T C Quinn

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore
    Kah Ying Ng
    Institute of Infectious Disease and Epidemiology, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore 308433, Singapore
    BMC Infect Dis 13:90. 2013
  2. pmc Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:381. 2012
  3. pmc Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV-2 DNA in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical data
    Bulbulgul Aumakhan
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Virol J 7:328. 2010
  4. pmc Development and evaluation of a clinical algorithm to monitor patients on antiretrovirals in resource-limited settings using adherence, clinical and CD4 cell count criteria
    David Meya
    Infectious Diseases Institute, Makerere University, Kampala, Uganda
    J Int AIDS Soc 12:3. 2009
  5. ncbi request reprint Feasibility of pooling sera for HIV-1 viral RNA to diagnose acute primary HIV-1 infection and estimate HIV incidence
    T C Quinn
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    AIDS 14:2751-7. 2000
  6. ncbi request reprint HIV/AIDS in women: an expanding epidemic
    Thomas C Quinn
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 308:1582-3. 2005
  7. doi request reprint The Johns Hopkins Center for Global Health: transcending borders for world health
    Thomas C Quinn
    Johns Hopkins Center for Global Health, Johns Hopkins University, Baltimore, Maryland 21205 2196, USA
    Acad Med 83:134-42. 2008
  8. ncbi request reprint Circumcision and HIV transmission
    Thomas C Quinn
    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    Curr Opin Infect Dis 20:33-8. 2007
  9. pmc HIV epidemiology and the effects of antiviral therapy on long-term consequences
    Thomas C Quinn
    Johns Hopkins Center for Global Health, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS 22:S7-12. 2008
  10. ncbi request reprint Sex differences in HIV-1 viral load and progression to AIDS
    H Farzadegan
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Lancet 352:1510-4. 1998

Detail Information

Publications138 found, 100 shown here

  1. pmc High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore
    Kah Ying Ng
    Institute of Infectious Disease and Epidemiology, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore 308433, Singapore
    BMC Infect Dis 13:90. 2013
    ..We examined the correlation between HIV-1 subtype and co-receptor usage among treatment-naïve HIV-1 subjects in Singapore. Additionally, we investigated whether the subtype co-receptor association was influenced by stage of infection...
  2. pmc Virologic versus immunologic monitoring and the rate of accumulated genotypic resistance to first-line antiretroviral drugs in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    BMC Infect Dis 12:381. 2012
    ..We compared the genotypic resistance patterns between clients with VLM versus immunological monitoring (IM)...
  3. pmc Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV-2 DNA in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical data
    Bulbulgul Aumakhan
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Virol J 7:328. 2010
    ....
  4. pmc Development and evaluation of a clinical algorithm to monitor patients on antiretrovirals in resource-limited settings using adherence, clinical and CD4 cell count criteria
    David Meya
    Infectious Diseases Institute, Makerere University, Kampala, Uganda
    J Int AIDS Soc 12:3. 2009
    ..abstract:..
  5. ncbi request reprint Feasibility of pooling sera for HIV-1 viral RNA to diagnose acute primary HIV-1 infection and estimate HIV incidence
    T C Quinn
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    AIDS 14:2751-7. 2000
    ..To develop a pooling method for detection of viral RNA for diagnosis of acute HIV infection and estimation of HIV-1 incidence...
  6. ncbi request reprint HIV/AIDS in women: an expanding epidemic
    Thomas C Quinn
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 308:1582-3. 2005
    ..Prevention strategies must address the wide range of gender inequalities that promote the dissemination of HIV-1...
  7. doi request reprint The Johns Hopkins Center for Global Health: transcending borders for world health
    Thomas C Quinn
    Johns Hopkins Center for Global Health, Johns Hopkins University, Baltimore, Maryland 21205 2196, USA
    Acad Med 83:134-42. 2008
    ..The author elaborates on these initiatives and discusses challenges experienced in establishing the center, as well as evaluation methods for determining the center's success...
  8. ncbi request reprint Circumcision and HIV transmission
    Thomas C Quinn
    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    Curr Opin Infect Dis 20:33-8. 2007
    ..To review the recent literature on male circumcision and its effect on HIV acquisition...
  9. pmc HIV epidemiology and the effects of antiviral therapy on long-term consequences
    Thomas C Quinn
    Johns Hopkins Center for Global Health, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS 22:S7-12. 2008
    ..As HIV/AIDS shifts from a fatal to a chronic disease, however, a new range of health complications and threats to mortality are beginning to arise...
  10. ncbi request reprint Sex differences in HIV-1 viral load and progression to AIDS
    H Farzadegan
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Lancet 352:1510-4. 1998
    ..Plasma HIV-1 RNA measurements are used for initiation of antiretroviral treatments. Whether the viral-load association with prognosis is similar in women and men is unknown...
  11. ncbi request reprint Sex differences in longitudinal human immunodeficiency virus type 1 RNA levels among seroconverters
    T R Sterling
    Division of Infectious Diseases, Johns Hopkins University Schoolof Medicine, Baltimore, Maryland 21287, USA
    J Infect Dis 180:666-72. 1999
    ..Understanding the mechanisms responsible for the sex difference in VL may provide insight into HIV-1 pathogenesis...
  12. ncbi request reprint Male circumcision and HIV acquisition and transmission: cohort studies in Rakai, Uganda. Rakai Project Team
    R H Gray
    Johns Hopkins University, School of Hygiene and Public Health, Department of Population and Family Health Sciences, Baltimore, MD 21205, USA
    AIDS 14:2371-81. 2000
    ..Male circumcision is associated with reduced HIV acquisition...
  13. ncbi request reprint Incident Chlamydia trachomatis infections among inner-city adolescent females
    G R Burstein
    Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 280:521-6. 1998
    ..Current guidelines for delivery of adolescent primary care services recommend yearly chlamydia screening for those adolescent females considered to be at risk...
  14. ncbi request reprint Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda
    R H Gray
    Departments of Population and Family Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Lancet 357:1149-53. 2001
    ..The probability of HIV-1 transmission per coital act in representative African populations is unknown. We aimed to calculate this probability overall, and to estimate how it is affected by various factors thought to influence infectivity...
  15. ncbi request reprint Initial plasma HIV-1 RNA levels and progression to AIDS in women and men
    T R Sterling
    Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, MD, USA
    N Engl J Med 344:720-5. 2001
    ..Currently, the guidelines for initiating antiretroviral therapy are applied uniformly to women and men...
  16. pmc Comparison of two measures of human immunodeficiency virus (HIV) type 1 load in HIV risk groups
    C M Lyles
    Departments of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland, USA
    J Clin Microbiol 36:3647-52. 1998
    ..These data also confirm a moderate correlation between cell-associated infectious viral load and plasma HIV RNA load, which appears to be similar by gender and across risk groups...
  17. pmc Evaluation of multiplex real-time PCR for detection of Haemophilus ducreyi, Treponema pallidum, herpes simplex virus type 1 and 2 in the diagnosis of genital ulcer disease in the Rakai District, Uganda
    T R Suntoke
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Sex Transm Infect 85:97-101. 2009
    ....
  18. ncbi request reprint Evaluation of use of a single intravaginal swab to detect multiple sexually transmitted infections in active-duty military women
    A M Rompalo
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Clin Infect Dis 33:1455-61. 2001
    ..Therefore, the use of SISs is acceptable for the simultaneous diagnosis of multiple sexually transmitted infections and has potential for use as a self-administered diagnostic tool with widespread applicability among women...
  19. pmc Predictors of repeat Chlamydia trachomatis infections diagnosed by DNA amplification testing among inner city females
    G R Burstein
    Division of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA
    Sex Transm Infect 77:26-32. 2001
    ..To describe the epidemiology of prevalent and incident chlamydia infection in order to assess the appropriate interval for chlamydia screening; and to identify risk factors predictive of infection and repeat infections...
  20. ncbi request reprint Molecular amplification assays to detect chlamydial infections in urine specimens from high school female students and to monitor the persistence of chlamydial DNA after therapy
    C A Gaydos
    Infectious Disease Division, Johns Hopkins University, Baltimore City Health Department, Maryland, USA
    J Infect Dis 177:417-24. 1998
    ..Use of urine assays for screening sexually active adolescents has the potential to significantly improve control of chlamydial infections...
  21. pmc Use of ligase chain reaction with urine versus cervical culture for detection of Chlamydia trachomatis in an asymptomatic military population of pregnant and nonpregnant females attending Papanicolaou smear clinics
    C A Gaydos
    Infectious Disease Division, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Microbiol 36:1300-4. 1998
    ..The use of LCR testing of urine specimens from asymptomatic women, whether pregnant or not, offers a sensitive and easy method to detect C. trachomatis infection in women...
  22. ncbi request reprint Chlamydia, gonorrhea, and HIV-1 prevalence among five populations of women in the Czech and Slovak Republics
    K A Kacena
    Division of Infectious Diseases, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Sex Transm Dis 28:356-62. 2001
    ....
  23. pmc Mycoplasma genitalium compared to chlamydia, gonorrhoea and trichomonas as an aetiological agent of urethritis in men attending STD clinics
    C Gaydos
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Sex Transm Infect 85:438-40. 2009
    ..To investigate prevalence of Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis in men, frequency of co-infections, and association of organisms with urethritis in men...
  24. pmc Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1
    Megan Wind-Rotolo
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Infect Dis 199:1301-9. 2009
    ..Although resistant viruses fade to undetectable levels in plasma, they may persist as stably integrated proviruses within the latent reservoir in resting CD4(+) T cells, potentially complicating future treatment...
  25. pmc Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure
    Christian T Ruff
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 76:9481-92. 2002
    ....
  26. ncbi request reprint Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads
    Tara L Kieffer
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025, USA
    J Infect Dis 189:1452-65. 2004
    ..Thus, in some patients, HAART suppresses replication to a level that does not allow the evolution of drug resistance over a time frame of years...
  27. ncbi request reprint Risk factors for trachoma: 6-year follow-up of children aged 1 and 2 years
    Y H Hsieh
    Department of Pediatrics, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 152:204-11. 2000
    ..75, 95% CI: 1.09, 12.98). The results suggest that risk factor reduction could diminish persistent disease...
  28. ncbi request reprint Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda
    R H Gray
    Department of Population and Family Health Sciences, The Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Obstet Gynecol 185:1209-17. 2001
    ..The purpose of this study was to assess presumptive sexually transmitted disease treatment on pregnancy outcome and HIV transmission...
  29. ncbi request reprint Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy
    Deborah Persaud
    Department of Pediatrics and Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 23:381-90. 2007
    ..The effect of early therapy on HIV-1 evolution may have implications for long-term pharmacologic control of HIV-1...
  30. pmc Male circumcision for the prevention of HSV-2 and HPV infections and syphilis
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    N Engl J Med 360:1298-309. 2009
    ..We assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) infections and syphilis in HIV-negative adolescent boys and men...
  31. pmc The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia
    G Pantaleo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:254-8. 1997
    ....
  32. doi request reprint Herpes simplex virus type 2 infection among commercial sex workers in Kunming, Yunnan Province, China
    T D Ngo
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Int J STD AIDS 19:694-7. 2008
    ..9, P < 0.001) and having a sex partner within the last six months (OR: 2.2, P < 0.05) showed greater odds of being infected with HSV-2. A strong relationship was found between HSV-2, HIV and HCV infections...
  33. ncbi request reprint Features of Chlamydia trachomatis and Neisseria gonorrhoeae infection in male Army recruits
    J A Cecil
    Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA
    J Infect Dis 184:1216-9. 2001
    ..A substantial number of male army recruits are infected with C. trachomatis, but few are infected with N. gonorrhoeae. Screening on the basis of symptoms alone would miss the majority of both infections...
  34. ncbi request reprint The association of syphilis with risk of human immunodeficiency virus infection in patients attending sexually transmitted disease clinics
    T C Quinn
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD
    Arch Intern Med 150:1297-302. 1990
    ..This study underscores the need for a more comprehensive control program for sexually transmitted diseases, including syphilis and HIV infection...
  35. ncbi request reprint HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy
    M Hermankova
    Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe St, 256 Park Bldg, Baltimore, MD 21287, USA
    JAMA 286:196-207. 2001
    ....
  36. ncbi request reprint Determinants of HIV-1 load in subjects with early and later HIV infections, in a general-population cohort of Rakai, Uganda
    Ronald H Gray
    Department of Population and Family Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Infect Dis 189:1209-15. 2004
    ..GUD was consistently associated with higher HIV loads in subjects with incident and those with prevalent HIV infection, suggesting that treatment of GUD might reduce HIV viremia...
  37. ncbi request reprint Stochastic simulation of the impact of antiretroviral therapy and HIV vaccines on HIV transmission; Rakai, Uganda
    Ronald H Gray
    Department of Population and Family Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA
    AIDS 17:1941-51. 2003
    ..To model the effects of antiretroviral therapy (ART) and HIV vaccines on HIV transmission using empirical data from studies in Rakai, Uganda...
  38. pmc Emergence and persistence of CXCR4-tropic HIV-1 in a population of men from the multicenter AIDS cohort study
    James C Shepherd
    School of Medicine, Johns Hopkins University, MD, USA
    J Infect Dis 198:1104-12. 2008
    ..We conclude that HIV-1 variants that used X4 frequently emerged at high CD4(+) T cell counts and may contribute to the decrease in T cell numbers during late HIV-1 infection...
  39. pmc A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patients
    Daphne Monie
    Johns Hopkins University School of Medicine, Broadway Research Building, Room 879, 733 North Broadway St, Baltimore, MD 21205, USA
    J Virol 79:5185-202. 2005
    ..The ability to analyze archival species in viremic patients may have clinical utility in detecting drug-resistant variants not present in the plasma...
  40. ncbi request reprint Unsuspected gonorrhea and chlamydia in patients of an urban adult emergency department: a critical population for STD control intervention
    S D Mehta
    Department of Epidemiology, Johns Hopkins School of Public Health and Hygiene, Baltimore, Maryland, USA
    Sex Transm Dis 28:33-9. 2001
    ..Many of these infections were clinically unsuspected. These data demonstrate that the ED is a high-risk setting and may be an appropriate site for routine GC and CT screening in 18- to 31-year-old patients...
  41. pmc Diagnostic accuracy of ultrasensitive heat-denatured HIV-1 p24 antigen in non-B subtypes in Kampala, Uganda
    L A Spacek
    Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Int J STD AIDS 22:310-4. 2011
    ..Moreover, the Up24 was positive in 33% of samples deemed undetectable by RT-PCR, which may limit the use of the Up24 to detect viral suppression...
  42. ncbi request reprint A serosurvey of Haemophilus ducreyi, syphilis, and herpes simplex virus type 2 and their association with human immunodeficiency virus among female sex workers in Lagos, Nigeria
    A J Dada
    Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
    Sex Transm Dis 25:237-42. 1998
    ..ducreyi, Treponema pallidum, and herpes simplex virus type 2 (HSV-2) antibodies among female sex workers (FSWs) and their association with human immunodeficiency virus (HIV) antibody status...
  43. ncbi request reprint Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART
    Richard E Nettles
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 293:817-29. 2005
    ....
  44. pmc Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda
    Ronald H Gray
    Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 201:1455-62. 2010
    ..HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression...
  45. pmc Effect of sexually transmitted disease (STD) coinfections on performance of three commercially available immunosorbent assays used for detection of herpes simplex virus type 2-specific antibody in men attending Baltimore, Maryland, STD clinics
    Jean Summerton
    Division of Infectious Diseases, The Johns Hopkins University, 1721 E Madison St, Ross Research Bldg 1159, Baltimore, MD 21205 2196, USA
    Clin Vaccine Immunol 14:1545-9. 2007
    ..The recommended index cutoff value of 1.1 for the Focus and Kalon assays was found to be optimal for this population...
  46. ncbi request reprint Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction
    S R Permar
    W. Harry Feinstone Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
    J Infect Dis 183:532-8. 2001
    ..HIV-infected children with measles may have a prolonged infectious period that potentially enhances measles virus transmission and hinders measles control...
  47. pmc Performance of the Euroline Western blot assay in the detection of herpes simplex virus type 2 antibody in Uganda, China and the USA
    J D Neal
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J STD AIDS 22:342-4. 2011
    ..Among the 437 Ugandans in Rakai, 67.3% were HSV-2-positive by Euroline WB (sensitivity 98.7%, specificity 65.4%). The Euroline WB has a consistently high sensitivity, but specificity varied significantly among the different locations...
  48. ncbi request reprint Human immunodeficiency virus load in breast milk, mastitis, and mother-to-child transmission of human immunodeficiency virus type 1
    R D Semba
    Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Infect Dis 180:93-8. 1999
    ..0001). Mastitis and breast milk HIV-1 load may increase the risk of vertical transmission of HIV-1 through breast-feeding...
  49. ncbi request reprint Molecular epidemiology of HIV-1 subtypes in southern China
    Oliver Laeyendecker
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 38:356-62. 2005
    ....
  50. pmc Performance of a commercial, type-specific enzyme-linked immunosorbent assay for detection of herpes simplex virus type 2-specific antibodies in Ugandans
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Clin Microbiol 42:1794-6. 2004
    ..A higher index cutoff value was required for optimal sensitivity and specificity, and overall performance of the assay was not affected by HIV status...
  51. pmc Effects of genital ulcer disease and herpes simplex virus type 2 on the efficacy of male circumcision for HIV prevention: Analyses from the Rakai trials
    Ronald H Gray
    Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 6:e1000187. 2009
    ..We assessed the role of GUD and HSV-2 in the protection against HIV afforded by MC...
  52. ncbi request reprint Antiretroviral therapy where resources are limited
    Steven J Reynolds
    Division of Infectious Diseases, Johns Hopkins Medical School, Baltimore, USA
    N Engl J Med 348:1806-9. 2003
  53. ncbi request reprint Increased risk of incident HIV during pregnancy in Rakai, Uganda: a prospective study
    Ronald H Gray
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, USA
    Lancet 366:1182-8. 2005
    ..HIV acquisition is significantly higher during pregnancy than in the postpartum period. We did a prospective study to estimate HIV incidence rates during pregnancy and lactation...
  54. pmc Foreskin inflammation is associated with HIV and herpes simplex virus type-2 infections in Rakai, Uganda
    Kristine E Johnson
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, USA
    AIDS 23:1807-15. 2009
    ..We assessed foreskin inflammation associated with HIV and herpes simplex virus type 2 (HSV-2) in circumcised men...
  55. pmc Suppression of human immunodeficiency virus type 1 viral load during acute measles
    William J Moss
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD
    Pediatr Infect Dis J 28:63-5. 2009
    ....
  56. ncbi request reprint Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis
    Michael Davidson
    Center for Clinical Trials, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Infect Dis 186:1013-8. 2002
    ..87 (P=.12) and respective log mean rates of change per month of -0.08 versus -0.21 (P=.08). This latter difference has borderline statistical significance, which suggests that filgrastim may reduce the decline of HIV-1 RNA loads...
  57. pmc The microbicide tenofovir does not inhibit nucleic acid amplification tests for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine samples
    Billie Jo Wood
    The Johns Hopkins University School of Medicine, Division of Infectious Diseases, Baltimore, Maryland, USA
    J Clin Microbiol 46:763-5. 2008
    ..Concentrations of 5% to 0% of tenofovir and the placebo were added to dilutions of C. trachomatis and N. gonorrhoeae. No appreciable inhibition was observed...
  58. pmc Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy
    Justin R Bailey
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Virol 80:4758-70. 2006
    ..Both drug-mediated and natural suppression of HIV-1 replication to levels below 50 copies/ml may limit the stimulation and maintenance of effective NAb responses...
  59. ncbi request reprint Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    Janet D Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA
    Nat Med 9:727-8. 2003
    ..Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely...
  60. pmc Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells
    Justin R Bailey
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Virol 80:6441-57. 2006
    ..The sequences have been deposited in GenBank. The accession numbers are DQ 391282 to DQ 391351 (for env) and DQ 391352 to DQ 392955 (for RT)...
  61. ncbi request reprint Emergency department-based HIV screening and counseling: experience with rapid and standard serologic testing
    G D Kelen
    Department of Emergency Medicine and the Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Emerg Med 33:147-55. 1999
    ....
  62. ncbi request reprint Modification of syphilitic genital ulcer manifestations by coexistent HIV infection
    A M Rompalo
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0003, USA
    Sex Transm Dis 28:448-54. 2001
    ..Conflicting data exist regarding whether HIV infection leads to changes in the clinical manifestations and severity of genital ulcer disease (GUD)...
  63. pmc Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study
    B Aumakhan
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J STD AIDS 22:273-7. 2011
    ..This study provides genital HSV-2 DNA titre as a quantitative and symptom- and sign-based measures as qualitative predictors of HSV-2 shedding from the lower genital tract among HIV-infected women...
  64. ncbi request reprint Myelopathy among Brazilians coinfected with human T-cell lymphotropic virus type I and HIV
    L H Harrison
    Department of International Health, Johns Hopkins University School of Hygiene, Baltimore, MD, USA
    Neurology 48:13-8. 1997
    ..To determine whether subjects coinfected with HTLV-I and HIV have a higher frequency of myelopathy than subjects singly infected with HIV...
  65. pmc Performance of the APTIMA Combo 2 assay for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in female urine and endocervical swab specimens
    C A Gaydos
    Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Microbiol 41:304-9. 2003
    ..trachomatis and N. gonorrhoeae infections in sexually active women and to prevent their costly and serious sequelae...
  66. ncbi request reprint Hospitalization rates in female US Army recruits associated with a screening program for Chlamydia trachomatis
    Kathryn L Clark
    Allied Technology Group, Rockville, Maryland, USA
    Sex Transm Dis 29:1-5. 2002
    ..A volunteer program to test non-healthcare-seeking women for genital Chlamydia trachomatis infection was instituted at the US Army's largest basic training center and evaluated for its effectiveness in reducing sequelae...
  67. ncbi request reprint Prospective study of measles in hospitalized, human immunodeficiency virus (HIV)-infected and HIV-uninfected children in Zambia
    William J Moss
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2179, USA
    Clin Infect Dis 35:189-96. 2002
    ..HIV-infected children constitute a significant proportion of children hospitalized with measles in countries with high HIV prevalence and are more likely to be younger than the age for routine measles immunization...
  68. pmc The effect of viral suppression on cross-sectional incidence testing in the johns hopkins hospital emergency department
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 48:211-5. 2008
    ..To determine the effect of viral suppression on cross-sectional incidence testing...
  69. pmc A randomized, controlled, trial of short cycle intermittent compared to continuous antiretroviral therapy for the treatment of HIV infection in Uganda
    Steven J Reynolds
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e10307. 2010
    ..Short cycle treatment interruption could reduce toxicity and drug costs and contribute to further expansion of antiretroviral therapy (ART) programs...
  70. pmc Update on male circumcision: prevention success and challenges ahead
    Kristine E Johnson
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 401, Baltimore, MD 21205, USA
    Curr Infect Dis Rep 10:243-51. 2008
    ..Efforts should include attention to safety, implications for women, and risk compensation. Rapid, careful establishment of circumcision services is essential to optimize HIV prevention in countries with the highest prevalence...
  71. ncbi request reprint Can nucleic acid amplification tests be used to test for chlamydia and gonorrhoea in microbicide trials?
    Patricia Rizzo-Price
    Division of Infectious Diseases, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Int J STD AIDS 18:543-5. 2007
    ..The potential inhibitory effects of microbicides on the NAATs selected for detection of Ct and Ng should be considered in clinical trials involving topical microbicides...
  72. pmc Evaluation of dry and wet transported intravaginal swabs in detection of Chlamydia trachomatis and Neisseria gonorrhoeae infections in female soldiers by PCR
    Charlotte A Gaydos
    Johns Hopkins University School of Medicine Johns Hopkins University School of Public Health and Hygiene, Baltimore, Maryland 21205, USA
    J Clin Microbiol 40:758-61. 2002
    ..9% (24 of 27) and 98.3% (753 of 766), respectively. PCR testing of wet and dry transported intravaginal swabs to detect chlamydia and gonorrhea infections was an accurate diagnostic method for military women...
  73. pmc Two-year virologic outcomes of an alternative AIDS care model: evaluation of a peer health worker and nurse-staffed community-based program in Uganda
    Larry W Chang
    Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 50:276-82. 2009
    ..We evaluated an alternative model, community-based, comprehensive antiretroviral program staffed primarily by peer health workers and nurses...
  74. pmc Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University School of Medicine, Maryland, USA
    J Infect Dis 199:945-9. 2009
    ..70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878 .)...
  75. pmc Geographic HIV type 1 subtype distribution in Rakai district, Uganda
    Aleisha N Collinson-Streng
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 25:1045-8. 2009
    ..001) and more subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design...
  76. pmc Pregnancy does not affect HIV incidence test results obtained using the BED capture enzyme immunoassay or an antibody avidity assay
    Oliver Laeyendecker
    Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e13259. 2010
    ..Accurate incidence estimates are needed for surveillance of the HIV epidemic. HIV surveillance occurs at maternal-child health clinics, but it is not known if pregnancy affects HIV incidence testing...
  77. pmc Changes in the distribution of HIV type 1 subtypes D and A in Rakai District, Uganda between 1994 and 2002
    Samantha A Conroy
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA
    AIDS Res Hum Retroviruses 26:1087-91. 2010
    ..Over this 8-year period, the overall viral population in this region evolved toward the less virulent HIV-1A strain, most likely as a consequence of the faster disease progression and lower transmissibility of HIV-1D...
  78. pmc Epidemiologic approaches to global health
    Thomas C Quinn
    Johns Hopkins University Center for Global Health, Rangos Building, 855 North Wolfe Street, Suite 530, Baltimore, MD 21205, USA
    Epidemiol Rev 32:1-4. 2010
    ..The authors emphasize the need for ongoing research related to the methods used in global health and for comprehensive surveillance, and they offer suggestions for future directions in global health research...
  79. pmc Setting the stage: current state of affairs and major challenges
    Steven J Reynolds
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Clin Infect Dis 50:S71-6. 2010
    ..The global health community and political leaders will need to overcome these challenges if a long-term effective response to the HIV pandemic is to be achieved...
  80. pmc T-cell enumeration from dried blood spots by quantifying rearranged T-cell receptor-beta genes
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Immunol Methods 354:40-4. 2010
    ..This technique as well as other dried blood spot based technologies could increase the diagnostic and monitoring capabilities in resource-limited settings...
  81. pmc Male circumcision for the prevention of acquisition and transmission of sexually transmitted infections: the case for neonatal circumcision
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Arch Pediatr Adolesc Med 164:78-84. 2010
    ..This review evaluates the recent data that support revision of the AAP policy to fully reflect the evidence of long-term health benefits of male circumcision...
  82. ncbi request reprint Urine nucleic acid amplification tests for the diagnosis of sexually transmitted infections in clinical practice
    Charlotte A Gaydos
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Infect Dis 18:55-66. 2005
    ....
  83. pmc Mycoplasma genitalium as a contributor to the multiple etiologies of cervicitis in women attending sexually transmitted disease clinics
    Charlotte Gaydos
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Sex Transm Dis 36:598-606. 2009
    ....
  84. pmc HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda
    Ned Sacktor
    Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Clin Infect Dis 49:780-6. 2009
    ..The objective of this study was to examine the relationship between HIV subtype and the severity of HIV-associated cognitive impairment among individuals initiating antiretroviral therapy in Uganda...
  85. pmc Evolution of drug resistance after virological failure of a first-line highly active antiretroviral therapy regimen in Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 14:293-7. 2009
    ..This study aimed to determine the extent of viral resistance over time among non-clade B HIV type-1-infected patients in Uganda who were maintained on first-line highly active antiretroviral therapy (HAART) following virological failure...
  86. pmc Antiretroviral drug susceptibility among drug-naive adults with recent HIV infection in Rakai, Uganda
    Susan H Eshleman
    Department of Pathology, Johns Hopkins University School of Medicine, 646 Ross Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    AIDS 23:845-52. 2009
    ..To analyze antiretroviral drug susceptibility in HIV from recently infected adults in Rakai, Uganda, prior to the availability of antiretroviral drug treatment...
  87. ncbi request reprint Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial
    Ronald H Gray
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21215, USA
    Lancet 369:657-66. 2007
    ..Ecological and observational studies suggest that male circumcision reduces the risk of HIV acquisition in men. Our aim was to investigate the effect of male circumcision on HIV incidence in men...
  88. ncbi request reprint Response to antiretroviral therapy in HIV-infected patients attending a public, urban clinic in Kampala, Uganda
    Lisa A Spacek
    Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Infect Dis 42:252-9. 2006
    ..We evaluated clinical, behavioral, and demographic risk factors associated with virologic suppression in a public, urban clinic in Kampala, Uganda...
  89. ncbi request reprint Developments in STD/HIV interactions: the intertwining epidemics of HIV and HSV-2
    Steven J Reynolds
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Ross 1159, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Infect Dis Clin North Am 19:415-25. 2005
    ..Treatment of HSV-2/HIV dually infected individuals may prove to be a low-cost intervention to improve clinical outcomes and delay the need for antiretroviral therapy...
  90. pmc Comparison of three nucleic acid amplification tests for detection of Chlamydia trachomatis in urine specimens
    Charlotte A Gaydos
    Johns Hopkins University, 720 Rutland Ave, Ross 1159, Baltimore, MD 21205, USA
    J Clin Microbiol 42:3041-5. 2004
    ..We found that the LCx, ProbeTec, and AC2 NAATs are highly sensitive and specific methods for the detection of C. trachomatis in urine specimens and can be recommended for noninvasive screening of C. trachomatis in urine...
  91. ncbi request reprint Association of Gag-specific T lymphocyte responses during the early phase of human immunodeficiency virus type 1 infection and lower virus load set point
    Deepa S Patke
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Ross 1150, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Infect Dis 186:1177-80. 2002
    ..733; P=.025). Early sustained T lymphocyte responses to HIV-1 Gag may be important for the establishment of virus load set point...
  92. ncbi request reprint Sustained high prevalence of Chlamydia trachomatis infections in female army recruits
    Charlotte A Gaydos
    Infectious Disease Division, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Sex Transm Dis 30:539-44. 2003
    ..Screening and treatment of infected females has been demonstrated to prevent sequelae such as pelvic inflammatory disease...
  93. pmc Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo
    Monika Hermankova
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 77:7383-92. 2003
    ..In these cells, latency appears to reflect regulation at the level of mRNA production rather than at the level of splicing or nuclear export of viral mRNAs...
  94. ncbi request reprint Screening for HIV infection in high-risk communities by urine antibody testing
    Carol Hilton
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205 2103, USA
    J Acquir Immune Defic Syndr 31:416-21. 2002
    ..To evaluate the effectiveness of urine screening to detect HIV-infected individuals in high-prevalence communities...
  95. ncbi request reprint Correlation of chlamydia pneumoniae infection and severity of accelerated graft arteriosclerosis after cardiac transplantation
    Aruna K Subramanian
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Transplantation 73:761-4. 2002
    ..This study evaluated association between C. pneumoniae infection and accelerated graft arteriosclerosis (AGA), also known as cardiac allograft vasculopathy (CAV), after cardiac transplantation...
  96. pmc Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads
    Deborah Persaud
    Department of Pediatrics, Johns Hopkins University School of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 78:968-79. 2004
    ..Thus, in most children on HAART with clinically undetectable viremia, there is continued virus production without evolution of resistance in the protease gene...
  97. ncbi request reprint Detection of bacteremia in emergency department patients at risk for infective endocarditis using universal 16S rRNA primers in a decontaminated polymerase chain reaction assay
    Richard E Rothman
    Department of Emergency Medicine, Johns Hopkins University, Bethesda, Maryland 21205, USA
    J Infect Dis 186:1677-81. 2002
    ..This assay provides a promising diagnostic for rapid identification of bacteremia, particularly valuable in acute care settings...
  98. ncbi request reprint Total lymphocyte count and hemoglobin combined in an algorithm to initiate the use of highly active antiretroviral therapy in resource-limited settings
    Lisa A Spacek
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AIDS 17:1311-7. 2003
    ..To develop clinical algorithms that improve the sensitivity of surrogate markers to initiate the use of highly active antiretroviral therapy (HAART) in resource-limited settings...
  99. pmc Performance of the MagNA pure LC robot for extraction of Chlamydia trachomatis and Neisseria gonorrhoeae DNA from urine and swab specimens
    Nicholas Dalesio
    School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Microbiol 42:3300-2. 2004
    ..The robot provided a highly sensitive and specific method of DNA extraction...
  100. pmc Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda
    Steven J Reynolds
    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    AIDS 23:697-700. 2009
    ..Our objective was to evaluate immunologic failure criteria against gold standard virologic monitoring...
  101. ncbi request reprint Clinical illness as a marker for initiation of HIV antiretroviral therapy in a rural setting, Rakai, Uganda
    Lisa A Spacek
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J STD AIDS 17:116-20. 2006
    ..6%; P = 0.001).HIV-related illness and WHO stage predicted disease progression. The specificity of clinical illness to predict viral load >55,000 copies/mL was high and could be used to rule in HIV disease requiring ART...