Research Topics
Species | James PotashSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33Fernando S Goes
Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
Am J Psychiatry 164:236-47. 2007..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...- Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationshipsJ B Potash
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
Am J Psychiatry 157:2048-50. 2000..This study examined the clinical and familial relationships between comorbid alcoholism and attempted suicide in affectively ill relatives of probands with bipolar I disorder... 
Neuropsychiatric disorders: Shared genetics of bipolar disorder and schizophreniaJames B Potash
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
Nat Rev Neurol 5:299-300. 2009..An assessment of 73,929 people with bipolar disorder and/or schizophrenia from a Swedish registry found evidence that the two disorders also share more than half of their genetic determinants...- The bipolar disorder phenome database: a resource for genetic studiesJames B Potash
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
Am J Psychiatry 164:1229-37. 2007..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies... - Carving chaos: genetics and the classification of mood and psychotic syndromesJames B Potash
Mood Disorders Program, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Harv Rev Psychiatry 14:47-63. 2006..No gene variants have yet met these tests in bipolar disorder or schizophrenia... - Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorderJames B Potash
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
Am J Psychiatry 160:680-6. 2003.... - Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigreesJames B Potash
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 116:90-7. 2003..Families with this subtype should be used to search for susceptibility genes common to bipolar disorder and schizophrenia, and for biological markers that may be shared with schizophrenia... - Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1James B Potash
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008..Further work is needed to confirm these results and uncover the functional variation underlying the association signal... - The familial aggregation of psychotic symptoms in bipolar disorder pedigreesJ B Potash
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, 600 North Wolfe St, Baltimore, MD 21287, USA
Am J Psychiatry 158:1258-64. 2001..The authors tested this hypothesis in families ascertained for a genetic study of bipolar disorder... - Searching high and low: a review of the genetics of bipolar disorderJ B Potash
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Bipolar Disord 2:8-26. 2000..To review the methodologies and findings in the genetics of bipolar disorder (BPD), and to suggest future directions for research... - Genetics of recurrent early-onset major depression (GenRED): significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markersDouglas F Levinson
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
Am J Psychiatry 164:259-64. 2007.... - Genetics of recurrent early-onset major depression (GenRED): final genome scan reportPeter Holmans
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
Am J Psychiatry 164:248-58. 2007.... - Genome-wide linkage and follow-up association study of postpartum mood symptomsPamela Belmonte Mahon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
Am J Psychiatry 166:1229-37. 2009..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms... - Clinical correlates and familial aggregation of age at onset in bipolar disorderPing-I Lin
Dept. of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N. Broadway, 8th Floor, Baltimore, MD 21205, USA
Am J Psychiatry 163:240-6. 2006..Thus, age at onset may conceivably be used to identify more homogeneous groups of bipolar disorder families and thereby facilitate the mapping of bipolar disorder susceptibility genes... - Family-based association of FKBP5 in bipolar disorderV L Willour
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Mol Psychiatry 14:261-8. 2009..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses... - The genetics of psychotic bipolar disorderFernando S Goes
Johns Hopkins Hospital, 600 North Wolfe Street, Meyer 4 119, Baltimore, MD 21287, USA
Curr Psychiatry Rep 10:178-89. 2008..These tentative results are consistent with the hypothesis that the subphenotype of psychotic BP may represent a clinical manifestation of "overlap" genes between schizophrenia and mood disorder syndromes... - Family-based association study of Neuregulin 1 with psychotic bipolar disorderFernando S Goes
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009.... - SNP fine mapping of chromosome 8q24 in bipolar disorderPeter P Zandi
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Med Genet B Neuropsychiatr Genet 144:625-30. 2007..Several other interesting candidate genes are also located nearby. The congruence of findings across methods and samples suggests further investigation is warranted in these two targeted regions... 
Neurotransmission and bipolar disorder: a systematic family-based association studyJiajun Shi
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008....- Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3Ranjana Verma
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Biol Psychiatry 63:1185-9. 2008..Here we present initial linkage-disequilibrium (LD) fine mapping of this signal and sequence analysis of NTRK3 (neurotrophic receptor kinase-3), a biologically plausible candidate gene... - Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and XPeter P Zandi
Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003..Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes... - QuickSNP: an automated web server for selection of tagSNPsDeepak Grover
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Nucleic Acids Res 35:W115-20. 2007..The server is freely available and can be accessed at the URL http://bioinformoodics.jhmi.edu/quickSNP.pl... - Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythmJiajun Shi
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008..00000172). It remains significant after correcting for multiple testing using the False Discovery Rate method. Our results indicate an interaction between three circadian genes in susceptibility to bipolar disorder... - Case-control association study of TGOLN2 in attempted suicidePamela B Mahon
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 153:1016-23. 2010..Taken together, these analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders... - A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicityFrancis M Mondimore
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
J Affect Disord 100:171-7. 2007..Because familial clustering is one component of diagnostic validity we compared family clustering of chronicity as defined in the DSM-IV to that of chronicity determined by an assessment of lifetime course of depressive illness... - Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Psychiatry 159:30-5. 2002..This study used diagnostic data from the NIMH Bipolar Disorder Genetics Initiative to assess in a separate, larger family set the familiality of panic combined with bipolar disorder... - Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21Virginia L Willour
The Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35... - Association study of Wnt signaling pathway genes in bipolar disorderPeter P Zandi
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
Arch Gen Psychiatry 65:785-93. 2008..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder... - Recent findings on the genetic basis of bipolar disorderJennifer L Payne
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, 600 North Wolfe Street, Meyer 3 181, Baltimore, MD 21287, USA
Psychiatr Clin North Am 28:481-98, ix. 2005..This article reviews the most recent findings and the emerging picture in the genetics of bipolar disorder... - Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigreesJennifer L Payne
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
Arch Womens Ment Health 12:27-34. 2009..Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use... - Familial aggregation of postpartum mood symptoms in bipolar disorder pedigreesJennifer L Payne
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Bipolar Disord 10:38-44. 2008..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees... - Psychotic features in bipolar and unipolar depressionFernando S Goes
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
Bipolar Disord 9:901-6. 2007..We examined the relationship of psychotic depression to polarity in several large familial samples of mood disorder... - Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigreesFrancis M Mondimore
Johns Hopkins Hospital, Meyer 3 181, 600 North Wolfe St, Baltimore, MD 21287, USA
Am J Psychiatry 163:1554-60. 2006..The authors used a large sample collected for genetic studies to determine whether a chronic course of illness defines a familial clinical subtype in major depressive disorder... - Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depressionRanjana Verma
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 144:1079-82. 2007..2%, P = 0.15). None of the tag SNPs showed any evidence of association. Our results do not support a major role for either common or rare p11 SNPs with MDD. Several limitations of the study are discussed... - Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12Virginia L Willour
Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Psychiatry 61:725-7. 2007..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide... - Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorderSarven Sabunciyan
Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 144:1083-6. 2007..All individuals with the rs28757218 polymorphism were heterozygous for the allele. Based on this positive case-control association finding, we conclude that variations in OTX2 might confer risk for the development of bipolar disorder... - Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorderJennifer L Payne
Department of Psychiatry, Women s Mood Disorders Center, The Johns Hopkins Hospital, 600 North Wolfe Street Meyer 3 181, Baltimore, MD 21287 7381, United States
J Affect Disord 99:221-9. 2007..We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP)... - Rapid mood switching and suicidality in familial bipolar disorderDean F MacKinnon
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Bipolar Disord 7:441-8. 2005.... - Family-based association of YWHAH in psychotic bipolar disorderDeepak Grover
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Am J Med Genet B Neuropsychiatr Genet 150:977-83. 2009.... - Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigreesMelvin G McInnis
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287-7463, USA
Biol Psychiatry 54:1265-73. 2003..Application of conditional analyses is potentially useful in larger sample collections to identify susceptibility genes of modest influence that may not be identified in a genome-wide scan aimed to identify single gene effects... - Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot studyHeather C Strasser
Division of Psychiatric Neuroimaging, Johns Hopkins University, Baltimore, Catonsville, Maryland
Biol Psychiatry 57:633-9. 2005..CONCLUSIONS: These results suggest that PBP but not NPBP is associated with increased ventricle volumes and a trend toward smaller left hippocampal volumes, as observed in SZ... - Family-based SNP association study on 8q24 in bipolar disorderPeter P Zandi
Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
Am J Med Genet B Neuropsychiatr Genet 147:612-8. 2008..These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility... - Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in miceRichard S Lee
Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
Endocrinology 151:4332-43. 2010..In the CORT-treated mice, we also observed changes in blood DNAm in Fkbp5. Our results suggest DNAm plays a role in mediating effects of glucocorticoid exposure on Fkbp5 function, with potential consequences for behavior... - Characterization of CTG/CAG repeats on chromosome 18: a study of bipolar disorderTheresa Swift-Scanlan
George Browne Genetics Laboratory, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287-7463, USA
Psychiatr Genet 15:91-9. 2005..These 29 trinucleotide-repeat-containing genes may be involved in functional modulation of their respective proteins, and may be candidates for other diseases or disease mechanisms that map to this region... - Is perinatal depression familial?Kathleen Murphy-Eberenz
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
J Affect Disord 90:49-55. 2006.... - Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21qPing-I Lin
Department of Mental Health, The Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
Am J Hum Genet 77:545-55. 2005..This inconsistency may be due to differences in the AAO characteristics of the samples examined. Future studies to fine map susceptibility genes for BP on chromosomes 21q22.13 and 18p11.2 should take AAO into account... - DNA methylation signatures within the human brainChristine Ladd Acosta
Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Hum Genet 81:1304-15. 2007..These results were validated for all six genes tested in a replicate set of 57 samples. Our data suggest that DNA methylation signatures distinguish brain regions and may help account for region-specific functional specialization... - Relationship between cortisol responses to stress and personalityLynn M Oswald
Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuropsychopharmacology 31:1583-91. 2006..These findings suggest that personality traits that have been traditionally associated with greater psychopathology were also associated with blunted HPA axis responses to stress... - The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shoresRafael A Irizarry
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Nat Genet 41:178-86. 2009.... - Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigreesThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
Biol Psychiatry 56:18-23. 2004.... - Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8qMatthew B McQueen
Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
Am J Hum Genet 77:582-95. 2005..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches... - Sequence variation in DOCK9 and heterogeneity in bipolar disorderSevilla D Detera-Wadleigh
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
Psychiatr Genet 17:274-86. 2007..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region... - Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection... - Delirium from baclofen withdrawal after suicide attemptR Robert Auger
Sleep Disorders Center, Mayo Medical Center, Eisenberg 8G, 200 First St. Southwest, Rochester, MN 55905, USA
Psychosomatics 46:151-2. 2005
Research Grants
- STUDIES OF GENOMIC IMPRINTING IN BIPOLAR DISORDERJames Potash; Fiscal Year: 2005....
- A genome-wide approach to the epigenetics of stress and depressionJames B Potash; Fiscal Year: 2010..By identifying genomic locations where stress changes DNA methylation in the brain, we hope to glean fundamental new insights into the pathogenesis of depression and thus advance the effort to improve treatments for this illness. ..
- Genetic Linkage and Association in Bipolar DisorderJames Potash; Fiscal Year: 2009..These new variants would then be tested for association in our sample. The important findings that have already emerged from our very carefully assessed sample argue for the benefits of extending this valuable resource. ..
- GENETICS OF EARLY ONSET DEPRESSIONJames Potash; Fiscal Year: 2007..abstract_text> ..
- Epigenetic Variation and its Determinants in DepressionJames Potash; Fiscal Year: 2007..Results from the novel studies proposed in this application should shed light on the epigenetic mechanisms and gene-environment interactions that result in vulnerability to depression. ..
- 1/2 Rare Bipolar Loci identification through Synaptome SequencingJames B Potash; Fiscal Year: 2010..We therefore consider that discovery of bipolar disorder genes encoding synaptic proteins has very high translational potential as these potentially represent the most "druggable" targets in bipolar disorder. ) ..