Research Topics
Species | W S PostSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of AtherosclerosisJon T Giles
Department of Medicine, The Johns Hopkins University, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
Arthritis Res Ther 11:R36. 2009..Although cardiovascular morbidity and mortality are increased in rheumatoid arthritis, little is known about the burden of subclinical coronary atherosclerosis in these patients...
Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular systemW S Post
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Cardiovasc Res 43:985-91. 1999..In this study, we sought to determine whether such age-related methylation occurs in the cardiovascular system, and whether it is associated with atherosclerotic disease...
Spot urinary albumin-creatinine ratio predicts left ventricular hypertrophy in young hypertensive African-American menW S Post
Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Hypertens 13:1168-72. 2000....
Determinants of coronary artery and aortic calcification in the Old Order AmishWendy Post
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Circulation 115:717-24. 2007..Our goal was to characterize risk factors for CAC and AC and to estimate the genetic contribution to their variation...
Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order AmishWendy Post
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Hum Hered 64:214-9. 2007..The purpose of the current study was to replicate this association in the Old Order Amish...
High prevalence of target organ damage in young, African American inner-city men with hypertensionWendy S Post
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Clin Hypertens (Greenwich) 5:24-30. 2003....
Association between levels of blood pressure and measures of subclinical disease multi-ethnic study of atherosclerosisBruce M Psaty
Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA
Am J Hypertens 19:1110-7. 2006..High blood pressure (BP) is associated with the presence and severity of subclinical disease. Less is known about associations between normal levels of BP and various measures of subclinical disease...
Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcificationHaiqing Shen
Division of Endocrinology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Arterioscler Thromb Vasc Biol 30:2648-54. 2010..We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might influence variation in coronary artery calcification (CAC)...
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populationsW H Linda Kao
Department of Epidemiology, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
Circulation 119:940-51. 2009....
Increased prevalence of carotid artery atherosclerosis in rheumatoid arthritis is artery-specificHitomi Kobayashi
Divisions of Rheumatology, Cardiology, and Immunogenetics, Department of Medicine, and Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
J Rheumatol 37:730-9. 2010..We compared carotid intima-media thickness (IMT) of both the common carotid (CCA) and proximal internal carotid (bulb-ICA) arteries, and plaque prevalence, between RA and non-RA participants...
Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: the Multi-Ethnic Study of AtherosclerosisAdam C Naj
Department of Medicine, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
Circ Cardiovasc Genet 3:47-52. 2010..We examined this relationship in the Multi-Ethnic Study of Atherosclerosis...
Attenuated myocardial vasodilator response in patients with hypertensive hypertrophy revealed by oxygenation-dependent magnetic resonance imagingG M Beache
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 104:1214-7. 2001..We applied blood oxygenation level-dependent (BOLD) MRI in conjunction with vasodilatory stress to index the ability to augment intramyocardial oxygenation in hypertensive hypertrophy, the primary cause of heart failure...
C-reactive protein is a marker for human immunodeficiency virus disease progressionBryan Lau
Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Arch Intern Med 166:64-70. 2006..Limited data on acute-phase C-reactive protein (CRP) levels in human immunodeficiency virus (HIV) infection exist...
25-hydroxyvitamin D levels and the risk of mortality in the general populationMichal L Melamed
Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann 615, Bronx, NY 10461, USA
Arch Intern Med 168:1629-37. 2008..However, whether low serum 25(OH)D levels are associated with mortality in the general population is unknown...
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotectionToni I Pollin
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Science 322:1702-5. 2008..Subclinical atherosclerosis, as measured by coronary artery calcification, was less common in carriers than noncarriers, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect...
Serum 25-hydroxyvitamin d levels are not associated with subclinical vascular disease or C-reactive protein in the old order amishErin D Michos
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Calcif Tissue Int 84:195-202. 2009..Either there is no causal relationship between 25(OH)D and CVD risk, or if there is, it may be mediated through mechanisms other than subclinical vascular disease severity...
Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic populationDan E Arking
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 4:e4333. 2009..These results highlight the consistent and complex role of NOS1AP genetic variants in modulating QT interval...
Abdominal adiposity in rheumatoid arthritis: association with cardiometabolic risk factors and disease characteristicsJon T Giles
Johns Hopkins University, Baltimore, Maryland 21224, USA
Arthritis Rheum 62:3173-82. 2010..This study was undertaken to investigate how abdominal fat is distributed in rheumatoid arthritis (RA), and its RA-related determinants...
Factors associated with low levels of subclinical vascular disease in older adults: multi-ethnic study of atherosclerosisErin D Michos
Division of Cardiology, Johns Hopkins University, Carnegie 568, 600 North Wolfe Street, Baltimore, MD 21287, USA
Prev Cardiol 12:72-9. 2009..Favorable levels of multiple traditional risk factors, but not several novel risk factors, were associated with subclinical markers of successful cardiovascular aging...
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarizationDan E Arking
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Genet 38:644-51. 2006..Approximately 60% of subjects of European ancestry carry at least one minor allele of the NOS1AP genetic variant, which explains up to 1.5% of QT interval variation...
NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) studyA Y Chu
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
Diabetologia 53:510-6. 2010....
Therapy Insight: managing cardiovascular risk in patients with rheumatoid arthritisJon T Giles
Division of Rheumatology, Johns Hopkins University, Baltimore, MD 21224, USA
Nat Clin Pract Rheumatol 2:320-9. 2006....
The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adultsEvadnie Rampersaud
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
Am J Epidemiol 168:1016-23. 2008..Results suggest that some of the same genes influence variation in CAC and low density lipoprotein cholesterol, whereas a different set of genes influences variation in CIMT and waist circumference...
Coronary artery calcification in patients with primary hyperparathyroidism in comparison with control subjects from the multi-ethnic study of atherosclerosisElizabeth A Streeten
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
Endocr Pract 14:155-61. 2008..To determine whether coronary artery calcification (CAC) is increased in patients with primary hyperparathyroidism (pHPT) because of the presence of hypercalcemia, which has been shown in vitro to promote vascular calcification...
Low free testosterone in HIV-infected men is not associated with subclinical cardiovascular diseaseA K Monroe
Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
HIV Med 13:358-66. 2012..This study examined the relationships among free testosterone (FT), subclinical CVD, and HIV disease...
COL4A1 is associated with arterial stiffness by genome-wide association scanKirill V Tarasov
Laboratory of Cardiovascular Science, Laboratory of Genetics, Clinical Research Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Circ Cardiovasc Genet 2:151-8. 2009..Heritability and linkage studies have pointed toward a genetic component affecting PWV. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with PWV...
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapyAlan R Shuldiner
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Room 494, Baltimore, MD 21201, USA
JAMA 302:849-57. 2009..However, nonresponsiveness is widely recognized and is related to recurrent ischemic events...
Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertensionDaniel L Dries
Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas at Southwestern Medical Center, Dallas, USA
Circulation 112:2403-10. 2005..The natriuretic peptide system contributes to blood pressure regulation. Atrial and brain natriuretic peptides are cleaved into smaller biologically active molecules by corin, a transmembrane serine protease expressed in cardiomyocytes...
Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterloadJ Eduardo Rame
Division of Cardiology, University of California San Francisco, USA
Hypertension 49:857-64. 2007..These data suggest that the corin I555(P568) allele represents a cardiac hypertrophy-sensitizing genetic locus in systemic hypertension...
Left ventricular structure and function in patients with rheumatoid arthritis, as assessed by cardiac magnetic resonance imagingJon T Giles
Johns Hopkins University, Baltimore, Maryland 21224, USA
Arthritis Rheum 62:940-51. 2010..This study was undertaken to assess the factors associated with progression to heart failure in patients with RA...
The relationship between vascular wall shear stress and flow-mediated dilation: endothelial function assessed by phase-contrast magnetic resonance angiographyH A Silber
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Am Coll Cardiol 38:1859-65. 2001..By allowing the calculation of vascular WSS, which is the stimulus for FMD, and by imaging a fixed arterial cross-section, thus reducing operator dependence, PCMRA enhances the assessment of vascular endothelial function...
Exploring the genetics of longevity in the Old Order AmishJohn Sorkin
Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
Mech Ageing Dev 126:347-50. 2005..In this article, we describe our strategy for identifying variants in genes that influence longevity in the Amish and present the results of our studies to date...
Predictors of low-density lipoprotein particle size in a high-risk African-American populationJeana L Benton
Division of Cardiology, Medical School, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 95:1320-3. 2005..77. Our data suggest that the standard lipid profile, primarily fasting triglyceride measurement, appears to be a useful surrogate for direct measurement of particle size in a high-risk African-American population...
Placing COURAGE in context: review of the recent literature on managing stable coronary artery diseaseMegan Coylewright
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Mayo Clin Proc 83:799-805. 2008..It is essential that systems are set in place to make the medical management of patients with CAD second nature; this focus could be one of the most powerful results of the COURAGE trial...
The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart StudyBraxton D Mitchell
Division of Endocrinology, Department of Medicine, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am Heart J 155:823-8. 2008..Efforts to identify genes influencing CVD risk have met with limited success to date, likely because of the small effect sizes of common CVD risk alleles and the presence of gene by gene and gene by environment interactions...
Associations between two common polymorphisms in the ABCA1 gene and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA)Jeana L Benton
The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Atherosclerosis 193:352-60. 2007..We examined these associations in a sample of Multi-Ethnic Study of Atherosclerosis (MESA) participants...
Hypertension care and control in underserved urban African American men: behavioral and physiologic outcomes at 36 monthsMartha N Hill
Johns Hopkins University School of Nursing, Baltimore, Maryland 21205 2110, USA
Am J Hypertens 16:906-13. 2003..African American men with hypertension in low socioeconomic urban populations achieve poor rates of hypertension control and suffer early from its complications...
Prevalence of significant noncardiac findings on electron-beam computed tomography coronary artery calcium screening examinationsKaren M Horton
Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Circulation 106:532-4. 2002..The purpose of this study was to determine the prevalence of significant noncardiac findings in a series of patients undergoing coronary artery calcification screening studies with EBCT scanning...
A look at hypertension in young African-American menPamela S Hall
Johns Hopkins School of Nursing, Baltimore, MD, USA
Nurse Pract 28:59-60. 2003
Electron beam CT versus helical CT scans for assessing coronary calcification: current utility and future directionsKhurram Nasir
Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Am Heart J 146:969-77. 2003..CONCLUSIONS: MDCT is a promising tool for coronary calcium scoring; however, more studies are needed comparing EBCT and MDCT, especially at lower CAC levels...
Results of an academic promotion and career path survey of faculty at the Johns Hopkins University School of MedicinePatricia A Thomas
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Acad Med 79:258-64. 2004..The authors sought to quantify the magnitude of this difference in career advancement and to explore the characteristics of faculty that might explain the difference...
Coronary artery calcium volume scores on electron beam tomography in 12,936 asymptomatic adultsKhurram Nasir
Ciccarone Preventive Cardiology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Am J Cardiol 93:1146-9. 2004..The 2 scores increased as the number of atherosclerotic risk factors increased. The volume scores were statistically smaller than the Agatston scores at the upper quartile level...
Utility of stress testing and coronary calcification measurement for detection of coronary artery disease in womenKhurram Nasir
Divisions of Cardiology, Johns Hopkins Hospital, Baltimore, Md. 21287, USA
Arch Intern Med 164:1610-20. 2004..For high-risk symptomatic women, a more aggressive approach involving coronary angiography appears to be the preferred initial diagnostic strategy...
Relation of degree of physical activity to coronary artery calcium score in asymptomatic individuals with multiple metabolic risk factorsMilind Y Desai
Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
Am J Cardiol 94:729-32. 2004..Thus, asymptomatic patients who have > or =2 metabolic risk factors and who regularly engage in long-duration PA have a lower prevalence of CAC than do those who are sedentary or participate in moderate-duration PA...
Coronary artery calcification and family history of premature coronary heart disease: sibling history is more strongly associated than parental historyKhurram Nasir
The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Circulation 110:2150-6. 2004..Furthermore, within the limits of self-reporting of family history, our findings suggest that a sibling history is more strongly associated with subclinical coronary atherosclerosis than a parental history of premature CHD...
Underlying risk factors incrementally add to the standard risk estimate in detecting subclinical atherosclerosis in low- and intermediate-risk middle-aged asymptomatic individualsMilind Y Desai
Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am Heart J 148:871-7. 2004..Adding family history, obesity, and physical inactivity to traditional risk assessment improves prediction of advanced CAC, which may lead these individuals to be treated more aggressively at an earlier age...
Underserved urban african american men: hypertension trial outcomes and mortality during 5 yearsCheryl R Dennison
School of Nursing, Johns Hopkins University, Baltimore, Maryland 21205, USA
Am J Hypertens 20:164-71. 2007..African American men with hypertension (HTN) in low socioeconomic urban environments continue to achieve poor rates of HTN control...
Framingham risk equation underestimates subclinical atherosclerosis risk in asymptomatic womenErin D Michos
Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Atherosclerosis 184:201-6. 2006..Determination of CAC may provide incremental value to FRE in identifying asymptomatic women who will benefit from targeted preventative measures...
Interaction of hemostatic genetics with hormone therapy: new insights to explain arterial thrombosis in postmenopausal womenJoel B Braunstein
The Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Divsion of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Chest 121:906-20. 2002..Genetic profiling has great potential to improve the safety and efficacy of individualized pharmacotherapy in postmenopausal women and other at-risk populations for the prevention of cardiovascular disease...
Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for VasculaJames H Stein
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
J Am Soc Echocardiogr 21:93-111; quiz 189-90. 2008
ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation ClPhilip Greenland
J Am Coll Cardiol 49:378-402. 2007
ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation ClPhilip Greenland
Circulation 115:402-26. 2007
Research Grants
- Subclinical Vascular Disease and Metabolic Abnormalities in MACSWendy S Post; Fiscal Year: 2010..Results can be used to target prevention strategies. (End of Abstract) ..
- MESA Family StudyWendy Post; Fiscal Year: 2004..abstract_text> ..
- MESA Family StudyWendy Post; Fiscal Year: 2007....
- Subclinical Vascular Disease and Metabolic Abnormalities in MACSWendy Post; Fiscal Year: 2009..Results can be used to target prevention strategies. (End of Abstract) ..
