Research Topics
| Corban G RiveraSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
NeMo: Network Module identification in CytoscapeCorban G Rivera
Department of Biomedical Engineering and High Throughput Biology Center, Johns Hopkins School of Medicine, Baltimore, MD 21218, USA
BMC Bioinformatics 11:S61. 2010..In this work, we present a novel method to identify densely connected and bipartite network modules based on a log odds score for shared neighbours...
Angiogenesis-associated crosstalk between collagens, CXC chemokines, and thrombospondin domain-containing proteinsCorban G Rivera
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Ann Biomed Eng 39:2213-22. 2011..We identified six proteins at the center of the angiogenesis-associated network including three syndecans, MMP9, CD44, and versican. These findings shed light on the complex signaling networks that govern angiogenesis phenomena...
Novel peptide-specific quantitative structure-activity relationship (QSAR) analysis applied to collagen IV peptides with antiangiogenic activityCorban G Rivera
Department of Biomedical Engineering, 613 Traylor Building, Johns Hopkins University, 720 Rutland Avenue, Baltimore, Maryland 21205, United States
J Med Chem 54:6492-500. 2011..We found that the models produced quantitatively accurate predictions of activity and provided insight into collagen IV derived peptide structure-activity relationships...
Analysis of VEGF--a regulated gene expression in endothelial cells to identify genes linked to angiogenesisCorban G Rivera
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 6:e24887. 2011..The analysis showed differential regulation of HIF-1α and HIF-2α. The data also provided additional evidence for the role of endothelial cells in Alzheimer's disease...
Synergy between a collagen IV mimetic peptide and a somatotropin-domain derived peptide as angiogenesis and lymphangiogenesis inhibitorsJacob E Koskimaki
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Angiogenesis 16:159-70. 2013....
Anti-angiogenic peptides for cancer therapeuticsElena V Rosca
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Curr Pharm Biotechnol 12:1101-16. 2011..g., through L-to-D and non-natural amino acid substitutions. We highlight technological advances in peptide discovery and optimization including computational and bioinformatics tools and novel experimental techniques...
Constructing the angiome: a global angiogenesis protein interaction networkLiang Hui Chu
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
Physiol Genomics 44:915-24. 2012..The results of this analysis can be used to identify genes and proteins in different disease conditions and putative targets for therapeutic interventions as high-ranked candidates for experimental validation...
Serpin-derived peptides are antiangiogenic and suppress breast tumor xenograft growthJacob E Koskimaki
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Transl Oncol 5:92-7. 2012..We tested the peptide derived from DEAH box helicase protein in a triple-negative MDA-MB-231 breast orthotopic xenograft model in severe combined immunodeficient mice and show significant tumor suppression...
