Research Topics
Species | Vsevolod PolotskySummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Intermittent hypoxia increases insulin resistance in genetically obese miceVsevolod Y Polotsky
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Physiol 552:253-64. 2003..001) and worsening glucose tolerance, consistent with an increase in insulin resistance. We conclude that the increase in insulin resistance in response to intermittent hypoxia is dependent on the disruption of leptin pathways...
Impact of interrupted leptin pathways on ventilatory controlVsevolod Y Polotsky
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
J Appl Physiol 96:991-8. 2004..We conclude that interruption of leptin pathways does not affect hypoxic sensitivity during sleep and wakefulness but that melanocortin 4 blockade is associated with depressed hypercapnic sensitivity in non-rapid eye movement sleep...- Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesityVsevolod Y Polotsky
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 179:228-34. 2009..Obstructive sleep apnea is associated with insulin resistance and liver injury. It is unknown whether apnea contributes to insulin resistance and steatohepatitis in severe obesity... - Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouseVsevolod Y Polotsky
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Sleep Med 7:7-16. 2006..We hypothesized that both intermittent hypoxia (IH) and non-hypoxic arousals of OSA result in significant disruption of non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS)... - Effects of leptin and obesity on the upper airway functionMikhael Polotsky
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Appl Physiol 112:1637-43. 2012..The findings suggest that weight and leptin deficiency produced defects in upper airway neuromechanical control and that leptin reversed defects in active neuromuscular responses acutely without reducing mechanical loads... - Effect of age and weight on upper airway function in a mouse modelMikhael Polotsky
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Appl Physiol 111:696-703. 2011..The susceptibility to upper airway obstruction increases with age and weight as tonic neuromuscular activity falls. IFL can elicit phasic responses in normal mice that mitigate or eliminate the obstruction altogether... - Neuromechanical control of the isolated upper airway of miceAudrey Liu
Johns Hopkins Sleep Disorders Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Appl Physiol 105:1237-45. 2008..Our findings in mice imply that anatomic and neuromuscular factors interact dynamically to modulate upper airway function, and provide a novel approach to modeling the impact of genetic and environmental factors in inbred murine strains... - Behavioral and respiratory characteristics during sleep in neonatal DBA/2J and A/J miceAlexander Balbir
Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, E7610, 615 N Wolfe Street, Baltimore, MD 21205, USA
Brain Res 1241:84-91. 2008..Carotid body-mediated respiratory responses (decreased ventilation upon hyperoxia and increased ventilation upon mild hypoxia) during sleep were clearly observed in these neonatal mice with or without EMG instrumentation... - Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approachesAlan R Schwartz
Johns Hopkins Sleep Disorders Center, Baltimore, MD 21224, USA
Proc Am Thorac Soc 5:185-92. 2008..Examining responses to specific weight loss strategies will provide critical insight into mechanisms linking obesity and sleep apnea, and will help to elucidate the humoral and molecular predictors of weight loss responses... - Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liverVladimir Savransky
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Physiol Gastrointest Liver Physiol 293:G871-7. 2007..We conclude that CIH induces lipid peroxidation and inflammation in the livers of mice on a high-fat, high-cholesterol diet... - Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxiaJianguo Li
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Physiol Genomics 31:273-80. 2007..We conclude that hyperlipidemia in response to IH is mediated via the SREBP-1 pathway. Our data suggest that the SREBP-1 pathway could be used as a therapeutic target in patients with both OSA and hyperlipidemia... - Chronic intermittent hypoxia predisposes to liver injuryVladimir Savransky
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Hepatology 45:1007-13. 2007..CONCLUSION: In the absence of obesity, CIH leads to mild liver injury via oxidative stress and excessive glycogen accumulation in hepatocytes and sensitizes the liver to a second insult, whereas NASH does not develop... - Sleep-disordered breathing, glucose intolerance, and insulin resistanceNaresh M Punjabi
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Respir Physiol Neurobiol 136:167-78. 2003..Potential mediators of this association include altered adrenergic function, the direct effects of hypoxemia on glucose regulation, and release of proinflammatory cytokines that affect metabolism... - Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strainsArnon E Rubin
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 168:1520-7. 2003..Our data imply that individuals with low hypoxic sensitivity may be at a greater risk for hypoxia-related complications of obstructive sleep apnea... - Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese miceJianguo Li
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Appl Physiol 99:1643-8. 2005..In conclusion, we have shown that CIH may exacerbate preexisting fatty liver of obesity via upregulation of the pathways of lipid biosynthesis in the liver... - Intermittent hypoxia induces hyperlipidemia in lean miceJianguo Li
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Circ Res 97:698-706. 2005.... - Disorders of glucose metabolism in sleep apneaNaresh M Punjabi
Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Appl Physiol 99:1998-2007. 2005.... - Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alphaJianguo Li
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Physiol Genomics 25:450-7. 2006.... - Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activityNao Iiyori
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Respir Crit Care Med 175:851-7. 2007..Furthermore, we assessed the impact of IH on specific metabolic function in liver and muscle. Finally, we examined the potential mechanistic role of the autonomic nervous system (ANS) in mediating insulin resistance in response to IH... - Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxiaJianguo Li
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Appl Physiol 102:557-63. 2007..In conclusion, CIH leads to hypercholesterolemia and lipid peroxidation in the absence of obesity, and the degree of metabolic dysregulation is dependent on the severity of the hypoxic stimulus... - Genomics of sleep-disordered breathingVsevolod Y Polotsky
Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Medical School, Baltimore Maryland, USA
Proc Am Thorac Soc 4:121-6. 2007.... - Chronic intermittent hypoxia induces atherosclerosisVladimir Savransky
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 175:1290-7. 2007..A causal link between obstructive sleep apnea and atherosclerosis has not been established... - Mouse model of the metabolic syndrome: the quest continuesVsevolod Y Polotsky
J Appl Physiol 102:2088-9. 2007
Research Grants
- Sleep Disordered Breathing and Glucose RegulationVsevolod Polotsky; Fiscal Year: 2006..Thus, this study will examine mechanistically how SDB affects glucose regulation, which could have a significant impact on both fields of SDB and diabetes. ..
- Sleep Apnea and Dysregulation of Lipid MetabolismVsevolod Polotsky; Fiscal Year: 2007..The proposal will elucidate causative pathways linking SA and dysregulation of lipid metabolism and identify potential intervention for preventing hyperlipidemia and reducing cardiovascular risk in patients with sleep apnea. ..
- Sleep Apnea and Dysregulation of Lipid MetabolismVsevolod Y Polotsky; Fiscal Year: 2010..We propose to use a mouse model of sleep apnea to explore these mechanisms and identify novel therapeutic targets, which may improve outcomes in patients with sleep apnea and the cardiovascular disease. ..