Vsevolod Polotsky

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Obstructive sleep apnea and non-alcoholic Fatty liver disease: is the liver another target?
    Aibek E Mirrakhimov
    I K Akhunbaev Kyrgyz State Medical Academy Bishkek, Kyrgyzstan
    Front Neurol 3:149. 2012
  2. pmc Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α
    Mi Kyung Shin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e46562. 2012
  3. ncbi Simultaneous operations in thoraco-abdominal clinical oncology
    M I Davydov
    Surgical Department of Thoraco-Abdominal Oncology, N.N. Blokhin Memorial Cancer Research Centre of Russian Federation, Russian Academy of Medical Sciences, Kashirskoye sh. 24, 115478, Moscow, Russia
    Eur J Cardiothorac Surg 20:1020-4. 2001
  4. pmc Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity
    Vsevolod Y Polotsky
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 179:228-34. 2009
  5. ncbi Impact of interrupted leptin pathways on ventilatory control
    Vsevolod Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 96:991-8. 2004
  6. pmc Intermittent hypoxia increases insulin resistance in genetically obese mice
    Vsevolod Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 552:253-64. 2003
  7. ncbi Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse
    Vsevolod Y Polotsky
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 7:7-16. 2006
  8. pmc Effects of leptin and obesity on the upper airway function
    Mikhael Polotsky
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Appl Physiol (1985) 112:1637-43. 2012
  9. pmc Effect of age and weight on upper airway function in a mouse model
    Mikhael Polotsky
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Appl Physiol (1985) 111:696-703. 2011
  10. pmc Neuromechanical control of the isolated upper airway of mice
    Audrey Liu
    Johns Hopkins Sleep Disorders Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 105:1237-45. 2008

Research Grants

  1. Sleep Apnea and Dysregulation of Lipid Metabolism
    Vsevolod Polotsky; Fiscal Year: 2005
  2. Sleep Apnea and Dysregulation of Lipid Metabolism
    Vsevolod Polotsky; Fiscal Year: 2006
  3. Sleep Disordered Breathing and Glucose Regulation
    Vsevolod Polotsky; Fiscal Year: 2006
  4. Sleep Apnea and Dysregulation of Lipid Metabolism
    Vsevolod Polotsky; Fiscal Year: 2007
  5. Sleep Apnea and Dysregulation of Lipid Metabolism
    Vsevolod Y Polotsky; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. pmc Obstructive sleep apnea and non-alcoholic Fatty liver disease: is the liver another target?
    Aibek E Mirrakhimov
    I K Akhunbaev Kyrgyz State Medical Academy Bishkek, Kyrgyzstan
    Front Neurol 3:149. 2012
    ..Thus, multiple lines of evidence suggest that IH of OSA may contribute to the progression of NAFLD but definitive clinical studies and experiments in the mouse model have yet to be done...
  2. pmc Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α
    Mi Kyung Shin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e46562. 2012
    ..2 mg/dl in untreated mice, p<0.01), plasma insulin, hepatic glucose output, and liver fat content. These findings demonstrate that the metabolic consequences of DIO are attenuated by HIF-1α ASO treatment...
  3. ncbi Simultaneous operations in thoraco-abdominal clinical oncology
    M I Davydov
    Surgical Department of Thoraco-Abdominal Oncology, N.N. Blokhin Memorial Cancer Research Centre of Russian Federation, Russian Academy of Medical Sciences, Kashirskoye sh. 24, 115478, Moscow, Russia
    Eur J Cardiothorac Surg 20:1020-4. 2001
    ..CONCLUSION: Simultaneous operations increase resectability, radicality and functional operability and therefore promise improvement of follow-up results in the most serious category of cancer patients in question...
  4. pmc Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity
    Vsevolod Y Polotsky
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 179:228-34. 2009
    ..Obstructive sleep apnea is associated with insulin resistance and liver injury. It is unknown whether apnea contributes to insulin resistance and steatohepatitis in severe obesity...
  5. ncbi Impact of interrupted leptin pathways on ventilatory control
    Vsevolod Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 96:991-8. 2004
    ..We conclude that interruption of leptin pathways does not affect hypoxic sensitivity during sleep and wakefulness but that melanocortin 4 blockade is associated with depressed hypercapnic sensitivity in non-rapid eye movement sleep...
  6. pmc Intermittent hypoxia increases insulin resistance in genetically obese mice
    Vsevolod Y Polotsky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 552:253-64. 2003
    ..001) and worsening glucose tolerance, consistent with an increase in insulin resistance. We conclude that the increase in insulin resistance in response to intermittent hypoxia is dependent on the disruption of leptin pathways...
  7. ncbi Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse
    Vsevolod Y Polotsky
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 7:7-16. 2006
    ..We hypothesized that both intermittent hypoxia (IH) and non-hypoxic arousals of OSA result in significant disruption of non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS)...
  8. pmc Effects of leptin and obesity on the upper airway function
    Mikhael Polotsky
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Appl Physiol (1985) 112:1637-43. 2012
    ..The findings suggest that weight and leptin deficiency produced defects in upper airway neuromechanical control and that leptin reversed defects in active neuromuscular responses acutely without reducing mechanical loads...
  9. pmc Effect of age and weight on upper airway function in a mouse model
    Mikhael Polotsky
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Appl Physiol (1985) 111:696-703. 2011
    ..The susceptibility to upper airway obstruction increases with age and weight as tonic neuromuscular activity falls. IFL can elicit phasic responses in normal mice that mitigate or eliminate the obstruction altogether...
  10. pmc Neuromechanical control of the isolated upper airway of mice
    Audrey Liu
    Johns Hopkins Sleep Disorders Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 105:1237-45. 2008
    ..Our findings in mice imply that anatomic and neuromuscular factors interact dynamically to modulate upper airway function, and provide a novel approach to modeling the impact of genetic and environmental factors in inbred murine strains...
  11. pmc Behavioral and respiratory characteristics during sleep in neonatal DBA/2J and A/J mice
    Alexander Balbir
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, E7610, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Brain Res 1241:84-91. 2008
    ..Carotid body-mediated respiratory responses (decreased ventilation upon hyperoxia and increased ventilation upon mild hypoxia) during sleep were clearly observed in these neonatal mice with or without EMG instrumentation...
  12. pmc Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches
    Alan R Schwartz
    Johns Hopkins Sleep Disorders Center, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 5:185-92. 2008
    ..Examining responses to specific weight loss strategies will provide critical insight into mechanisms linking obesity and sleep apnea, and will help to elucidate the humoral and molecular predictors of weight loss responses...
  13. ncbi Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia
    Jianguo Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Physiol Genomics 31:273-80. 2007
    ..We conclude that hyperlipidemia in response to IH is mediated via the SREBP-1 pathway. Our data suggest that the SREBP-1 pathway could be used as a therapeutic target in patients with both OSA and hyperlipidemia...
  14. ncbi Chronic intermittent hypoxia predisposes to liver injury
    Vladimir Savransky
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Hepatology 45:1007-13. 2007
    ..CONCLUSION: In the absence of obesity, CIH leads to mild liver injury via oxidative stress and excessive glycogen accumulation in hepatocytes and sensitizes the liver to a second insult, whereas NASH does not develop...
  15. ncbi Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver
    Vladimir Savransky
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Gastrointest Liver Physiol 293:G871-7. 2007
    ..We conclude that CIH induces lipid peroxidation and inflammation in the livers of mice on a high-fat, high-cholesterol diet...
  16. pmc Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity
    Nao Iiyori
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Respir Crit Care Med 175:851-7. 2007
    ..Furthermore, we assessed the impact of IH on specific metabolic function in liver and muscle. Finally, we examined the potential mechanistic role of the autonomic nervous system (ANS) in mediating insulin resistance in response to IH...
  17. ncbi Sleep-disordered breathing, glucose intolerance, and insulin resistance
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Physiol Neurobiol 136:167-78. 2003
    ..Potential mediators of this association include altered adrenergic function, the direct effects of hypoxemia on glucose regulation, and release of proinflammatory cytokines that affect metabolism...
  18. ncbi Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha
    Jianguo Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Physiol Genomics 25:450-7. 2006
    ....
  19. ncbi Disorders of glucose metabolism in sleep apnea
    Naresh M Punjabi
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 99:1998-2007. 2005
    ....
  20. ncbi Intermittent hypoxia induces hyperlipidemia in lean mice
    Jianguo Li
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circ Res 97:698-706. 2005
    ....
  21. ncbi Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice
    Jianguo Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 99:1643-8. 2005
    ..In conclusion, we have shown that CIH may exacerbate preexisting fatty liver of obesity via upregulation of the pathways of lipid biosynthesis in the liver...
  22. ncbi Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains
    Arnon E Rubin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 168:1520-7. 2003
    ..Our data imply that individuals with low hypoxic sensitivity may be at a greater risk for hypoxia-related complications of obstructive sleep apnea...
  23. pmc Chronic intermittent hypoxia induces atherosclerosis
    Vladimir Savransky
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 175:1290-7. 2007
    ..A causal link between obstructive sleep apnea and atherosclerosis has not been established...
  24. ncbi Genomics of sleep-disordered breathing
    Vsevolod Y Polotsky
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Medical School, Baltimore Maryland, USA
    Proc Am Thorac Soc 4:121-6. 2007
    ....
  25. ncbi Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia
    Jianguo Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Appl Physiol 102:557-63. 2007
    ..In conclusion, CIH leads to hypercholesterolemia and lipid peroxidation in the absence of obesity, and the degree of metabolic dysregulation is dependent on the severity of the hypoxic stimulus...
  26. ncbi Mouse model of the metabolic syndrome: the quest continues
    Vsevolod Y Polotsky
    J Appl Physiol 102:2088-9. 2007

Research Grants6

  1. Sleep Apnea and Dysregulation of Lipid Metabolism
    Vsevolod Polotsky; Fiscal Year: 2005
    ..The proposal will elucidate causative pathways linking SA and dysregulation of lipid metabolism and identify potential intervention for preventing hyperlipidemia and reducing cardiovascular risk in patients with sleep apnea. ..
  2. Sleep Apnea and Dysregulation of Lipid Metabolism
    Vsevolod Polotsky; Fiscal Year: 2006
    ..The proposal will elucidate causative pathways linking SA and dysregulation of lipid metabolism and identify potential intervention for preventing hyperlipidemia and reducing cardiovascular risk in patients with sleep apnea. ..
  3. Sleep Disordered Breathing and Glucose Regulation
    Vsevolod Polotsky; Fiscal Year: 2006
    ..Thus, this study will examine mechanistically how SDB affects glucose regulation, which could have a significant impact on both fields of SDB and diabetes. ..
  4. Sleep Apnea and Dysregulation of Lipid Metabolism
    Vsevolod Polotsky; Fiscal Year: 2007
    ..The proposal will elucidate causative pathways linking SA and dysregulation of lipid metabolism and identify potential intervention for preventing hyperlipidemia and reducing cardiovascular risk in patients with sleep apnea. ..
  5. Sleep Apnea and Dysregulation of Lipid Metabolism
    Vsevolod Y Polotsky; Fiscal Year: 2010
    ..We propose to use a mouse model of sleep apnea to explore these mechanisms and identify novel therapeutic targets, which may improve outcomes in patients with sleep apnea and the cardiovascular disease. ..