James Potash

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
  2. ncbi request reprint Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships
    J B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Am J Psychiatry 157:2048-50. 2000
  3. doi request reprint Neuropsychiatric disorders: Shared genetics of bipolar disorder and schizophrenia
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Nat Rev Neurol 5:299-300. 2009
  4. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
  5. ncbi request reprint Carving chaos: genetics and the classification of mood and psychotic syndromes
    James B Potash
    Mood Disorders Program, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Harv Rev Psychiatry 14:47-63. 2006
  6. ncbi request reprint Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
    Am J Psychiatry 160:680-6. 2003
  7. ncbi request reprint Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 116:90-7. 2003
  8. ncbi request reprint Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1
    James B Potash
    Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
    Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008
  9. ncbi request reprint The familial aggregation of psychotic symptoms in bipolar disorder pedigrees
    J B Potash
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 158:1258-64. 2001
  10. ncbi request reprint Searching high and low: a review of the genetics of bipolar disorder
    J B Potash
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bipolar Disord 2:8-26. 2000

Detail Information

Publications54

  1. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  2. ncbi request reprint Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships
    J B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Am J Psychiatry 157:2048-50. 2000
    ..This study examined the clinical and familial relationships between comorbid alcoholism and attempted suicide in affectively ill relatives of probands with bipolar I disorder...
  3. doi request reprint Neuropsychiatric disorders: Shared genetics of bipolar disorder and schizophrenia
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Nat Rev Neurol 5:299-300. 2009
    ..An assessment of 73,929 people with bipolar disorder and/or schizophrenia from a Swedish registry found evidence that the two disorders also share more than half of their genetic determinants...
  4. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
    ..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies...
  5. ncbi request reprint Carving chaos: genetics and the classification of mood and psychotic syndromes
    James B Potash
    Mood Disorders Program, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Harv Rev Psychiatry 14:47-63. 2006
    ..No gene variants have yet met these tests in bipolar disorder or schizophrenia...
  6. ncbi request reprint Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
    Am J Psychiatry 160:680-6. 2003
    ....
  7. ncbi request reprint Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 116:90-7. 2003
    ..Families with this subtype should be used to search for susceptibility genes common to bipolar disorder and schizophrenia, and for biological markers that may be shared with schizophrenia...
  8. ncbi request reprint Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1
    James B Potash
    Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
    Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008
    ..Further work is needed to confirm these results and uncover the functional variation underlying the association signal...
  9. ncbi request reprint The familial aggregation of psychotic symptoms in bipolar disorder pedigrees
    J B Potash
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 158:1258-64. 2001
    ..The authors tested this hypothesis in families ascertained for a genetic study of bipolar disorder...
  10. ncbi request reprint Searching high and low: a review of the genetics of bipolar disorder
    J B Potash
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bipolar Disord 2:8-26. 2000
    ..To review the methodologies and findings in the genetics of bipolar disorder (BPD), and to suggest future directions for research...
  11. ncbi request reprint Genetics of recurrent early-onset major depression (GenRED): significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markers
    Douglas F Levinson
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
    Am J Psychiatry 164:259-64. 2007
    ....
  12. ncbi request reprint Genetics of recurrent early-onset major depression (GenRED): final genome scan report
    Peter Holmans
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
    Am J Psychiatry 164:248-58. 2007
    ....
  13. pmc Genome-wide linkage and follow-up association study of postpartum mood symptoms
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 166:1229-37. 2009
    ..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms...
  14. ncbi request reprint Clinical correlates and familial aggregation of age at onset in bipolar disorder
    Ping I Lin
    Dept of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N Broadway, 8th Floor, Baltimore, MD 21205, USA
    Am J Psychiatry 163:240-6. 2006
    ....
  15. doi request reprint Family-based association of FKBP5 in bipolar disorder
    V L Willour
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 14:261-8. 2009
    ..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses...
  16. ncbi request reprint The genetics of psychotic bipolar disorder
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe Street, Meyer 4 119, Baltimore, MD 21287, USA
    Curr Psychiatry Rep 10:178-89. 2008
    ..These tentative results are consistent with the hypothesis that the subphenotype of psychotic BP may represent a clinical manifestation of "overlap" genes between schizophrenia and mood disorder syndromes...
  17. doi request reprint Family-based association study of Neuregulin 1 with psychotic bipolar disorder
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009
    ....
  18. ncbi request reprint SNP fine mapping of chromosome 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 144:625-30. 2007
    ..Several other interesting candidate genes are also located nearby. The congruence of findings across methods and samples suggests further investigation is warranted in these two targeted regions...
  19. pmc Neurotransmission and bipolar disorder: a systematic family-based association study
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008
    ....
  20. pmc Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3
    Ranjana Verma
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Biol Psychiatry 63:1185-9. 2008
    ..Here we present initial linkage-disequilibrium (LD) fine mapping of this signal and sequence analysis of NTRK3 (neurotrophic receptor kinase-3), a biologically plausible candidate gene...
  21. ncbi request reprint Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
    Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003
    ..Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes...
  22. pmc QuickSNP: an automated web server for selection of tagSNPs
    Deepak Grover
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Nucleic Acids Res 35:W115-20. 2007
    ..The server is freely available and can be accessed at the URL http://bioinformoodics.jhmi.edu/quickSNP.pl...
  23. pmc Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008
    ..00000172). It remains significant after correcting for multiple testing using the False Discovery Rate method. Our results indicate an interaction between three circadian genes in susceptibility to bipolar disorder...
  24. pmc Case-control association study of TGOLN2 in attempted suicide
    Pamela B Mahon
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1016-23. 2010
    ..Taken together, these analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders...
  25. pmc A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicity
    Francis M Mondimore
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Affect Disord 100:171-7. 2007
    ..Because familial clustering is one component of diagnostic validity we compared family clustering of chronicity as defined in the DSM-IV to that of chronicity determined by an assessment of lifetime course of depressive illness...
  26. ncbi request reprint Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Psychiatry 159:30-5. 2002
    ..This study used diagnostic data from the NIMH Bipolar Disorder Genetics Initiative to assess in a separate, larger family set the familiality of panic combined with bipolar disorder...
  27. ncbi request reprint Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21
    Virginia L Willour
    The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003
    ..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35...
  28. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    ..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder...
  29. ncbi request reprint Recent findings on the genetic basis of bipolar disorder
    Jennifer L Payne
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, 600 North Wolfe Street, Meyer 3 181, Baltimore, MD 21287, USA
    Psychiatr Clin North Am 28:481-98, ix. 2005
    ..This article reviews the most recent findings and the emerging picture in the genetics of bipolar disorder...
  30. doi request reprint Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
    Arch Womens Ment Health 12:27-34. 2009
    ..Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use...
  31. doi request reprint Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Bipolar Disord 10:38-44. 2008
    ..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees...
  32. ncbi request reprint Psychotic features in bipolar and unipolar depression
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Bipolar Disord 9:901-6. 2007
    ..We examined the relationship of psychotic depression to polarity in several large familial samples of mood disorder...
  33. ncbi request reprint Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees
    Francis M Mondimore
    Johns Hopkins Hospital, Meyer 3 181, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 163:1554-60. 2006
    ..The authors used a large sample collected for genetic studies to determine whether a chronic course of illness defines a familial clinical subtype in major depressive disorder...
  34. ncbi request reprint Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depression
    Ranjana Verma
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1079-82. 2007
    ..2%, P = 0.15). None of the tag SNPs showed any evidence of association. Our results do not support a major role for either common or rare p11 SNPs with MDD. Several limitations of the study are discussed...
  35. ncbi request reprint Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12
    Virginia L Willour
    Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 61:725-7. 2007
    ..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide...
  36. ncbi request reprint Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorder
    Sarven Sabunciyan
    Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1083-6. 2007
    ..All individuals with the rs28757218 polymorphism were heterozygous for the allele. Based on this positive case-control association finding, we conclude that variations in OTX2 might confer risk for the development of bipolar disorder...
  37. ncbi request reprint Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder
    Jennifer L Payne
    Department of Psychiatry, Women s Mood Disorders Center, The Johns Hopkins Hospital, 600 North Wolfe Street Meyer 3 181, Baltimore, MD 21287 7381, United States
    J Affect Disord 99:221-9. 2007
    ..We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP)...
  38. ncbi request reprint Rapid mood switching and suicidality in familial bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bipolar Disord 7:441-8. 2005
    ....
  39. doi request reprint Family-based association of YWHAH in psychotic bipolar disorder
    Deepak Grover
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:977-83. 2009
    ....
  40. ncbi request reprint Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  41. ncbi request reprint Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study
    Heather C Strasser
    Division of Psychiatric Neuroimaging, Johns Hopkins University, Baltimore, Catonsville, Maryland
    Biol Psychiatry 57:633-9. 2005
    ..One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests that psychotic (PBP) and nonpsychotic (NPBP) forms of BP are two subtypes that might differ in pathophysiology...
  42. pmc Family-based SNP association study on 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 147:612-8. 2008
    ..These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility...
  43. pmc Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice
    Richard S Lee
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
    Endocrinology 151:4332-43. 2010
    ..In the CORT-treated mice, we also observed changes in blood DNAm in Fkbp5. Our results suggest DNAm plays a role in mediating effects of glucocorticoid exposure on Fkbp5 function, with potential consequences for behavior...
  44. ncbi request reprint Characterization of CTG/CAG repeats on chromosome 18: a study of bipolar disorder
    Theresa Swift-Scanlan
    George Browne Genetics Laboratory, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7463, USA
    Psychiatr Genet 15:91-9. 2005
    ..These 29 trinucleotide-repeat-containing genes may be involved in functional modulation of their respective proteins, and may be candidates for other diseases or disease mechanisms that map to this region...
  45. ncbi request reprint Is perinatal depression familial?
    Kathleen Murphy-Eberenz
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
    J Affect Disord 90:49-55. 2006
    ....
  46. pmc Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q
    Ping I Lin
    Department of Mental Health, The Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Hum Genet 77:545-55. 2005
    ..This inconsistency may be due to differences in the AAO characteristics of the samples examined. Future studies to fine map susceptibility genes for BP on chromosomes 21q22.13 and 18p11.2 should take AAO into account...
  47. pmc DNA methylation signatures within the human brain
    Christine Ladd-Acosta
    Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Hum Genet 81:1304-15. 2007
    ..These results were validated for all six genes tested in a replicate set of 57 samples. Our data suggest that DNA methylation signatures distinguish brain regions and may help account for region-specific functional specialization...
  48. ncbi request reprint Relationship between cortisol responses to stress and personality
    Lynn M Oswald
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropsychopharmacology 31:1583-91. 2006
    ..These findings suggest that personality traits that have been traditionally associated with greater psychopathology were also associated with blunted HPA axis responses to stress...
  49. pmc The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    Rafael A Irizarry
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Nat Genet 41:178-86. 2009
    ....
  50. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  51. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  52. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
    ..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region...
  53. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  54. ncbi request reprint Delirium from baclofen withdrawal after suicide attempt
    R Robert Auger
    Sleep Disorders Center, Mayo Medical Center, Eisenberg 8G, 200 First St Southwest, Rochester, MN 55905, USA
    Psychosomatics 46:151-2. 2005

Research Grants15

  1. STUDIES OF GENOMIC IMPRINTING IN BIPOLAR DISORDER
    James Potash; Fiscal Year: 2005
    ....
  2. A genome-wide approach to the epigenetics of stress and depression
    James B Potash; Fiscal Year: 2010
    ..By identifying genomic locations where stress changes DNA methylation in the brain, we hope to glean fundamental new insights into the pathogenesis of depression and thus advance the effort to improve treatments for this illness. ..
  3. Genetic Linkage and Association in Bipolar Disorder
    James Potash; Fiscal Year: 2009
    ..These new variants would then be tested for association in our sample. The important findings that have already emerged from our very carefully assessed sample argue for the benefits of extending this valuable resource. ..
  4. GENETICS OF EARLY ONSET DEPRESSION
    James Potash; Fiscal Year: 2007
    ..abstract_text> ..
  5. Epigenetic Variation and its Determinants in Depression
    James Potash; Fiscal Year: 2007
    ..Results from the novel studies proposed in this application should shed light on the epigenetic mechanisms and gene-environment interactions that result in vulnerability to depression. ..
  6. 1/2 Rare Bipolar Loci identification through Synaptome Sequencing
    James B Potash; Fiscal Year: 2010
    ..We therefore consider that discovery of bipolar disorder genes encoding synaptic proteins has very high translational potential as these potentially represent the most "druggable" targets in bipolar disorder. ) ..