Research Topics
| Fernando P PolackSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Detail Information
Publications
Altered synthesis of interleukin-12 and type 1 and type 2 cytokinesin rhesus macaques during measles and atypical measlesFernando P Polack
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
J Infect Dis 185:13-9. 2002..In vivo production of IL-12 was decreased during the viremic phase of the illness, and production of IL-4 was increased during and after atypical measles, compared with measles...
A role for immune complexes in enhanced respiratory syncytial virus diseaseFernando P Polack
Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
J Exp Med 196:859-65. 2002..Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease...- Differential effects of priming with DNA vaccines encoding the hemagglutinin and/or fusion proteins on cytokine responses after measles virus challengeFernando P Polack
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Infect Dis 187:1794-800. 2003..Responses were modulated when both proteins were used for priming. Therefore, the specific proteins included in a new measles vaccine will affect the type of cytokine response elicited... - A role for nonprotective complement-fixing antibodies with low avidity for measles virus in atypical measlesFernando P Polack
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Nat Med 9:1209-13. 2003..Only FIMV recipients had immune complex deposition. Failure of FIMV to induce affinity maturation results in anamnestic production of nonprotective, complement-fixing antibodies, immune complex deposition and atypical measles... 
The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxinFernando P Polack
Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:8996-9001. 2005..These findings have important implications for RSV pathogenesis and describe an inhibitor of TLR-mediated inflammatory responses that could have clinical applications...- Atypical measles and enhanced respiratory syncytial virus disease (ERD) made simpleFernando P Polack
Department of Pediatrics, Johns Hopkins University School of Medicine Baltimore, MD 21205, USA
Pediatr Res 62:111-5. 2007.... - Use of Vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virusChien Hsiung Pan
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
Clin Vaccine Immunol 15:1214-21. 2008..The use of Vaxfectin-formulated DNA is a promising approach to the development of a measles vaccine for young infants... - Inaugural Article: Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particlesChien-Hsiung Pan
W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:11581-8. 2005..Viremia was cleared within 14 days, but MV RNA was detectable for 4-5 months. These studies suggest that complete clearance of MV after infection is a prolonged, phased, and complex process influenced by prior vaccination... - Vaccination of rhesus macaques with a recombinant measles virus expressing interleukin-12 alters humoral and cellular immune responsesScott J Hoffman
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Infect Dis 188:1553-61. 2003..Reduced IL-12 levels are not the sole factor in MV-induced immunosuppression... - Dose-dependent protection against or exacerbation of disease by a polylactide glycolide microparticle-adsorbed, alphavirus-based measles virus DNA vaccine in rhesus macaquesChien Hsiung Pan
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
Clin Vaccine Immunol 15:697-706. 2008..We conclude that PLG/SINCP-H is most efficacious when delivered intramuscularly but does not provide an advantage over standard DNA vaccines for protection against measles... - Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infantsRuth A Karron
Center for Immunization Research, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Infect Dis 191:1093-104. 2005..Recombination technology can be used to create live attenuated respiratory syncytial virus (RSV) vaccines that contain combinations of known attenuating mutations... - A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinovirusesE Kathryn Miller
Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
Am J Respir Crit Care Med 185:508-16. 2012..Moreover, although several hypotheses have been advanced to explain virus-induced exacerbations, their mechanism remains unclear... - Measles virus infection of rhesus macaques affects neutrophil expression of IL-12 and IL-10Scott J Hoffman
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Viral Immunol 16:369-79. 2003..Subsequently, IL-12 levels were restored, and IL-10 expression rose above baseline in both cell types. Increased IL-10 production by neutrophils and monocytes during MV infection may play a role in measles-induced immunosuppression... - Mechanisms of illness during respiratory syncytial virus infection: the lungs, the virus and the immune responseScott J Hoffman
Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Microbes Infect 6:767-72. 2004..A better understanding of the factors affecting the course of illness and their interplay should allow development of effective therapies in the future... - The future of respiratory syncytial virus vaccine developmentFernando P Polack
Department of Intenational Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Pediatr Infect Dis J 23:S65-73. 2004..CONCLUSIONS: During the past 10 years, considerable progress has been made in RSV vaccine development. It is likely that different RSV vaccines will be needed for the various populations at risk... - Human rhinoviruses in severe respiratory disease in very low birth weight infantsE Kathryn Miller
Department of Pediatrics, Vanderbilt University, Nashville, TN 37232 2007, USA
Pediatrics 129:e60-7. 2012..To assess incidence, burden of illness, and risk factors for human rhinoviruses (HRVs) in a cohort of very low birth weight (VLBW) infants... - Differential gender response to respiratory infections and to the protective effect of breast milk in preterm infantsM Ines Klein
Johns Hopkins University, 615 N Wolfe St, E5202, Baltimore, MD 21205, USA
Pediatrics 121:e1510-6. 2008..The objective of this study was to determine whether the effect of breastfeeding on susceptibility to severe acute lung disease among infants at high risk is different for girls and boys... - Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeysSallie R Permar
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 77:4396-400. 2003..These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies... - Cytokine profiles in the respiratory tract during primary infection with human metapneumovirus, respiratory syncytial virus, or influenza virus in infantsGuillermina A Melendi
Fundacion INFANT, Buenos Aires, Argentina
Pediatrics 120:e410-5. 2007.... - Involvement of antibody, complement and cellular immunity in the pathogenesis of enhanced respiratory syncytial virus diseaseM Florencia Delgado
INFANT Fundacion, Buenos Aires, Argentina
Expert Rev Vaccines 3:693-700. 2004..In this review, the pathogenesis of enhanced respiratory disease is discussed and the characteristics of protective and pathogenic respiratory syncytial virus vaccines are examined... - The cysteine-rich region and secreted form of the attachment G glycoprotein of respiratory syncytial virus enhance the cytotoxic T-lymphocyte response despite lacking major histocompatibility complex class I-restricted epitopesAlexander Bukreyev
National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
J Virol 80:5854-61. 2006..These findings reveal a novel function for the GCRR with potential implications for the generation of protective cellular responses and vaccine development... - Differential production of inflammatory cytokines in primary infection with human metapneumovirus and with other common respiratory viruses of infancyFederico R Laham
, Buenos Aires, Argentina
J Infect Dis 189:2047-56. 2004..These findings suggest that hMPV and RSV either cause disease via different mechanisms or share a common mechanism that is distinct from innate immune activation... - Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeysSallie R Permar
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Infect Dis 190:998-1005. 2004.... - C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expressionGuillermina A Melendi
INFANT Fundacion, Buenos Aires, Argentina
J Virol 81:991-9. 2007..These findings reveal a novel autoregulatory mechanism for the complement cascade that affects the innate and adaptive immune responses... - Mapping and characterization of the primary and anamnestic H-2(d)-restricted cytotoxic T-lymphocyte response in mice against human metapneumovirusGuillermina A Melendi
Fundacion INFANT, Buenos Aires, Argentina
J Virol 81:11461-7. 2007..An understanding of the CTL response against hMPV is important for developing preventive and therapeutic strategies against the virus...