Michael J Polydefkis

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies
    Camilo Rojas
    Brain Science Institute, Johns Hopkins School of Medicine, 855 North Wolfe Street, Baltimore, MD 21205, USA
    J Transl Med 9:27. 2011
  2. ncbi request reprint Subclinical sensory neuropathy in late-onset restless legs syndrome
    M Polydefkis
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 55:1115-21. 2000
  3. ncbi request reprint Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy
    M Polydefkis
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 58:115-9. 2002
  4. ncbi request reprint New insights into diabetic polyneuropathy
    Michael Polydefkis
    Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    JAMA 290:1371-6. 2003
  5. ncbi request reprint The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy
    Michael Polydefkis
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 127:1606-15. 2004
  6. ncbi request reprint Factors influencing nerve regeneration in a trial of timcodar dimesylate
    M Polydefkis
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 66:259-61. 2006
  7. doi request reprint Peripheral nerve toxic effects of nitrofurantoin
    Ik Lin Tan
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Neurol 69:265-8. 2012
  8. ncbi request reprint The incidence of, risk factors for, and sequelae of herpes zoster among HIV patients in the highly active antiretroviral therapy era
    Kelly A Gebo
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 40:169-74. 2005
  9. pmc Longitudinal assessment of oxaliplatin-induced neuropathy
    A Z Burakgazi
    Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 77:980-6. 2011
  10. pmc Impaired neurovascular repair in subjects with diabetes following experimental intracutaneous axotomy
    Gigi J Ebenezer
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287 7609, USA
    Brain 134:1853-63. 2011

Research Grants

  1. HUMAN AXONAL REGENERATION IN DIABETIC NEUROPATHY
    Michael Polydefkis; Fiscal Year: 2005

Collaborators

Detail Information

Publications11

  1. pmc Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies
    Camilo Rojas
    Brain Science Institute, Johns Hopkins School of Medicine, 855 North Wolfe Street, Baltimore, MD 21205, USA
    J Transl Med 9:27. 2011
    ..The PD marker will determine the effect of GCP inhibitors on GCP enzymatic activity in human skin as measure of inhibition in peripheral nerve and help predict drug doses required to elicit pharmacologic responses...
  2. ncbi request reprint Subclinical sensory neuropathy in late-onset restless legs syndrome
    M Polydefkis
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 55:1115-21. 2000
    ..To determine the prevalence of different forms of peripheral neuropathy in patients with restless legs syndrome (RLS) and correlate the findings with other clinical characteristics...
  3. ncbi request reprint Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy
    M Polydefkis
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Neurology 58:115-9. 2002
    ..To explore the relationship between intraepidermal nerve fiber (IENF) density in HIV-associated sensory neuropathy (HIV-SN) to measurements of neuropathy severity and progression of HIV disease...
  4. ncbi request reprint New insights into diabetic polyneuropathy
    Michael Polydefkis
    Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    JAMA 290:1371-6. 2003
    ..Such approaches may address some of the challenges of past diabetic polyneuropathy trials...
  5. ncbi request reprint The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy
    Michael Polydefkis
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 127:1606-15. 2004
    ..These results suggest that regenerative neuropathy trials could include non-neuropathic subjects and that trial duration can be dramatically shortened...
  6. ncbi request reprint Factors influencing nerve regeneration in a trial of timcodar dimesylate
    M Polydefkis
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 66:259-61. 2006
    ..While there was no difference in the regeneration rate between the treatment and placebo arms, the baseline ENFD (p = 0.006), height (p = 0.02), and race (p = 0.03) were associated with the regeneration rate...
  7. doi request reprint Peripheral nerve toxic effects of nitrofurantoin
    Ik Lin Tan
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Neurol 69:265-8. 2012
    ..To investigate the role of skin biopsy in nitrofurantoin peripheral neuropathy...
  8. ncbi request reprint The incidence of, risk factors for, and sequelae of herpes zoster among HIV patients in the highly active antiretroviral therapy era
    Kelly A Gebo
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 40:169-74. 2005
    ....
  9. pmc Longitudinal assessment of oxaliplatin-induced neuropathy
    A Z Burakgazi
    Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 77:980-6. 2011
    ..In addition, we sought to assess the potential of ON as a neuroprotection model and gain insight into the relationship between axon loss and neuropathic symptoms...
  10. pmc Impaired neurovascular repair in subjects with diabetes following experimental intracutaneous axotomy
    Gigi J Ebenezer
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287 7609, USA
    Brain 134:1853-63. 2011
    ..These models are useful tools for the efficient investigation of neurotrophic and regenerative drugs, and also to explore factors that may differentially affect axonal regeneration...
  11. ncbi request reprint Peripheral neuropathy and HIV
    Michael J Polydefkis
    Hopkins HIV Rep 14:6-7. 2002

Research Grants1

  1. HUMAN AXONAL REGENERATION IN DIABETIC NEUROPATHY
    Michael Polydefkis; Fiscal Year: 2005
    ..Polydefkis the skills he needs to develop into an independent clinician researcher in the field of peripheral nerve disease. ..