Sekhar P M Reddy

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells
    Sekhar P M Reddy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Respir Cell Mol Biol 27:64-70. 2002
  2. ncbi request reprint Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection
    Narsa M Reddy
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Physiol Genomics 32:74-81. 2007
  3. pmc The antioxidant response element and oxidative stress modifiers in airway diseases
    Sekhar P Reddy
    The Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences Division of Physiology, Rm E7547, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Curr Mol Med 8:376-83. 2008
  4. ncbi request reprint Redox imbalance and ventilator-induced lung injury
    Sekhar P Reddy
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 9:2003-12. 2007
  5. pmc Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants
    Narsa M Reddy
    The Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 37:3-8. 2007
  6. ncbi request reprint Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins
    Sekhar P M Reddy
    Department of Environmental Health Sciences, Division of Physiology, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 278:21378-87. 2003
  7. ncbi request reprint Role and regulation of activator protein-1 in toxicant-induced responses of the lung
    Sekhar P M Reddy
    Department of Environmental Health Sciences and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1161-78. 2002
  8. ncbi request reprint JNK1 and AP-1 regulate PMA-inducible squamous differentiation marker expression in Clara-like H441 cells
    Hue Vuong
    Department of Environmental Health Sciences, The Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Am J Physiol Lung Cell Mol Physiol 282:L215-25. 2002
  9. ncbi request reprint Role of NRF2 in protection against hyperoxic lung injury in mice
    Hye Youn Cho
    Department of Environmental Health Sciences, The Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 26:175-82. 2002
  10. ncbi request reprint The transcription factor NRF2 protects against pulmonary fibrosis
    Hye Youn Cho
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    FASEB J 18:1258-60. 2004

Collaborators

Detail Information

Publications46

  1. ncbi request reprint BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells
    Sekhar P M Reddy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Respir Cell Mol Biol 27:64-70. 2002
    ..Thus, in addition to JNK1, the activation of MEK5-ERK5 MAPK pathway probably plays a pivotal role in transcriptional regulation of AP-1-mediated SPRR1B expression in the distal bronchiolar region...
  2. ncbi request reprint Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection
    Narsa M Reddy
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Physiol Genomics 32:74-81. 2007
    ..Collectively, these findings uncover an important insight into the nature of genes regulated by Nrf2-dependent redox signaling through GSH that are involved in cellular detoxification and proliferation...
  3. pmc The antioxidant response element and oxidative stress modifiers in airway diseases
    Sekhar P Reddy
    The Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences Division of Physiology, Rm E7547, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Curr Mol Med 8:376-83. 2008
    ..It also provides a perspective on whether boosting ARE-mediated gene expression with dietary plants and synthetic plant products will offer a better therapeutic strategy for mitigating oxidative stress and respiratory pathogenesis...
  4. ncbi request reprint Redox imbalance and ventilator-induced lung injury
    Sekhar P Reddy
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 9:2003-12. 2007
    ..Potential therapeutic avenues for the treatment of VILI with exogenous administration of antioxidants also are discussed...
  5. pmc Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants
    Narsa M Reddy
    The Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 37:3-8. 2007
    ..Our data suggest that dysfunctional Nrf2-regulated GSH-induced signaling is associated with deregulation of type II cell proliferation, which contributes to abnormal injury and repair and leads to respiratory impairment...
  6. ncbi request reprint Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins
    Sekhar P M Reddy
    Department of Environmental Health Sciences, Division of Physiology, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 278:21378-87. 2003
    ....
  7. ncbi request reprint Role and regulation of activator protein-1 in toxicant-induced responses of the lung
    Sekhar P M Reddy
    Department of Environmental Health Sciences and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1161-78. 2002
    ..These studies might offer a unique opportunity to use AP-1 family members and transactivation as potential diagnostic markers or drug targets for early detection and/or prevention of various lung diseases...
  8. ncbi request reprint JNK1 and AP-1 regulate PMA-inducible squamous differentiation marker expression in Clara-like H441 cells
    Hue Vuong
    Department of Environmental Health Sciences, The Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Am J Physiol Lung Cell Mol Physiol 282:L215-25. 2002
    ..Thus either temporal expression and/or spatial activation of AP-1 proteins by JNK1 might contribute to the induction of SCD in Clara cells...
  9. ncbi request reprint Role of NRF2 in protection against hyperoxic lung injury in mice
    Hye Youn Cho
    Department of Environmental Health Sciences, The Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 26:175-82. 2002
    ..Results demonstrated that NRF2 has a significant protective role against pulmonary hyperoxic injury in mice, possibly through transcriptional activation of lung antioxidant defense enzymes...
  10. ncbi request reprint The transcription factor NRF2 protects against pulmonary fibrosis
    Hye Youn Cho
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    FASEB J 18:1258-60. 2004
    ..This study has important implications for the development of intervention strategies against fibrosis...
  11. ncbi request reprint Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene
    Hye Youn Cho
    Department of Environmental Health Sciences, Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 26:42-51. 2002
    ..Results from this study have important implications for understanding the mechanisms through which oxidants mediate the pathogenesis of lung disease...
  12. pmc EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation
    Srinivas Papaiahgari
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Respir Cell Mol Biol 36:304-12. 2007
    ..Collectively, these novel findings suggest that EGFR-activated signaling and actin remodeling act in concert to regulate the CS-induced Nrf2-ARE transcriptional response and subsequent AOE expression...
  13. pmc MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma
    Sanjit K Roy
    Department of Microbiology and Immunology, Molecular and Cellular Biology Program, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 99:7945-50. 2002
    ..A dominant negative MEKK1 blocks C/EBP-beta-driven gene expression stimulated by IFN-gamma. These studies describe an IFN-gamma-stimulated pathway that involves MEKK1-MEK1-ERK1/2 kinases to regulate C/EBP-beta-dependent gene expression...
  14. ncbi request reprint Gene expression profiling of NRF2-mediated protection against oxidative injury
    Hye Youn Cho
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Free Radic Biol Med 38:325-43. 2005
    ..These NRF2-dependent gene products might have key roles in protection against hyperoxic lung injury. Results from our global gene expression profiles provide putative downstream molecular mechanisms of oxygen tissue toxicity...
  15. ncbi request reprint NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells
    Srinivas Papaiahgari
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Biol Chem 279:42302-12. 2004
    ..Collectively, our findings suggest that hyperoxia-induced, ARE-driven, Nrf2-dependent transcription is controlled by NADPH oxidase and ERK-1 signaling...
  16. pmc Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice
    Narsa M Reddy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 182:7264-71. 2009
    ....
  17. doi request reprint Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice
    Manchang Liu
    Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Kidney Int 76:277-85. 2009
    ..Our study demonstrates that Nrf2-deficiency enhances susceptibility to both ischemic and nephrotoxic acute kidney injury, and identifies this transcription factor as a potential therapeutic target in these injuries...
  18. pmc Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice
    Srinivas Papaiahgari
    Department of Environmental Health Sciences Division of Physiology, Room E7547, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 176:1222-35. 2007
    ..Mechanical ventilation (MV) is an indispensable therapy for critically ill patients with acute lung injury and the adult respiratory distress syndrome. However, the mechanisms by which conventional MV induces lung injury remain unclear...
  19. pmc The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice
    Narsa M Reddy
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Respir Crit Care Med 180:867-74. 2009
    ..Moreover, we have recently demonstrated that Nrf2-deficiency impairs the resolution of lung injury and inflammation after nonlethal hyperoxia exposure...
  20. pmc Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice
    Narsa M Reddy
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room E7610, 615 North Wolfe Street, Baltimore, Maryland 21205, USA
    J Immunol 183:4601-8. 2009
    ..Thus, loss of Nrf2 impairs lung innate immunity and promotes susceptibility to bacterial infection after hyperoxia exposure, ultimately leading to death of the host...
  21. doi request reprint Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy
    Koichi Uno
    Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Exp Eye Res 90:493-500. 2010
    ..Hyperoxia treatment revealed a similar window of time where Nrf2 regulated anti-oxidant production was beneficial and contributed to the endothelial survival...
  22. ncbi request reprint Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells
    Srinivas Papaiahgari
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    Antioxid Redox Signal 8:43-52. 2006
    ..Collectively, our data suggest that EGFR-PI3K signaling through Akt and ERK kinases regulates ROS-dependent, hyperoxia-induced Nrf2 activation in pulmonary epithelial cells...
  23. ncbi request reprint Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways
    Raja Elie E Abdulnour
    Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 291:L345-53. 2006
    ..We conclude that XOR enzymatic activity is significantly increased by mechanical stress via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with VILI...
  24. pmc Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
    Rajesh K Thimmulappa
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 116:984-95. 2006
    ..Our study reveals Nrf2 as a novel modifier gene of sepsis that determines survival by mounting an appropriate innate immune response...
  25. ncbi request reprint Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 278:47423-33. 2003
    ..These results underscore the regulatory role of c-Jun, Jun-D, and Fra-2 in TPA-inducible fra-1 expression in HBE cells in vivo...
  26. pmc Synergism between rhinovirus infection and oxidant pollutant exposure enhances airway epithelial cell cytokine production
    E William Spannhake
    Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Health Perspect 110:665-70. 2002
    ....
  27. pmc A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Cell Physiol 216:405-12. 2008
    ..Taken together, our data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of MMPs, in particular MMP-2 and MMP-9, and EGFR-activated signaling...
  28. ncbi request reprint Matrix metalloproteinase/epidermal growth factor receptor/mitogen-activated protein kinase signaling regulate fra-1 induction by cigarette smoke in lung epithelial cells
    Qin Zhang
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Respir Cell Mol Biol 32:72-81. 2005
    ..Collectively, our findings indicate an obligatory role for metalloproteinase-EGFR-mediated mitogen-activated protein kinase signaling in controlling CS-induced fra-1 expression...
  29. ncbi request reprint Tumor-suppressive activity of the cell death activator GRIM-19 on a constitutively active signal transducer and activator of transcription 3
    Sudhakar Kalakonda
    Department of Microbiology and Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cancer Res 67:6212-20. 2007
    ..In this study, we show that GRIM-19 suppresses constitutive STAT3-induced cellular transformation in vitro and in vivo by down-regulating the expression of a number of cellular genes involved in cell proliferation and apoptosis...
  30. ncbi request reprint FRA-1 proto-oncogene induces lung epithelial cell invasion and anchorage-independent growth in vitro, but is insufficient to promote tumor growth in vivo
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Res 67:6204-11. 2007
    ..In contrast, FRA-1 failed to promote tumor formation by BEAS-2B. We suggest that FRA-1 can promote motility, invasion, and anchorage-independent growth of lung epithelial cells in vitro, but is insufficient for tumor formation...
  31. ncbi request reprint DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung
    Qin Zhang
    The Johns Hopkins University, Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Physiol Lung Cell Mol Physiol 286:L427-36. 2004
    ..Collectively, these findings suggest that fra-1 induction by DEP may play a role in selectively regulating gene expression involved in alveolar epithelial cell injury and repair...
  32. ncbi request reprint A JNK-independent signaling pathway regulates TNF alpha-stimulated, c-Jun-driven FRA-1 protooncogene transcription in pulmonary epithelial cells
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 177:7193-202. 2006
    ..Our findings collectively indicate that ERK signaling plays key roles in both Elk1, CREB, and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in response to TNF-alpha in pulmonary epithelial cells...
  33. pmc The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma
    Hui Li
    Department of Microbiology and Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 283:13077-86. 2008
    ..Last, an ERK-regulated site in Med1 protein is also essential for up-regulating IFN-induced transcription although not critical for binding to C/EBP-beta...
  34. pmc Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice
    Alexis Bierman
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Transl Res 152:265-72. 2008
    ..However, intratracheal instillation of EGF alone failed to induce lung injury. Collectively, our findings suggest that EGFR-activated signaling is necessary but not sufficient to produce acute lung injury in mice...
  35. pmc ERK signaling regulates tumor promoter induced c-Jun recruitment at the Fra-1 promoter
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Room E7610, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 371:304-8. 2008
    ..Inhibition of ERK1/2 pathway suppresses Elk1 activation, and c-Jun and Fra-2 recruitment to the promoter...
  36. pmc Activated protein C protects against ventilator-induced pulmonary capillary leak
    James H Finigan
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1002-11. 2009
    ..blood vessel development) and specific gene (e.g., MAPK-associated kinase 2 and integrin-beta(6)) levels. These findings indicate that APC is barrier-protective in VILI and that EPCR is a critical participant in APC-mediated protection...
  37. ncbi request reprint Development of monoclonal antibodies against GBF1 and their use in studying its functions
    Sanjit K Roy
    Greenebaum Cancer Center, Department of Microbiology and Immunology, 655 W Baltimore Street, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Interferon Cytokine Res 25:666-73. 2005
    ..Furthermore, other cytokines, such as interleukin-1 (IL-1) and IL-6, induced the expression of GBF1. These antibodies may be useful tools for investigating the role of GBF1 in cytokine-induced responses...
  38. ncbi request reprint A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression
    Qin Zhang
    Department of Environmental Health Sciences, Bloomberg School of Public Health and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 281:10174-81. 2006
    ....
  39. pmc Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2
    Melanie Theodore
    School of Medicine, Meharry Medical College, Nashville, TN 37208 3599, USA
    J Biol Chem 283:8984-94. 2008
    ....
  40. ncbi request reprint Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Oncogene 24:4193-205. 2005
    ..Thus, a bipartite enhancer formed by an upstream TRE and the downstream SRE and ATF sites and the cognate factors is necessary and sufficient for the regulation of FRA-1 in response to mitogens...
  41. pmc Oxidants and signaling by mitogen-activated protein kinases in lung epithelium
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 34:666-9. 2006
    ....
  42. pmc Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate
    Daphne Yuan-Chen Wu
    Center for Comparative Respiratory Biology and Medicine, Genome and Biomedical Science Facility, Suite 6510 University of California, Davis, 451 East Health Sciences Dr, Davis, CA 95616, USA
    Am J Pathol 170:20-32. 2007
    ....
  43. ncbi request reprint Nrf2 defends the lung from oxidative stress
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Antioxid Redox Signal 8:76-87. 2006
    ....
  44. ncbi request reprint Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
    Jacqui M Marzec
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 21:2237-46. 2007
    ..Furthermore, these findings may have important implications in other oxidative stress related illnesses...
  45. pmc Tumor suppressive protein gene associated with retinoid-interferon-induced mortality (GRIM)-19 inhibits src-induced oncogenic transformation at multiple levels
    Sudhakar Kalakonda
    Department of Microbiology and Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, 660 West Redwood St, Howard Hall 350, Baltimore, MD 21201, USA
    Am J Pathol 171:1352-68. 2007
    ..Thus, GRIM-19 not only blocks src-induced gene expression through STAT3 but also the activation of cell adhesion molecules...
  46. pmc Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression
    Lei Wang
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:10289-97. 2005
    ..Thus, breast tumorigenesis and progression resulting from the loss of SYK are underscored by the derepression of Sp1-mediated oncogene transcription...

Research Grants16

  1. The role and biology of Fra-1 in lung injury and repair
    SEKHAR POTHIREDDY; Fiscal Year: 2006
    ..abstract_text> ..
  2. The role and biology of Fra-1 in lung injury and repair
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ....
  3. MOLECULAR BASIS OF AIRWAY SQUAMOUS CELL DIFFERENTIATION
    SEKHAR POTHIREDDY; Fiscal Year: 2001
    ..This study will help us better understand the plasticity of airway epithelial cell differentiation and the response of airway epithelial cells to environmental insults. ..
  4. Human NRF2 Promoter Functional Polymorphisms and Acute Lung Injury
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ....
  5. The role and biology of Fra-1 in lung injury and repair
    SEKHAR POTHIREDDY; Fiscal Year: 2009
    ....
  6. Human NRF2 Promoter Functional Polymorphisms and Acute Lung Injury
    SEKHAR POTHIREDDY; Fiscal Year: 2009
    ....
  7. The role and biology of Fra-1 in lung injury and repair
    SEKHAR POTHIREDDY; Fiscal Year: 2005
    ..abstract_text> ..
  8. The role and biology of Fra-1 in lung injury and repair
    SEKHAR POTHIREDDY; Fiscal Year: 2004
    ..abstract_text> ..
  9. A GENETIC MODEL OF HYPEROXIC LUNG INJURY: ROLE OF NRF2
    SEKHAR POTHIREDDY; Fiscal Year: 2004
    ....
  10. The role and biology of Fra-1 in lung injury and repair
    SEKHAR POTHIREDDY; Fiscal Year: 2003
    ..abstract_text> ..
  11. A GENETIC MODEL OF HYPEROXIC LUNG INJURY: ROLE OF NRF2
    SEKHAR POTHIREDDY; Fiscal Year: 2003
    ....
  12. MOLECULAR BASIS OF AIRWAY SQUAMOUS CELL DIFFERENTIATION
    SEKHAR POTHIREDDY; Fiscal Year: 2002
    ..This study will help us better understand the plasticity of airway epithelial cell differentiation and the response of airway epithelial cells to environmental insults. ..
  13. The role and biology of Fra-1 in lung injury and repair
    SEKHAR POTHIREDDY; Fiscal Year: 2002
    ..abstract_text> ..
  14. A GENETIC MODEL OF HYPEROXIC LUNG INJURY: ROLE OF NRF2
    SEKHAR POTHIREDDY; Fiscal Year: 2002
    ....
  15. The role and biology of Fra-1 in lung injury and repair
    SEKHAR POTHIREDDY; Fiscal Year: 2009
    ....