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Genomes and Genes | Alfredo Quinones-HinojosaSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Insight into glaucoma treatment in the early 1900s: Harvey Cushing's 1905 operationKatherine Latimer
Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Arch Ophthalmol 130:510-3. 2012..Respected neurosurgeon Cushing undertook surgical treatment of glaucoma at the turn of the 20th century. His approach provides insight into contemporary glaucoma therapies and pathophysiology...
Neurotransplantation: lux et veritas, fiction or reality?C Pendleton
Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA
J Neurosurg Sci 55:297-304. 2011....- Surgical considerations in the management of falcotentorial meningiomas: advantages of the bilateral occipital transtentorial/transfalcine craniotomy for large tumorsAlfredo Quinones-Hinojosa
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Neurosurgery 64:260-8; discussion 268. 2009..Meningiomas arising from the falcotentorial junction are relatively rare, and the description of the surgical nuances in approaching these tumors is limited. We describe our surgical management of these lesions in detail... - The human subventricular zone: a source of new cells and a potential source of brain tumorsAlfredo Quinones-Hinojosa
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Neurol 205:313-24. 2007..Such an understanding may lead to novel therapeutic strategies for both neurodegenerative diseases and currently intractable brain tumors... - Angled screw holes for anterior posts and a frame-positioning device for gamma knife radiosurgery: allowing for better targeting of intracranial lesionsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Johns Hopkins University, Baltimore, Maryland 21231, USA
Neurosurgery 60:339-43; discussion 343-4. 2007..In this study, we report the use of two devices developed by the senior author (MWM) that facilitate these two crucial objectives in the treatment of intracranial targets using the gamma knife... - The human brain subventricular zone: stem cells in this niche and its organizationAlfredo Quinones-Hinojosa
Stem Cell Laboratory, Brain Tumor Program, Department of Neurological Surgery, Johns Hopkins University School of Medicine, Cancer Research Building II, 1550 Orleans Street, Room 253, Baltimore, MD 21231, USA
Neurosurg Clin N Am 18:15-20, vii. 2007..Understanding the organization of the adult human SVZ represents a necessary first step in understanding cellular proliferation, precursor migration, and the neurogenic niche of the largest known germinal region in the adult human brain... - Mesenchymal stem cells: new approaches for the treatment of neurological diseasesEric N Momin
Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Curr Stem Cell Res Ther 5:326-44. 2010..With additional pre-clinical and clinical studies that focus on their potential benefits as well as dangers, MSCs may one day find translation to clinical use in the setting of neurological disease... - Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cellsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Brain Tumor Research Center, Developmental Stem Cell Biology Program, University of California, San Francisco, San Francisco, California 94143 0112, USA
J Comp Neurol 494:415-34. 2006..Ultrastructural analysis of this layer revealed a remarkable network of astrocytic and ependymal processes. This work provides a basic description of the organization of the adult human SVZ... - Transcranial motor evoked potentials during basilar artery aneurysm surgery: technique application for 30 consecutive patientsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0112, USA
Neurosurgery 54:916-24; discussion 924. 2004..Transcranial motor evoked potential (TcMEP) monitoring was added to determine whether this modality improved intraoperative monitoring... - Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experienceFrank J Attenello
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA
Ann Surg Oncol 15:2887-93. 2008..Various complications of Gliadel wafers have been reported but not consistently reproduced. We set out to characterize Gliadel-associated morbidity in our 10-year experience with Gliadel wafers for treatment of malignant glioma... - Preoperative charlson comorbidity score predicts postoperative outcomes among older intracranial meningioma patientsRachel Grossman
Department of Neurosurgery, Johns Hopkins School of Medicine, Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
World Neurosurg 75:279-85. 2011.... - Prognostic significance of contrast-enhancing anaplastic astrocytomas in adultsKaisorn L Chaichana
Department of Neurosurgery, Neurology, and Oncology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Neurosurg 113:286-92. 2010..The prognostic implications of a preoperative contrast-enhancing AA remain poorly understood... - The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survivalKaisorn L Chaichana
Department of Neurosurgery, The Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurol Res 33:759-64. 2011..Peak incidence of glioblastoma multiforme (GBM) occurs in individuals aged 65 years and older. The goal was to evaluate the efficacy of carmustine wafers in prolonging survival for older GBM patients... - Prognostic significance of contrast-enhancing low-grade gliomas in adults and a review of the literatureKaisorn L Chaichana
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Neurol Res 31:931-9. 2009..The prognostic implications of a contrast-enhancing low-grade glioma remain less well understood... - Neurophysiological monitoring for safe surgical tethered cord syndrome release in adultsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, Moffitt Hospital Room M779, Box 112, San Francisco, CA 94143 0112, USA
Surg Neurol 62:127-33; discussion 133-5. 2004..Intraoperative neurophysiological monitoring techniques can help to minimize these adverse neurologic outcomes... - Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. Clinical articleKaisorn L Chaichana
Department of Neurosurgery, Johns Hopkins University and School of Medicine, Baltimore, Maryland, USA
J Neurosurg 114:587-94. 2011..The identification of these factors may provide insight into which patients would benefit most from aggressive surgery... - Complications and death among elderly patients undergoing pituitary tumour surgeryRachel Grossman
Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Neuro Oncology Surgical Outcomes Research Laboratory, Baltimore, MD, USA
Clin Endocrinol (Oxf) 73:361-8. 2010..Preoperative determinants of surgical risk in elderly patients with pituitary tumour are not fully defined. The aim of this study was to quantify operative risk for these patients... - Subventricular zone localized irradiation affects the generation of proliferating neural precursor cells and the migration of neuroblastsPragathi Achanta
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA
Stem Cells 30:2548-60. 2012.... - Harvey Cushing's contributions to motor mapping: 1902-1912Courtney Pendleton
Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Cortex 48:7-14. 2012..This review of Cushing's early intra-operative motor mapping illuminates his contributions, and clarifies his influence on the evolution of cortical mapping from an experimental technique to a staple of contemporary neurosurgery... - Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migrationNader Sanai
Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
Nature 427:740-4. 2004..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain... - Factors involved in maintaining prolonged functional independence following supratentorial glioblastoma resection. Clinical articleKaisorn L Chaichana
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Neurosurg 114:604-12. 2011..The aims of this study were to evaluate functional outcomes over time for patients with glioblastoma, as well as identify factors associated with prolonged functional independence... - Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomasKaisorn L Chaichana
Department of Neurosurgery, Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, Maryland, USA
J Neurosurg 112:10-7. 2010..The authors set out to determine factors that were independently associated with recurrence and malignant degeneration in patients who underwent resection of a hemispheric low-grade glioma... - A surgical modification for performing orbitozygomatic osteotomies: technical noteJames E Conway
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA
Neurosurg Rev 33:491-500. 2010..This manuscript details the use of a single drill system that can be used for both the craniotomy and the safe and efficient generation of orbitozygomatic osteotomies... - Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomasMatthew J McGirt
Department of Neurosurgery, The Johns Hopkins School of Medicine, and Neuro Oncology Surgical Outcomes Research Laboratory, Baltimore, Maryland 21231, USA
Neurosurgery 63:700-7; author reply 707-8. 2008..It remains unknown whether the extent of surgical resection affects survival or disease progression in patients with supratentorial low-grade gliomas... - Cytoarchitecture of the lateral ganglionic eminence and rostral extension of the lateral ventricle in the human fetal brainHugo Guerrero-Cazares
Department of Neurosurgery, Brain Tumor Stem Cell Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Comp Neurol 519:1165-80. 2011..The lack of these structures closer to the olfactory bulb could indicate a destination for the migratory neuroblasts outside the olfactory bulb in the human brain... - Combined microsurgical and endovascular management of complex intracranial aneurysmsMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0012, USA
Neurosurgery 52:263-74; discussion 274-5. 2003.... - Radiographic and anatomic basis of endoscopic anterior craniocervical decompression: a comparison of endonasal, transoral, and transcervical approachesClinton J Baird
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Neurosurgery 65:158-63; discussion 63-4. 2009..To evaluate surgical access to the craniocervical junction using 3 endoscopic approaches: endonasal, transoral, and transcervical... - Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomasKaisorn L Chaichana
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Neurol Res 32:442-8. 2010..Hyperglycemia has been shown to augment tumor growth in vitro. However, the effects of persistent hyperglycemia on survival, recurrence and malignant degeneration in patients undergoing surgery for low grade gliomas remain unknown... - Thrombotic intracranial aneurysms: classification scheme and management strategies in 68 patientsMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 56:441-54; discussion 441-54. 2005..A classification scheme was devised on the basis of aneurysm, thrombus, and lumen morphology to relate these anatomic features to surgical therapy... 
c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotypeYunqing Li
Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 108:9951-6. 2011..These findings show that c-Met enhances the population of glioblastoma stem cells (GBM SCs) via a mechanism requiring Nanog and potentially other c-Met-responsive reprogramming transcription factors...- Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patientsKaisorn L Chaichana
The Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Department of Neurosurgery, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 18:239-45. 2011..However, studies on this patient group remain limited. The goal of this study is to evaluate the efficacy of surgery versus biopsy for older patients with these lesions... - Disparities in access to pediatric neurooncological surgery in the United StatesDebraj Mukherjee
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Pediatrics 124:e688-96. 2009..The objective of this study was to investigate whether disparities in access to high-volume centers for neurooncological care existed in the United States in 1988-2005... - The extended retrosigmoid approach for neoplastic lesions in the posterior fossa: technique modificationShaan M Raza
Department of Neurosurgery, The Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Baltimore, MD, USA
Neurosurg Rev 34:123-9. 2011..This technical modification over the standard retrosigmoid approach may provide a useful advantage to neurosurgeons dealing with these complex lesions... - Treatment of pituitary adenomas using radiosurgery and radiotherapy: a single center experience and review of literatureDaniel Q Sun
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neurosurg Rev 34:181-9. 2010.... - Variations in referral patterns for hypophysectomies among pediatric patients with sellar and parasellar tumorsDebraj Mukherjee
Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, 1550 Orleans Street, Suite 253, Baltimore, MD 21231, USA
Childs Nerv Syst 26:305-11. 2010..It remains unknown what preoperative factors influence admission to high-volume centers. We report a nationwide analysis of patients <18 years of age undergoing neurosurgical intervention for these lesions... - A modified frontal-nasal-orbital approach to midline lesions of the anterior cranial fossa and skull base: technical note with case illustrationsShaan M Raza
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Neurosurg Rev 33:63-70. 2010..The frontal-nasal-orbital craniotomy is a useful technique for midline lesions of the anterior skull base, and it should be in the armamentarium of neurological surgeons... - Harvey Cushing's repair of a dural defect after a traumatic brain injury: novel use of a fat graftHasan A Zaidi
Department of Neurosurgery and Oncology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
World Neurosurg 75:696-9. 2011..A review of Harvey Cushing's surgical cases at Johns Hopkins Hospital revealed new information about his early work with the use of fat grafts to close dural defects... - Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseasesKaisorn L Chaichana
Department of Neurosurgery, Cancer Research Building, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neurosci Methods 164:261-70. 2007.... - Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomasEdward F Chang
Department of Neurological Surgery, Division of Endocrinology, University of California, San Francisco, California 94143, USA
J Neurosurg 108:736-45. 2008..The authors' aim was to determine predictors of recurrence and overall survival and to define patient subgroups that may benefit from radiotherapy... - In situ bypass in the management of complex intracranial aneurysms: technique application in 13 patientsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Center for Stroke and Cerebrovascular Disease, University of California, San Francisco, California 94143 0112, USA
Neurosurgery 57:140-5; discussion 140-5. 2005..An experience with in situ bypasses was retrospectively reviewed... - Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastomaThomas W Link
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Clin Neurosci 19:996-1000. 2012..These results suggest, together with the broad literature supporting a role for hyperglycemia in neurological injury, that this may represent a modifiable factor in the peri-operative care of these patients... - Pre-operative factors affecting resectability of giant intracranial meningiomasAlfredo Quinones-Hinojosa
Johns Hopkins Hospital, Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21231, USA
Can J Neurol Sci 36:623-30. 2009..As a group, it remains largely unknown whether these relatively rare lesions are amenable to radical resection, and what factors influence their resectability... - Relationship of glioblastoma multiforme to the lateral ventricles predicts survival following tumor resectionKaisorn L Chaichana
Department of Neurosurgery, The Johns Hopkins Hospital, Johns Hopkins School of Medicine, Johns Hopkins University, CRB II, 1550 Orleans Street, Room 247, Baltimore, MD, 21231, USA
J Neurooncol 89:219-24. 2008..We set out to determine if glioblastoma multiforme (GBM) bordering the LV was associated with decreased survival as compared to non-LV GBM... - Predictors of inpatient death and complications among postoperative elderly patients with metastatic brain tumorsRachel Grossman
Department of Neurosurgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 18:521-8. 2011..Risks of brain surgery in elderly patients with brain metastases are not well defined. This study was designed to quantify the postoperative risk for these patients after brain surgery for metastatic disease to the brain... - Changes in transcranial motor evoked potentials during intramedullary spinal cord tumor resection correlate with postoperative motor functionAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 56:982-93; discussion 982-93. 2005..In this study, we hypothesized that changes in the intraoperative MEPs during tumor resection correlate with postoperative motor function deficits... - Unique challenges faced by pediatric neurosurgeon Harvey Cushing in 1909 at Johns Hopkins: a choroid plexus tumor of the lateral ventricle mimicking a cerebellar lesionCourtney Pendleton
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Childs Nerv Syst 27:1145-8. 2011..In absence of detailed neuroimaging, erroneous diagnoses and misdirected operative explorations were common within pediatric populations... - Diagnosis and management of adult pyogenic osteomyelitis of the cervical spineFrank L Acosta
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
Neurosurg Focus 17:E2. 2004.... - "No clinical puzzles more interesting": Harvey Cushing and spinal trauma, the Johns Hopkins Hospital 1896-1912Hormuzdiyar H Dasenbrock
School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Neurosurgery 68:420-30; discussion 430. 2011..These cases illustrate Cushing's dedication to and rapport with his patients, even in the face of a dismal prognosis... - Preoperative correlation of intraoperative cortical mapping with magnetic resonance imaging landmarks to predict localization of the Broca areaAlfredo Quinones-Hinojosa
Department of Neurosurgery, The Brain Tumor Research Center, University of California at San Francisco, California 94143 0112, USA
J Neurosurg 99:311-8. 2003..These landmarks demonstrate novel structural-functional relationships that can be used preoperatively to predict the location of the Broca area... - Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomasMatthew J McGirt
Department of Neurosurgery, Johns Hopkins School of Medicine, and The Johns Hopkins Neuro oncology Surgical Outcomes Research Laboratory, Baltimore, Maryland, USA
Neurosurgery 63:286-91; discussion 291. 2008..We hypothesized that persistent hyperglycemic states in the outpatient setting may serve as a prognostic marker of decreased survival in patients with malignant brain astrocytomas... - "Fulfilling the chief of his duties as a physician": Harvey Cushing, selective dorsal rhizotomy and elective spine surgery for quality of lifeHormuzdiyar H Dasenbrock
The Johns Hopkins University School of Medicine, Johns Hopkins Medicine, Baltimore, Maryland 21287, USA
J Neurosurg Spine 14:421-7. 2011.... - Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cellsMingyao Ying
Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland 21205, USA
Stem Cells 29:20-31. 2011..Our results show for the first time that KLF9 has differentiating and tumor-suppressing functions in tumor-initiating stem cells... - Prognostic factors and survival in primary malignant astrocytomas of the spinal cord: a population-based analysis from 1973 to 2007Hadie Adams
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Spine (Phila Pa 1976) 37:E727-35. 2012..Observational cross-sectional study... - Harvey Cushing's case series of trigeminal neuralgia at the Johns Hopkins Hospital: a surgeon's quest to advance the treatment of the 'suicide disease'Hadie Adams
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Acta Neurochir (Wien) 153:1043-50. 2011..There was perhaps no other affliction that captured his attention in the way that TN did, and he built a remarkable legacy of successful treatment. At the time, surgical interventions carried an operative mortality of 20%... - Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosisRussell K Hales
Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, 401 North Broadway, Suite 1440, Baltimore, MD 21231, USA
J Neurooncol 99:65-71. 2010..Pathologic misdiagnosis should be suspected in patients who are long term survivors of a pediatric high grade astrocytoma... - Disparities in access to neuro-oncologic care in the United StatesDebraj Mukherjee
Neuro Oncology Surgical Outcomes Research Laboratory, Department of Neurosurgery and Oncology, The Johns Hopkins School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
Arch Surg 145:247-53. 2010..Race/ethnicity and social status influence admission to high-volume hospitals among patients who undergo craniotomy for tumor biopsy or resection... - Intraoperative motor mapping of the cerebral peduncle during resection of a midbrain cavernous malformation: technical case reportAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 56:E439; discussion E439. 2005..In addition, intermittent monitoring with transcranial motor evoked potentials (TcMEPs) helps to protect this vital pathway during resection of the lesion... - Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiformeMatthew J McGirt
Departments of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
J Neurosurg 110:583-8. 2009..The authors reviewed their initial experience utilizing combined Gliadel, TMZ, and radiation therapy for the treatment of GBM... - Harvey Cushing and early spinal dysraphism repair at Johns Hopkins HospitalCourtney Pendleton
Department of Neurosurgery, Johns Hopkins School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
J Neurosurg Pediatr 7:47-51. 2011.... - Intra-operatively obtained human tissue: protocols and techniques for the study of neural stem cellsKaisorn L Chaichana
Department of Neurosurgery, Brain Tumors Surgery Program, The Johns Hopkins, University School of Medicine, Baltimore, MD 21205, USA
J Neurosci Methods 180:116-25. 2009..This study describes in detail both current and newly developed laboratory techniques, which in our experience are used to process and study human NSCs and BTSCs from tissue obtained directly from the operating room... - Frame-based stereotactic biopsy remains an important diagnostic tool with distinct advantages over frameless stereotactic biopsyJustin S Smith
Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, 505 Parnassus Avenue, 94143 0112 San Francisco, California, USA
J Neurooncol 73:173-9. 2005..We retrospectively reviewed the UCSF experience with stereotactic brain biopsy from a 9 year period... - Role of cancer stem cells in spine tumors: review of current literatureWesley Hsu
Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston Salem, NC 27157 1029, USA
Neurosurgery 71:117-25. 2012..This discussion is followed by a review of what is known about the role of CSCs in the most common primary tumors of the osseous spine... - Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulationTomas Garzon-Muvdi
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS Biol 10:e1001320. 2012..Due to the ubiquitous expression of NKCC1 in mammalian tissues, its regulation by WNK kinases may serve as new therapeutic targets for GB aggressiveness and can be exploited by other highly invasive neoplasms... - Safety and efficacy of the direct endonasal transsphenoidal approach for challenging sellar tumorsNader Sanai
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M 779, P O Box 0112, San Francisco, CA 94143, USA
J Neurooncol 87:317-25. 2008..Large macroadenomas (3-4 cm) can still be addressed with this simple, unmodified direct endonasal approach. We present our experience with this unique and challenging patient population... - Harvey Cushing's surgical treatment of a pediatric patient with an intraventricular gliomaCourtney Pendleton
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Pediatr Neurosurg 46:475-9. 2010..The combination of inadequate technology and incomplete nomenclature systems created challenges for early neurosurgeons, and contributed to the dismal prognosis for brain tumors, particularly within the pediatric population... - Harvey Cushing and pediatric brain tumors at Johns Hopkins: the early stages of developmentCourtney Pendleton
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Neurosurg Pediatr 7:575-88. 2011..However, his contributions to the surgical treatment of these lesions during the early stages of his tenure at the Johns Hopkins Hospital, from 1896 to 1912, remain largely unknown... - Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastomaStephany Y Tzeng
Department of Biomedical Engineering and the Institute for NanoBioTechnology, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA
Biomaterials 32:5402-10. 2011.... - On the shoulders of giants: Harvey Cushing's experience with acromegaly and gigantism at the Johns Hopkins Hospital, 1896-1912Courtney Pendleton
Brain Tumor Stem Cell Laboratory, Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Pituitary 14:53-60. 2011.... - Spinal cord mapping as an adjunct for resection of intramedullary tumors: surgical technique with case illustrationsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, Room M 779, San Francisco, CA 94143 9112, USA
Neurosurgery 51:1199-206; discussion 1206-7. 2002..We used both antidromically elicited SSEPs for planning the myelotomy site and direct mapping of spinal cord tracts during tumor resection to reduce the risk of neurological deficits and increase the extent of tumor resection... - Assessment of image guided accuracy in a skull model: comparison of frameless stereotaxy techniques vs. frame-based localizationAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA, USA
J Neurooncol 76:65-70. 2006..We sought to evaluate the accuracy of a plastic, disposable burr hole mounted guide for stereotactic biopsy using an IGS and compare the results of different targeting methods with those of frame based localization... - Gliomagenesis and the use of neural stem cells in brain tumor treatmentPragathi Achanta
Department of Neurosurgery, Johns Hopkins University, School of Medicine, CRB II, Room 272, 1550 Orleans Street, Baltimore, MD 21231, USA
Anticancer Agents Med Chem 10:121-30. 2010..Here, the proposed mechanisms of how brain tumors emerge, the molecular pathways interrupted in NSC pathogenesis and the most recent preclinical results in the use of NSCs for glioma treatment are reviewed... - Association of preoperative depression and survival after resection of malignant brain astrocytomaMuraya Gathinji
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Surg Neurol 71:299-303, discussion 303. 2009..We set out to determine whether patients with a diagnosis of clinical depression before surgery experienced decreased survival independent of treatment modality or degree of disability... - Neuromonitoring during surgery for metastatic tumors to the spine: intraoperative interpretation and management strategiesAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Avenue, M 779, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 15:537-47. 2004..Further experience with these techniques should allow improved results follow-ing surgical procedures in functionally eloquent are as of the spinal cord during the surgical management of metastatic tumors... - Neurosphere culture and human organotypic model to evaluate brain tumor stem cellsHugo Guerrero-Cazares
Brain Tumor Stem Cell Laboratory, Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Methods Mol Biol 568:73-83. 2009..In this chapter, we summarize a method to culture, analyze the cellular characteristics, and study the invasion of BTSCs using a neurosphere assay, cryostat sectioning, and human organotypic brain cortex migration assay, respectively... - Harvey Cushing's operative treatment of metastatic breast cancer to the central nervous system in the early 1900sKatherine Latimer
Department of Neurosurgery and Oncology, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Arch Surg 146:975-9. 2011..At the time, neurologic surgery was in its infancy. Metastases of breast carcinoma to the CNS were recognized; however, many surgeons of the era adhered to a general principle of not operating in these situations... - Applications of neural and mesenchymal stem cells in the treatment of gliomasThomas Kosztowski
The Johns Hopkins Hospital, Department of Neurosurgery, Johns Hopkins University, CRB II, 1550 Orleans Street, Room 247, Baltimore, MD 21231, USA
Expert Rev Anticancer Ther 9:597-612. 2009.... - Incidence of venous thromboembolism in patients undergoing craniotomy and motor mapping for glioma without intraoperative mechanical prophylaxis to the contralateral legKurtis I Auguste
Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco School of Medicine, San Francisco, California 94143-0112, USA
J Neurosurg 99:680-4. 2003..There appears to be no preferential distribution of VTE in contralateral lower extremities that do not receive immediate preoperative and intraoperative mechanical prophylaxis... - Frameless stereotactic image-guided C1-C2 transarticular screw fixation for atlantoaxial instability: review of 20 patientsFrank L Acosta
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143 0112, USA
J Spinal Disord Tech 18:385-91. 2005..We retrospectively studied 20 adults who underwent C1-C2 transarticular screw (TAS) fixation utilizing frameless stereotaxy... - Biological horizons for targeting brain malignancySamuel A Hughes
Department of Neurological Surgery, Oregan Health and Sciences University, Portland, Oregon, USA
Adv Exp Med Biol 671:93-104. 2010..This coming progression of applied cancer stem cell research, coupled with current modalities, promises more comprehensive brain cancer interventions... - Spinal meningiomas: surgical management and outcomeOren N Gottfried
Department of Neurosurgery, University of Utah, Salt Lake City, USA
Neurosurg Focus 14:e2. 2003..Overall, surgical treatment of spinal meningiomas is associated with favorable outcomes. Spinal meningiomas can be completely resected, are associated with postoperative functional improvement, and the rate of recurrence is low... - Falcotentorial meningiomas: clinical, neuroimaging, and surgical features in six patientsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, The Brain Tumor Research Center, University of California at San Francisco, California 94143 0112, USA
Neurosurg Focus 14:e11. 2003..As a result, their clinical presentation and surgical management are not well described. During the past 3 years, the authors have treated six patients with falcotentorial meningiomas... - Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiformeMatthew J McGirt
Department of Neurosurgery, The Neuro Oncology Surgical Outcomes Research Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Neurosurgery 65:463-9; discussion 469-70. 2009..We set out to determine whether new-onset postoperative motor or speech deficits were associated with survival in our institutional experience with glioblastoma multiforme (GBM)... - Combined endoscopic and microscopic management of pediatric pituitary region tumors through one nostril: technical note with case illustrationsJames L Frazier
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Childs Nerv Syst 24:1469-78. 2008.... - Renal cell carcinoma metastatic to the choroid mimicking intraventricular meningiomaAlfredo Quinones-Hinojosa
Department of Neurosurgery, University of California San Francisco, San Francisco, California 94143-0112, USA
Can J Neurol Sci 31:115-20. 2004..We also discuss the use of an under-utilized technique, the contralateral transcallosal approach, in the surgical treatment of this intraventricular lesion... - Spontaneous intracerebral hemorrhage due to coagulation disordersAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California San Francisco School of Medicine, San Francisco, California 94143 0112, USA
Neurosurg Focus 15:E3. 2003..The authors also discuss clinical features, diagnosis, and management of intracranial hemorrhage resulting from these bleeding disorders... - Pediatric intracranial aneurysms: durability of treatment following microsurgical and endovascular managementNader Sanai
Department of Neurological Surgery, University of California at San Francisco, California 94143-0112, USA
J Neurosurg 104:82-9. 2006..Parental biases toward nonoperative therapy should be thoroughly addressed before ultimately selecting a treatment strategy... - A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiformeKaisorn Chaichana
Department of Neurosurgery, Johns Hopkins School of Medicine, and The Johns Hopkins Neuro oncology Surgical Outcomes Research Laboratory, Baltimore, Maryland 21231, USA
J Neurosurg 112:997-1004. 2010.... - PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signalingErica L Jackson
Department of Neurological Surgery and Program in Developmental and Stem Cell Biology, University of California, San Francisco, San Francisco, California 94143, USA
Neuron 51:187-99. 2006..Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation... - Isolated Whipple disease of the brain resembling a tumourJames L Frazier
Department of Neurosurgery and Oncology, The Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA
Acta Neurochir (Wien) 151:173-5. 2009.... - Accuracy over space and time of computer-assisted fluoroscopic navigation in the lumbar spine in vivoAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California, San Francisco, USA
J Spinal Disord Tech 19:109-13. 2006..We sought to study the intraoperative accuracy of VF over time and space during lumbar pedicle screw placement in human patients... - Diagnosis and management of sacral Tarlov cysts. Case report and review of the literatureFrank L Acosta
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143-0112, USA
Neurosurg Focus 15:E15. 2003..They review the medical literature, describe various theories on the origin and pathogenesis of Tarlov cysts, and assess alternative treatment strategies... - Clinical outcome in children undergoing tethered cord release utilizing intraoperative neurophysiological monitoringCornelia S von Koch
Department of Neurological Surgery, Room M 779, Box 0112, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0112, USA
Pediatr Neurosurg 37:81-6. 2002..A ratio, rather than an absolute number, is beneficial in distinguishing motor roots from the filum and eliminates variability due to patients' individual differences in electrical thresholds... - Oxygen in stem cell biology: a critical component of the stem cell nicheAhmed Mohyeldin
Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Cell Stem Cell 7:150-61. 2010..These findings have important implications on our understanding of development, disease, and tissue-engineering practices and furthermore elucidate an added dimension of stem cell control within the niche... - DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagationPeng Sun
Department of Neurology, The Johns Hopkins University School of Medicine and The Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland 21205, USA
Stem Cells 27:1473-86. 2009..Our findings are the first to implicate noncanonical Notch signaling in the regulation of neoplastic stem-like cells and suggest novel neoplastic stem cell targeting treatment strategies for GBM and potentially other solid malignancies... - Predictors of access to pituitary tumor resection in the United States, 1988-2005Debraj Mukherjee
Brain Tumor Stem Cell and Neuro Oncology Surgical Outcomes Research Laboratory, Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, 1550 Orleans Street, Cancer Research Building II, Room 253, Baltimore, Maryland 21231, USA
Eur J Endocrinol 161:259-65. 2009..We set out to determine which factors most influenced admission to these high-volume centers... - Origins and clinical implications of the brain tumor stem cell hypothesisHasan A Zaidi
The Johns Hopkins Hospital, Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21231, USA
J Neurooncol 93:49-60. 2009.... - Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical articleKaisorn L Chaichana
Department of Neurosurgery, Johns Hopkins School of Medicine, and Neuro Oncology Surgical Outcomes Research Laboratory, Baltimore, Maryland 21231, USA
J Neurosurg 111:282-92. 2009..The authors set out to determine preoperative seizure characteristics, effects of surgery on seizure control, and factors associated with prolonged seizure control in patients with malignant astrocytomas... - Giant encephaloceleDebraj Mukherjee
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Br J Neurosurg 24:219-20. 2010..The etiology, epidemiology, classification, clinical presentation, imaging, and surgical approaches used for encephaloceles are discussed... - Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literatureJames L Frazier
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
World Neurosurg 73:53-62; discussion e5. 2010..Several studies have investigated the evolution of low-grade gliomas into malignant gliomas by CT and MRI characteristics, but many have not documented the timing of these transformation processes... - A histology-based atlas of the C57BL/6J mouse brain deformably registered to in vivo MRI for localized radiation and surgical targetingDavid Purger
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, 401 North Broadway, Suite 1440, Baltimore, MD 21231, USA
Phys Med Biol 54:7315-27. 2009.... - Neural stem cell niches and homing: recruitment and integration into functional tissuesTomas Garzon-Muvdi
The Johns Hopkins Hospital, Department of Neurosurgery, Brain Stem Cell Laboratory, Johns Hopkins University, Baltimore, MD 21231, USA
ILAR J 51:3-23. 2009..We also discuss animal models of important human neurodegenerative diseases in which transplantation of neural stem cells has been tested...
Research Grants
- Neurogenesis in the Human BrainAlfredo Quinones Hinojosa; Fiscal Year: 2003....
- Migration of Human Neural Stem Cells In Vitro and In VivoAlfredo Quinones Hinojosa; Fiscal Year: 2007..In addition, neural stem cells and cancer stem cells may share similar mechanisms of migration and invasion and understanding this mechanism may lead to better treatments of brain tumors. ..
- Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 StimulationAlfredo Quinones Hinojosa; Fiscal Year: 2010..In this study, we propose to understand the role of pro-migratory signals in brain tumor invasion in order to increase the available targets to prevent brain tumor dispersal. ..