MARTIN G contact POMPER

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Translational molecular imaging for cancer
    Martin G Pomper
    The Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21287 2182, USA
    Cancer Imaging 5:S16-26. 2005
  2. pmc Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans
    Christopher J Endres
    Division of Neuroradiology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 50:1276-82. 2009
  3. pmc Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT
    Luis A Diaz
    The Howard Hughes Medical Institute, The Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins, Baltimore, Maryland, United States of America
    PLoS ONE 2:e1007. 2007
  4. pmc Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression
    Hyo Eun C Bhang
    Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Nat Med 17:123-9. 2011
  5. pmc A modular strategy to prepare multivalent inhibitors of prostate-specific membrane antigen (PSMA)
    Sangeeta Ray Banerjee
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD, USA
    Oncotarget 2:1244-53. 2011
  6. pmc Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation
    Divya Sagar
    Drexel Institute for Biotechnology and Virology Research and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neuroinflammation 9:245. 2012
  7. pmc PET imaging in prostate cancer: focus on prostate-specific membrane antigen
    Ronnie C Mease
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD 21287, USA
    Curr Top Med Chem 13:951-62. 2013
  8. pmc GCPII imaging and cancer
    C A Foss
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD 21231, USA
    Curr Med Chem 19:1346-59. 2012
  9. ncbi request reprint 11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase)
    Martin G Pomper
    Division of Neuroradiology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2182, USA
    Mol Imaging 1:96-101. 2002
  10. ncbi request reprint Synthesis and biodistribution of radiolabeled alpha 7 nicotinic acetylcholine receptor ligands
    Martin G Pomper
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287 2182, USA
    J Nucl Med 46:326-34. 2005

Research Grants

  1. CNS METABOLIC CORRELATES OF HIV DEMENTIA BY MRS IMAGING
    Martin Pomper; Fiscal Year: 1999
  2. PSMA-based Gene Reporter-Probe System(RMI)
    Martin Pomper; Fiscal Year: 2007
  3. PSMA-based PET Ligands for Prostate Cancer Imaging
    Martin Pomper; Fiscal Year: 2007
  4. Imaging Serotonergic Transmission in HIV Depression
    Martin Pomper; Fiscal Year: 2006
  5. CNS METABOLIC CORRELATES OF HIV DEMENTIA BY MRS IMAGING
    Martin Pomper; Fiscal Year: 2000
  6. BETR Therapy for Herpesvirus-Associated Tumors
    MARTIN G contact POMPER; Fiscal Year: 2010
  7. PSMA-based Cancer Imaging Agents
    Martin G Pomper; Fiscal Year: 2010
  8. PSMA-based Cancer Imaging Agents
    Martin Pomper; Fiscal Year: 2009
  9. GCPII-Based Brain Imaging Agents
    Martin Pomper; Fiscal Year: 2007
  10. Small Animal Imaging Resource (SAIR)
    Martin Pomper; Fiscal Year: 2007

Detail Information

Publications77

  1. pmc Translational molecular imaging for cancer
    Martin G Pomper
    The Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21287 2182, USA
    Cancer Imaging 5:S16-26. 2005
    ..This brief review outlines several of the more promising areas of pursuit in molecular imaging for oncology with an emphasis on those that show the most immediate likelihood for clinical translation...
  2. pmc Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans
    Christopher J Endres
    Division of Neuroradiology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 50:1276-82. 2009
    ..Here, we report the first examination of (11)C-DPA-713 in human subjects using PET...
  3. pmc Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT
    Luis A Diaz
    The Howard Hughes Medical Institute, The Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins, Baltimore, Maryland, United States of America
    PLoS ONE 2:e1007. 2007
    ..The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria...
  4. pmc Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression
    Hyo Eun C Bhang
    Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Nat Med 17:123-9. 2011
    ..Because of its strong promoter activity, tumor specificity and capacity for clinical translation, PEG-3 promoter-driven gene expression may represent a practical, new system for facilitating cancer imaging and therapy...
  5. pmc A modular strategy to prepare multivalent inhibitors of prostate-specific membrane antigen (PSMA)
    Sangeeta Ray Banerjee
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD, USA
    Oncotarget 2:1244-53. 2011
    ..isogenic PSMA-negative PC3-flu tumors in vivo. The click chemistry approach affords a convenient strategy toward multivalent PSMA inhibitors of enhanced affinity and superior pharmacokinetics for imaging...
  6. pmc Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation
    Divya Sagar
    Drexel Institute for Biotechnology and Virology Research and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Neuroinflammation 9:245. 2012
    ..Chemokine ligand 2 (CCL2) is a potent chemoattractant known to be secreted by the BBB but has not been implicated in the recruitment of DCs specifically at the BBB...
  7. pmc PET imaging in prostate cancer: focus on prostate-specific membrane antigen
    Ronnie C Mease
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD 21287, USA
    Curr Top Med Chem 13:951-62. 2013
    ..These early clinical results suggest that PET/CT using PSMA-targeted agents, especially with compounds of low molecular weight, will make valuable contributions to the management of PCa...
  8. pmc GCPII imaging and cancer
    C A Foss
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical School, Baltimore, MD 21231, USA
    Curr Med Chem 19:1346-59. 2012
    ..An overview of GCPII/PSMA in cancer, as well as a discussion of imaging and therapy of prostate cancer using a wide variety of PSMA-targeting agents is provided...
  9. ncbi request reprint 11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase)
    Martin G Pomper
    Division of Neuroradiology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2182, USA
    Mol Imaging 1:96-101. 2002
    ..For PET, distribution volumes (DVs) were 1.38 then 0.87 pre- and postblocker (PMPA). Little metabolism of 11C-MCG occurred in the mouse or baboon. These results suggest that 11C-MCG may be useful for imaging GCP II in the periphery...
  10. ncbi request reprint Synthesis and biodistribution of radiolabeled alpha 7 nicotinic acetylcholine receptor ligands
    Martin G Pomper
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287 2182, USA
    J Nucl Med 46:326-34. 2005
    ..Our objective was to develop an array of alpha(7)-selective nicotinic cholinergic receptor (nAChR)-based imaging agents for PET and SPECT...
  11. ncbi request reprint Positron emission tomography in molecular imaging. Could the promise of personalized patient care be reaching fruition?
    Martin G Pomper
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287 2182, USA
    IEEE Eng Med Biol Mag 23:28-37. 2004
  12. ncbi request reprint Small animal imaging in drug development
    Martin G Pomper
    Johns Hopkins University School of Medicine, Department of Radiology, MD, USA
    Curr Pharm Des 11:3247-72. 2005
    ..The ability to study those animals noninvasively and quantitatively with new, high-resolution imaging devices provides the most relevant milieu in which to find and examine new therapies...
  13. ncbi request reprint Can small animal imaging accelerate drug development?
    Martin G Pomper
    Johns Hopkins University School of Medicine, Department of Radiology, Baltimore, Maryland 21287 2182, USA
    J Cell Biochem Suppl 39:211-20. 2002
    ..The ability to study those animals noninvasively and quantitatively with new, high-resolution imaging devices provides the most relevant milieu in which to find and examine new therapies...
  14. ncbi request reprint Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models
    Martin G Pomper
    Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cell Res 19:370-9. 2009
    ..Noninvasive imaging methods such as these may enable us to monitor the presence and distribution of transplanted human stem cells repetitively within live recipients over a long term through the expression of a reporter gene...
  15. pmc Immunoimaging of CXCR4 expression in brain tumor xenografts using SPECT/CT
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    J Nucl Med 50:1124-30. 2009
    ..Here we report the results of SPECT/CT of CXCR4 expression levels in experimental brain tumors using (125)I-labeled anti-CXCR4 monoclonal antibodies (mAbs)...
  16. ncbi request reprint Radiolabeled small-molecule ligands for prostate-specific membrane antigen: in vivo imaging in experimental models of prostate cancer
    Catherine A Foss
    Johns Hopkins University, Baltimore, Maryland 21287 2182, USA
    Clin Cancer Res 11:4022-8. 2005
    ..Our goal in this study was to develop a series of PSMA-based imaging agents for clinical use...
  17. ncbi request reprint Synthesis and biodistribution of (11)C-GW7845, a positron-emitting agonist for peroxisome proliferator-activated receptor-{gamma}
    William B Mathews
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Nucl Med 46:1719-26. 2005
    ..Compound 1 is an analog of tyrosine (inhibitor constant, 3.7 nmol/L), which is an inhibitor of experimental mammary carcinogenesis...
  18. pmc 68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer
    Sangeeta Ray Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, Maryland 21231, USA
    J Med Chem 53:5333-41. 2010
    ..Both compounds delineated tumor clearly by small animal PET. The urea series of imaging agents for PSMA can be radiolabeled with (68)Ga, a cyclotron-free isotope useful for clinical PET studies, with maintenance of target specificity...
  19. ncbi request reprint Glutamate carboxypeptidase II levels in rodent brain using [125I]DCIT quantitative autoradiography
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins School of Public Health, Baltimore, MD 21287 2182, USA
    Neurosci Lett 387:141-4. 2005
    ..We propose that [125I]DCIT is a selective radioligand that can be used to quantify brain GCPII levels in vitro using quantitative autoradiography...
  20. pmc Synthesis of [(125)I]iodoDPA-713: a new probe for imaging inflammation
    Haofan Wang
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Biochem Biophys Res Commun 389:80-3. 2009
    ..Compound [(125)I]1 is a new, convenient probe for preclinical studies of TSPO activity...
  21. ncbi request reprint Detection of dose response in chronic doxorubicin-mediated cell death with cardiac technetium 99m annexin V single-photon emission computed tomography
    Kathleen L Gabrielson
    Department of Molecular and Comparative Pathobiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Imaging 7:132-8. 2008
    ..99mTc-HYNIC-annexin V SPECT-based molecular imaging may provide an attractive new technique for assessing early changes in myocardial function in patients undergoing DOX therapy...
  22. pmc Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 70:3935-44. 2010
    ..Our findings show the feasibility of imaging CXCR4 by positron emission tomography using a clinically approved agent as a molecular scaffold...
  23. pmc Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors
    De Xue Fu
    Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Nat Med 14:1118-22. 2008
    ..Bortezomib-induced enzyme-targeted radiation therapy illustrates the possibility of pharmacologically modulating tumor gene expression to result in targeted radiotherapy...
  24. pmc Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    J Med Chem 51:7933-43. 2008
    ..Because of the many radiohalogenated moieties that can be attached via the epsilon amino group, the intermediate Lys-C(O)-Glu is an attractive template upon which to develop new imaging agents for prostate cancer...
  25. ncbi request reprint Predicting the success of a radiopharmaceutical for in vivo imaging of central nervous system neuroreceptor systems
    Dean F Wong
    Johns Hopkins University, Department of Radiology, Baltimore, MD 21287, USA
    Mol Imaging Biol 5:350-62. 2003
    ..This article is intended to present a pragmatic overview of the radiopharmaceutical development process with emphasis on the CNS...
  26. ncbi request reprint Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
    Young H Ko
    The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem Biophys Res Commun 324:269-75. 2004
    ..In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers...
  27. pmc Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria
    Chetan Bettegowda
    Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 100:15083-8. 2003
    ..C. novyi-NT spores added little toxicity to the radiotherapeutic regimens, and the combination resulted in long-term remissions in a significant fraction of animals...
  28. ncbi request reprint Autoimmune hypophysitis
    Patrizio Caturegli
    Johns Hopkins Pathology, Ross 656, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Endocr Rev 26:599-614. 2005
    ..The present review synthesizes the clinical and research data reported in this body of scientific literature...
  29. ncbi request reprint A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia
    Ned Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Magn Reson Imaging 21:325-33. 2005
    ..To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia...
  30. pmc High-throughput screen identifies novel inhibitors of cancer biomarker α-methylacyl coenzyme A racemase (AMACR/P504S)
    Brice A P Wilson
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mol Cancer Ther 10:825-38. 2011
    ..This report shows the first high-throughput screen for the discovery of novel AMACR inhibitors, characterizes the first nonsubstrate-based inhibitors, and validates that AMACR is a viable chemotherapeutic target in vitro...
  31. pmc Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21231, USA
    Neoplasia 11:477-84. 2009
    ....
  32. ncbi request reprint PET imaging of GRP receptor expression in prostate cancer
    Ursula Scheffel
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nucl Med 45:1277-8. 2004
  33. ncbi request reprint Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS
    Dima A Hammoud
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2182, USA
    J Neurovirol 11:346-55. 2005
    ..The findings of this pilot study support a role for glial cell activation in HAD, and that PET with [11C]-R-PK11195 can detect the concomitants of neuronal damage in individuals infected with HIV...
  34. ncbi request reprint Virus-associated tumor imaging by induction of viral gene expression
    De Xue Fu
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 13:1453-8. 2007
    ..The goal of this study is to image EBV-associated tumors by induction of viral TK expression with radiolabeled 2'-fluoro-2'-deoxy-beta-D-5-iodouracil-arabinofuranoside (FIAU)...
  35. pmc A low molecular weight PSMA-based fluorescent imaging agent for cancer
    Ying Chen
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    Biochem Biophys Res Commun 390:624-9. 2009
    ..PSMA-negative PC3-flu tumors in vivo. YC-27 3 may be useful for study of PSMA-expressing tissue in preclinical models or for intraoperative guidance...
  36. ncbi request reprint FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer
    Jae Sung Lee
    Department of Radiology, Johns Hopkins Medical Institutions, 1550 Orleans Street, 492 CRB II, Baltimore, Maryland 21231, USA
    Pharm Res 24:1202-7. 2007
    ..The aim of this study was to use positron emission tomography with [(18)F]fluorodeoxyglucose (FDG-PET) to monitor the effects of the FAS inhibitor C75 on tumor glucose metabolism in a rodent model of human A549 lung cancer...
  37. pmc Imaging serotonergic transmission with [11C]DASB-PET in depressed and non-depressed patients infected with HIV
    Dima A Hammoud
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    Neuroimage 49:2588-95. 2010
    ..The goal of this study was to evaluate the involvement of serotonergic transmission in HIV-associated depression using [(11)C]DASB, a serotonin transporter (5-HTT)-specific radiopharmaceutical for positron emission tomography (PET)...
  38. ncbi request reprint In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation
    Matthew J Hardwick
    Loyola College, Baltimore, MD, USA
    Mol Imaging 4:432-8. 2005
    ..This study suggests that measuring PBR expression using in vivo imaging techniques may be a useful biomarker to image lung inflammation...
  39. ncbi request reprint Quantitative MR spectroscopic imaging of brain lesions in patients with AIDS: correlation with [11C-methyl]thymidine PET and thallium-201 SPECT
    Martin G Pomper
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287 2182, USA
    Acad Radiol 9:398-409. 2002
    ..The purpose of this study was to examine the metabolic basis for magnetic resonance (MR) spectroscopic imaging findings in focal brain lesions of patients with acquired immunodeficiency syndrome (AIDS)...
  40. pmc An immunotolerant HER-2/neu transgenic mouse model of metastatic breast cancer
    Hong Song
    Division of Nuclear Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Clin Cancer Res 14:6116-24. 2008
    ..We have developed and characterized a preclinical model for the evaluation of immune-mediated metastatic breast cancer therapies...
  41. pmc Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA)
    Sangeeta R Banerjee
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    J Med Chem 51:4504-17. 2008
    ..PSMA can accommodate the steric requirements of (99m)Tc/Re complexes within PSMA inhibitors, the best results achieved with a linker moiety between the epsilon amine of the urea lysine and the chelator...
  42. pmc Identification of inhibitors of ABCG2 by a bioluminescence imaging-based high-throughput assay
    Yimao Zhang
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Cancer Res 69:5867-75. 2009
    ..The BLI-based assay is an efficient method to identify new inhibitors of ABCG2. As they were derived from a FDA-approved compound library, many of the inhibitors uncovered in this study are ready for clinical testing...
  43. pmc Targeted molecular imaging in oncology: focus on radiation therapy
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, MD
    Semin Radiat Oncol 18:136-48. 2008
    ..This review focuses on recent advances in molecular imaging strategies and probes that may aid in improving the efficacy of radiotherapy...
  44. pmc Factor analysis of proton MR spectroscopic imaging data in HIV infection: metabolite-derived factors help identify infection and dementia
    Mona A Mohamed
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, 1550 Orleans St, 492 CRB II, Baltimore, MD 21231, USA
    Radiology 254:577-86. 2010
    ....
  45. ncbi request reprint Workshop on imaging science development for cancer prevention and preemption
    Gary J Kelloff
    NIH NCI DCTD, Cancer Imaging Program, Bethesda, MD, USA
    Cancer Biomark 3:1-33. 2007
    ..Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer...
  46. pmc Imaging virus-associated cancer
    De Xue Fu
    Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Curr Pharm Des 14:3048-65. 2008
    ..Under certain conditions, and particularly during pharmacologic stimulation, gammaherpesviruses will express genes that enable imaging and therapy in vivo. The techniques discussed are readily translatable to the clinic...
  47. pmc Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals
    Stephanie L Davis
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    PLoS ONE 4:e6297. 2009
    ..Our goal was to use this reporter and develop non-invasive methods to detect and localize Mycobacterium tuberculosis...
  48. pmc EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts
    Bachchu Lal
    Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
    Mol Cancer Ther 8:1751-60. 2009
    ..They also provide insights into how EGFRvIII and c-Met may alter signaling networks and reveal the potential limitations of certain biochemical biomarkers to predict the efficacy of RTK inhibition in genetically diverse cancers...
  49. pmc Noninvasive pulmonary [18F]-2-fluoro-deoxy-D-glucose positron emission tomography correlates with bactericidal activity of tuberculosis drug treatment
    Stephanie L Davis
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Antimicrob Agents Chemother 53:4879-84. 2009
    ..By reducing animal numbers, these biomarkers will allow cost-effective studies of more expensive animal models of TB. Validated markers may also be useful as "point-of-care" methods to monitor TB treatment in humans...
  50. pmc Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies
    Haofan Wang
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Bioorg Med Chem Lett 20:392-7. 2010
    ..A novel conformational change of amino acids in the S1' pharmacophore pocket was observed in the X-ray crystal structure of GCPII complexed with 32d...
  51. ncbi request reprint Quantitative proton magnetic resonance spectroscopic imaging: regional variations in the corpus callosum and cortical gray matter
    Mahaveer N Degaonkar
    Division of Neuroradiology, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Magn Reson Imaging 22:175-9. 2005
    ..To evaluate regional variations of metabolite concentrations in normal adult brain cortical gray matter regions, and the genu and splenium of the corpus callosum, using proton magnetic resonance spectroscopic imaging (MRSI)...
  52. pmc Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil
    Chetan Bettegowda
    Howard Hughes Medical Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 102:1145-50. 2005
    ..Such imaging provides a general method for the diagnosis of localized bacterial infections that could be translatable to the clinic...
  53. pmc Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging
    Jinyuan Zhou
    Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 60:842-9. 2008
    ..In high-grade tumors, regions of increased APT extended outside of the core into peripheral zones, indicating the potential of this technique for more accurate delineation of the heterogeneous areas of brain cancers...
  54. ncbi request reprint Radiolabeled anti-claudin 4 and anti-prostate stem cell antigen: initial imaging in experimental models of pancreatic cancer
    Catherine A Foss
    Department of Radiology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Univeristy, Baltimore, MD 21287 2182, USA
    Mol Imaging 6:131-9. 2007
    ..6PL orthotopic xenograft model showed strong tumor and spleen uptake at 5 days postinjection. Both anti-claudin 4 and anti-PSCA demonstrate promise as radiodiagnostic and possibly radiotherapeutic agents for human pancreatic cancers...
  55. ncbi request reprint In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla
    Richard A E Edden
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Magn Reson Med 57:977-82. 2007
    ..White matter concentrations of NAA (6.7 +/- 0.3 mM) and NAAG (2.2 +/- 0.3 mM) were measured in 10 healthy volunteers to demonstrate the method...
  56. ncbi request reprint Molecular neuroimaging: from conventional to emerging techniques
    Dima A Hammoud
    Department of Radiology, Johns Hopkins University School of Medicine, 1550 Orleans St, CRB 2, Room 492, Baltimore, MD 21231, USA
    Radiology 245:21-42. 2007
    ..Molecular neuroimaging of the brain shows tremendous promise for clinical application. In this article, the current state and clinical applications of molecular neuroimaging will be reviewed...
  57. pmc Dysregulation of glutamate carboxypeptidase II in psychiatric disease
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Schizophr Res 99:324-32. 2008
    ..GCPII may represent a viable therapeutic target for intervention in psychiatric disease...
  58. pmc N-[N-[(S)-1,3-Dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine, [18F]DCFBC: a new imaging probe for prostate cancer
    Ronnie C Mease
    Russell H Morgan Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 14:3036-43. 2008
    ..Herein, we extend that work by preparing and testing a PSMA inhibitor of the same class labeled with fluorine-18...
  59. pmc Characterization of a targeted nanoparticle functionalized with a urea-based inhibitor of prostate-specific membrane antigen (PSMA)
    Sachin S Chandran
    The Department of Chemical and Biomolecular Engineering, The Johns Hopkins University Whiting School of Engineering, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 7:974-82. 2008
    ..Ongoing in vivo studies address the localization, activity and toxicity of these targeted nanoparticles against PSMA-producing human prostate tumor xenografts...
  60. pmc Optimization of peptide-based inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate cancer
    Aaron M LeBeau
    Department of Pharmacology and Molecular Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bioorg Med Chem 17:4888-93. 2009
    ..This result suggests that a platform of PSA inhibitor chelates could be developed as SPECT or PET-based imaging agents for prostate cancer...
  61. ncbi request reprint Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma
    John D Port
    Neuroradiology Division, Johns Hopkins Hospital, Baltimore, MD, USA
    AJNR Am J Neuroradiol 23:243-7. 2002
    ..The solid component of the mass has a bubbly appearance and a T2 signal that is isointense to gray matter. Punctate calcifications are often present. Neuroradiologists should be familiar with the characteristic appearance of this tumor...
  62. ncbi request reprint Proton MR spectroscopy in hyperhomocysteinemia with elevated blood methionine levels
    L Patricia Franco
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Magn Reson Imaging 23:404-7. 2006
    ..Normal MRSI at presentation was predictive of a positive outcome despite the markedly abnormal initial MRI results...
  63. ncbi request reprint Amide proton transfer imaging of human brain tumors at 3T
    Craig K Jones
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Magn Reson Med 56:585-92. 2006
    ..These preliminary data from patients with brain tumors show that the APT is a unique contrast that can provide complementary information to standard clinical MRI measures...
  64. ncbi request reprint Positron emission tomography for serial imaging of the contused adult rat spinal cord
    Rishi D S Nandoe Tewarie
    International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA
    Mol Imaging 9:108-16. 2010
    ..This approach may become a tool to assess the efficacy of spinal cord repair strategies...
  65. ncbi request reprint Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging
    Lidia M Nagae-Poetscher
    Kennedy Krieger Institute, Baltimore, Maryland, USA
    J Magn Reson Imaging 20:496-500. 2004
    ..These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously...
  66. pmc Spatio-temporal modification of collagen scaffolds mediated by triple helical propensity
    Allen Y Wang
    Department of Materials Science and Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biomacromolecules 9:1755-63. 2008
    ....
  67. pmc New agents and techniques for imaging prostate cancer
    Atif Zaheer
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nucl Med 50:1387-90. 2009
    ..This review briefly describes the key clinical issues in prostate cancer imaging and therapy and summarizes the various new imaging modalities and agents in use and on the horizon...
  68. ncbi request reprint ABCG2/BCRP expression modulates D-Luciferin based bioluminescence imaging
    Yimao Zhang
    Russell H Morgan Department of Radiology, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Cancer Res 67:9389-97. 2007
    ..These findings highlight the need to consider ABCG2/BCRP effects during d-luciferin-based BLI and suggest novel high throughput methods for identifying new ABCG2/BCRP inhibitors...
  69. ncbi request reprint Performance evaluation of the GE healthcare eXplore VISTA dual-ring small-animal PET scanner
    Yuchuan Wang
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nucl Med 47:1891-900. 2006
    ....
  70. ncbi request reprint The surgical bed after BCNU polymer wafer placement for recurrent glioma: serial assessment on CT and MR imaging
    Dima A Hammoud
    Department of Radiology, Division of Neuroradiology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2182, USA
    AJR Am J Roentgenol 180:1469-75. 2003
    ....
  71. pmc Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp
    Yimao Zhang
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Neoplasia 11:96-101. 2009
    ..In addition to its effect on Hh signaling, the ability of HhAntag691 and related compounds to inhibit two key ABC transporters could contribute to their effectiveness in treating malignancies...
  72. ncbi request reprint Tissue sodium concentration in human brain tumors as measured with 23Na MR imaging
    Ronald Ouwerkerk
    Department of Radiology, Division of MR Research, Johns Hopkins University School of Medicine, 610 N Caroline St, JHOC 4241, Baltimore, MD 21287 0845, USA
    Radiology 227:529-37. 2003
    ..To use combined proton (1H) and sodium 23 (23Na) magnetic resonance (MR) imaging to noninvasively quantify total tissue sodium concentration and to determine if concentration is altered in malignant human brain tumors...
  73. ncbi request reprint NAAG peptidase inhibitors and their potential for diagnosis and therapy
    Jia Zhou
    Acenta Discovery, Inc, 9030 South Rita Road, Suite 300, Tucson, Arizona 85747, USA
    Nat Rev Drug Discov 4:1015-26. 2005
    ....
  74. ncbi request reprint Molecular imaging: the future of modern medicine
    Peter S Conti
    University of Southern California, Los Angeles, CA, USA
    J Nucl Med 49:16N-20N. 2008
  75. ncbi request reprint New techniques for imaging Human Immunodeficiency Virus associated cognitive impairment in the era of highly active antiretroviral therapy
    Martin G Pomper
    Arch Neurol 64:1233-5. 2007
  76. doi request reprint Molecular imaging of metastatic potential
    Paul T Winnard
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore 21231, Maryland, USA
    J Nucl Med 49:96S-112S. 2008
    ..Below are examples of uses of molecular imaging of metastases as well as of metastatic potential, the former being a far more developed area of clinical inquiry...
  77. ncbi request reprint Potential clinical role of FDG-PET in detecting sarcomatous transformation in von Recklinghausen's disease
    Martin G Pomper
    J Neurooncol 82:329. 2007

Research Grants16

  1. CNS METABOLIC CORRELATES OF HIV DEMENTIA BY MRS IMAGING
    Martin Pomper; Fiscal Year: 1999
    ..abstract_text> ..
  2. PSMA-based Gene Reporter-Probe System(RMI)
    Martin Pomper; Fiscal Year: 2007
    ....
  3. PSMA-based PET Ligands for Prostate Cancer Imaging
    Martin Pomper; Fiscal Year: 2007
    ....
  4. Imaging Serotonergic Transmission in HIV Depression
    Martin Pomper; Fiscal Year: 2006
    ..abstract_text> ..
  5. CNS METABOLIC CORRELATES OF HIV DEMENTIA BY MRS IMAGING
    Martin Pomper; Fiscal Year: 2000
    ..abstract_text> ..
  6. BETR Therapy for Herpesvirus-Associated Tumors
    MARTIN G contact POMPER; Fiscal Year: 2010
    ..This is a prospective, pilot trial of Bortezomib-induced Enzyme-Targeted Radiation (BETR) therapy in patients with relapsed/refractory EBV-associated malignancy. ..
  7. PSMA-based Cancer Imaging Agents
    Martin G Pomper; Fiscal Year: 2010
    ..which may progress. ..
  8. PSMA-based Cancer Imaging Agents
    Martin Pomper; Fiscal Year: 2009
    ..which may progress. ..
  9. GCPII-Based Brain Imaging Agents
    Martin Pomper; Fiscal Year: 2007
    ..Working with our knowledge of PSMA/GCPII imaging and the recently published crystal structure of PSMA, we intend to pursue new derivatives suitable for imaging GCPII within the central nervous system ..
  10. Small Animal Imaging Resource (SAIR)
    Martin Pomper; Fiscal Year: 2007
    ..Our ultimate goal is to move small animal imaging science forward - to the point where the incorporation of such imaging techniques becomes second nature in the daily practice of cancer researchers. ..
  11. PSMA-based SPECT Tracers for Prostate Cancer Imaging
    Martin Pomper; Fiscal Year: 2007
    ....
  12. CNS METABOLIC CORRELATES OF HIV DEMENTIA BY MRS IMAGING
    Martin Pomper; Fiscal Year: 2001
    ..abstract_text> ..
  13. TK-based Infection Imaging
    Martin G Pomper; Fiscal Year: 2010
    ....