, 21287 Baltimore, MD, USA
    Acta Neuropathol Commun 2:59. 2014
  3. pmc Identification of t(1;19)(q12;p13) and ploidy changes in an ependymosarcoma: a cytogenetic evaluation
    Abeer Z Tabbarah
    Department of Pathology, George Washington University, Washington, D C, USA
    Clin Neuropathol 31:142-5. 2012
  4. pmc Rosette forming glioneuronal tumor in association with Noonan syndrome: pathobiological implications
    M Karafin
    Department of Pathology, Division of Neuropathology, and Neurosurgery, Johns Hopkins University, Baltimore, MD, USA
    Clin Neuropathol 30:297-300. 2011
  5. pmc Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target
    Marianne Hütt-Cabezas
    Corresponding Authors Fausto J Rodriguez, MD, Division of Neuropathology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21231 Eric H Raabe, MD, PhD, Division of Neuropathology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21231
    Neuro Oncol 15:1604-14. 2013
  6. pmc BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper
    Fausto J Rodriguez
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21205, USA
    J Neuropathol Exp Neurol 71:789-94. 2012
  7. doi request reprint Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity
    Fausto J Rodriguez
    Department of Pathology, Division of Neuropathology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, 21231, USA
    Acta Neuropathol 124:627-41. 2012
  8. pmc Neoplastic cells are a rare component in human glioblastoma microvasculature
    Fausto J Rodriguez
    Department of Pathology, Division of Neuropathology, Johns Hopkins University, MD, USA
    Oncotarget 3:98-106. 2012
  9. pmc Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems
    Fausto J Rodriguez
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, 720 Rutland Avenue, Ross Building, 512B, Baltimore, MD 21205, USA
    Acta Neuropathol 123:295-319. 2012
  10. doi request reprint Superficial neurofibromas in the setting of schwannomatosis: nosologic implications
    Fausto J Rodriguez
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Acta Neuropathol 121:663-8. 2011

Collaborators

Detail Information

Publications28

  1. pmc Genetic predisposition to peripheral nerve neoplasia: diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes
    Fausto J Rodriguez
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, 720 Rutland Avenue, Ross Building, 512B, Baltimore, MD 21205, USA
    Acta Neuropathol 123:349-67. 2012
    ..In this review, we provide a concise update on the diagnostic criteria, pathology and molecular pathogenesis of these enigmatic syndromes in relation to peripheral nerve sheath neoplasia...
  2. ncbi request reprint Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma
    Sama Ahsan
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 1800 Orleans St, 21287 Baltimore, MD, USA
    Acta Neuropathol Commun 2:59. 2014
    ..An H-score was derived by multiplying intensity (0-2) by percentage of positive tumor nuclei (0-100%)...
  3. pmc Identification of t(1;19)(q12;p13) and ploidy changes in an ependymosarcoma: a cytogenetic evaluation
    Abeer Z Tabbarah
    Department of Pathology, George Washington University, Washington, D C, USA
    Clin Neuropathol 31:142-5. 2012
    ..The significance of the genetic alterations we describe associated with sarcomatoid change in ependymal neoplasms, and ultimately their prognostic relevance, merits further study...
  4. pmc Rosette forming glioneuronal tumor in association with Noonan syndrome: pathobiological implications
    M Karafin
    Department of Pathology, Division of Neuropathology, and Neurosurgery, Johns Hopkins University, Baltimore, MD, USA
    Clin Neuropathol 30:297-300. 2011
    ..We review the literature regarding the molecular pathogenesis of Noonan syndrome and primary brain tumors, and consider the intriguing link between their common molecular pathways...
  5. pmc Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target
    Marianne Hütt-Cabezas
    Corresponding Authors Fausto J Rodriguez, MD, Division of Neuropathology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21231 Eric H Raabe, MD, PhD, Division of Neuropathology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21231
    Neuro Oncol 15:1604-14. 2013
    ..Here we further evaluate the role of the mTORC1/mTORC2 pathway in order to better direct pharmacologic blockade in these common childhood tumors...
  6. pmc BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper
    Fausto J Rodriguez
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21205, USA
    J Neuropathol Exp Neurol 71:789-94. 2012
    ....
  7. doi request reprint Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity
    Fausto J Rodriguez
    Department of Pathology, Division of Neuropathology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, 21231, USA
    Acta Neuropathol 124:627-41. 2012
    ..We report a series of a neoplasm with distinct clinicopathologic and molecular features. Although most progress slowly, a significant fraction develop aggressive features...
  8. pmc Neoplastic cells are a rare component in human glioblastoma microvasculature
    Fausto J Rodriguez
    Department of Pathology, Division of Neuropathology, Johns Hopkins University, MD, USA
    Oncotarget 3:98-106. 2012
    ....
  9. pmc Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems
    Fausto J Rodriguez
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, 720 Rutland Avenue, Ross Building, 512B, Baltimore, MD 21205, USA
    Acta Neuropathol 123:295-319. 2012
    ..In the current review, we attempt to provide some useful guidelines for the surgical neuropathologist to help navigate these persistent, challenging problems...
  10. doi request reprint Superficial neurofibromas in the setting of schwannomatosis: nosologic implications
    Fausto J Rodriguez
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
    Acta Neuropathol 121:663-8. 2011
    ..In particular, the presence of a cutaneous neurofibroma in a patient with multiple schwannomas should not lead to a diagnosis of NF2...
  11. pmc Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    Yuchen Jiao
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, The Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Oncotarget 3:709-22. 2012
    ....
  12. pmc Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas
    Doreen N Nguyen
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain Pathol 23:237-43. 2013
    ..Future studies are required to clarify the clinical and biological significance of ALT in high-grade astrocytomas...
  13. pmc cMYC expression in infiltrating gliomas: associations with IDH1 mutations, clinicopathologic features and outcome
    Yazmin Odia
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurooncol 115:249-59. 2013
    ..In summary, our findings suggest that cMYC may be associated with a unique clinicopathologic and biologic group of infiltrating gliomas and help mediate the malignant transformation of IDH1 mutant gliomas...
  14. pmc Exomic sequencing of four rare central nervous system tumor types
    Chetan Bettegowda
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 4:572-83. 2013
    ..Our study supports the hypothesis that pathologically similar tumors arising in different age groups and from different compartments may represent distinct disease processes with varied genetic composition...
  15. doi request reprint BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants
    Alex Lin
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neuropathol Exp Neurol 71:66-72. 2012
    ..The prognostic and therapeutic significance of this alteration is unclear and merits further study...
  16. pmc Phenotypic variations in NF1-associated low grade astrocytomas: possible role for increased mTOR activation in a subset
    Mark Jentoft
    Departments of Laboratory Medicine and Pathology, Johns Hopkins University, Baltimore, MD, USA
    Int J Clin Exp Pathol 4:43-57. 2010
    ..In summary, differential expression of neuronal-related genes and increased mTOR activation may underlie phenotypic variations in NF1-associated low grade astrocytomas...
  17. pmc MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2
    Cheng Ying Ho
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Neuro Oncol 15:69-82. 2013
    ..A unique miRNA profile exists in PA, compared with brain tissue. These miRNAs and their targets may play a role in the pathogenesis of PA...
  18. pmc Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas
    Leomar Y Ballester
    Laboratory of Pathology Pediatric Oncology Branch, NCI, NIH, Bethesda Department of Pathology, Division of Neuropathology, Johns Hopkins Hospital, Baltimore, MD Children s National Medical Center, Research Center for Genetic Medicine, Washington, DC
    Am J Surg Pathol 37:1357-64. 2013
    ..Targeted therapies against these proteins could be beneficial in treatment. ..
  19. pmc Mutations in CIC and FUBP1 contribute to human oligodendroglioma
    Chetan Bettegowda
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA
    Science 333:1453-5. 2011
    ..These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes...
  20. ncbi request reprint Ependymomas with neuronal differentiation: a morphologic and immunohistochemical spectrum
    Fausto J Rodriguez
    Department of Pathology, Mayo Clinic, Rochester, MN, USA
    Acta Neuropathol 113:313-24. 2007
    ..The clinical significance of these observations is unknown but deserves further exploration...
  21. doi request reprint Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma
    Jian He
    Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    J Neurooncol 114:275-9. 2013
    ..Alternative strategies to develop circulating biomarkers for PCNSL patients need to be explored...
  22. pmc Pathological and molecular advances in pediatric low-grade astrocytoma
    Fausto J Rodriguez
    Department of Pathology, Johns Hopkins UniversitySchool of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Pathol 8:361-79. 2013
    ..In this review, we attempt to summarize this rapidly developing field and discuss the potential for translating our growing molecular knowledge into improved diagnostic and prognostic biomarkers and new targeted therapies...
  23. pmc Altered telomeres in tumors with ATRX and DAXX mutations
    Christopher M Heaphy
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Science 333:425. 2011
    ..ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system. These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes...
  24. ncbi request reprint Clinicopathologic features of pediatric oligodendrogliomas: a series of 50 patients
    Fausto J Rodriguez
    Departments of Pathology Radiology The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD Departments of Pathology Neurological Surgery, University of California San Francisco School of Medicine, San Francisco, CA Hospital Pathology Associates, Minneapolis, St Paul, MN University of Arizona, College of Medicine, Phoenix, AZ
    Am J Surg Pathol 38:1058-70. 2014
    ..They are predominantly low grade, recur/clinically progress in a subset, but demonstrate a relatively low frequency of histologic progression. ..
  25. pmc Genetic and pathologic evolution of early secondary gliosarcoma
    Kari Elise T Codispoti
    Department of Pathology, Johns Hopkins University, Baltimore, USA
    Brain Tumor Pathol 31:40-6. 2014
    ..3qter), and del(16)(p11.2pter). In conclusion, unique copy number alterations were identified during tumor progression from a low-grade glioma to gliosarcoma. A subset of alterations developed specifically in the sarcomatous component. ..
  26. pmc Cytologic features in vitreous preparations of patients with suspicion of intraocular lymphoma
    Erika F Rodriguez
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland
    Diagn Cytopathol 42:37-44. 2014
    ..The most useful cytologic features include increased cellularity, necrosis, and nuclear enlargement. Ancillary immunocytochemical studies are useful and support the morphologic impression in a subset of cases...
  27. doi request reprint Cellular pleomorphism in papillary tumors of the pineal region
    Juliana Magalhães
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, Sheikh Zayed Tower, Room M2101, 1800 Orleans Street, Baltimore, MD 21231, USA
    Brain Tumor Pathol 30:93-8. 2013
    ..Variable pleomorphism may be present, reflected in size variation and nuclear hyperchromasia, but was not accompanied by increased proliferative activity in these cases, suggesting a degenerative phenomenon...
  28. doi request reprint BRAF alterations are frequent in cerebellar low-grade astrocytomas with diffuse growth pattern
    Cristiane M Ida
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neuropathol Exp Neurol 71:631-9. 2012
    ....