Alfredo Quinones-Hinojosa

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint The human subventricular zone: a source of new cells and a potential source of brain tumors
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Neurol 205:313-24. 2007
  2. doi request reprint Insight into glaucoma treatment in the early 1900s: Harvey Cushing's 1905 operation
    Katherine Latimer
    Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Arch Ophthalmol 130:510-3. 2012
  3. doi request reprint Surgical considerations in the management of falcotentorial meningiomas: advantages of the bilateral occipital transtentorial/transfalcine craniotomy for large tumors
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Neurosurgery 64:260-8; discussion 268. 2009
  4. ncbi request reprint Mesenchymal stem cells: new approaches for the treatment of neurological diseases
    Eric N Momin
    Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Curr Stem Cell Res Ther 5:326-44. 2010
  5. ncbi request reprint Angled screw holes for anterior posts and a frame-positioning device for gamma knife radiosurgery: allowing for better targeting of intracranial lesions
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Neurosurgery 60:339-43; discussion 343-4. 2007
  6. ncbi request reprint The human brain subventricular zone: stem cells in this niche and its organization
    Alfredo Quinones-Hinojosa
    Stem Cell Laboratory, Brain Tumor Program, Department of Neurological Surgery, Johns Hopkins University School of Medicine, Cancer Research Building II, 1550 Orleans Street, Room 253, Baltimore, MD 21231, USA
    Neurosurg Clin N Am 18:15-20, vii. 2007
  7. ncbi request reprint Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Brain Tumor Research Center, Developmental Stem Cell Biology Program, University of California, San Francisco, San Francisco, California 94143 0112, USA
    J Comp Neurol 494:415-34. 2006
  8. ncbi request reprint Neurotransplantation: lux et veritas, fiction or reality?
    C Pendleton
    Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA
    J Neurosurg Sci 55:297-304. 2011
  9. doi request reprint Preoperative charlson comorbidity score predicts postoperative outcomes among older intracranial meningioma patients
    Rachel Grossman
    Department of Neurosurgery, Johns Hopkins School of Medicine, Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    World Neurosurg 75:279-85. 2011
  10. doi request reprint Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience
    Frank J Attenello
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA
    Ann Surg Oncol 15:2887-93. 2008

Research Grants

  1. Neurogenesis in the Human Brain
    Alfredo Quinones Hinojosa; Fiscal Year: 2003
  2. Migration of Human Neural Stem Cells In Vitro and In Vivo
    Alfredo Quinones Hinojosa; Fiscal Year: 2007
  3. Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 Stimulation
    Alfredo Quinones Hinojosa; Fiscal Year: 2010

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint The human subventricular zone: a source of new cells and a potential source of brain tumors
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Neurol 205:313-24. 2007
    ..Such an understanding may lead to novel therapeutic strategies for both neurodegenerative diseases and currently intractable brain tumors...
  2. doi request reprint Insight into glaucoma treatment in the early 1900s: Harvey Cushing's 1905 operation
    Katherine Latimer
    Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Arch Ophthalmol 130:510-3. 2012
    ..Respected neurosurgeon Cushing undertook surgical treatment of glaucoma at the turn of the 20th century. His approach provides insight into contemporary glaucoma therapies and pathophysiology...
  3. doi request reprint Surgical considerations in the management of falcotentorial meningiomas: advantages of the bilateral occipital transtentorial/transfalcine craniotomy for large tumors
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Neurosurgery 64:260-8; discussion 268. 2009
    ..Meningiomas arising from the falcotentorial junction are relatively rare, and the description of the surgical nuances in approaching these tumors is limited. We describe our surgical management of these lesions in detail...
  4. ncbi request reprint Mesenchymal stem cells: new approaches for the treatment of neurological diseases
    Eric N Momin
    Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Curr Stem Cell Res Ther 5:326-44. 2010
    ..With additional pre-clinical and clinical studies that focus on their potential benefits as well as dangers, MSCs may one day find translation to clinical use in the setting of neurological disease...
  5. ncbi request reprint Angled screw holes for anterior posts and a frame-positioning device for gamma knife radiosurgery: allowing for better targeting of intracranial lesions
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Neurosurgery 60:339-43; discussion 343-4. 2007
    ..In this study, we report the use of two devices developed by the senior author (MWM) that facilitate these two crucial objectives in the treatment of intracranial targets using the gamma knife...
  6. ncbi request reprint The human brain subventricular zone: stem cells in this niche and its organization
    Alfredo Quinones-Hinojosa
    Stem Cell Laboratory, Brain Tumor Program, Department of Neurological Surgery, Johns Hopkins University School of Medicine, Cancer Research Building II, 1550 Orleans Street, Room 253, Baltimore, MD 21231, USA
    Neurosurg Clin N Am 18:15-20, vii. 2007
    ..Understanding the organization of the adult human SVZ represents a necessary first step in understanding cellular proliferation, precursor migration, and the neurogenic niche of the largest known germinal region in the adult human brain...
  7. ncbi request reprint Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Brain Tumor Research Center, Developmental Stem Cell Biology Program, University of California, San Francisco, San Francisco, California 94143 0112, USA
    J Comp Neurol 494:415-34. 2006
    ..Ultrastructural analysis of this layer revealed a remarkable network of astrocytic and ependymal processes. This work provides a basic description of the organization of the adult human SVZ...
  8. ncbi request reprint Neurotransplantation: lux et veritas, fiction or reality?
    C Pendleton
    Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA
    J Neurosurg Sci 55:297-304. 2011
    ....
  9. doi request reprint Preoperative charlson comorbidity score predicts postoperative outcomes among older intracranial meningioma patients
    Rachel Grossman
    Department of Neurosurgery, Johns Hopkins School of Medicine, Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    World Neurosurg 75:279-85. 2011
    ....
  10. doi request reprint Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience
    Frank J Attenello
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA
    Ann Surg Oncol 15:2887-93. 2008
    ..Various complications of Gliadel wafers have been reported but not consistently reproduced. We set out to characterize Gliadel-associated morbidity in our 10-year experience with Gliadel wafers for treatment of malignant glioma...
  11. ncbi request reprint Transcranial motor evoked potentials during basilar artery aneurysm surgery: technique application for 30 consecutive patients
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0112, USA
    Neurosurgery 54:916-24; discussion 924. 2004
    ..Transcranial motor evoked potential (TcMEP) monitoring was added to determine whether this modality improved intraoperative monitoring...
  12. doi request reprint Seizure control for patients undergoing meningioma surgery
    Kaisorn L Chaichana
    Department of Neurosurgery, Neuro Oncology Outcomes Laboratory, Johns Hopkins University, Baltimore, Maryland, USA
    World Neurosurg 79:515-24. 2013
    ..The factors associated with the onset of seizures as well as factors associated with seizure control remains poorly understood...
  13. doi request reprint The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival
    Kaisorn L Chaichana
    Department of Neurosurgery, The Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurol Res 33:759-64. 2011
    ..Peak incidence of glioblastoma multiforme (GBM) occurs in individuals aged 65 years and older. The goal was to evaluate the efficacy of carmustine wafers in prolonging survival for older GBM patients...
  14. doi request reprint Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults
    Kaisorn L Chaichana
    Department of Neurosurgery, Neurology, and Oncology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurosurg 113:286-92. 2010
    ..The prognostic implications of a preoperative contrast-enhancing AA remain poorly understood...
  15. doi request reprint Prognostic significance of contrast-enhancing low-grade gliomas in adults and a review of the literature
    Kaisorn L Chaichana
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Neurol Res 31:931-9. 2009
    ..The prognostic implications of a contrast-enhancing low-grade glioma remain less well understood...
  16. doi request reprint Factors associated with survival for patients with glioblastoma with poor pre-operative functional status
    Kaisorn L Chaichana
    Neuro Oncology Outcomes Laboratory, Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21202, USA
    J Clin Neurosci 20:818-23. 2013
    ..005), tumor size >2 cm (p = 0.01), radical tumor resection (p=0.01), and temozolomide (p = 0.001). This study identifies a subset of patients with poor functional status who may benefit from aggressive surgical resection...
  17. doi request reprint Increased subventricular zone radiation dose correlates with survival in glioblastoma patients after gross total resection
    Linda Chen
    Department of Neurosurgery, The Johns Hopkins University, Baltimore, Maryland, USA
    Int J Radiat Oncol Biol Phys 86:616-22. 2013
    ..The purpose of this study was to examine the relationship between radiation dose to the SVZ and survival in GBM patients...
  18. doi request reprint Complications and death among elderly patients undergoing pituitary tumour surgery
    Rachel Grossman
    Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Neuro Oncology Surgical Outcomes Research Laboratory, Baltimore, MD, USA
    Clin Endocrinol (Oxf) 73:361-8. 2010
    ..Preoperative determinants of surgical risk in elderly patients with pituitary tumour are not fully defined. The aim of this study was to quantify operative risk for these patients...
  19. doi request reprint Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. Clinical article
    Kaisorn L Chaichana
    Department of Neurosurgery, Johns Hopkins University and School of Medicine, Baltimore, Maryland, USA
    J Neurosurg 114:587-94. 2011
    ..The identification of these factors may provide insight into which patients would benefit most from aggressive surgery...
  20. doi request reprint Harvey Cushing's early treatment of meningiomas: the untold story
    Courtney Pendleton
    Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    World Neurosurg 80:217-21. 2013
    ..Cushing provided basic demographic, perioperative, and outcomes data in his tables, but the operative details for many of his early meningioma cases have not been previously described...
  21. ncbi request reprint Neurophysiological monitoring for safe surgical tethered cord syndrome release in adults
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, Moffitt Hospital Room M779, Box 112, San Francisco, CA 94143 0112, USA
    Surg Neurol 62:127-33; discussion 133-5. 2004
    ..Intraoperative neurophysiological monitoring techniques can help to minimize these adverse neurologic outcomes...
  22. pmc Multiple resections for patients with glioblastoma: prolonging survival
    Kaisorn L Chaichana
    Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21202, USA
    J Neurosurg 118:812-20. 2013
    ....
  23. doi request reprint Subventricular zone localized irradiation affects the generation of proliferating neural precursor cells and the migration of neuroblasts
    Pragathi Achanta
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA
    Stem Cells 30:2548-60. 2012
    ....
  24. doi request reprint Harvey Cushing's contributions to motor mapping: 1902-1912
    Courtney Pendleton
    Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cortex 48:7-14. 2012
    ..This review of Cushing's early intra-operative motor mapping illuminates his contributions, and clarifies his influence on the evolution of cortical mapping from an experimental technique to a staple of contemporary neurosurgery...
  25. doi request reprint Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas
    Kaisorn L Chaichana
    Department of Neurosurgery, Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, Maryland, USA
    J Neurosurg 112:10-7. 2010
    ..The authors set out to determine factors that were independently associated with recurrence and malignant degeneration in patients who underwent resection of a hemispheric low-grade glioma...
  26. doi request reprint A surgical modification for performing orbitozygomatic osteotomies: technical note
    James E Conway
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA
    Neurosurg Rev 33:491-500. 2010
    ..This manuscript details the use of a single drill system that can be used for both the craniotomy and the safe and efficient generation of orbitozygomatic osteotomies...
  27. doi request reprint Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas
    Matthew J McGirt
    Department of Neurosurgery, The Johns Hopkins School of Medicine, and Neuro Oncology Surgical Outcomes Research Laboratory, Baltimore, Maryland 21231, USA
    Neurosurgery 63:700-7; author reply 707-8. 2008
    ..It remains unknown whether the extent of surgical resection affects survival or disease progression in patients with supratentorial low-grade gliomas...
  28. ncbi request reprint Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
    Nader Sanai
    Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 427:740-4. 2004
    ..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain...
  29. pmc Factors involved in maintaining prolonged functional independence following supratentorial glioblastoma resection. Clinical article
    Kaisorn L Chaichana
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurosurg 114:604-12. 2011
    ..The aims of this study were to evaluate functional outcomes over time for patients with glioblastoma, as well as identify factors associated with prolonged functional independence...
  30. doi request reprint Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients
    Kaisorn L Chaichana
    The Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Department of Neurosurgery, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 18:239-45. 2011
    ..However, studies on this patient group remain limited. The goal of this study is to evaluate the efficacy of surgery versus biopsy for older patients with these lesions...
  31. pmc Cytoarchitecture of the lateral ganglionic eminence and rostral extension of the lateral ventricle in the human fetal brain
    Hugo Guerrero-Cazares
    Department of Neurosurgery, Brain Tumor Stem Cell Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Comp Neurol 519:1165-80. 2011
    ..The lack of these structures closer to the olfactory bulb could indicate a destination for the migratory neuroblasts outside the olfactory bulb in the human brain...
  32. pmc c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype
    Yunqing Li
    Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:9951-6. 2011
    ..These findings show that c-Met enhances the population of glioblastoma stem cells (GBM SCs) via a mechanism requiring Nanog and potentially other c-Met-responsive reprogramming transcription factors...
  33. doi request reprint Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas
    Kaisorn L Chaichana
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Neurol Res 32:442-8. 2010
    ..Hyperglycemia has been shown to augment tumor growth in vitro. However, the effects of persistent hyperglycemia on survival, recurrence and malignant degeneration in patients undergoing surgery for low grade gliomas remain unknown...
  34. doi request reprint Radiographic and anatomic basis of endoscopic anterior craniocervical decompression: a comparison of endonasal, transoral, and transcervical approaches
    Clinton J Baird
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neurosurgery 65:158-63; discussion 63-4. 2009
    ..To evaluate surgical access to the craniocervical junction using 3 endoscopic approaches: endonasal, transoral, and transcervical...
  35. ncbi request reprint Combined microsurgical and endovascular management of complex intracranial aneurysms
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0012, USA
    Neurosurgery 52:263-74; discussion 274-5. 2003
    ....
  36. ncbi request reprint Thrombotic intracranial aneurysms: classification scheme and management strategies in 68 patients
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:441-54; discussion 441-54. 2005
    ..A classification scheme was devised on the basis of aneurysm, thrombus, and lumen morphology to relate these anatomic features to surgical therapy...
  37. doi request reprint Posthemorrhagic hydrocephalus in preterm neonates: socioeconomic characteristics in a single-institution experience
    Courtney Pendleton
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Pediatr Neurosurg 48:80-5. 2012
    ..The aim of this study is to characterize the demographic profile and follow-up patterns in this subpopulation of surgically treated infants with PHH from prematurity...
  38. doi request reprint Disparities in access to pediatric neurooncological surgery in the United States
    Debraj Mukherjee
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatrics 124:e688-96. 2009
    ..The objective of this study was to investigate whether disparities in access to high-volume centers for neurooncological care existed in the United States in 1988-2005...
  39. doi request reprint Variations in referral patterns for hypophysectomies among pediatric patients with sellar and parasellar tumors
    Debraj Mukherjee
    Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, 1550 Orleans Street, Suite 253, Baltimore, MD 21231, USA
    Childs Nerv Syst 26:305-11. 2010
    ..It remains unknown what preoperative factors influence admission to high-volume centers. We report a nationwide analysis of patients <18 years of age undergoing neurosurgical intervention for these lesions...
  40. doi request reprint Harvey Cushing's repair of a dural defect after a traumatic brain injury: novel use of a fat graft
    Hasan A Zaidi
    Department of Neurosurgery and Oncology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    World Neurosurg 75:696-9. 2011
    ..A review of Harvey Cushing's surgical cases at Johns Hopkins Hospital revealed new information about his early work with the use of fat grafts to close dural defects...
  41. doi request reprint Treatment of pituitary adenomas using radiosurgery and radiotherapy: a single center experience and review of literature
    Daniel Q Sun
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurosurg Rev 34:181-9. 2010
    ....
  42. doi request reprint A modified frontal-nasal-orbital approach to midline lesions of the anterior cranial fossa and skull base: technical note with case illustrations
    Shaan M Raza
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurosurg Rev 33:63-70. 2010
    ..The frontal-nasal-orbital craniotomy is a useful technique for midline lesions of the anterior skull base, and it should be in the armamentarium of neurological surgeons...
  43. doi request reprint The extended retrosigmoid approach for neoplastic lesions in the posterior fossa: technique modification
    Shaan M Raza
    Department of Neurosurgery, The Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurosurg Rev 34:123-9. 2011
    ..This technical modification over the standard retrosigmoid approach may provide a useful advantage to neurosurgeons dealing with these complex lesions...
  44. doi request reprint Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas
    Edward F Chang
    Department of Neurological Surgery, Division of Endocrinology, University of California, San Francisco, California 94143, USA
    J Neurosurg 108:736-45. 2008
    ..The authors' aim was to determine predictors of recurrence and overall survival and to define patient subgroups that may benefit from radiotherapy...
  45. doi request reprint Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors
    Kaisorn L Chaichana
    Johns Hopkins University School of Medicine, Department of Neurosurgery, Baltimore, MD, USA
    Neurol Res 35:206-11. 2013
    ..An understanding may help risk stratify patients and guide subsequent therapy aimed at reducing the risk of DVTs/PEs...
  46. pmc Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases
    Kaisorn L Chaichana
    Department of Neurosurgery, Cancer Research Building, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurosci Methods 164:261-70. 2007
    ....
  47. ncbi request reprint In situ bypass in the management of complex intracranial aneurysms: technique application in 13 patients
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Center for Stroke and Cerebrovascular Disease, University of California, San Francisco, California 94143 0112, USA
    Neurosurgery 57:140-5; discussion 140-5. 2005
    ..An experience with in situ bypasses was retrospectively reviewed...
  48. doi request reprint Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma
    Thomas W Link
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Neurosci 19:996-1000. 2012
    ..These results suggest, together with the broad literature supporting a role for hyperglycemia in neurological injury, that this may represent a modifiable factor in the peri-operative care of these patients...
  49. doi request reprint Unique challenges faced by pediatric neurosurgeon Harvey Cushing in 1909 at Johns Hopkins: a choroid plexus tumor of the lateral ventricle mimicking a cerebellar lesion
    Courtney Pendleton
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Childs Nerv Syst 27:1145-8. 2011
    ..In absence of detailed neuroimaging, erroneous diagnoses and misdirected operative explorations were common within pediatric populations...
  50. doi request reprint Relationship of glioblastoma multiforme to the lateral ventricles predicts survival following tumor resection
    Kaisorn L Chaichana
    Department of Neurosurgery, The Johns Hopkins Hospital, Johns Hopkins School of Medicine, Johns Hopkins University, CRB II, 1550 Orleans Street, Room 247, Baltimore, MD, 21231, USA
    J Neurooncol 89:219-24. 2008
    ..We set out to determine if glioblastoma multiforme (GBM) bordering the LV was associated with decreased survival as compared to non-LV GBM...
  51. doi request reprint Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas
    Matthew J McGirt
    Department of Neurosurgery, Johns Hopkins School of Medicine, and The Johns Hopkins Neuro oncology Surgical Outcomes Research Laboratory, Baltimore, Maryland, USA
    Neurosurgery 63:286-91; discussion 291. 2008
    ..We hypothesized that persistent hyperglycemic states in the outpatient setting may serve as a prognostic marker of decreased survival in patients with malignant brain astrocytomas...
  52. ncbi request reprint Pre-operative factors affecting resectability of giant intracranial meningiomas
    Alfredo Quinones-Hinojosa
    Johns Hopkins Hospital, Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21231, USA
    Can J Neurol Sci 36:623-30. 2009
    ..As a group, it remains largely unknown whether these relatively rare lesions are amenable to radical resection, and what factors influence their resectability...
  53. doi request reprint "No clinical puzzles more interesting": Harvey Cushing and spinal trauma, the Johns Hopkins Hospital 1896-1912
    Hormuzdiyar H Dasenbrock
    School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Neurosurgery 68:420-30; discussion 430. 2011
    ..These cases illustrate Cushing's dedication to and rapport with his patients, even in the face of a dismal prognosis...
  54. pmc Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells
    Mingyao Ying
    Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland 21205, USA
    Stem Cells 29:20-31. 2011
    ..Our results show for the first time that KLF9 has differentiating and tumor-suppressing functions in tumor-initiating stem cells...
  55. doi request reprint Predictors of inpatient death and complications among postoperative elderly patients with metastatic brain tumors
    Rachel Grossman
    Department of Neurosurgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 18:521-8. 2011
    ..Risks of brain surgery in elderly patients with brain metastases are not well defined. This study was designed to quantify the postoperative risk for these patients after brain surgery for metastatic disease to the brain...
  56. doi request reprint "Fulfilling the chief of his duties as a physician": Harvey Cushing, selective dorsal rhizotomy and elective spine surgery for quality of life
    Hormuzdiyar H Dasenbrock
    The Johns Hopkins University School of Medicine, Johns Hopkins Medicine, Baltimore, Maryland 21287, USA
    J Neurosurg Spine 14:421-7. 2011
    ....
  57. ncbi request reprint Diagnosis and management of adult pyogenic osteomyelitis of the cervical spine
    Frank L Acosta
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Neurosurg Focus 17:E2. 2004
    ....
  58. ncbi request reprint Changes in transcranial motor evoked potentials during intramedullary spinal cord tumor resection correlate with postoperative motor function
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:982-93; discussion 982-93. 2005
    ..In this study, we hypothesized that changes in the intraoperative MEPs during tumor resection correlate with postoperative motor function deficits...
  59. ncbi request reprint Preoperative correlation of intraoperative cortical mapping with magnetic resonance imaging landmarks to predict localization of the Broca area
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, The Brain Tumor Research Center, University of California at San Francisco, California 94143 0112, USA
    J Neurosurg 99:311-8. 2003
    ..These landmarks demonstrate novel structural-functional relationships that can be used preoperatively to predict the location of the Broca area...
  60. ncbi request reprint Neurosphere assays: growth factors and hormone differences in tumor and nontumor studies
    Kaisorn Chaichana
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Stem Cells 24:2851-7. 2006
    ..This illustrates the need for a standardized protocol to allow proper comparison among studies and a better assessment of the effects of different factors...
  61. ncbi request reprint Continuous EMG recordings and intraoperative electrical stimulation for identification and protection of cervical nerve roots during foraminal tumor surgery
    LanJun Guo
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 0112, USA
    J Spinal Disord Tech 19:37-42. 2006
    ....
  62. doi request reprint Harvey Cushing's case series of trigeminal neuralgia at the Johns Hopkins Hospital: a surgeon's quest to advance the treatment of the 'suicide disease'
    Hadie Adams
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Acta Neurochir (Wien) 153:1043-50. 2011
    ..There was perhaps no other affliction that captured his attention in the way that TN did, and he built a remarkable legacy of successful treatment. At the time, surgical interventions carried an operative mortality of 20%...
  63. pmc Prognostic factors and survival in primary malignant astrocytomas of the spinal cord: a population-based analysis from 1973 to 2007
    Hadie Adams
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Spine (Phila Pa 1976) 37:E727-35. 2012
    ..Observational cross-sectional study...
  64. doi request reprint Harvey Cushing and early spinal dysraphism repair at Johns Hopkins Hospital
    Courtney Pendleton
    Department of Neurosurgery, Johns Hopkins School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
    J Neurosurg Pediatr 7:47-51. 2011
    ....
  65. ncbi request reprint Frame-based stereotactic biopsy remains an important diagnostic tool with distinct advantages over frameless stereotactic biopsy
    Justin S Smith
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, 505 Parnassus Avenue, 94143 0112 San Francisco, California, USA
    J Neurooncol 73:173-9. 2005
    ..We retrospectively reviewed the UCSF experience with stereotactic brain biopsy from a 9 year period...
  66. pmc Intra-operatively obtained human tissue: protocols and techniques for the study of neural stem cells
    Kaisorn L Chaichana
    Department of Neurosurgery, Brain Tumors Surgery Program, The Johns Hopkins, University School of Medicine, Baltimore, MD 21205, USA
    J Neurosci Methods 180:116-25. 2009
    ..This study describes in detail both current and newly developed laboratory techniques, which in our experience are used to process and study human NSCs and BTSCs from tissue obtained directly from the operating room...
  67. doi request reprint Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme
    Matthew J McGirt
    Departments of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    J Neurosurg 110:583-8. 2009
    ..The authors reviewed their initial experience utilizing combined Gliadel, TMZ, and radiation therapy for the treatment of GBM...
  68. doi request reprint Disparities in access to neuro-oncologic care in the United States
    Debraj Mukherjee
    Neuro Oncology Surgical Outcomes Research Laboratory, Department of Neurosurgery and Oncology, The Johns Hopkins School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
    Arch Surg 145:247-53. 2010
    ..Race/ethnicity and social status influence admission to high-volume hospitals among patients who undergo craniotomy for tumor biopsy or resection...
  69. doi request reprint Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis
    Russell K Hales
    Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, 401 North Broadway, Suite 1440, Baltimore, MD 21231, USA
    J Neurooncol 99:65-71. 2010
    ..Pathologic misdiagnosis should be suspected in patients who are long term survivors of a pediatric high grade astrocytoma...
  70. ncbi request reprint Intraoperative motor mapping of the cerebral peduncle during resection of a midbrain cavernous malformation: technical case report
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:E439; discussion E439. 2005
    ..In addition, intermittent monitoring with transcranial motor evoked potentials (TcMEPs) helps to protect this vital pathway during resection of the lesion...
  71. doi request reprint Role of cancer stem cells in spine tumors: review of current literature
    Wesley Hsu
    Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston Salem, NC 27157 1029, USA
    Neurosurgery 71:117-25. 2012
    ..This discussion is followed by a review of what is known about the role of CSCs in the most common primary tumors of the osseous spine...
  72. pmc Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation
    Tomas Garzon-Muvdi
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Biol 10:e1001320. 2012
    ..Due to the ubiquitous expression of NKCC1 in mammalian tissues, its regulation by WNK kinases may serve as new therapeutic targets for GB aggressiveness and can be exploited by other highly invasive neoplasms...
  73. ncbi request reprint Safety and efficacy of the direct endonasal transsphenoidal approach for challenging sellar tumors
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M 779, P O Box 0112, San Francisco, CA 94143, USA
    J Neurooncol 87:317-25. 2008
    ..Large macroadenomas (3-4 cm) can still be addressed with this simple, unmodified direct endonasal approach. We present our experience with this unique and challenging patient population...
  74. pmc Gliomagenesis and the use of neural stem cells in brain tumor treatment
    Pragathi Achanta
    Department of Neurosurgery, Johns Hopkins University, School of Medicine, CRB II, Room 272, 1550 Orleans Street, Baltimore, MD 21231, USA
    Anticancer Agents Med Chem 10:121-30. 2010
    ..Here, the proposed mechanisms of how brain tumors emerge, the molecular pathways interrupted in NSC pathogenesis and the most recent preclinical results in the use of NSCs for glioma treatment are reviewed...
  75. ncbi request reprint Spinal cord mapping as an adjunct for resection of intramedullary tumors: surgical technique with case illustrations
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, Room M 779, San Francisco, CA 94143 9112, USA
    Neurosurgery 51:1199-206; discussion 1206-7. 2002
    ..We used both antidromically elicited SSEPs for planning the myelotomy site and direct mapping of spinal cord tracts during tumor resection to reduce the risk of neurological deficits and increase the extent of tumor resection...
  76. pmc Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastoma
    Stephany Y Tzeng
    Department of Biomedical Engineering and the Institute for NanoBioTechnology, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA
    Biomaterials 32:5402-10. 2011
    ....
  77. doi request reprint On the shoulders of giants: Harvey Cushing's experience with acromegaly and gigantism at the Johns Hopkins Hospital, 1896-1912
    Courtney Pendleton
    Brain Tumor Stem Cell Laboratory, Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Pituitary 14:53-60. 2011
    ....
  78. ncbi request reprint Assessment of image guided accuracy in a skull model: comparison of frameless stereotaxy techniques vs. frame-based localization
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA, USA
    J Neurooncol 76:65-70. 2006
    ..We sought to evaluate the accuracy of a plastic, disposable burr hole mounted guide for stereotactic biopsy using an IGS and compare the results of different targeting methods with those of frame based localization...
  79. doi request reprint Association of preoperative depression and survival after resection of malignant brain astrocytoma
    Muraya Gathinji
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Surg Neurol 71:299-303, discussion 303. 2009
    ..We set out to determine whether patients with a diagnosis of clinical depression before surgery experienced decreased survival independent of treatment modality or degree of disability...
  80. doi request reprint Harvey Cushing's surgical treatment of a pediatric patient with an intraventricular glioma
    Courtney Pendleton
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Pediatr Neurosurg 46:475-9. 2010
    ..The combination of inadequate technology and incomplete nomenclature systems created challenges for early neurosurgeons, and contributed to the dismal prognosis for brain tumors, particularly within the pediatric population...
  81. doi request reprint Harvey Cushing and pediatric brain tumors at Johns Hopkins: the early stages of development
    Courtney Pendleton
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Neurosurg Pediatr 7:575-88. 2011
    ..However, his contributions to the surgical treatment of these lesions during the early stages of his tenure at the Johns Hopkins Hospital, from 1896 to 1912, remain largely unknown...
  82. pmc Neurosphere culture and human organotypic model to evaluate brain tumor stem cells
    Hugo Guerrero-Cazares
    Brain Tumor Stem Cell Laboratory, Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 568:73-83. 2009
    ..In this chapter, we summarize a method to culture, analyze the cellular characteristics, and study the invasion of BTSCs using a neurosphere assay, cryostat sectioning, and human organotypic brain cortex migration assay, respectively...
  83. ncbi request reprint Neuromonitoring during surgery for metastatic tumors to the spine: intraoperative interpretation and management strategies
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Avenue, M 779, San Francisco, CA 94143 0112, USA
    Neurosurg Clin N Am 15:537-47. 2004
    ..Further experience with these techniques should allow improved results follow-ing surgical procedures in functionally eloquent are as of the spinal cord during the surgical management of metastatic tumors...
  84. doi request reprint Harvey Cushing's operative treatment of metastatic breast cancer to the central nervous system in the early 1900s
    Katherine Latimer
    Department of Neurosurgery and Oncology, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Arch Surg 146:975-9. 2011
    ..At the time, neurologic surgery was in its infancy. Metastases of breast carcinoma to the CNS were recognized; however, many surgeons of the era adhered to a general principle of not operating in these situations...
  85. pmc Applications of neural and mesenchymal stem cells in the treatment of gliomas
    Thomas Kosztowski
    The Johns Hopkins Hospital, Department of Neurosurgery, Johns Hopkins University, CRB II, 1550 Orleans Street, Room 247, Baltimore, MD 21231, USA
    Expert Rev Anticancer Ther 9:597-612. 2009
    ....
  86. ncbi request reprint Incidence of venous thromboembolism in patients undergoing craniotomy and motor mapping for glioma without intraoperative mechanical prophylaxis to the contralateral leg
    Kurtis I Auguste
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco School of Medicine, San Francisco, California 94143 0112, USA
    J Neurosurg 99:680-4. 2003
    ....
  87. ncbi request reprint Falcotentorial meningiomas: clinical, neuroimaging, and surgical features in six patients
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, The Brain Tumor Research Center, University of California at San Francisco, California 94143 0112, USA
    Neurosurg Focus 14:e11. 2003
    ..As a result, their clinical presentation and surgical management are not well described. During the past 3 years, the authors have treated six patients with falcotentorial meningiomas...
  88. doi request reprint Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme
    Matthew J McGirt
    Department of Neurosurgery, The Neuro Oncology Surgical Outcomes Research Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurosurgery 65:463-9; discussion 469-70. 2009
    ..We set out to determine whether new-onset postoperative motor or speech deficits were associated with survival in our institutional experience with glioblastoma multiforme (GBM)...
  89. ncbi request reprint Frameless stereotactic image-guided C1-C2 transarticular screw fixation for atlantoaxial instability: review of 20 patients
    Frank L Acosta
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143 0112, USA
    J Spinal Disord Tech 18:385-91. 2005
    ..We retrospectively studied 20 adults who underwent C1-C2 transarticular screw (TAS) fixation utilizing frameless stereotaxy...
  90. ncbi request reprint Spinal meningiomas: surgical management and outcome
    Oren N Gottfried
    Department of Neurosurgery, University of Utah, Salt Lake City, USA
    Neurosurg Focus 14:e2. 2003
    ..Overall, surgical treatment of spinal meningiomas is associated with favorable outcomes. Spinal meningiomas can be completely resected, are associated with postoperative functional improvement, and the rate of recurrence is low...
  91. ncbi request reprint Biological horizons for targeting brain malignancy
    Samuel A Hughes
    Department of Neurological Surgery, Oregan Health and Sciences University, Portland, Oregon, USA
    Adv Exp Med Biol 671:93-104. 2010
    ..This coming progression of applied cancer stem cell research, coupled with current modalities, promises more comprehensive brain cancer interventions...
  92. doi request reprint Combined endoscopic and microscopic management of pediatric pituitary region tumors through one nostril: technical note with case illustrations
    James L Frazier
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Childs Nerv Syst 24:1469-78. 2008
    ....
  93. ncbi request reprint Spontaneous intracerebral hemorrhage due to coagulation disorders
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California San Francisco School of Medicine, San Francisco, California 94143 0112, USA
    Neurosurg Focus 15:E3. 2003
    ..The authors also discuss clinical features, diagnosis, and management of intracranial hemorrhage resulting from these bleeding disorders...
  94. ncbi request reprint Renal cell carcinoma metastatic to the choroid mimicking intraventricular meningioma
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Can J Neurol Sci 31:115-20. 2004
    ..Metastatic renal cell carcinoma to the choroid plexus is a rare condition and can be easily confused with meningioma...
  95. ncbi request reprint Pediatric intracranial aneurysms: durability of treatment following microsurgical and endovascular management
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
    J Neurosurg 104:82-9. 2006
    ..The authors reviewed their experience at one institution regarding patients treated between 1977 and 2003, focusing on the issue of treatment durability...
  96. doi request reprint Isolated Whipple disease of the brain resembling a tumour
    James L Frazier
    Department of Neurosurgery and Oncology, The Johns Hopkins Neuro Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA
    Acta Neurochir (Wien) 151:173-5. 2009
    ..Isolated Whipple disease of the central nervous system is a rare occurrence. Migratory arthralgias and gastrointestinal problems, including malabsorption, abdominal pain, diarrhea, and weight loss, are common presenting symptoms...
  97. ncbi request reprint PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling
    Erica L Jackson
    Department of Neurological Surgery and Program in Developmental and Stem Cell Biology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 51:187-99. 2006
    ..Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation...
  98. doi request reprint A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiforme
    Kaisorn Chaichana
    Department of Neurosurgery, Johns Hopkins School of Medicine, and The Johns Hopkins Neuro oncology Surgical Outcomes Research Laboratory, Baltimore, Maryland 21231, USA
    J Neurosurg 112:997-1004. 2010
    ....
  99. ncbi request reprint Accuracy over space and time of computer-assisted fluoroscopic navigation in the lumbar spine in vivo
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California, San Francisco, USA
    J Spinal Disord Tech 19:109-13. 2006
    ..We sought to study the intraoperative accuracy of VF over time and space during lumbar pedicle screw placement in human patients...
  100. doi request reprint Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article
    Kaisorn L Chaichana
    Department of Neurosurgery, Johns Hopkins School of Medicine, and Neuro Oncology Surgical Outcomes Research Laboratory, Baltimore, Maryland 21231, USA
    J Neurosurg 111:282-92. 2009
    ..The authors set out to determine preoperative seizure characteristics, effects of surgery on seizure control, and factors associated with prolonged seizure control in patients with malignant astrocytomas...
  101. doi request reprint Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literature
    James L Frazier
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    World Neurosurg 73:53-62; discussion e5. 2010
    ..Several studies have investigated the evolution of low-grade gliomas into malignant gliomas by CT and MRI characteristics, but many have not documented the timing of these transformation processes...

Research Grants4

  1. Neurogenesis in the Human Brain
    Alfredo Quinones Hinojosa; Fiscal Year: 2003
    ....
  2. Migration of Human Neural Stem Cells In Vitro and In Vivo
    Alfredo Quinones Hinojosa; Fiscal Year: 2007
    ..In addition, neural stem cells and cancer stem cells may share similar mechanisms of migration and invasion and understanding this mechanism may lead to better treatments of brain tumors. ..
  3. Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 Stimulation
    Alfredo Quinones Hinojosa; Fiscal Year: 2010
    ..In this study, we propose to understand the role of pro-migratory signals in brain tumor invasion in order to increase the available targets to prevent brain tumor dispersal. ..