Joshua R Porter
Affiliation: Johns Hopkins University
- Identifying a static nonlinear structure in a biological system using noisy, sparse dataJoshua R Porter
Department of Electrical and Computer Engineering, Johns Hopkins University, 105 Barton Hall, 3400 N Charles Street, Baltimore, MD 21218, USA
J Theor Biol 300:232-41. 2012..Simulations with this model produced outputs consistent with experimental observations. The techniques introduced here will provide researchers with a new tool by which biological systems can be identified and characterized...
- Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradationJoshua R Porter
Department of Electrical and Computer Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Biol Cell 23:3764-74. 2012..This model quantifies our understanding of a novel oxygen-sensing mechanism that is widely conserved...
- Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeastJoshua R Porter
Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
J Biol Chem 285:41051-61. 2010..Based on this relationship, we predict that the Sre1-Scp1 complex exists under "active" and "inactive" states and that the transition between these states is cooperatively mediated by ergosterol...
- A framework for designing and analyzing binary decision-making strategies in cellular systemsJoshua R Porter
Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
Integr Biol (Camb) 4:310-7. 2012..As proof of concept, we use the framework to quantify the goals of the externally triggered apoptosis pathway...