Research Topics
Genomes and Genes
| Elizabeth A PlatzSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Publications
A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatmentElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Cancer Discov 1:68-77. 2011..By coupling laboratory and epidemiologic methods and thinking, we reduced the probability of identifying false-positive candidate drugs for the next steps in testing...- Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrencePaul J Dluzniewski
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 21:1774-82. 2012.... - Incidence and progression of lower urinary tract symptoms in a large prospective cohort of United States menElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Urol 188:496-501. 2012.... - The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult menAndy Menke
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
BMC Public Health 8:72. 2008..Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small... 
Prostate cancer association studies: pitfalls and solutions to cancer misclassification in the PSA eraElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Cell Biochem 91:553-71. 2004....- Association between plasma cholesterol and prostate cancer in the PSA eraElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Int J Cancer 123:1693-8. 2008..These results coupled with prior statin findings suggest that mechanistic studies on cholesterol metabolism should be pursued to understand a possible target for preventing poorly differentiated prostate cancers... - Low testosterone and risk of premature death in older men: analytical and preanalytical issues in measuring circulating testosteroneElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Clin Chem 54:1110-2. 2008 - Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort studyElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 159:444-53. 2004..64, 95% CI: 1.13, 2.38). These results suggest that moderate or greater alcohol consumption is not a strong contributor to prostate cancer risk, except possibly in men who consume large amounts infrequently... - No association between pre-diagnostic plasma C-reactive protein concentration and subsequent prostate cancerElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Prostate 59:393-400. 2004..We evaluated the association of pre-diagnostic plasma concentration of C-reactive protein, a sensitive, but non-specific indicator of inflammation, with subsequent risk of prostate cancer... - Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent risk of prostate cancerElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Cancer Causes Control 15:255-65. 2004..To address this hypothesis, we evaluated the association of circulating concentrations of 1,25(OH)2D and its precursor 25-hydroxyvitamin D (25(OH)D) with subsequent risk of prostate cancer... - Genetic variation at 8q24 as a susceptibility factor for prostate cancer: definitive results from epidemiologic studies?Elizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Cancer Res 67:2905-7. 2007 - Statin drugs and risk of advanced prostate cancerElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Rm E6138, 615 N Wolfe St, Baltimore, MD 21205, USA
J Natl Cancer Inst 98:1819-25. 2006..We investigated the association of statin use with total and advanced prostate cancer, the latter being the most important endpoint to prevent... - Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA eraElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Brady Urological Institute and the Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
Cancer Causes Control 16:255-62. 2005..We prospectively investigated the associations of plasma IGF-1 and IGFBP-3 concentrations with prostate cancer detected in the PSA era... - Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of AgingElizabeth A Platz
Department of Epidemiology, Room E6138, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 14:390-6. 2005..We evaluated the association of aspirin and nonaspirin NSAIDs with subsequent prostate cancer in a prospective study. We also assessed whether use of these drugs influences serum prostate-specific antigen (PSA) concentration... - Epidemiology of inflammation and prostate cancerElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Brady Urological Institute, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21205, USA
J Urol 171:S36-40. 2004.... - Interrelation of energy intake, body size, and physical activity with prostate cancer in a large prospective cohort studyElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Heath, The Brady Urological Institute, Baltimore, Maryland 21205, USA
Cancer Res 63:8542-8. 2003.... - Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen eraElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 14:1262-9. 2005..We investigated plasma levels of sex steroid hormones and length of the androgen receptor gene CAG repeat in relation to incident prostate cancer diagnosed in the prostate-specific antigen (PSA) era... - Racial variation in insulin-like growth factor-1 and binding protein-3 concentrations in middle-aged menE A Platz
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 8:1107-10. 1999..Although differences in circulating IGF-1 do not seem to account for the greater prostate cancer risk among African-American men, their absolute lower levels of IGFBP-3 may be contributory... - Racial variation in prostate cancer incidence and in hormonal system markers among male health professionalsE A Platz
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
J Natl Cancer Inst 92:2009-17. 2000..Whether differences in the distribution of known or suspected risk factors among racial groups explain this variation is unknown... - Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studiesElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Rm E6132, Baltimore, MD 21205, USA
Cancer Causes Control 21:847-51. 2010..The authors estimated the size of this source of variability and consequent attenuation of the relative risk (RR)... - Prediagnostic toenail cadmium and zinc and subsequent prostate cancer riskElizabeth A Platz
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Prostate 52:288-96. 2002..We evaluated the association between prediagnostic toenail cadmium and zinc concentrations and risk of prostate cancer in a cohort in which the primary route of exposure to cadmium and zinc is the diet... - Energy imbalance and prostate cancerElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Nutr 132:3471S-3481S. 2002.... - Men with low serum cholesterol have a lower risk of high-grade prostate cancer in the placebo arm of the prostate cancer prevention trialElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The James Buchanan Brady Urological Institute, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Cancer Epidemiol Biomarkers Prev 18:2807-13. 2009..Given these findings, we investigated the association between low serum cholesterol and prostate cancer risk in the Prostate Cancer Prevention Trial... 
Is prostate cancer prevention with selenium all in the genes?Elizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Cancer Prev Res (Phila) 3:576-8. 2010..These inferences point toward how to reconcile inconsistent prostate cancer risk results from the two randomized trials of selenium conducted to date...- Does statin use affect the risk of developing prostate cancer?Elizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Nat Clin Pract Urol 6:70-1. 2009..Consideration of the harms and benefits when prescribing a statin for vascular indications, including in obese men, should not presently include prostate cancer risk... - Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancerKonstantinos K Tsilidis
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
Cancer Causes Control 20:1739-51. 2009..Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression... - Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US menMeredith S Shiels
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Cancer Causes Control 20:877-86. 2009.... - Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatmentAngelo M De Marzo
Department of Oncology, The Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231 1000, USA
J Cell Biochem 91:459-77. 2004..We also present the implications of these changes for prostate cancer diagnosis, detection, prevention, and treatment... - Increased gene copy number of ERG on chromosome 21 but not TMPRSS2-ERG fusion predicts outcome in prostatic adenocarcinomasAntoun Toubaji
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Mod Pathol 24:1511-20. 2011..In summary, TMPRSS2-ERG fusion was not prognostic for recurrence after retropubic radical prostatectomy for clinically localized prostate cancer, although men with ERG gene copy number gain without fusion were twice more likely to recur... - Human prostate cancer precursors and pathobiologyAngelo M De Marzo
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
Urology 62:55-62. 2003..Additional results show that AMACR may be an important new marker of prostate cancer, and its use in combination with p63 staining may provide the basis for an improved method for identification of prostate cancer... - Association of energy intake with prostate cancer in a long-term aging study: Baltimore Longitudinal Study of Aging (United States)Lillian J Hsieh
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Urology 61:297-301. 2003..CONCLUSIONS: This analysis, in which we used current energy intake as a surrogate for past prediagnostic intake, suggests a higher risk of prostate cancer with increased energy intake... - Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer riskBahar Mikhak
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 29:2335-40. 2008..On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer... - Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancerSarah E Daugherty
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Prostate 67:1487-97. 2007..Significant differences in AMACR allele frequencies have been reported for hereditary prostate cancer (HPC), but the relevance of AMACR in the context of its substrates have not been studied... - Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality: Physicians' Health StudyJennifer R Stark
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
J Natl Cancer Inst 101:1406-11. 2009..We confirmed these findings in an independent population and related serostatus for antibodies against T vaginalis to prostate cancer incidence and mortality... - C47T polymorphism in manganese superoxide dismutase (MnSOD), antioxidant intake and survivalJeanine M Genkinger
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, MA, United States
Mech Ageing Dev 127:371-7. 2006..A C47T transition in the MnSOD gene may affect the enzyme's distribution to the mitochondrion, a site of high oxidative stress. We examined the association between this polymorphism and survival... - A prospective cohort study of red wine consumption and risk of prostate cancerSiobhan Sutcliffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Int J Cancer 120:1529-35. 2007..These findings suggest that red wine does not contribute appreciably to the etiology of prostate cancer... - Immunohistochemical expression of minichromosome maintenance complex protein 2 predicts biochemical recurrence in prostate cancer: a tissue microarray and digital imaging analysis-based study of 428 casesAntoun Toubaji
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hum Pathol 43:1852-65. 2012.... - Association of serum cholesterol and cholesterol-lowering drug use with serum sex steroid hormones in men in NHANES IIIAlison M Mondul
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Cancer Causes Control 21:1575-83. 2010..We evaluated whether serum testosterone and estradiol differ by cholesterol or cholesterol-lowering drug use... - Prediagnostic plasma vitamin C levels and the subsequent risk of prostate cancerSonja I Berndt
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Nutrition 21:686-90. 2005..CONCLUSIONS: This small but prospective study suggests that higher plasma vitamin C concentrations within the normal physiologic range are not associated with a lower risk of prostate cancer in well-nourished men... - Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, MarylandJeanine M Genkinger
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Am J Epidemiol 160:1223-33. 2004..These findings support the general health recommendation to consume multiple servings of fruits and vegetables (5-9/day)... - Association of prostate cancer risk with insulin, glucose, and anthropometry in the Baltimore longitudinal study of agingJ Slade Hubbard
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Urology 63:253-8. 2004..Additional larger prospective studies with repeated measure of these parameters are warranted to explore these associations further... - Risk factors for prostate cancer incidence and progression in the health professionals follow-up studyEdward Giovannucci
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
Int J Cancer 121:1571-8. 2007..The complexity of the clinical and pathologic manifestations of prostate cancer must be considered in the design and interpretation of studies... - Racial variation in umbilical cord blood leptin concentration in male babiesGabriel Y Lai
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 20:665-71. 2011..We hypothesize that racial differences in utero contribute to the racial disparity in prostate cancer risk. Leptin is a candidate for evaluating this hypothesis because it influences fetal development and newborn growth... - Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancerAlcides Chaux
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Mod Pathol 25:1543-9. 2012..In summary, in patients with clinically localized prostate cancer treated by prostatectomy, decreased PTEN expression was associated with an increased risk of recurrence, independent of known clinicopathological factors... - Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE IIMing Hsi Wang
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Prostate 69:874-85. 2009..Chronic intra-prostatic inflammation and obesity are thought to influence prostate carcinogenesis. Thus, variants in genes in these pathways could be associated with prostate cancer risk... - Cigarette smoking and prostate cancer recurrence after prostatectomyCorinne E Joshu
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Natl Cancer Inst 103:835-8. 2011..31, 95% confidence interval = 1.05 to 5.10). This result suggests an association between cigarette smoking and risk of prostate cancer recurrence... - Plasma antibodies against Chlamydia trachomatis, human papillomavirus, and human herpesvirus type 8 in relation to prostate cancer: a prospective studySiobhan Sutcliffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6132 A, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 16:1573-80. 2007..70; 95% CI, 0.52-0.95). As this study is the first, to our knowledge, to observe such an inverse association, similar additional studies are warranted... - Viral infections and lower urinary tract symptoms in the third national health and nutrition examination surveySiobhan Sutcliffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Urol 178:2181-5. 2007..Therefore, we examined each of these associations in the Third National Health and Nutrition Examination Survey... - Risk factors for hearing loss in US adults: data from the National Health and Nutrition Examination Survey, 1999 to 2002Yuri Agrawal
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Otol Neurotol 30:139-45. 2009.... - Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control studyKana Wu
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 13:260-9. 2004..In addition, our findings also suggest that among younger men, diets rich in beta-carotene may also play a protective role in prostate carcinogenesis... - Metabolic syndrome components and colorectal adenoma in the CLUE II cohortKonstantinos K Tsilidis
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Cancer Causes Control 21:1-10. 2010..Thus, we evaluated the association between markers of the metabolic syndrome with colorectal adenoma development in a nested case-control study... - Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA eraCorinne E Joshu
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Rm E6137, Baltimore, MD 21205, USA
Cancer Prev Res (Phila) 4:544-51. 2011..Physical activity (≥ 5 h/wk) did not attenuate risk in men who gained more than 2.2 kg. By avoiding weight gain, men with prostate cancer may both prevent recurrence and improve overall well-being... - Plasma antibodies against Trichomonas vaginalis and subsequent risk of prostate cancerSiobhan Sutcliffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 15:939-45. 2006..As this study is the first, to our knowledge, to investigate associations between T. vaginalis serology and prostate cancer, additional studies are necessary before conclusions can be made... - A simulation study of control sampling methods for nested case-control studies of genetic and molecular biomarkers and prostate cancer progressionMing Hsi Wang
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, and Department of Medicine, Saint Agnes Hospital, Room E6132, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 18:706-11. 2009..Thus, we examined the validity of relative risk (RR) estimates of prostate cancer progression using three methods for control sampling from cohorts of men with prostate cancer generated by Monte Carlo simulation... - Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)Elizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Diabetes Care 30:234-8. 2007..The objective of this study is to test the hypothesis that low normal levels of total, free, and bioavailable testosterone are associated with prevalent diabetes in men... - Mismatch repair polymorphisms and the risk of colorectal cancerSonja I Berndt
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Int J Cancer 120:1548-54. 2007..No association was observed with the MSH6 and MLH1 polymorphisms overall. This study suggests that common polymorphisms in the mismatch repair gene, MSH3, may increase the risk of colorectal cancer, especially proximal colon cancer... - Association between serum adiponectin, and pathological stage and grade in men undergoing radical prostatectomyStephen J Freedland
The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
J Urol 174:1266-70. 2005..Obesity has been associated with advanced stage and a higher risk of biochemical progression following radical prostatectomy (RP) in several series. We examined whether serum adiponectin is associated with advanced disease stage at RP... - Stronger association between obesity and biochemical progression after radical prostatectomy among men treated in the last 10 yearsStephen J Freedland
Departments of Urology, and Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Clin Cancer Res 11:2883-8. 2005..Whether the association between obesity and aggressive disease has changed as a result of these temporal changes is unclear... - Genetic variation in the nucleotide excision repair pathway and colorectal cancer riskSonja I Berndt
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Cancer Epidemiol Biomarkers Prev 15:2263-9. 2006..00003). Our study suggests that genetic polymorphisms in the NER genes, ERCC6 and XPC, may be associated with an increased risk of colorectal cancer... - Inflammation in prostate carcinogenesisAngelo M De Marzo
Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA
Nat Rev Cancer 7:256-69. 2007.... - A prospective study of the associations between treated diabetes and cancer outcomesHsin Chieh Yeh
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Diabetes Care 35:113-8. 2012.... - Sexually transmitted infections, prostatitis, ejaculation frequency, and the odds of lower urinary tract symptomsSiobhan Sutcliffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 162:898-906. 2005..These results suggest that early genitourinary infections may contribute to later development of LUTS, although confirmation in additional population settings is warranted... - Sex steroid hormone concentrations and risk of death in US menAndy Menke
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 171:583-92. 2010..Future studies should be conducted to fully characterize the association of low free and bioavailable testosterone concentrations and mortality in men and to describe the mechanism underlying the association... - Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of AgingSonja I Berndt
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Urology 60:1118-23. 2002..73) for men with high dairy intakes compared with those with low dairy intakes. CONCLUSIONS: The results of this study suggest that calcium intake within moderate limits is not associated with a notably increased risk of prostate cancer... - C-reactive protein and colorectal adenoma in the CLUE II cohortKonstantinos K Tsilidis
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Cancer Causes Control 19:559-67. 2008..Thus, we evaluated the association between plasma C-reactive protein concentration and development of colorectal adenoma in a nested case-control study... - Associations of obesity with lower urinary tract symptoms and noncancer prostate surgery in the Third National Health and Nutrition Examination SurveySabine Rohrmann
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 159:390-7. 2004..Results suggest that being overweight in young adulthood may be associated with a lower prevalence of LUTS later in life, whereas weight gain and central adiposity in adulthood are possibly associated with a higher prevalence of LUTS... - Endogenous sex steroid hormones and measures of chronic kidney disease (CKD) in a nationally representative sample of menStella Yi
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Clin Endocrinol (Oxf) 71:246-52. 2009..Sex steroid hormones may play a role in the pathogenesis of chronic kidney disease (CKD)... - Nutritional predictors of insulin-like growth factor I and their relationships to cancer in menEdward Giovannucci
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:84-9. 2003..The age-related decline in plasma IGF-I may be exacerbated by low intakes of protein and minerals. The potential role of these dietary factors on cancer risk through altering IGF-I levels requires study... - Decreased expression of Cyr61 is associated with prostate cancer recurrence after surgical treatmentKatherine B D'Antonio
Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Clin Cancer Res 16:5908-13. 2010..In this study, we evaluated the association between Cyr61 staining intensity and subsequent recurrence after surgical treatment of clinically localized prostate cancer... - Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of menChanning J Paller
Department of Endocrinology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Clin Endocrinol (Oxf) 70:26-34. 2009..We evaluated the association of serum total and free sex steroid hormones and SHBG with osteopaenia in a nationally representative sample of men aged 20-90 years... - ATAAA repeat upstream of glutathione S-transferase P1 and prostate cancer riskElizabeth A Platz
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Urology 59:159-64. 2002..Upstream of its promoter is a polymorphic ATAAA repeat of unknown functional significance. We evaluated whether this polymorphism is associated with prostate cancer... - Dinucleotide repeat in the insulin-like growth factor-I gene is not related to risk of colorectal adenomaEdward Giovannucci
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 11:1509-10. 2002 - Association of markers of insulin and glucose control with subsequent colorectal cancer riskSharon H Saydah
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Cancer Epidemiol Biomarkers Prev 12:412-8. 2003.... - C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort studyKathy J Helzlsouer
Prevention and Research Center, Mercy Medical Center, 6th Floor, 227 St Paul Place, Baltimore, MD 21202, USA
Eur J Cancer 42:704-7. 2006..However, the potential benefits of anti-inflammatory chemopreventive agents must be weighed against their adverse effects before widespread use is recommended... - C-reactive protein and colorectal cancer risk: a systematic review of prospective studiesKonstantinos K Tsilidis
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Int J Cancer 123:1133-40. 2008..More work is needed to understand the extent to which circulating high-sensitivity C-reactive protein or other blood inflammatory markers are related to colonic inflammation... - Prevalence and risk factors for erectile dysfunction in the USElizabeth Selvin
Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
Am J Med 120:151-7. 2007..To assess the prevalence of erectile dysfunction and to quantify associations between putative risk factors and erectile dysfunction in the US adult male population... - RNASEL Arg462Gln polymorphism and prostate cancer in PLCOSarah E Daugherty
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Prostate 67:849-54. 2007..The relationship of this variant to sporadic prostate cancer remains uncertain... - Acne and risk of prostate cancerSiobhan Sutcliffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Int J Cancer 121:2688-92. 2007..acnes infection. Therefore, additional biologic and epidemiologic studies are necessary to determine and elucidate the possible role of P. acnes infection in prostate carcinogenesis... - What can geography tell us about prostate cancer?Ann C Klassen
Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Prev Med 30:S7-15. 2006..A model is presented for geographically integrated research in prostate cancer, with discussion of how spatially referenced data and methods could enhance approaches to answering remaining questions in prostate cancer... - Missing stage and grade in Maryland prostate cancer surveillance data, 1992-1997Ann C Klassen
Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Prev Med 30:S77-87. 2006..Two clinical elements often missing in surveillance data are histologic grade and stage of disease. Missing data are either not clinically ascertained or not successfully abstracted... - Association of vasectomy and prostate cancer among men in a Maryland cohortSabine Rohrmann
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St, Room E6138, Baltimore, MD 21205, USA
Cancer Causes Control 16:1189-94. 2005..63; 95% CI 1.40-4.94) than in men who were younger at vasectomy. CONCLUSIONS: The results from this prospective study suggest a positive association between vasectomy and prostate cancer, especially low-grade disease... - Gonorrhea, syphilis, clinical prostatitis, and the risk of prostate cancerSiobhan Sutcliffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 15:2160-6. 2006..Clinical prostatitis is also unlikely to be a risk factor, although possible roles for prostatitis in younger men and asymptomatic prostatic infection and inflammation cannot be ruled out... - Physical activity and benign prostatic hyperplasiaE A Platz
Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA
Arch Intern Med 158:2349-56. 1998..Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study... - No association between the I105V polymorphism of the glutathione S-transferase P1 gene (GSTP1) and prostate cancer risk: a prospective studyT F Shepard
The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 9:1267-8. 2000 - A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in womenE Giovannucci
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 9:345-9. 2000..These analyses indicate that high levels of circulating IGF-1 and particularly low levels of IGFBP-3 are associated independently with an elevated risk of large or tubulovillous/villous colorectal adenoma and cancer... - Early prostate cancer antigen expression in predicting presence of prostate cancer in men with histologically negative biopsiesD E Hansel
Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21231, USA
J Urol 177:1736-40. 2007.... - Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III)S Rohrmann
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Int J Obes (Lond) 29:310-6. 2005..80; 95% CI 1.11-2.94). CONCLUSION: These findings support the role for metabolic perturbations in the etiology of LUTS... - Obesity, adipokines, and prostate cancer in a prospective population-based studyJacques Baillargeon
Center for Epidemiology and Biostatistics, University of Texas Health Sciences Center at San Antonio, 78284 7802, USA
Cancer Epidemiol Biomarkers Prev 15:1331-5. 2006..The purpose of this investigation was to examine the association of obesity and the adipokines leptin, adiponectin, and interleukin-6 (IL-6) with prostate cancer risk and aggressiveness... - Epidemiologic musing on statin drugs in the prevention of advanced prostate cancerElizabeth A Platz
Cancer Epidemiol Biomarkers Prev 16:2175-80. 2007 - Association of cigarette smoking, alcohol consumption and physical activity with lower urinary tract symptoms in older American men: findings from the third National Health And Nutrition Examination SurveySabine Rohrmann
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
BJU Int 96:77-82. 2005..Current cigarette smoking was not consistently associated with the condition. The possible association in former smokers warrants further investigation... - Re: Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasiaSabine Rohrmann
J Urol 172:779. 2004 - Fiber from fruit and colorectal neoplasiaMia A Papas
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6143, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 13:1267-70. 2004 - Assessment of 54 biomarkers for biopsy-detectable prostate cancerDipen J Parekh
Department of Urology, University of Texas Health Sciences Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7802, USA
Cancer Epidemiol Biomarkers Prev 16:1966-72. 2007.... - Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III)Sabine Rohrmann
Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
Urology 69:708-13. 2007..To evaluate the association of circulating sex steroid hormones and sex hormone binding globulin (SHBG) with lower urinary tract symptoms (LUTS)... - Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trialZhihong Gong
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 15:1977-83. 2006..Obesity increases the risk of high-grade but decreases the risk of low-grade prostate cancer, and this relationship is independent of the lower risk for prostate cancer among men with diabetes... - Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studiesKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 29:568-72. 2008.... - The influence of statin medications on prostate-specific antigen levelsRobert J Hamilton
Division of Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
J Natl Cancer Inst 100:1511-8. 2008..However, the influence of statins on prostate-specific antigen (PSA) levels and what effect this could potentially have on prostate cancer diagnosis are unknown... - Intakes of energy and macronutrients and the risk of benign prostatic hyperplasiaSadao Suzuki
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 75:689-97. 2002..Because eicosapentaenoic, docosahexaenoic, and arachidonic acids are highly unsaturated fatty acids, our findings support a possible role of oxidative stress in the etiology of BPH... - Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenomaSarah E Daugherty
Divison of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, 6120 Executive Boulevard, EPS Rm 8113, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 16:1536-42. 2007..AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis... - Obesity and prostate cancer: making sense out of apparently conflicting dataStephen J Freedland
Department of Surgery, Veterans Affairs Medical Center, Durham, NC 27710, USA
Epidemiol Rev 29:88-97. 2007..Emerging data suggest a differential effect of obesity by disease aggressiveness: obesity may reduce the risk of nonaggressive disease while it may promote aggressive disease... - Metabolic factors associated with benign prostatic hyperplasiaJ Kellogg Parsons
Division of Urology, University of California San Diego, 200 West Arbor Drive, San Diego, California 21287, USA
J Clin Endocrinol Metab 91:2562-8. 2006..Obesity and associated abnormalities in glucose homeostasis may play a role in benign prostatic hyperplasia development by influencing prostate growth...
Research Grants
- INSTITUTIONAL RESEARCH CANCER EPIDEMIOLOGY FELLOWSHIPElizabeth Platz; Fiscal Year: 2007....