Research Topics
Species | HARRY ALAN QUIGLEYSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Clinical trials for glaucoma neuroprotection are not impossibleHarry A Quigley
Glaucoma Services and Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Curr Opin Ophthalmol 23:144-54. 2012..To discuss issues that affect development of new glaucoma treatments known as neuroprotection...
Evaluation of a combined index of optic nerve structure and function for glaucoma diagnosisMichael V Boland
Glaucoma Service, Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA
BMC Ophthalmol 11:6. 2011..We have therefore defined and tested a new approach to glaucoma diagnosis by combining imaging and visual field data, using the anatomical organization of retinal ganglion cells...- Iris cross-sectional area decreases with pupil dilation and its dynamic behavior is a risk factor in angle closureHarry A Quigley
Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Glaucoma 18:173-9. 2009..To estimate the change in iris cross-sectional (CS) area with pupil dilation using anterior segment optical coherence tomography comparing eyes with angle closure (AC) to open angle glaucoma (OAG)... 
How are glaucoma patients identified?Harry A Quigley
Glaucoma Service and Dana Center for Preventive Ophthalmology Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Glaucoma 12:451-5. 2003..To determine the events that lead to the diagnosis of glaucoma...- Long term results of glaucoma surgery among participants in an east African population surveyH A Quigley
Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Br J Ophthalmol 84:860-4. 2000..To evaluate the long term results of glaucoma surgery among people in East Africa... - Improving eye drop treatment for glaucoma through better adherenceHarry A Quigley
Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2020, USA
Optom Vis Sci 85:374-5. 2008 - New paradigms in the mechanisms and management of glaucomaH A Quigley
Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
Eye (Lond) 19:1241-8. 2005..Diagnostic methods for glaucoma need improvement. The pathogenetic steps to loss of neurons in glaucoma are increasingly understood and non-pressure lowering therapies are on the horizon... - Evaluation of practice patterns for the care of open-angle glaucoma compared with claims data: the Glaucoma Adherence and Persistency StudyHarry A Quigley
Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ophthalmology 114:1599-606. 2007..To perform a chart review to measure the validity of large claims databases in estimating patient cooperation with eyedrop therapy and to assess physician adherence with guidelines for a preferred practice pattern (PPP) using a new metric... - Glaucoma: macrocosm to microcosm the Friedenwald lectureHarry A Quigley
Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Invest Ophthalmol Vis Sci 46:2662-70. 2005 - Possible mechanisms of primary angle-closure and malignant glaucomaHarry A Quigley
Glaucoma Service and the Dana Center for Preventive Ophthamology, Wilmer Ophthamological Institute, John Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Glaucoma 12:167-80. 2003 - Angle-closure glaucoma-simpler answers to complex mechanisms: LXVI Edward Jackson Memorial LectureHarry A Quigley
Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Ophthalmol 148:657-669.e1. 2009..To present evidence-based concepts that will explain mechanisms of angle-closure glaucoma... - Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in ratsH A Quigley
Glaucoma Research Laboratory, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Invest Ophthalmol Vis Sci 41:3460-6. 2000..To determine whether acute experimental glaucoma in rats obstructs retrograde transport of brain-derived neurotrophic factor (BDNF) to retinal ganglion cells (RGCs)... - The prevalence of glaucoma in a population-based study of Hispanic subjects: Proyecto VERH A Quigley
Dana Center for Preventive Ophthalmology, Wilmer Institute, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
Arch Ophthalmol 119:1819-26. 2001..To determine the prevalence of glaucoma in a population-based sample of Hispanic adults older than 40 years... - GlaucomaHarry A Quigley
Glaucoma Service and Dana Center for Preventive Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Lancet 377:1367-77. 2011..Successful gene therapy, which has been used for other eye diseases might be possible for the treatment of glaucoma in the future... - The number of people with glaucoma worldwide in 2010 and 2020H A Quigley
The Glaucoma Service and the Dana Center for Preventive Opthalmalogy, Wilmer Opthalmological Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
Br J Ophthalmol 90:262-7. 2006..To estimate the number of people with open angle (OAG) and angle closure glaucoma (ACG) in 2010 and 2020... - Community screening for eye disease by laypersons: the Hoffberger programHarry A Quigley
Glaucoma Service and the Dana Center for Preventive Ophthalmology and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Ophthalmol 133:386-92. 2002..To describe the results of a community-based eye screening program in Baltimore... - Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout miceHarry A Quigley
Glaucoma Research Laboratory, Wilmer Eye Institute, 600 North Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9205, USA
Exp Eye Res 92:299-305. 2011..Counts of RGC layer cells and optic nerve axons indicate that Jnk3(-/-) mice have an increased number of amacrine cells compared to WT controls... - Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma modelKeith R G Martin
Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287, USA
Invest Ophthalmol Vis Sci 44:4357-65. 2003..Overexpression of the BDNF gene protects RGC as estimated by axon counts in a rat glaucoma model, further supporting the potential feasibility of neurotrophic therapy as a complement to the lowering of IOP in the treatment of glaucoma... - Comparison of optic nerve head topography and visual field in eyes with open-angle and angle-closure glaucomaMichael V Boland
Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA
Ophthalmology 115:239-245.e2. 2008..To compare the optic disc and visual field (VF) alterations in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG)... - Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injectionFrances E Cone
Glaucoma Research Laboratory, Johns Hopkins University School of Medicine, Wilmer Institute, Wilmer 122, 600 North Wolfe Street, Baltimore, MD 21287, USA
Exp Eye Res 91:415-24. 2010..Factors that determine sensitivity to RGC injury can be studied using transgenic mouse strains with inducible models... - Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte lossJanice L Son
Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland, USA
Glia 58:780-9. 2010..In contrast, a large increase in astrocyte reactivity occurred early in both animal models. These results are consistent with astrocytes playing a prominent role in regulating axon loss in glaucoma... - Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanismsZhiyong Yang
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9019, USA
Invest Ophthalmol Vis Sci 48:5539-48. 2007..The authors studied retinal gene expression changes in rats after experimental intraocular pressure elevation and optic nerve transection to elucidate molecular mechanisms of retinal ganglion cell (RGC) death... - Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in ratsHana Levkovitch-Verbin
Glaucoma Research Laboratory, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Invest Ophthalmol Vis Sci 43:402-10. 2002..Light microscopic examination showed only loss of RGCs and their nerve fibers. CONCLUSIONS: Increased IOP caused by a laser injury to the trabecular meshwork represents a useful and efficient model of experimental glaucoma in rats... - Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucomaKeith R G Martin
Glaucoma Research Laboratory, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA
Exp Eye Res 83:255-62. 2006..The effect of IOP elevation on other motor proteins deserves further investigation in the future... - Long-term outcomes in fellow eyes after acute primary angle closure in the contralateral eyeDavid S Friedman
Wilmer Eye Institute, Johns Hopkins University, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Ophthalmology 113:1087-91. 2006..To determine the long-term outcome of the contralateral eye in Asian persons with a unilateral attack of acute primary angle closure (APAC)... - Using pharmacy claims data to study adherence to glaucoma medications: methodology and findings of the Glaucoma Adherence and Persistency Study (GAPS)David S Friedman
Wilmer Eye Institute, Baltimore, MD, USA
Invest Ophthalmol Vis Sci 48:5052-7. 2007..To develop methods for investigating adherence to glaucoma medications by using a modified claims data-based measure of adherence, validation by chart review, and patient and physician interviews... - The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retinaJennifer L Kielczewski
Glaucoma Research Laboratory, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, USA
Invest Ophthalmol Vis Sci 46:3188-96. 2005..After nerve transection, neurotransmitter presence declines, but many amacrine cell bodies remain. Differences among optic nerve injury models, as well as effects on "untreated" fellow eyes, should be recognized... - Variations in treatment among adult-onset open-angle glaucoma patientsDavid S Friedman
Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Ophthalmology 112:1494-9. 2005..To determine the predictors of treatment for glaucoma and suspect glaucoma in a nationally representative sample of diagnosed persons... - Gene expression profiling of purified rat retinal ganglion cellsRonald H Farkas
Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Invest Ophthalmol Vis Sci 45:2503-13. 2004..Retinal ganglion cells (RGCs) are of wide interest in neuroscience and die in glaucoma and other optic neuropathies. In this study the genes expressed by RGCs were profiled by expressed sequence tag (EST) analysis... - A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transectionHana Levkovitch-Verbin
Department of Ophthalmology, Wilmer Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA
Invest Ophthalmol Vis Sci 44:3388-93. 2003..The findings confirm similar results in monkey eyes and provide a rodent model in which pharmacologic interventions against secondary degeneration can be tested... - Glaucoma management among individuals enrolled in a single comprehensive insurance planDavid S Friedman
Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Ophthalmology 112:1500-4. 2005..To determine the management patterns for glaucoma and suspect glaucoma in a nationally representative sample of newly treated persons... - Risk factors for poor adherence to eyedrops in electronically monitored patients with glaucomaDavid S Friedman
Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA
Ophthalmology 116:1097-105. 2009..To identify risk factors for poor adherence to topical once daily therapy for glaucoma... - Increased expression of iron-regulating genes in monkey and human glaucomaRonald H Farkas
Guerrieri Center for Genetic Engineering and Molecular Ophthalmology, Wilmer Ophthalmological Institute, Baltimore, Maryland 21287, USA
Invest Ophthalmol Vis Sci 45:1410-7. 2004..To understand the mechanisms mediating retinal ganglion cell loss in glaucoma, the gene expression patterns were compared for transferrin, ceruloplasmin, and ferritin between normal and glaucomatous retina in monkey and human eyes... - The presence and distribution of elastin in the posterior and retrobulbar regions of the mouse eyeScott Gelman
Glaucoma Research Laboratory, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Exp Eye Res 90:210-5. 2010..Elastin comprises a portion of the mouse sclera and its distribution in the peripapillary area is similar to that in human eyes... - The impact of visual impairment and eye disease on vision-related quality of life in a Mexican-American population: proyecto VERAimee Teo Broman
Dana Center for Preventive Ophthalmology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Invest Ophthalmol Vis Sci 43:3393-8. 2002..Further work on the specific measures of vision associated with reported decreases in quality of life, such as visual field or contrast sensitivity, is warranted... - Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the ratKeith R G Martin
Glaucoma Research Laboratory, Wilmer Eye Institute, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA
Invest Ophthalmol Vis Sci 43:2236-43. 2002..Reductions in GLT-1 and GLAST may increase the potential for glutamate-induced injury to RGC in glaucoma... - Effect of CNTF on retinal ganglion cell survival in experimental glaucomaMary Ellen Pease
Department of Ophthalmology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, 175 Woods Research Building, Baltimore, MD 21287, USA
Invest Ophthalmol Vis Sci 50:2194-200. 2009..To assess the neuroprotective effect of virally mediated overexpression of ciliary-derived neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in experimental rat glaucoma... - Characteristics of progenitor cells derived from adult ciliary body in mouse, rat, and human eyesHangxiu Xu
Glaucoma Research Laboratory, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
Invest Ophthalmol Vis Sci 48:1674-82. 2007..To isolate and characterize progenitor cells derived from adult mammalian ciliary body... - The TRAVATAN Dosing Aid accurately records when drops are takenDavid S Friedman
Glaucoma Division of the Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA
Am J Ophthalmol 143:699-701. 2007..To assess the accuracy of Travatan Dosing Aid recordings... - Manometric calibration and comparison of TonoLab and TonoPen tonometers in rats with experimental glaucoma and in normal miceMary E Pease
Glaucoma Service, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Glaucoma 15:512-9. 2006..To compare the TonoPen and TonoLab tonometers to each other and to manometrically set intraocular pressure (IOP) in the eyes of normal mice, normal rats, and rats with chronic IOP elevation... - Influence of corneal structure, corneal responsiveness, and other ocular parameters on tonometric measurement of intraocular pressureAimee Teo Broman
Dana Center for Preventive Ophthalmology, The Johns Hopkins School of Medicine, Baltimore, MD, USA
J Glaucoma 16:581-8. 2007.... - Gaze behavior of the visually impaired during street crossingDuane R Geruschat
The Maryland School for the Blind, Baltimore, MD, USA
Optom Vis Sci 83:550-8. 2006..This study explored the gaze patterns of fully sighted and visually impaired subjects during the high-risk activity of crossing the street... - Central corneal thickness and corneal hysteresis associated with glaucoma damageNathan G Congdon
Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
Am J Ophthalmol 141:868-75. 2006..We sought to measure the impact of central corneal thickness (CCT), a possible risk factor for glaucoma damage, and corneal hysteresis, a proposed measure of corneal resistance to deformation, on various indicators of glaucoma damage... - Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional dataAimee Teo Broman
Dana Center for Preventive Ophthalmology and the Glaucoma Service, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Invest Ophthalmol Vis Sci 49:66-76. 2008..To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies... - Measurement of amino acid levels in the vitreous humor of rats after chronic intraocular pressure elevation or optic nerve transectionHana Levkovitch-Verbin
Glaucoma Service, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Glaucoma 11:396-405. 2002..In the vitreous of rats with experimental glaucoma, a number of free amino acids were transiently elevated to a modest degree, but no significant difference in vitreous glutamate concentration was detected ( > 0.01)... - The in vitro inflation response of mouse scleraKristin M Myers
Department of Mechanical Engineering, Johns Hopkins University, 3400 North Charles St, Latrobe 125, Baltimore, MD 21218, USA
Exp Eye Res 91:866-75. 2010..Further, the specimen-specific scleral displacement profile and thickness measurements will enable future development of specimen-specific finite element models to analyze the inflation data for material properties... - In vivo time-lapse fluorescence imaging of individual retinal ganglion cells in miceMark K Walsh
Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
J Neurosci Methods 169:214-21. 2008..Additionally, the same RGC that was imaged in vivo could then be located and imaged in fixed retinal whole mount preparations. This novel technique has many potential applications... - Gene delivery to the eye using adeno-associated viral vectorsKeith R G Martin
Wilmer Eye Institute, Wilmer 122, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
Methods 28:267-75. 2002..Our techniques facilitate the study of the pathogenesis of RGC diseases such as glaucoma and the development of novel new treatments based on gene therapy... - Doctor-patient communication in glaucoma care: analysis of videotaped encounters in community-based office practiceDavid S Friedman
Wilmer Eye Institute, Baltimore, Maryland, USA
Ophthalmology 116:2277-85.e1-3. 2009..To assess doctor-patient communication in patients with glaucoma... - Adherence and persistence with glaucoma therapyGail F Schwartz
Greater Baltimore Medical Center, Baltimore, Maryland 21204, USA
Surv Ophthalmol 53:S57-68. 2008..Greater physician awareness of adherence and persistence issues is necessary in order to help the patient become more adherent... - Doctor-patient communication, health-related beliefs, and adherence in glaucoma results from the Glaucoma Adherence and Persistency StudyDavid S Friedman
Wilmer Eye Institute, Baltimore, Maryland 21287, USA
Ophthalmology 115:1320-7, 1327.e1-3. 2008..To use multiple data sources to determine drivers of patient adherence to topical ocular hypotensive therapy... - Risk factors and open-angle glaucoma: classification and applicationMichael V Boland
Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Glaucoma 16:406-18. 2007..We also describe methods for using risk factors in clinical practice and describe ways that a large and complex body of knowledge can be applied to individual patients... - A self-assessment instrument designed for measuring independent mobility in RP patients: generalizability to glaucoma patientsKathleen A Turano
Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Invest Ophthalmol Vis Sci 43:2874-81. 2002....
Research Grants
- PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGEHarry Quigley; Fiscal Year: 2002..In these rats, induced neuronal expression will be studied in a chronic glaucoma model to assess beneficial effects. ..
- Wilmer Inst. Mentored Clinical Research Scholar ProgramHarry Quigley; Fiscal Year: 2007..The Wilmer CRS will administer didactic courses and personal mentored instruction in a wide variety of research areas to two candidates per year. ..
- PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGEHarry Quigley; Fiscal Year: 2007..The studies proposed here have already suggested several new avenues of non-intraocular pressure lowering therapy for glaucoma. ..
- PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGEHarry Quigley; Fiscal Year: 1993....
- THE PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGEHarry Quigley; Fiscal Year: 1980
- PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGEHARRY ALAN QUIGLEY; Fiscal Year: 2010..To complete the project in 2 years, we eliminated from the 5 year proposal Hypotheses 7, 8, 9, and 11. ..