Srinivasa Raja

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Modulating pain in the periphery: gene-based therapies to enhance peripheral opioid analgesia: Bonica lecture, ASRA 2010
    Srinivasa N Raja
    Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Reg Anesth Pain Med 37:210-4. 2012
  2. ncbi request reprint Complex regional pain syndrome I (reflex sympathetic dystrophy)
    Srinivasa N Raja
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Anesthesiology 96:1254-60. 2002
  3. ncbi request reprint Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial
    S N Raja
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 59:1015-21. 2002
  4. ncbi request reprint Basal heat pain thresholds predict opioid analgesia in patients with postherpetic neuralgia
    Robert R Edwards
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Anesthesiology 104:1243-8. 2006
  5. ncbi request reprint Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain
    Esther M Pogatzki-Zahn
    Department of Anesthesiology, Johns Hopkins University, Baltimore, MD, USA
    Pain 115:296-307. 2005
  6. ncbi request reprint Severing the link between acute and chronic pain: the anesthesiologist's role in preventive medicine
    Allan Gottschalk
    Anesthesiology 101:1063-5. 2004
  7. ncbi request reprint Are synaptic MAGUK proteins involved in chronic pain?
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Pharmacol Sci 25:397-400. 2004
  8. ncbi request reprint Opioid effectiveness, addiction, and depression in chronic pain
    Paul J Christo
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Adv Psychosom Med 25:123-37. 2004
  9. ncbi request reprint Complex regional pain syndrome: diagnostic controversies, psychological dysfunction, and emerging concepts
    Theodore S Grabow
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Adv Psychosom Med 25:89-101. 2004
  10. ncbi request reprint Enhanced thermal avoidance in mice lacking the ATP receptor P2X3
    Isao Shimizu
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 408 Biophysics Building, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Pain 116:96-108. 2005

Collaborators

Detail Information

Publications40

  1. pmc Modulating pain in the periphery: gene-based therapies to enhance peripheral opioid analgesia: Bonica lecture, ASRA 2010
    Srinivasa N Raja
    Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Reg Anesth Pain Med 37:210-4. 2012
    ..Ongoing research on virus-mediated gene transfer strategies to enhance peripheral opioid analgesia is presented...
  2. ncbi request reprint Complex regional pain syndrome I (reflex sympathetic dystrophy)
    Srinivasa N Raja
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Anesthesiology 96:1254-60. 2002
  3. ncbi request reprint Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial
    S N Raja
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 59:1015-21. 2002
    ..Tricyclic antidepressants (TCA) provide less than satisfactory pain relief for postherpetic neuralgia (PHN), and the role of opioids is controversial...
  4. ncbi request reprint Basal heat pain thresholds predict opioid analgesia in patients with postherpetic neuralgia
    Robert R Edwards
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Anesthesiology 104:1243-8. 2006
    ....
  5. ncbi request reprint Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain
    Esther M Pogatzki-Zahn
    Department of Anesthesiology, Johns Hopkins University, Baltimore, MD, USA
    Pain 115:296-307. 2005
    ..Thus, TRPV1 is important for the generation of thermal hyperalgesia after incision. Our observations suggest that all experimental pain models may not be equally appropriate to guide the development of postoperative pain therapies...
  6. ncbi request reprint Severing the link between acute and chronic pain: the anesthesiologist's role in preventive medicine
    Allan Gottschalk
    Anesthesiology 101:1063-5. 2004
  7. ncbi request reprint Are synaptic MAGUK proteins involved in chronic pain?
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Pharmacol Sci 25:397-400. 2004
    ..Recent studies of the role of a family of synaptic membrane-associated guanylate kinase proteins in chronic pain provide new insights into central mechanisms of chronic pain that could result in new biochemical targets for its treatment...
  8. ncbi request reprint Opioid effectiveness, addiction, and depression in chronic pain
    Paul J Christo
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Adv Psychosom Med 25:123-37. 2004
    ..Our ability to determine the validity of such assertions and the exact role of opioids in the treatment of chronic pain will benefit from further study...
  9. ncbi request reprint Complex regional pain syndrome: diagnostic controversies, psychological dysfunction, and emerging concepts
    Theodore S Grabow
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Adv Psychosom Med 25:89-101. 2004
    ..Current strides in our understanding of the pathophysiology of this disease have improved treatment options...
  10. ncbi request reprint Enhanced thermal avoidance in mice lacking the ATP receptor P2X3
    Isao Shimizu
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 408 Biophysics Building, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Pain 116:96-108. 2005
    ..Regardless, this study illustrates the utility of thermal preference assays as part of a comprehensive approach to the analysis of mouse thermosensation...
  11. ncbi request reprint Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain
    Ya Chun Chu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pain 119:113-23. 2005
    ..Our findings suggest that spinal cord nNOS might play a critical role in central mechanisms of the development and/or maintenance of chronic inflammatory pain...
  12. ncbi request reprint Windup in dorsal horn neurons is modulated by endogenous spinal mu-opioid mechanisms
    Yun Guan
    Department ofAnesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:4298-307. 2006
    ..However, MORs may play an important role in endogenous inhibitory mechanisms that regulate the development of spinal neuronal sensitization...
  13. ncbi request reprint Advances in treatment of complex regional pain syndrome: recent insights on a perplexing disease
    Amit Sharma
    Division of Pain Medicine, Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Curr Opin Anaesthesiol 19:566-72. 2006
    ..Rapidly changing concepts related to the pathophysiology of this disease has transformed its current management and necessitates an updated review of the literature...
  14. ncbi request reprint The middle way: a practical approach to prescribing opioids for chronic pain
    Steven P Cohen
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Nat Clin Pract Neurol 2:580-1. 2006
  15. ncbi request reprint Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain
    Steven P Cohen
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Anesthesiology 106:591-614. 2007
    ..In this article, the authors provide a comprehensive review of the anatomy, biomechanics, and function of the lumbar zygapophysial joints, along with a systematic analysis of the diagnosis and treatment of facet joint pain...
  16. ncbi request reprint Transdermal fentanyl reduces pain and improves functional activity in neuropathic pain states
    Shefali Agarwal
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Pain Med 8:554-62. 2007
    ..The efficacy of transdermal fentanyl in chronic neuropathic pain has not been well studied. We examined the effects of transdermal fentanyl on pain and function in patients with chronic neuropathic pain states...
  17. pmc Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Mol Pain 3:29. 2007
    ..Our findings suggest that nNOS, especially in the dorsal root ganglion, may participate in the development and/or maintenance of mechanical hypersensitivity after nerve injury...
  18. ncbi request reprint Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat
    Jill M Tall
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, 600 North Wolfe Street, Osler 292, Baltimore, MD 21287, USA
    Behav Brain Res 153:181-8. 2004
    ..A better understanding of the modulatory role of dietary constituents and phytonutrients on pain will offer further therapeutic options for treating patients with persistent and chronic pain conditions...
  19. ncbi request reprint Mechanism-based therapies for pain
    Brian M Block
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Drug News Perspect 17:172-86. 2004
    ..The first part discusses nociception at the peripheral nerve ending, while the second discusses the neurotransmission of pain signals to the spinal cord and up to the brain...
  20. ncbi request reprint Drug infusions for the diagnosis and treatment of chronic pain
    David A O'Gorman
    Division of Pain Medicine, Anesthesiology, and Critical Care Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 5354, USA
    Curr Pain Headache Rep 6:452-9. 2002
    ..Clinical application of these agents in the management of chronic pain also is outlined...
  21. ncbi request reprint Opioids: more to learn, improvements to be made
    Charles B Berde
    Anesthesiology 98:1309-12. 2003
  22. ncbi request reprint Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 23:6703-12. 2003
    ..PSD-93 appears to be important for NMDAR synaptic targeting and function and to be a potential biochemical target for the treatment of persistent pain...
  23. ncbi request reprint Spinal cord stimulation for complex regional pain syndrome: an evidence-based medicine review of the literature
    Theodore S Grabow
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Clin J Pain 19:371-83. 2003
    ..The purpose of this investigation is to assess the evidence for efficacy of SCS in the management of pain in patients with CRPS...
  24. ncbi request reprint Pain coping strategies play a role in the persistence of pain in post-herpetic neuralgia
    Jennifer A Haythornthwaite
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 101 Meyer, 600 N Wolfe St, Baltimore, MD 21287 7218, USA
    Pain 106:453-60. 2003
    ..These findings support a role for the continued investigation of cognitive-behavioral factors affecting the adaptation of elderly individuals experiencing PHN...
  25. ncbi request reprint Role of micro-opioid receptors in formalin-induced pain behavior in mice
    Cheng Shui Zhao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Exp Neurol 184:839-45. 2003
    ..These results suggest an important modulatory role of endogenous micro-opioid receptor mechanisms in tonic pain states...
  26. ncbi request reprint Analgesic effects of a soy-containing diet in three murine bone cancer pain models
    Chengshui Zhao
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Pain 5:104-10. 2004
    ..Morphine dose-dependently reduced hyperalgesia with no diet-based difference. These results suggest that a soy diet might provide analgesia in certain forms of hyperalgesia associated with bone cancer...
  27. ncbi request reprint Antiallodynic effects of systemic and intrathecal morphine in the spared nerve injury model of neuropathic pain in rats
    Chengshui Zhao
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Anesthesiology 100:905-11. 2004
    ..The effects of morphine on pain behavior were investigated in two animal models of neuropathic pain: the spared nerve injury (SNI) model and the spinal nerve ligation (SNL) model...
  28. ncbi request reprint Postoperative cognitive function as an outcome of regional anesthesia and analgesia
    Christopher L Wu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Carnegie 280, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Reg Anesth Pain Med 29:257-68. 2004
    ..We systematically reviewed the data from published studies to determine the effect of intraoperative neuraxial anesthesia versus general anesthesia on postoperative cognitive dysfunction and delirium...
  29. ncbi request reprint Dietary constituents as novel therapies for pain
    Jill M Tall
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Clin J Pain 20:19-26. 2004
    ..Specifically, the antinociceptive and analgesic properties of soybeans, sucrose, and tart cherries are discussed. The potential actions of dietary constituents as antiinflammatory and antioxidant agents are presented...
  30. pmc Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial
    Christopher L Wu
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Anesthesiology 109:289-96. 2008
    ..Stump and phantom pains are debilitating sequelae of amputations that are often resistant to treatment. The efficacy of pharmacologic therapies, including opioids and sodium channel blockers, for postamputation pain is uncertain...
  31. ncbi request reprint What can we learn from failed neuropathic pain trials?
    Michael Polydefkis
    Neurology 70:250-1. 2008
  32. doi request reprint Diagnosis and assessment of pain associated with herpes zoster and postherpetic neuralgia
    Robert H Dworkin
    Department of Anesthesiology and Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Pain 9:S37-44. 2008
    ..PERSPECTIVE: Comprehensive assessments of pain are necessary for clinical research on the epidemiology, natural history, pathophysiologic mechanisms, treatment, and prevention of pain in herpes zoster and PHN...
  33. doi request reprint An update on the treatment of postherpetic neuralgia
    Christopher L Wu
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Pain 9:S19-30. 2008
    ..These data may potentially help clinicians who attempt to provide analgesia in patients with PHN...
  34. ncbi request reprint Analgesic effects of intravenous lidocaine and morphine on postamputation pain: a randomized double-blind, active placebo-controlled, crossover trial
    Christopher L Wu
    Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Anesthesiology 96:841-8. 2002
    ..The authors hypothesized that morphine and lidocaine may have differential effectiveness on stump and phantom pains...
  35. ncbi request reprint Optimizing postoperative analgesia: the use of global outcome measures
    Christopher L Wu
    Anesthesiology 97:533-4. 2002
  36. ncbi request reprint Lumbar sympathectomy attenuates cold allodynia but not mechanical allodynia and hyperalgesia in rats with spared nerve injury
    Chengshui Zhao
    Department of Anesthesiology and Critical Care Medicine, Baltimore, Maryland, USA
    J Pain 8:931-7. 2007
    ..However, the sympathetic nervous system may be involved, in part, in the mechanisms of cold allodynia in the SNI model...
  37. ncbi request reprint Nerve injury induces a tonic bilateral mu-opioid receptor-mediated inhibitory effect on mechanical allodynia in mice
    Heikki Mansikka
    Department of Anesthesiology and Critical Care Medicine, Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Anesthesiology 100:912-21. 2004
    ..In this study, the authors determined the role of mu-opioid receptors in neuropathic pain behaviors and the effectiveness of mu- and kappa-opioid receptor agonists on this behavior in mice...
  38. ncbi request reprint A mouse model of incisional pain
    Esther M Pogatzki
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 99:1023-7. 2003
  39. ncbi request reprint Combination therapy for neuropathic pain--which drugs, which combination, which patients?
    Srinivasa N Raja
    N Engl J Med 352:1373-5. 2005
  40. ncbi request reprint The correlation between dietary soy phytoestrogens and neuropathic pain behavior in rats after partial denervation
    Yoram Shir
    Department of Anesthesiology and Pain Relief Unit, Hadassah University Hospital, Jerusalem, Israel
    Anesth Analg 94:421-6, table of contents. 2002
    ..Low and high plasma phytoestrogen levels were not analgesic in these tests. This report is the first to show that, at certain plasma concentrations, phytoestrogens reduce neuropathic pain in rats...

Research Grants20

  1. INJURY-INDUCES PAIN-- CHEMICAL MODULATION OF NOCICEPTORS
    Srinivasa Raja; Fiscal Year: 2004
    ..The results of these studies should provide new insights into the peripheral and central mechanisms of neuropathic pain and may lead to novel diagnostic and therapeutic strategies. ..
  2. Injury-Induced Pain: Chemical Modulation of Nociceptors
    Srinivasa Raja; Fiscal Year: 2007
    ..The proposed studies should provide new insights into the mechanisms of the peripheral antihyperalgesic effects of opioids on neuropathic pain and should lead to novel therapeutic strategies. ..
  3. Injury-Induced Pain: Chemical Modulation of Nociceptors
    Srinivasa N Raja; Fiscal Year: 2010
    ..The proposed studies should provide new insights into the mechanisms of the peripheral antihyperalgesic effects of opioids on neuropathic pain and should lead to novel therapeutic strategies. ..
  4. INJURY INDUCED PAIN--CHEMICAL MODULATION OF NOCICEPTORS
    Srinivasa Raja; Fiscal Year: 1999
    ....
  5. INJURY-INDUCED PAIN--CHEMICAL MODULATION OF NOCICEPTORS
    Srinivasa Raja; Fiscal Year: 1993
    ....
  6. INJURY-INDUCED PAIN--CHEMICAL MODULATION OF NOCICEPTORS
    Srinivasa Raja; Fiscal Year: 1991
    ..An understanding of the chemosensitivity of nociceptive afferents following cutaneous or nerve injury may lead to better pharmacological therapies to alleviate pain...