Research Topics
Genomes and Genes | M V PletnikovSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Neonatal Borna disease virus infection (BDV)-induced damage to the cerebellum is associated with sensorimotor deficits in developing Lewis ratsM V Pletnikov
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
Brain Res Dev Brain Res 126:1-12. 2001..Further studies of this model may elucidate specific pathogenic mechanisms that that may have implications in the study of neurodevelopmental human disorders...
Toxoplasma gondii and cognitive deficits in schizophrenia: an animal model perspectiveGeetha Kannan
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Schizophr Bull 38:1155-61. 2012..gondii infection and cognitive impairment, (2) critically analyze current rodent models of cognitive deficits resulting from T. gondii infection, and (3) explore possible mechanisms whereby the parasite may affect cognitive function...- Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampusMikhail V Ovanesov
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neuroinflammation 5:16. 2008..The data demonstrate for the first time that a non-lytic persistent virus infection of neurons activates microglia long before any measurable neuronal loss... - Astrocytes play a key role in activation of microglia by persistent Borna disease virus infectionMikhail V Ovanesov
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neuroinflammation 5:50. 2008..The data are consistent with the hypothesis that microglia activation in the absence of neuronal damage may represent initial steps in the gradual neurodegeneration observed in brains of neonatally BDV-infected rats... 
Inducible and conditional transgenic mouse models of schizophreniaMikhail V Pletnikov
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Prog Brain Res 179:35-47. 2009..We also consider the strength and weaknesses of each model. We will argue that further development of more sophisticated genetic animal models is crucial for clarifying the unknowns of schizophrenia...- Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophreniaM V Pletnikov
Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Mol Psychiatry 13:173-86, 115. 2008..The present mouse model may facilitate the study of aspects of the pathogenesis of schizophrenia... - PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiationMikhail V Pletnikov
Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neurosci Res 58:234-44. 2007..Thus, inducible expression of DISC1 in PC12 cell clones is a valuable in vitro model for further studying the molecular mechanisms likely due to loss of function of DISC1 relevant to the pathogenesis of major mental illnesses... - Exploring the cerebellum with a new tool: neonatal Borna disease virus (BDV) infection of the rat's brainMikhail V Pletnikov
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cerebellum 2:62-70. 2003.... - Enlargement of the lateral ventricles in mutant DISC1 transgenic miceM V Pletnikov
Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Mol Psychiatry 13:115. 2008 - Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systemsM V Pletnikov
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
Brain Res Dev Brain Res 119:179-85. 2000..This pattern of changes is consistent with the previously reported behavioral abnormalities resulting from neonatal BDV infection... - Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autismM V Pletnikov
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Behav Brain Res 100:43-50. 1999..These data demonstrate deficits in play behavior and other social interactions following BDV-associated developmental brain injury, thus supporting the value of the neonatally BDV-infected rat as an animal model of autism... - Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disordersY Ayhan
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Mol Psychiatry 16:293-306. 2011..The multiple and diverse abnormalities detected in mutant DISC1 mice are reminiscent of findings in major mental diseases... - Animal models of gene-environment interactions in schizophreniaYavuz Ayhan
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Behav Brain Res 204:274-81. 2009..We propose that animal models based on identified genetic mutations and measurable environment factors will help advance studies of the molecular mechanisms of gene-environment interplay... - Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletionT M Ma
The Solomon H Snyder Department of Neuroscience, Baltimore, MD, USA
Mol Psychiatry 18:557-67. 2013.... - Neuron-glia interactions clarify genetic-environmental links in mental illnessAkira Sawa
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 2 181, Baltimore, MD 21287, USA
Trends Neurosci 27:294-7. 2004..The key role for glial BDV-P implicates neuron-glia interactions in the pathogenesis of psychiatric conditions... - Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatmentsMikhail V Pletnikov
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Brain Res 944:108-23. 2002..The present data provide new insights into the pathogenic events that lead to differential responses to pharmacological treatments in genetically different animals following exposure to the same environmental challenge... - Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virusKaren Lancaster
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Behav Brain Res 176:141-8. 2007..Co-localization of activated microglia and dying Purkinje cells in BDV-infected rats suggests that the BDV model could be used to study a pathogenic link of Purkinje cell dropout and neuroinflammation to abnormal social behaviors... - Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. I. Brain pathology and behavioral deficitsMikhail V Pletnikov
Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Brain Res 944:97-107. 2002..The present data demonstrate that the same environmental insult can produce differential neuroanatomical and behavioral abnormalities in genetically different inbred rat strains... - Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatumMikhail V Ovanesov
Division of Neurobiology, Johns Hopkins University, Baltimore, Maryland, USA
J Neurovirol 13:185-94. 2007..The present data are the first in vivo evidence that GLU excitotoxicity might contribute to BDV-associated neuronal injury in the striatum... - Postnatal weight gain inhibition does not account for neurobehavioral consequences of neonatal Borna disease virus infectionDavid M Dietz
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
Physiol Behav 80:359-66. 2003.... - Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disordersMikhail V Pletnikov
Department of Psychiatry, The Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
Front Biosci 7:d593-607. 2002.... - Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic modelsHanna Jaaro-Peled
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Schizophr Bull 36:301-13. 2010..Finally, in comparison with the changes in patients and nongenetic models, we will discuss the anatomical and neuropathological manifestation in genetic models for schizophrenia... - Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genesYoshii Nishino
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Virol 76:8650-8. 2002..These results suggest that small numbers of genomic differences between BDV variants in the G protein and/or L polymerase can contribute to the variability in BD outcomes... - Activation of microglia by borna disease virus infection: in vitro studyMikhail V Ovanesov
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, CMSC 8-121, Baltimore, MD 21287, USA
J Virol 80:12141-8. 2006..Taken together, the present data are the first in vitro evidence that persistent BDV infection of neurons and astrocytes rather than direct exposure to the virus or dying neurons is critical for activating microglia...
Research Grants
- BORNA VIRUS ALTERS PERINATAL BEHAVIOR DEVELOPMENTMikhail Pletnikov; Fiscal Year: 2003....
- Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessMikhail Pletnikov; Fiscal Year: 2009..We hypothesize that mutant hDISC1 affects neurodevelopment via dominant-negative mechanisms by altering the functions of endogenous mouse Dics1, Lis1, and Ndel1. ..
- Inducible expression of mutant DISC1: transgenic mouse modelMikhail Pletnikov; Fiscal Year: 2007....
- Viral Pathogenesis of Neural and Behavior InjuryMikhail Pletnikov; Fiscal Year: 2007..abstract_text> ..
- Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessMikhail V Pletnikov; Fiscal Year: 2010..We hypothesize that mutant hDISC1 affects neurodevelopment via dominant-negative mechanisms by altering the functions of endogenous mouse Dics1, Lis1, and Ndel1. ..