Tamara Ratovitski

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity
    Birgit Schilling
    The Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 281:23686-97. 2006
  2. pmc Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis
    Tamara Ratovitski
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 11:2006-21. 2012
  3. ncbi request reprint N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease
    Tamara Ratovitski
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cell Cycle 6:2970-81. 2007
  4. pmc Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells
    Tamara Ratovitski
    Division of Neurobiology, Department of Psychiatry, Mass Spectrometry and Proteomics Facility, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 284:10855-67. 2009
  5. pmc Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin
    Tamara Ratovitski
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Biol Chem 286:12578-89. 2011
  6. pmc ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line
    Yideng Liang
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, CMSC 8 121, 600 N Wolfe St, Baltimore, MD 21287, USA
    Brain Res 1286:221-9. 2009
  7. pmc Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin
    Elaine Waldron-Roby
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 32:183-93. 2012
  8. pmc Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein
    Leslie G Nucifora
    Division of Neurobiology, Department of Psychiatry, Children s Medical Surgical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 287:16017-28. 2012
  9. pmc Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity
    Erin E Watkin
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 9:e88284. 2014
  10. ncbi request reprint Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice
    David R Borchelt
    Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Neurobiol Aging 23:171-7. 2002

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity
    Birgit Schilling
    The Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 281:23686-97. 2006
    ..Dissection of phosphorylation modifications in Htt may provide clues to Huntington disease pathogenesis and targets for therapeutic development...
  2. pmc Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis
    Tamara Ratovitski
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 11:2006-21. 2012
    ....
  3. ncbi request reprint N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease
    Tamara Ratovitski
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cell Cycle 6:2970-81. 2007
    ..Further delineation of huntingtin cleavage events may lead to novel therapeutic targets for HD...
  4. pmc Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells
    Tamara Ratovitski
    Division of Neurobiology, Department of Psychiatry, Mass Spectrometry and Proteomics Facility, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 284:10855-67. 2009
    ..These data suggest that cleavage of huntingtin at residue Arg(167) may mediate mutant huntingtin toxicity in Huntington disease...
  5. pmc Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin
    Tamara Ratovitski
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Biol Chem 286:12578-89. 2011
    ..Our findings further validate the cysteine protease family, and BLMH and cathepsin Z in particular, as potential novel targets for HD therapeutics...
  6. pmc ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line
    Yideng Liang
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, CMSC 8 121, 600 N Wolfe St, Baltimore, MD 21287, USA
    Brain Res 1286:221-9. 2009
    ..These results indicated that ATF3 plays a critical role in toxicity induced by mutant Htt-N63 and may lead to a useful therapeutic target...
  7. pmc Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin
    Elaine Waldron-Roby
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 32:183-93. 2012
    ....
  8. pmc Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein
    Leslie G Nucifora
    Division of Neurobiology, Department of Psychiatry, Children s Medical Surgical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 287:16017-28. 2012
    ..In addition, these studies demonstrate the fundamental differences in early aggregation events between mutant huntingtin exon-1 and shortstop proteins that may underlie the differences in toxicity...
  9. pmc Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity
    Erin E Watkin
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 9:e88284. 2014
    ..The results suggest that S116 is a potential therapeutic target, and indicate that our screening method is useful for identifying candidate phosphorylation sites. ..
  10. ncbi request reprint Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice
    David R Borchelt
    Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Neurobiol Aging 23:171-7. 2002
    ....
  11. ncbi request reprint Characterization and identification of the inhibitory domain of GDF-8 propeptide
    Man Shiow Jiang
    MetaMorphix, Inc, Savage, MD 20763, USA
    Biochem Biophys Res Commun 315:525-31. 2004
    ..The data suggest that the C-terminal region may play a role in the stability of the GDF-8 propeptide and that the inhibitory domain is located in the region between amino acids 42 and 115...