Edward A Ratovitski
Affiliation: Johns Hopkins University
Ratovitski E. LKB1/PEA3/?Np63 pathway regulates PTGS-2 (COX-2) transcription in lung cancer cells upon cigarette smoke exposure. Oxid Med Cell Longev. 2010;3:317-24 pubmed
Ratovitski E. Phospho-?Np63?-dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: at the crossroads of cell life and death. FEBS Lett. 2013;587:2536-41 pubmed publisher
..The specific microRNAs were further shown to modulate the resistant phenotype of SCC cells in vitro, thereby providing groundwork for novel chemotherapeutic venues for head and neck cancer. ..
Ratovitski E. Phospho-?Np63? regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation. FEBS Lett. 2013;587:3581-6 pubmed publisher
..Further studies of the AQP3, CASP14, ALOX12B, and CLDN1 contributions to chemoresistance may assist in developing novel microRNA-based therapies for human SCC. ..
Ratovitski E. Phospho-Î”Np63Î±-responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure. FEBS Lett. 2015;589:1352-8 pubmed publisher
..This is the first report showing the modulatory effect of Î”Np63Î±-responsive microRNAs on the specific members of necroptotic pathway in SCC tumor cells variably responding to platinum chemotherapy. ..
Ratovitski E. Delta Np63 alpha â€“ Responsive microRNA Modulate the Expression of Metabolic Enzymes. Curr Pharm Biotechnol. 2015;16:832-50 pubmed
..Thus, the Î” Np63Î±-regulated microRNAs were found to regulate the levels of several metabolic factors and enzymes, thereby potentially contributing to the response of larynx and tongue-derived SCC cells to platinum chemotherapy. ..
Ratovitski E. Tumor Protein (TP)-p53 Members as Regulators of Autophagy in Tumor Cells upon Marine Drug Exposure. Mar Drugs. 2016;14: pubmed publisher
Huang Y, Sook Kim M, Ratovitski E. Midkine promotes tetraspanin-integrin interaction and induces FAK-Stat1alpha pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells. Biochem Biophys Res Commun. 2008;377:474-478 pubmed publisher
..The major finding of this study is a novel MK-triggered signaling mechanism implicated in migration and invasiveness of HNSCC cells. ..
Ratovitski E. ?Np63?/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure. Arch Biochem Biophys. 2011;506:208-15 pubmed publisher
..Overall, these data support the notion that ?Np63?/IRF6 interplay regulates NOS2 transcription, thereby underlying the autophagic-related cancer cell response to tobacco exposure. ..