Ann Pulver

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes
    A E Pulver
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Mol Psychiatry 5:650-3. 2000
  2. ncbi request reprint An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophrenia
    Ann E Pulver
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Am J Med Genet B Neuropsychiatr Genet 124:6-9. 2004
  3. pmc Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women
    Yaping Liu
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychiatr Genet 20:184-6. 2010
  4. pmc Functional consequences of PRODH missense mutations
    Hans Ulrich Bender
    Howard Hughes Medical Institute, and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 76:409-20. 2005
  5. ncbi request reprint Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study
    Heather C Strasser
    Division of Psychiatric Neuroimaging, Johns Hopkins University, Baltimore, Catonsville, Maryland
    Biol Psychiatry 57:633-9. 2005
  6. pmc Neuropsychological functioning in bipolar disorder and schizophrenia
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, and Olin Neuropsychiatric Research Center, Hartford Hospital Institute of Living, CT, USA
    Biol Psychiatry 62:179-86. 2007
  7. ncbi request reprint Five latent factors underlying schizophrenia: analysis and relationship to illnesses in relatives
    John A McGrath
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Schizophr Bull 30:855-73. 2004
  8. pmc Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Hum Genet 75:204-19. 2004
  9. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
  10. ncbi request reprint Multipoint affected sibpair linkage methods for localizing susceptibility genes of complex diseases
    David V Glidden
    Department of Epidemiology and Biostatistics, Box 560, University of California, San Francisco, CA 94143 0560, USA
    Genet Epidemiol 24:107-17. 2003

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes
    A E Pulver
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Mol Psychiatry 5:650-3. 2000
    ..008). The identification of multiple susceptibility loci for schizophrenia may be enhanced by stratification of families using psychiatric diagnoses of the non-schizophrenic relatives...
  2. ncbi request reprint An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophrenia
    Ann E Pulver
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Am J Med Genet B Neuropsychiatr Genet 124:6-9. 2004
    ..The failure to support the paternal age hypothesis may be a function of heterogeneous samples, but calls for further research in the context of family studies...
  3. pmc Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women
    Yaping Liu
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychiatr Genet 20:184-6. 2010
    ..Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype--phenotype correlations...
  4. pmc Functional consequences of PRODH missense mutations
    Hans Ulrich Bender
    Howard Hughes Medical Institute, and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 76:409-20. 2005
    ..These observations plus the high degree of polymorphism at the PRODH locus are consistent with the hypothesis that reduction in POX function is a risk factor for schizophrenia...
  5. ncbi request reprint Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study
    Heather C Strasser
    Division of Psychiatric Neuroimaging, Johns Hopkins University, Baltimore, Catonsville, Maryland
    Biol Psychiatry 57:633-9. 2005
    ..One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests that psychotic (PBP) and nonpsychotic (NPBP) forms of BP are two subtypes that might differ in pathophysiology...
  6. pmc Neuropsychological functioning in bipolar disorder and schizophrenia
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, and Olin Neuropsychiatric Research Center, Hartford Hospital Institute of Living, CT, USA
    Biol Psychiatry 62:179-86. 2007
    ..Some patients with bipolar disorder (BD) demonstrate neuropsychological deficits even when stable. However, it remains unclear whether these differ qualitatively from those seen in schizophrenia (SZ)...
  7. ncbi request reprint Five latent factors underlying schizophrenia: analysis and relationship to illnesses in relatives
    John A McGrath
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Schizophr Bull 30:855-73. 2004
    ..Increased early onset/developmental signs in the proband were also associated with increased risk for depression in relatives. These findings suggest a possible endophenotypic role for the factor scores in future studies...
  8. pmc Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Hum Genet 75:204-19. 2004
    ....
  9. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
    ..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
  10. ncbi request reprint Multipoint affected sibpair linkage methods for localizing susceptibility genes of complex diseases
    David V Glidden
    Department of Epidemiology and Biostatistics, Box 560, University of California, San Francisco, CA 94143 0560, USA
    Genet Epidemiol 24:107-17. 2003
    ....
  11. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  12. pmc Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
    Am J Hum Genet 77:918-36. 2005
    ..They provide further support for shared genetic susceptibility between these two disorders that involve glutamate-signaling pathways...
  13. pmc Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21231, USA
    Am J Hum Genet 73:601-11. 2003
    ..2 Mb for the location of the trait locus (D10S1677 to D10S1753). We find these results encouraging for the study of schizophrenia among Ashkenazi families and suggest further linkage and association studies in this chromosome 10q region...
  14. ncbi request reprint Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene
    Dimitrios Avramopoulos
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Genet Med 9:745-51. 2007
    ..This study is a second stage follow-up focusing on regions that showed positive linkage scores in our previous scan but were not fine-mapped at that time...
  15. pmc Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses
    Atsushi Kamiya
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Gen Psychiatry 65:996-1006. 2008
    ..A role for the centrosome has been suggested in the pathology of major mental illnesses, especially schizophrenia (SZ)...
  16. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...

Research Grants24

  1. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Ann Pulver; Fiscal Year: 2007
    ..abstract_text> ..
  2. Chronic Psychiatric Disorders: Linking Genes to Functional Disability
    Ann Pulver; Fiscal Year: 2007
    ....
  3. A Genome Wide SNP Association Study: Schizophrenia
    Ann Pulver; Fiscal Year: 2007
    ..We will make all SNP genotyping data publicly available and deposit dnas and clinical data into the national repository at the NIMH Center for Genetic Studies. ..
  4. Chronic Psychiatric Disorders: Linking Genes to Functional Disability
    Ann Pulver; Fiscal Year: 2009
    ....
  5. Schizophrenia Susceptibility Genes
    Ann Pulver; Fiscal Year: 2004
    ..abstract_text> ..
  6. HETEROGENEITY OF SCHIZOPHRENIA
    Ann Pulver; Fiscal Year: 2001
    ....
  7. HETEROGENEITY OF BIPOLAR DISORDER
    Ann Pulver; Fiscal Year: 2003
    ....
  8. Chronic Psychiatric Disorders: Linking Genes to Functional Disability
    Ann E Pulver; Fiscal Year: 2010
    ....