Zeshaan A Rasheed

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Biological and clinical relevance of stem cells in pancreatic adenocarcinoma
    Zeshaan A Rasheed
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Gastroenterol Hepatol 27:15-8. 2012
  2. pmc Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer
    Shinichi Yabuuchi
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Lett 335:41-51. 2013
  3. pmc The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models
    Masamichi Mizuma
    Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cancer Ther 11:1999-2009. 2012
  4. pmc A combination of DR5 agonistic monoclonal antibody with gemcitabine targets pancreatic cancer stem cells and results in long-term disease control in human pancreatic cancer model
    N V Rajeshkumar
    Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Mol Cancer Ther 9:2582-92. 2010
  5. pmc Heterogeneity and targeting of pancreatic cancer stem cells
    Vesselin R Penchev
    Department of Oncology and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Clin Cancer Res 18:4277-84. 2012
  6. pmc Concise review: Emerging concepts in clinical targeting of cancer stem cells
    Zeshaan A Rasheed
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Stem Cells 29:883-7. 2011
  7. pmc Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma
    Zeshaan A Rasheed
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Natl Cancer Inst 102:340-51. 2010

Collaborators

Detail Information

Publications7

  1. pmc Biological and clinical relevance of stem cells in pancreatic adenocarcinoma
    Zeshaan A Rasheed
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Gastroenterol Hepatol 27:15-8. 2012
    ..This review will discuss the biological and clinical relevance of CSC in pancreatic cancer, and will discuss novel therapeutic strategies to target them...
  2. pmc Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer
    Shinichi Yabuuchi
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Lett 335:41-51. 2013
    ..In summary, our preclinical data suggest that PF-03084014 has greater anti-tumor activity in combination with gemcitabine in PDA and provides rationale for further investigation of this combination in PDA...
  3. pmc The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models
    Masamichi Mizuma
    Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cancer Ther 11:1999-2009. 2012
    ..Our findings strengthen the rationale for small-molecule inhibition of Notch signaling as a therapeutic strategy in PDAC...
  4. pmc A combination of DR5 agonistic monoclonal antibody with gemcitabine targets pancreatic cancer stem cells and results in long-term disease control in human pancreatic cancer model
    N V Rajeshkumar
    Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Mol Cancer Ther 9:2582-92. 2010
    ..These data provide the rationale to explore the DR5-directed therapies in combination with chemotherapy as a therapeutic option to improve the current standard of care for pancreatic cancer patients...
  5. pmc Heterogeneity and targeting of pancreatic cancer stem cells
    Vesselin R Penchev
    Department of Oncology and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Clin Cancer Res 18:4277-84. 2012
    ..In this CCR Focus article, we discuss the potential relationships between different pancreatic CSC populations and strategies to identify novel targeting approaches...
  6. pmc Concise review: Emerging concepts in clinical targeting of cancer stem cells
    Zeshaan A Rasheed
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Stem Cells 29:883-7. 2011
    ..We will review current evidence supporting the role of CSCs in clinical oncology and discuss potential barriers and strategies in designing trials examining CSC-targeting agents...
  7. pmc Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma
    Zeshaan A Rasheed
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Natl Cancer Inst 102:340-51. 2010
    ..Aldehyde dehydrogenase (ALDH) activity can identify tumor-initiating cells and normal stem cells from several human tissues. We examined the prognostic significance and functional features of ALDH expression in pancreatic adenocarcinoma...