Research Topics
| M A RiddleSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
The Preschool Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS) 6-year follow-upMark A Riddle
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Baltimore, MD 21287, USA
J Am Acad Child Adolesc Psychiatry 52:264-278.e2. 2013..To describe the clinical course of attention-deficit/hyperactivity disorder (ADHD) symptom severity and diagnosis from ages 3 to 5 up to 9 to 12 years during a 6-year follow-up after the original Preschool ADHD Treatment Study (PATS)...
Commentary by an academic child and adolescent psychiatristMark A Riddle
Division of Child and Adolescent Psychiatry, Johns Hopkins Hospital, Baltimore, Maryland 21287-3325, USA
J Child Adolesc Psychopharmacol 17:300-2. 2007
Pediatric psychopharmacologyM A Riddle
Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, MD 21287 3325, USA
J Child Psychol Psychiatry 42:73-90. 2001..Finally, the authors offer some speculations regarding the future of pediatric psychopharmacology research...
Fluvoxamine for children and adolescents with obsessive-compulsive disorder: a randomized, controlled, multicenter trialM A Riddle
Division of Child and Adolescent Psychiatry, Johns Hopkins Hospital, CMSC 346, 600 North Wolfe Street, Baltimore, MD 21287 3325, USA
J Am Acad Child Adolesc Psychiatry 40:222-9. 2001..To determine the safety and efficacy of fluvoxamine for the treatment of children and adolescents with obsessive-compulsive disorder (OCD) with a double-blind, placebo-controlled, multicenter study...
Attention-deficit hyperactivity disorder: a view from the USAMark A Riddle
Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287-3325, USA
Nat Clin Pract Neurol 4:118-9. 2008
Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspectiveO J Bienvenu
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Psychol Med 42:1-13. 2012..The current study uses co-morbidity and familiality data to inform these issues...
Homeobox genes in obsessive-compulsive disorderG Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 159:53-60. 2012..The OCD Collaborative Genetics Study (OCGS) has identified several OCD susceptibility loci through linkage analysis...
The OCD collaborative genetics study: methods and sample descriptionJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-7228, USA
Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006....
Selective serotonin reuptake inhibitors for children and adolescentsE A Kastelic
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Johns Hopkins Medical Institutions, CMSC 346, 600 North Wolfe Street, Baltimore, MD 21287, USA
Curr Psychiatry Rep 2:117-23. 2000..Recent pharmacokinetic studies of SSRIs in children and adolescents are reviewed. Future SSRI research strategies are also discussed...
Neuroimaging correlates of anxiety after pediatric traumatic brain injuryRoma A Vasa
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Biol Psychiatry 55:208-16. 2004..Similar to adult data, these findings implicate OFC dysfunction in childhood anxiety. Temporal lobe damage did not correlate with anxiety, in contrast to the findings for PTSD...
Pharmacological treatment of childhood obsessive-compulsive disorder: from theory to practiceM A Grados
Johns Hopkins University School of Medicine and Kennedy Krieger Institute, Baltimore, MD, USA
J Clin Child Psychol 30:67-79. 2001..Genetic factors probably influence susceptibility to OCD as well as response to treatment, and the elucidation of these and other risk factors will be important elements in the future understanding and treatment of this disorder...
The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family studyM A Grados
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, USA
Biol Psychiatry 50:559-65. 2001..CONCLUSIONS: Tic disorders constitute an alternate expression of the familial OCD phenotype...
Hoarding in obsessive compulsive disorder: results from a case-control studyJ Samuels
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore 21287, USA
Behav Res Ther 40:517-28. 2002..Hoarding appears to be transmitted in some OCD families and may differentiate a clinical subgroup of OCD...
The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family StudyG Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
Psychol Med 31:481-7. 2001..CONCLUSION: GAD and agoraphobia share a common familial aetiology with OCD. The other anxiety and affective disorders, when comorbid with OCD, may emerge as a consequence of the OCD or as a more complex syndrome...
The pharmacological management of childhood anxiety disorders: a reviewShauna P Reinblatt
Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, The Johns Hopkins University School of Medicine, 600 N Wolfe St, CMSC 312, Baltimore, MD, USA
Psychopharmacology (Berl) 191:67-86. 2007..Psychopharmacological approaches to the treatment of pediatric anxiety have expanded over the past 20 years and increasing empirical evidence helps guide current clinical practice...
Somatic symptoms in children and adolescents with anxiety disordersGolda S Ginsburg
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Am Acad Child Adolesc Psychiatry 45:1179-87. 2006....
Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorderBernadette Cullen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Depress Anxiety 25:218-24. 2008..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner...
Factor analysis of the Yale-Brown Obsessive Compulsive Scale in a family study of obsessive-compulsive disorderBernadette Cullen
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Depress Anxiety 24:130-8. 2007..There were specific clinical correlates for these factors, and significant intrafamilial sib-sib correlations were found for the Symmetry/Order and Hoarding factors...
Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics StudyJack Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Meyer 4 181, Baltimore, MD 21287 7228, USA
Am J Psychiatry 164:493-9. 2007..The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder...
The association between parental bonding and obsessive compulsive disorder in offspring at high familial riskHolly C Wilcox
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7228, USA
J Affect Disord 111:31-9. 2008..The aim of the current study is to estimate the association between parenting factors derived from the Parental Bonding Instrument (PBI) and a lifetime DSM-IV diagnosis of OCD...
Introduction: issues and viewpoints in pediatric psychopharmacologyMark A Riddle
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int Rev Psychiatry 20:119-20. 2008
Do all obsessive-compulsive disorder subtypes respond to medication?Marco Grados
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int Rev Psychiatry 20:189-93. 2008..Strategies for treatment of the tic-related subtype of OCD, while strongly supporting the use of antipsychotic-augmentation for enhanced response in adults, are lacking controlled data in pediatric OCD...
Prevalence and correlates of hoarding behavior in a community-based sampleJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 109, Baltimore, MD 21287 7228, USA
Behav Res Ther 46:836-44. 2008..These findings suggest that hoarding may be relatively prevalent and that alcohol dependence, personality disorder traits, and specific childhood adversities are associated with hoarding in the community...
Childhood obsessive-compulsive disorder presenting as schizophrenia spectrum disordersMaria F Rodowski
Division of Child and Adolescent Psychiatry, Johns Hopkins University College of Medicine, Baltimore, Maryland 21287 3325, USA
J Child Adolesc Psychopharmacol 18:395-401. 2008..Awareness of the possibility of OCD presenting as if it were a schizophrenia spectrum disorder can facilitate proper diagnosis and treatment...
Activation adverse events induced by the selective serotonin reuptake inhibitor fluvoxamine in children and adolescentsShauna P Reinblatt
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Child Adolesc Psychopharmacol 19:119-26. 2009....
Sex-specific clinical correlates of hoarding in obsessive-compulsive disorderJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
Behav Res Ther 46:1040-6. 2008..These findings indicate that specific clinical correlates of hoarding in OCD are different in men and women and may reflect sex-specific differences in the course, expression, and/or etiology of hoarding behavior in OCD...
Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics StudyJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
Behav Res Ther 45:673-86. 2007..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families...
A guide for managing acute aggressive behavior of youths in residential and inpatient treatment facilitiesSusan dosReis
Division of Child and Adolescent Psychiatry at John Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Psychiatr Serv 54:1357-63. 2003..The authors caution that the recommendations should be used in accordance with current regulations of the Center for Medicaid and Medicare Services and the Joint Commission on Accreditation of Healthcare Organizations...
Selective serotonin reuptake inhibitor-induced apathy: a pediatric case seriesShauna P Reinblatt
Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Child Adolesc Psychopharmacol 16:227-33. 2006..This report describes two pediatric cases of SSRI-induced apathy, one of which is the first reported case in a child with a non-OCD (obsessive compulsive disorder) anxiety disorder...
New onset obsessive-compulsive symptoms in children and adolescents with severe traumatic brain injuryMarco A Grados
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Depress Anxiety 25:398-407. 2008..05). OCS are common after severe pediatric TBI and are associated with greater comorbidities. New onset obsessions are associated with female sex, psychosocial adversity, and mesial prefrontal and temporal lesions...
Improving the management of acute aggression in state residential and inpatient psychiatric facilities for youthsShannon R Barnett
Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
J Am Acad Child Adolesc Psychiatry 41:897-905. 2002..This report concludes with a brief discussion of future plans for the implementation and evaluation of this protocol in clinical practice...
Obsessive-compulsive disorder: defining the phenotypeGerald Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
J Clin Psychiatry 63:5-7. 2002..This article describes a family-study approach for identifying the spectrum of conditions related to OCD and subtyping OCD cases into homogeneous subtypes...
A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 familiesY Y Shugart
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21044, USA
Am J Med Genet B Neuropsychiatr Genet 150:886-92. 2009..5 kb away from the boundary of the SLC1A1 gene. However, this potential finding needs to be validated biologically. Further functional studies in this region are planned by this research group...
The relevance of prolonged QTc measurement to pediatric psychopharmacologyMichael J Labellarte
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3325, USA
J Am Acad Child Adolesc Psychiatry 42:642-50. 2003..To consider the relevance of prolonged QTc (QT interval corrected for rate) to pediatric psychopharmacology...
Factor structure of parent- and teacher-rated attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Kristina K Hardy
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
J Child Adolesc Psychopharmacol 17:621-34. 2007....
Obsessive-compulsive disorder: subclassification based on co-morbidityG Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Psychol Med 39:1491-501. 2009..Many patients manifest other psychiatric syndromes. This study investigated the relationship between OCD and co-morbid conditions to identify subtypes...
Psychostimulants in preschool children with attention-deficit/hyperactivity disorder: clinical evidence from a developmental disorders institutionJ K Ghuman
Division of Child and Adolescent Psychiatry, John Hopkins University School of Medicine, Baltimore, MD, USA
J Am Acad Child Adolesc Psychiatry 40:516-24. 2001....
Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6qY Y Shugart
Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21287, USA
Mol Psychiatry 11:763-70. 2006..Given probable etiologic heterogeneity in OCD, mapping gene(s) involved in the disorder may be enhanced by replication studies, large-scale family-based linkage studies, and the application of novel statistical methods...
Parent versus teacher ratings of attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Desiree W Murray
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
J Child Adolesc Psychopharmacol 17:605-20. 2007..To assess parent-teacher concordance on ratings of DSM-IV symptoms of attention-deficit/hyperactivity disorder (ADHD) in a sample of preschool children referred for an ADHD treatment study...
Anxiety after severe pediatric closed head injuryRoma A Vasa
Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Am Acad Child Adolesc Psychiatry 41:148-56. 2002..To assess the frequency of anxiety symptoms and disorders 1 year after severe pediatric closed head injury (CHI) and to determine the risk factors associated with these postinjury outcomes...
Psychotropic practice patterns for youth: a 10-year perspectiveJulie Magno Zito
Department of Pharmacy Practice and Science, University of Maryland, 100 Greene St, Room 5 13, Baltimore, MD 21201, USA
Arch Pediatr Adolesc Med 157:17-25. 2003..To examine changes in the full spectrum of psychotropic medication treatment for youths from 1987 to 1996...
Olanzapine-induced diabetes in a seven-year-old boyHelen E Courvoisie
Division of Child and Adolescent Psychiatry Division, Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, MD 21287 3325, USA
J Child Adolesc Psychopharmacol 14:612-6. 2004..Regular monitoring of glucose should be considered in children and adolescents who gain weight while treated with atypical antipsychotics...
Clinical correlates of recurrent major depression in obsessive-compulsive disorderJin Pyo Hong
Department of Psychiatry, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea
Depress Anxiety 20:86-91. 2004..In a multiple logistic regression model, only early age of OCD diagnosis was significantly associated with RDD. Early age at onset of OCD increases the risk of depressive disorder in individuals with OCD...
Treatment of pediatric anxiety disorders: an open-label extension of the research units on pediatric psychopharmacology anxiety studyJohn Walkup
Johns Hopkins University, USA
J Child Adolesc Psychopharmacol 12:175-88. 2002..Results suggest that an initial fluvoxamine response is likely to be retained with continued treatment, that some fluvoxamine nonresponders may respond to fluoxetine, and that some placebo nonresponders may respond to fluvoxamine...
Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics StudyGregor Hasler
Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Biol Psychiatry 61:617-25. 2007..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions...
Searching for moderators and mediators of pharmacological treatment effects in children and adolescents with anxiety disordersJohn T Walkup
Johns Hopkins University, USA
J Am Acad Child Adolesc Psychiatry 42:13-21. 2003..Attribution analyses indicated that study blindness remained intact. The presence of concomitant depressive symptoms deserves attention in future treatment studies of anxious children...
Two times four is four: OCD dimensions, classes, and categoriesMarco A Grados
J Am Acad Child Adolesc Psychiatry 47:731-3. 2008
Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categoriesAnthony Pinto
Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
Psychiatry Res 160:83-93. 2008..The results support investigation of this multidimensional model in OCD genetic linkage studies...
Efficacy and safety of extended-release venlafaxine in the treatment of generalized anxiety disorder in children and adolescents: two placebo-controlled trialsMoira A Rynn
New York State Psychiatric Institute, 1051 Riverside Drive, Unit 74, New York, NY 10032, USA
Am J Psychiatry 164:290-300. 2007..The authors evaluated the efficacy, safety, and tolerability of extended-release venlafaxine in the treatment of pediatric generalized anxiety disorder...
Review of safety assessment methods used in pediatric psychopharmacologyLaurence L Greenhill
New York State Psychiatric Institute Columbia University, New York 10032, USA
J Am Acad Child Adolesc Psychiatry 42:627-33. 2003..Elicitation is an essential and critical step in ascertaining adverse events (AEs). This report reviews elicitation methods used in published clinical trials of psychopharmacological agents in children...
Clinical presentation of attention-deficit/hyperactivity disorder in preschool children: the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Kelly Posner
New York State Psychiatric Institute Columbia University, 1041 Riverside Drive, New York, NY 10032, USA
J Child Adolesc Psychopharmacol 17:547-62. 2007..The diagnosis and evaluation process will also be described...
Comorbidity moderates response to methylphenidate in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Jaswinder K Ghuman
University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
J Child Adolesc Psychopharmacol 17:563-80. 2007..The aim of this study was to examine whether demographic or pretreatment clinical and social characteristics influenced the response to methylphenidate (MPH) in the Preschoolers with ADHD Treatment Study (PATS)...
Comparison of increasingly detailed elicitation methods for the assessment of adverse events in pediatric psychopharmacologyLaurence L Greenhill
New York State Psychiatric Institute, Columbia University, USA
J Am Acad Child Adolesc Psychiatry 43:1488-96. 2004..To improve the gathering of adverse events (AEs) in pediatric psychopharmacology by examining the value and acceptability of increasingly detailed elicitation methods...
Effects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)James M Swanson
Child Development Center, University of California Irvine, 19722 MacArthur Boulevard, Irvine, CA 92612, USA
J Child Adolesc Psychopharmacol 17:635-46. 2007....
Developing methodologies for monitoring long-term safety of psychotropic medications in children: report on the NIMH conference, September 25, 2000Laurence L Greenhill
New York State Psychiatric Institute, New York 10032, USA
J Am Acad Child Adolesc Psychiatry 42:651-5. 2003..To improve the methods for long-term assessment of drug-associated side effects and advance knowledge of the safety profile of psychotropic medications in children and adolescents...
The interface between publicly funded and industry-funded research in pediatric psychopharmacology: opportunities for integration and collaborationBenedetto Vitiello
Child and Adolescent Treatment and Preventive Intervention Research Branch, Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, Maryland, USA
Biol Psychiatry 56:3-9. 2004....
Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Benedetto Vitiello
Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA
J Child Adolesc Psychopharmacol 17:593-604. 2007..The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS)...
Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Howard B Abikoff
New York University Child Study Center, 215 Lexington Avenue, New York, NY 10016, USA
J Child Adolesc Psychopharmacol 17:581-92. 2007....
How can we improve the assessment of safety in child and adolescent psychopharmacology?Benedetto Vitiello
Division of Services and Intervention Research, NIMH, Bethesda, MD 20982 9633, USA
J Am Acad Child Adolesc Psychiatry 42:634-41. 2003..To identify approaches to improving methods for assessing tolerability and safety of psychotropic medications in children and adolescents...
Paroxetine and the FDAMark A Riddle
J Am Acad Child Adolesc Psychiatry 43:128-30. 2004
Research Grants
- Follow-up of the PATS SampleMark Riddle; Fiscal Year: 2007..Aim 4 is to determine the stability of the ADHD diagnosis and other comorbidities made for study entry at age 3-5 years across subsequent development ..
- RESEARCH TRAINING IN CHILD PSYCHOPATHOLOGY & TREATMENTMark Riddle; Fiscal Year: 2007..This training program is thoughtfully organized to produce a cadre of graduates who will become productive independent interventions researchers in child and adolescent major mental disorders. ..
- 1/3-Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT)Mark A Riddle; Fiscal Year: 2010..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
