Affiliation: Johns Hopkins University
- Chronic intermittent hypoxia induces lung growth in adult miceChristian Reinke
Department of Medicine, Div of Pulmonary Medicine, Johns Hopkins University, Baltimore, MD, USA
Am J Physiol Lung Cell Mol Physiol 300:L266-73. 2011..We conclude that IH increases alveolar surface area by stimulating lung growth in adult mice...
- Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient miceJonathan Jun
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, United States
Atherosclerosis 209:381-6. 2010..This increased risk may be attributable to more extensive or unstable atherosclerotic plaques in subjects with OSA. We studied the effect of chronic IH in atherosclerosis-prone mice...
- Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoeaLuciano F Drager
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Eur Heart J 33:783-90. 2012..This study examined whether chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnoea (OSA), can lead to hyperlipidaemia by inhibiting clearance of triglyceride rich lipoproteins (TRLP)...
- Intermittent hypoxia exacerbates metabolic effects of diet-induced obesityLuciano F Drager
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Obesity (Silver Spring) 19:2167-74. 2011..In conclusion, CIH exacerbates IR and induces steatohepatitis in DIO mice, suggesting that CIH may account for metabolic dysfunction in obesity...
- Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxiaRonghua Yang
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Am J Physiol Heart Circ Physiol 300:H1467-76. 2011..Taken together, these data suggest that restoring normal leptin signaling can reduce vascular stiffness, increase endothelial relaxation, and correct dyslipidemia associated with IH...
- Chronic intermittent hypoxia and acetaminophen induce synergistic liver injury in miceVladimir Savransky
Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Exp Physiol 94:228-39. 2009..We conclude that CIH and chronic APAP treatment lead to synergistic liver injury, which may have clinical implications for patients with OSA...