Fernando P Polack

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease
    Maria Florencia Delgado
    INFANT Foundation, Gavilan 94, Buenos Aires, Argentina
    Nat Med 15:34-41. 2009
  2. ncbi Altered synthesis of interleukin-12 and type 1 and type 2 cytokinesin rhesus macaques during measles and atypical measles
    Fernando P Polack
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 185:13-9. 2002
  3. ncbi Atypical measles and enhanced respiratory syncytial virus disease (ERD) made simple
    Fernando P Polack
    Department of Pediatrics, Johns Hopkins University School of Medicine Baltimore, MD 21205, USA
    Pediatr Res 62:111-5. 2007
  4. pmc The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:8996-9001. 2005
  5. ncbi A role for nonprotective complement-fixing antibodies with low avidity for measles virus in atypical measles
    Fernando P Polack
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Nat Med 9:1209-13. 2003
  6. ncbi Differential effects of priming with DNA vaccines encoding the hemagglutinin and/or fusion proteins on cytokine responses after measles virus challenge
    Fernando P Polack
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Infect Dis 187:1794-800. 2003
  7. pmc A role for immune complexes in enhanced respiratory syncytial virus disease
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 196:859-65. 2002
  8. pmc Use of Vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virus
    Chien Hsiung Pan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Clin Vaccine Immunol 15:1214-21. 2008
  9. ncbi Cytokine profiles in the respiratory tract during primary infection with human metapneumovirus, respiratory syncytial virus, or influenza virus in infants
    Guillermina A Melendi
    Fundacion INFANT, Buenos Aires, Argentina
    Pediatrics 120:e410-5. 2007
  10. pmc C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression
    Guillermina A Melendi
    INFANT Fundacion, Buenos Aires, Argentina
    J Virol 81:991-9. 2007

Collaborators

Detail Information

Publications33

  1. pmc Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease
    Maria Florencia Delgado
    INFANT Foundation, Gavilan 94, Buenos Aires, Argentina
    Nat Med 15:34-41. 2009
    ..It also suggests that inactivated RSV vaccines may be rendered safe and effective by inclusion of TLR agonists in their formulation, and it identifies affinity maturation as a key factor for the safe immunization of infants...
  2. ncbi Altered synthesis of interleukin-12 and type 1 and type 2 cytokinesin rhesus macaques during measles and atypical measles
    Fernando P Polack
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 185:13-9. 2002
    ..In vivo production of IL-12 was decreased during the viremic phase of the illness, and production of IL-4 was increased during and after atypical measles, compared with measles...
  3. ncbi Atypical measles and enhanced respiratory syncytial virus disease (ERD) made simple
    Fernando P Polack
    Department of Pediatrics, Johns Hopkins University School of Medicine Baltimore, MD 21205, USA
    Pediatr Res 62:111-5. 2007
    ....
  4. pmc The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:8996-9001. 2005
    ..These findings have important implications for RSV pathogenesis and describe an inhibitor of TLR-mediated inflammatory responses that could have clinical applications...
  5. ncbi A role for nonprotective complement-fixing antibodies with low avidity for measles virus in atypical measles
    Fernando P Polack
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Nat Med 9:1209-13. 2003
    ..Only FIMV recipients had immune complex deposition. Failure of FIMV to induce affinity maturation results in anamnestic production of nonprotective, complement-fixing antibodies, immune complex deposition and atypical measles...
  6. ncbi Differential effects of priming with DNA vaccines encoding the hemagglutinin and/or fusion proteins on cytokine responses after measles virus challenge
    Fernando P Polack
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Infect Dis 187:1794-800. 2003
    ..Responses were modulated when both proteins were used for priming. Therefore, the specific proteins included in a new measles vaccine will affect the type of cytokine response elicited...
  7. pmc A role for immune complexes in enhanced respiratory syncytial virus disease
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 196:859-65. 2002
    ..Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease...
  8. pmc Use of Vaxfectin adjuvant with DNA vaccine encoding the measles virus hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques against measles virus
    Chien Hsiung Pan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Clin Vaccine Immunol 15:1214-21. 2008
    ..The use of Vaxfectin-formulated DNA is a promising approach to the development of a measles vaccine for young infants...
  9. ncbi Cytokine profiles in the respiratory tract during primary infection with human metapneumovirus, respiratory syncytial virus, or influenza virus in infants
    Guillermina A Melendi
    Fundacion INFANT, Buenos Aires, Argentina
    Pediatrics 120:e410-5. 2007
    ....
  10. pmc C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression
    Guillermina A Melendi
    INFANT Fundacion, Buenos Aires, Argentina
    J Virol 81:991-9. 2007
    ..These findings reveal a novel autoregulatory mechanism for the complement cascade that affects the innate and adaptive immune responses...
  11. pmc Dose-dependent protection against or exacerbation of disease by a polylactide glycolide microparticle-adsorbed, alphavirus-based measles virus DNA vaccine in rhesus macaques
    Chien Hsiung Pan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Clin Vaccine Immunol 15:697-706. 2008
    ..We conclude that PLG/SINCP-H is most efficacious when delivered intramuscularly but does not provide an advantage over standard DNA vaccines for protection against measles...
  12. pmc Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles
    Chien Hsiung Pan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:11581-8. 2005
    ..Viremia was cleared within 14 days, but MV RNA was detectable for 4-5 months. These studies suggest that complete clearance of MV after infection is a prolonged, phased, and complex process influenced by prior vaccination...
  13. pmc A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinoviruses
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
    Am J Respir Crit Care Med 185:508-16. 2012
    ..Moreover, although several hypotheses have been advanced to explain virus-induced exacerbations, their mechanism remains unclear...
  14. ncbi Vaccination of rhesus macaques with a recombinant measles virus expressing interleukin-12 alters humoral and cellular immune responses
    Scott J Hoffman
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 188:1553-61. 2003
    ..Reduced IL-12 levels are not the sole factor in MV-induced immunosuppression...
  15. doi Breastfeeding prevents severe disease in full term female infants with acute respiratory infection
    Romina Libster
    Fundacion INFANT, Buenos Aires, Argentina
    Pediatr Infect Dis J 28:131-4. 2009
    ..Recently, a gender specific role for human milk has been described in very low birth weight infants and neonates: breast milk protected girls but not boys...
  16. ncbi Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants
    Ruth A Karron
    Center for Immunization Research, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Infect Dis 191:1093-104. 2005
    ..Recombination technology can be used to create live attenuated respiratory syncytial virus (RSV) vaccines that contain combinations of known attenuating mutations...
  17. doi Conserved cysteine residues within the attachment G glycoprotein of respiratory syncytial virus play a critical role in the enhancement of cytotoxic T-lymphocyte responses
    Guillermina A Melendi
    INFANT Fundacion, Buenos Aires, Argentina
    Virus Genes 42:46-54. 2011
    ..Our results indicate that these conserved residues are essential for the wide-spectrum pro-CTL activity displayed by the protein...
  18. ncbi The impact of infection with human metapneumovirus and other respiratory viruses in young infants and children at high risk for severe pulmonary disease
    M Ines Klein
    Fundacion INFANT, Buenos Aires, Argentina
    J Infect Dis 193:1544-51. 2006
    ..The present study of at-risk children suggests that hMPV and influenza virus are infrequent agents of severe disease and highlights the need for preventive interventions against RSV in developing countries...
  19. ncbi Differential production of inflammatory cytokines in primary infection with human metapneumovirus and with other common respiratory viruses of infancy
    Federico R Laham
    INFANT Fundacion, Buenos Aires, Argentina
    J Infect Dis 189:2047-56. 2004
    ..These findings suggest that hMPV and RSV either cause disease via different mechanisms or share a common mechanism that is distinct from innate immune activation...
  20. pmc Human rhinoviruses in severe respiratory disease in very low birth weight infants
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232 2007, USA
    Pediatrics 129:e60-7. 2012
    ..To assess incidence, burden of illness, and risk factors for human rhinoviruses (HRVs) in a cohort of very low birth weight (VLBW) infants...
  21. pmc Differential gender response to respiratory infections and to the protective effect of breast milk in preterm infants
    M Ines Klein
    Johns Hopkins University, 615 N Wolfe St, E5202, Baltimore, MD 21205, USA
    Pediatrics 121:e1510-6. 2008
    ..The objective of this study was to determine whether the effect of breastfeeding on susceptibility to severe acute lung disease among infants at high risk is different for girls and boys...
  22. ncbi Involvement of antibody, complement and cellular immunity in the pathogenesis of enhanced respiratory syncytial virus disease
    M Florencia Delgado
    INFANT Fundacion, Buenos Aires, Argentina
    Expert Rev Vaccines 3:693-700. 2004
    ..In this review, the pathogenesis of enhanced respiratory disease is discussed and the characteristics of protective and pathogenic respiratory syncytial virus vaccines are examined...
  23. doi Breastfeeding is associated with the production of type I interferon in infants infected with influenza virus
    Guillermina A Melendi
    Fundacion INFANT, Buenos Aires, Argentina
    Acta Paediatr 99:1517-21. 2010
    ..Type I interferons (IFN) mediate host defence against respiratory viruses, particularly influenza virus. The relationship among type I IFN, respiratory viral infections and breastfeeding has not been explored...
  24. pmc Poor immune responses of newborn rhesus macaques to measles virus DNA vaccines expressing the hemagglutinin and fusion glycoproteins
    Fernando P Polack
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Clin Vaccine Immunol 20:205-10. 2013
    ..We conclude that vaccination of infant macaques with DNA encoding MeV H and F provided only partial protection from MeV infection...
  25. ncbi Measles virus infection of rhesus macaques affects neutrophil expression of IL-12 and IL-10
    Scott J Hoffman
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Viral Immunol 16:369-79. 2003
    ..Subsequently, IL-12 levels were restored, and IL-10 expression rose above baseline in both cell types. Increased IL-10 production by neutrophils and monocytes during MV infection may play a role in measles-induced immunosuppression...
  26. pmc Mapping and characterization of the primary and anamnestic H-2(d)-restricted cytotoxic T-lymphocyte response in mice against human metapneumovirus
    Guillermina A Melendi
    Fundacion INFANT, Buenos Aires, Argentina
    J Virol 81:11461-7. 2007
    ..An understanding of the CTL response against hMPV is important for developing preventive and therapeutic strategies against the virus...
  27. ncbi Mechanisms of illness during respiratory syncytial virus infection: the lungs, the virus and the immune response
    Scott J Hoffman
    Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Microbes Infect 6:767-72. 2004
    ..A better understanding of the factors affecting the course of illness and their interplay should allow development of effective therapies in the future...
  28. doi T helper type 2 bias and type 17 suppression in primary dengue virus infection in infants and young children
    Laura B Talarico
    Fundacion INFANT, Gavilan 94, Buenos Aires 1406, Argentina
    Trans R Soc Trop Med Hyg 107:411-9. 2013
    ..In Northern Argentina, >90% of the population was DENV-naïve before the 2009 outbreak, allowing evaluation of age-dependent primary responses to infection...
  29. ncbi The future of respiratory syncytial virus vaccine development
    Fernando P Polack
    Department of Intenational Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Pediatr Infect Dis J 23:S65-73. 2004
    ..Despite decades of research there are currently no licensed vaccines for prevention of RSV disease...
  30. pmc Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
    Ana Clara Monsalvo
    Fundacion INFANT, Buenos Aires, Argentina
    Nat Med 17:195-9. 2011
    ..These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics...
  31. ncbi Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys
    Sallie R Permar
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Infect Dis 190:998-1005. 2004
    ....
  32. pmc Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys
    Sallie R Permar
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:4396-400. 2003
    ..These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies...
  33. pmc The cysteine-rich region and secreted form of the attachment G glycoprotein of respiratory syncytial virus enhance the cytotoxic T-lymphocyte response despite lacking major histocompatibility complex class I-restricted epitopes
    Alexander Bukreyev
    National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Virol 80:5854-61. 2006
    ..These findings reveal a novel function for the GCRR with potential implications for the generation of protective cellular responses and vaccine development...