Amina A Qutub

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Glucose transport to the brain: a systems model
    Amina A Qutub
    Joint Graduate Group in Bioengineering, University of California, Berkeley and San Francisco, USA
    Brain Res Brain Res Rev 49:595-617. 2005
  2. pmc Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting
    Amina A Qutub
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    BMC Syst Biol 3:13. 2009
  3. pmc Module-based multiscale simulation of angiogenesis in skeletal muscle
    Gang Liu
    Systems Biology Laboratory, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Theor Biol Med Model 8:6. 2011
  4. doi request reprint Computational models of VEGF-associated angiogenic processes in cancer
    Marianne O Stefanini
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Math Med Biol 29:85-94. 2012
  5. pmc Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia
    Amina A Qutub
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 613 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1773:1511-25. 2007
  6. pmc Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemia
    Amina A Qutub
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 613 Traylor Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    Mol Cell Biol 28:5106-19. 2008
  7. pmc Multiscale models of angiogenesis
    Amina A Qutub
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    IEEE Eng Med Biol Mag 28:14-31. 2009
  8. pmc Systems biology of pro-angiogenic therapies targeting the VEGF system
    Feilim Mac Gabhann
    Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Wiley Interdiscip Rev Syst Biol Med 2:694-707. 2010
  9. pmc A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha
    Amina A Qutub
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 613 Traylor Bldg, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Cell Sci 119:3467-80. 2006

Research Grants

Detail Information

Publications9

  1. ncbi request reprint Glucose transport to the brain: a systems model
    Amina A Qutub
    Joint Graduate Group in Bioengineering, University of California, Berkeley and San Francisco, USA
    Brain Res Brain Res Rev 49:595-617. 2005
    ..A developing complex systems simulation is introduced, initiating a single platform to represent the dynamics of glucose transport across the adapting human blood-brain barrier...
  2. pmc Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sprouting
    Amina A Qutub
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    BMC Syst Biol 3:13. 2009
    ..model that bridges the gap between these two perspectives, and addresses a remaining question in angiogenic sprouting: how do the processes of endothelial cell elongation, migration and proliferation contribute to vessel formation?..
  3. pmc Module-based multiscale simulation of angiogenesis in skeletal muscle
    Gang Liu
    Systems Biology Laboratory, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Theor Biol Med Model 8:6. 2011
    ..Integration of models at different scales is a challenging and currently unsolved problem...
  4. doi request reprint Computational models of VEGF-associated angiogenic processes in cancer
    Marianne O Stefanini
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Math Med Biol 29:85-94. 2012
    ....
  5. pmc Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia
    Amina A Qutub
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 613 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1773:1511-25. 2007
    ..The model provides quantitative insight critical for characterizing molecular mechanisms underlying a cell's response to long-term hypoxia...
  6. pmc Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemia
    Amina A Qutub
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 613 Traylor Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    Mol Cell Biol 28:5106-19. 2008
    ....
  7. pmc Multiscale models of angiogenesis
    Amina A Qutub
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    IEEE Eng Med Biol Mag 28:14-31. 2009
    ..As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia...
  8. pmc Systems biology of pro-angiogenic therapies targeting the VEGF system
    Feilim Mac Gabhann
    Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Wiley Interdiscip Rev Syst Biol Med 2:694-707. 2010
    ..Among the parameters that can be varied in order to determine optimal strategy are dosage, timing of multiple doses, route of administration, and the molecular target...
  9. pmc A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha
    Amina A Qutub
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 613 Traylor Bldg, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Cell Sci 119:3467-80. 2006
    ..The model advances quantitative molecular level understanding of HIF1 pathways--an endeavor that will help elucidate the diverse responses to hypoxia found in cancer, ischemia and exercise...

Research Grants2

  1. Modeling Intracellular Mechanisms of Hypoxic Response
    Amina Qutub; Fiscal Year: 2007
    ..In Specific Aim 2, differential effects of intermittent and chronic hypoxia on HIF1 alpha degradation will be characterized. Computational results will be validated by experimental data. ..