Elizabeth A Platz

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Discov 1:68-77. 2011
  2. pmc Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence
    Paul J Dluzniewski
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 21:1774-82. 2012
  3. pmc Incidence and progression of lower urinary tract symptoms in a large prospective cohort of United States men
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Urol 188:496-501. 2012
  4. pmc The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men
    Andy Menke
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    BMC Public Health 8:72. 2008
  5. ncbi request reprint Prostate cancer association studies: pitfalls and solutions to cancer misclassification in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Cell Biochem 91:553-71. 2004
  6. ncbi request reprint Does statin use affect the risk of developing prostate cancer?
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Nat Clin Pract Urol 6:70-1. 2009
  7. pmc Association between plasma cholesterol and prostate cancer in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Cancer 123:1693-8. 2008
  8. ncbi request reprint Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 159:444-53. 2004
  9. ncbi request reprint No association between pre-diagnostic plasma C-reactive protein concentration and subsequent prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Prostate 59:393-400. 2004
  10. doi request reprint Low testosterone and risk of premature death in older men: analytical and preanalytical issues in measuring circulating testosterone
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Clin Chem 54:1110-2. 2008

Research Grants

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. pmc A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Discov 1:68-77. 2011
    ..54, 95% CI 0.37-0.79, P-trend<0.001), had a lower prostate cancer risk. Digoxin was highly potent in inhibiting prostate cancer cell growth in vitro and its use was associated with a 25% lower prostate cancer risk...
  2. pmc Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence
    Paul J Dluzniewski
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 21:1774-82. 2012
    ....
  3. pmc Incidence and progression of lower urinary tract symptoms in a large prospective cohort of United States men
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Urol 188:496-501. 2012
    ....
  4. pmc The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men
    Andy Menke
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    BMC Public Health 8:72. 2008
    ..Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small...
  5. ncbi request reprint Prostate cancer association studies: pitfalls and solutions to cancer misclassification in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Cell Biochem 91:553-71. 2004
    ....
  6. ncbi request reprint Does statin use affect the risk of developing prostate cancer?
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Nat Clin Pract Urol 6:70-1. 2009
    ..Consideration of the harms and benefits when prescribing a statin for vascular indications, including in obese men, should not presently include prostate cancer risk...
  7. pmc Association between plasma cholesterol and prostate cancer in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Cancer 123:1693-8. 2008
    ..These results coupled with prior statin findings suggest that mechanistic studies on cholesterol metabolism should be pursued to understand a possible target for preventing poorly differentiated prostate cancers...
  8. ncbi request reprint Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 159:444-53. 2004
    ..64, 95% CI: 1.13, 2.38). These results suggest that moderate or greater alcohol consumption is not a strong contributor to prostate cancer risk, except possibly in men who consume large amounts infrequently...
  9. ncbi request reprint No association between pre-diagnostic plasma C-reactive protein concentration and subsequent prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Prostate 59:393-400. 2004
    ..We evaluated the association of pre-diagnostic plasma concentration of C-reactive protein, a sensitive, but non-specific indicator of inflammation, with subsequent risk of prostate cancer...
  10. doi request reprint Low testosterone and risk of premature death in older men: analytical and preanalytical issues in measuring circulating testosterone
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Clin Chem 54:1110-2. 2008
  11. ncbi request reprint Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent risk of prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Causes Control 15:255-65. 2004
    ..To address this hypothesis, we evaluated the association of circulating concentrations of 1,25(OH)2D and its precursor 25-hydroxyvitamin D (25(OH)D) with subsequent risk of prostate cancer...
  12. ncbi request reprint Genetic variation at 8q24 as a susceptibility factor for prostate cancer: definitive results from epidemiologic studies?
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Cancer Res 67:2905-7. 2007
  13. ncbi request reprint Statin drugs and risk of advanced prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Rm E6138, 615 N Wolfe St, Baltimore, MD 21205, USA
    J Natl Cancer Inst 98:1819-25. 2006
    ..We investigated the association of statin use with total and advanced prostate cancer, the latter being the most important endpoint to prevent...
  14. ncbi request reprint Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging
    Elizabeth A Platz
    Department of Epidemiology, Room E6138, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:390-6. 2005
    ..We evaluated the association of aspirin and nonaspirin NSAIDs with subsequent prostate cancer in a prospective study. We also assessed whether use of these drugs influences serum prostate-specific antigen (PSA) concentration...
  15. ncbi request reprint Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Brady Urological Institute and the Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
    Cancer Causes Control 16:255-62. 2005
    ..We prospectively investigated the associations of plasma IGF-1 and IGFBP-3 concentrations with prostate cancer detected in the PSA era...
  16. ncbi request reprint Epidemiology of inflammation and prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Brady Urological Institute, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21205, USA
    J Urol 171:S36-40. 2004
    ....
  17. ncbi request reprint Interrelation of energy intake, body size, and physical activity with prostate cancer in a large prospective cohort study
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Heath, The Brady Urological Institute, Baltimore, Maryland 21205, USA
    Cancer Res 63:8542-8. 2003
    ....
  18. ncbi request reprint Racial variation in insulin-like growth factor-1 and binding protein-3 concentrations in middle-aged men
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 8:1107-10. 1999
    ..Although differences in circulating IGF-1 do not seem to account for the greater prostate cancer risk among African-American men, their absolute lower levels of IGFBP-3 may be contributory...
  19. ncbi request reprint Racial variation in prostate cancer incidence and in hormonal system markers among male health professionals
    E A Platz
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 92:2009-17. 2000
    ..Whether differences in the distribution of known or suspected risk factors among racial groups explain this variation is unknown...
  20. ncbi request reprint Prediagnostic toenail cadmium and zinc and subsequent prostate cancer risk
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Prostate 52:288-96. 2002
    ..We evaluated the association between prediagnostic toenail cadmium and zinc concentrations and risk of prostate cancer in a cohort in which the primary route of exposure to cadmium and zinc is the diet...
  21. ncbi request reprint Energy imbalance and prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Brady Urological Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Nutr 132:3471S-3481S. 2002
    ....
  22. doi request reprint Is prostate cancer prevention with selenium all in the genes?
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Prev Res (Phila) 3:576-8. 2010
    ..These inferences point toward how to reconcile inconsistent prostate cancer risk results from the two randomized trials of selenium conducted to date...
  23. pmc Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Rm E6132, Baltimore, MD 21205, USA
    Cancer Causes Control 21:847-51. 2010
    ..The authors estimated the size of this source of variability and consequent attenuation of the relative risk (RR)...
  24. pmc Men with low serum cholesterol have a lower risk of high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The James Buchanan Brady Urological Institute, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 18:2807-13. 2009
    ..Given these findings, we investigated the association between low serum cholesterol and prostate cancer risk in the Prostate Cancer Prevention Trial...
  25. ncbi request reprint Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:1262-9. 2005
    ..We investigated plasma levels of sex steroid hormones and length of the androgen receptor gene CAG repeat in relation to incident prostate cancer diagnosed in the prostate-specific antigen (PSA) era...
  26. doi request reprint Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Cancer Causes Control 20:1739-51. 2009
    ..Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression...
  27. ncbi request reprint Human prostate cancer precursors and pathobiology
    Angelo M De Marzo
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Urology 62:55-62. 2003
    ..Additional results show that AMACR may be an important new marker of prostate cancer, and its use in combination with p63 staining may provide the basis for an improved method for identification of prostate cancer...
  28. pmc Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men
    Meredith S Shiels
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Cancer Causes Control 20:877-86. 2009
    ....
  29. ncbi request reprint Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatment
    Angelo M De Marzo
    Department of Oncology, The Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231 1000, USA
    J Cell Biochem 91:459-77. 2004
    ..We also present the implications of these changes for prostate cancer diagnosis, detection, prevention, and treatment...
  30. pmc Racial/ethnic differences in serum sex steroid hormone concentrations in US adolescent males
    David S Lopez
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Causes Control 24:817-26. 2013
    ..Unexpectedly, Mexican-American men had the highest testosterone level. Next, we evaluated whether the same patterns are observed during adolescence, the time of prostate maturation...
  31. pmc Increased gene copy number of ERG on chromosome 21 but not TMPRSS2-ERG fusion predicts outcome in prostatic adenocarcinomas
    Antoun Toubaji
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Mod Pathol 24:1511-20. 2011
    ..In summary, TMPRSS2-ERG fusion was not prognostic for recurrence after retropubic radical prostatectomy for clinically localized prostate cancer, although men with ERG gene copy number gain without fusion were twice more likely to recur...
  32. ncbi request reprint Association of energy intake with prostate cancer in a long-term aging study: Baltimore Longitudinal Study of Aging (United States)
    Lillian J Hsieh
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 61:297-301. 2003
    ..To examine the association of total energy intake and macronutrient contributors to energy with prostate cancer risk among men in the Baltimore Longitudinal Study of Aging...
  33. ncbi request reprint A prospective cohort study of red wine consumption and risk of prostate cancer
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Cancer 120:1529-35. 2007
    ..These findings suggest that red wine does not contribute appreciably to the etiology of prostate cancer...
  34. pmc Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2335-40. 2008
    ..On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer...
  35. ncbi request reprint Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancer
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Prostate 67:1487-97. 2007
    ..Significant differences in AMACR allele frequencies have been reported for hereditary prostate cancer (HPC), but the relevance of AMACR in the context of its substrates have not been studied...
  36. pmc Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality: Physicians' Health Study
    Jennifer R Stark
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 101:1406-11. 2009
    ..We confirmed these findings in an independent population and related serostatus for antibodies against T vaginalis to prostate cancer incidence and mortality...
  37. ncbi request reprint C47T polymorphism in manganese superoxide dismutase (MnSOD), antioxidant intake and survival
    Jeanine M Genkinger
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, MA, United States
    Mech Ageing Dev 127:371-7. 2006
    ..A C47T transition in the MnSOD gene may affect the enzyme's distribution to the mitochondrion, a site of high oxidative stress. We examined the association between this polymorphism and survival...
  38. pmc Immunohistochemical expression of minichromosome maintenance complex protein 2 predicts biochemical recurrence in prostate cancer: a tissue microarray and digital imaging analysis-based study of 428 cases
    Antoun Toubaji
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Pathol 43:1852-65. 2012
    ....
  39. ncbi request reprint Prediagnostic plasma vitamin C levels and the subsequent risk of prostate cancer
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Nutrition 21:686-90. 2005
    ..We assessed whether higher prediagnostic plasma concentrations of vitamin C were associated with a lower risk of prostate cancer in a well-nourished cohort of men...
  40. pmc Association of serum cholesterol and cholesterol-lowering drug use with serum sex steroid hormones in men in NHANES III
    Alison M Mondul
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Causes Control 21:1575-83. 2010
    ..We evaluated whether serum testosterone and estradiol differ by cholesterol or cholesterol-lowering drug use...
  41. ncbi request reprint Association of prostate cancer risk with insulin, glucose, and anthropometry in the Baltimore longitudinal study of aging
    J Slade Hubbard
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Urology 63:253-8. 2004
    ..To examine the relationship of insulin, glucose, and anthropometry with the subsequent risk of prostate cancer...
  42. pmc Racial variation in umbilical cord blood leptin concentration in male babies
    Gabriel Y Lai
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 20:665-71. 2011
    ..We hypothesize that racial differences in utero contribute to the racial disparity in prostate cancer risk. Leptin is a candidate for evaluating this hypothesis because it influences fetal development and newborn growth...
  43. ncbi request reprint Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland
    Jeanine M Genkinger
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Am J Epidemiol 160:1223-33. 2004
    ..These findings support the general health recommendation to consume multiple servings of fruits and vegetables (5-9/day)...
  44. pmc Risk factors for prostate cancer incidence and progression in the health professionals follow-up study
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Cancer 121:1571-8. 2007
    ..The complexity of the clinical and pathologic manifestations of prostate cancer must be considered in the design and interpretation of studies...
  45. doi request reprint Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer
    Alcides Chaux
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mod Pathol 25:1543-9. 2012
    ..In summary, in patients with clinically localized prostate cancer treated by prostatectomy, decreased PTEN expression was associated with an increased risk of recurrence, independent of known clinicopathological factors...
  46. pmc Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II
    Ming Hsi Wang
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Prostate 69:874-85. 2009
    ..Chronic intra-prostatic inflammation and obesity are thought to influence prostate carcinogenesis. Thus, variants in genes in these pathways could be associated with prostate cancer risk...
  47. doi request reprint Risk factors for hearing loss in US adults: data from the National Health and Nutrition Examination Survey, 1999 to 2002
    Yuri Agrawal
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Otol Neurotol 30:139-45. 2009
    ....
  48. ncbi request reprint Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:260-9. 2004
    ..In addition, our findings also suggest that among younger men, diets rich in beta-carotene may also play a protective role in prostate carcinogenesis...
  49. pmc Metabolic syndrome components and colorectal adenoma in the CLUE II cohort
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Causes Control 21:1-10. 2010
    ..Thus, we evaluated the association between markers of the metabolic syndrome with colorectal adenoma development in a nested case-control study...
  50. ncbi request reprint Viral infections and lower urinary tract symptoms in the third national health and nutrition examination survey
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 178:2181-5. 2007
    ..Therefore, we examined each of these associations in the Third National Health and Nutrition Examination Survey...
  51. pmc Plasma antibodies against Chlamydia trachomatis, human papillomavirus, and human herpesvirus type 8 in relation to prostate cancer: a prospective study
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6132 A, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 16:1573-80. 2007
    ..70; 95% CI, 0.52-0.95). As this study is the first, to our knowledge, to observe such an inverse association, similar additional studies are warranted...
  52. pmc Cigarette smoking and prostate cancer recurrence after prostatectomy
    Corinne E Joshu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Natl Cancer Inst 103:835-8. 2011
    ..31, 95% confidence interval = 1.05 to 5.10). This result suggests an association between cigarette smoking and risk of prostate cancer recurrence...
  53. pmc Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA era
    Corinne E Joshu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Rm E6137, Baltimore, MD 21205, USA
    Cancer Prev Res (Phila) 4:544-51. 2011
    ..Physical activity (≥ 5 h/wk) did not attenuate risk in men who gained more than 2.2 kg. By avoiding weight gain, men with prostate cancer may both prevent recurrence and improve overall well-being...
  54. ncbi request reprint Genetic variation in the nucleotide excision repair pathway and colorectal cancer risk
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:2263-9. 2006
    ..00003). Our study suggests that genetic polymorphisms in the NER genes, ERCC6 and XPC, may be associated with an increased risk of colorectal cancer...
  55. ncbi request reprint Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Diabetes Care 30:234-8. 2007
    ..The objective of this study is to test the hypothesis that low normal levels of total, free, and bioavailable testosterone are associated with prevalent diabetes in men...
  56. doi request reprint A simulation study of control sampling methods for nested case-control studies of genetic and molecular biomarkers and prostate cancer progression
    Ming Hsi Wang
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, and Department of Medicine, Saint Agnes Hospital, Room E6132, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 18:706-11. 2009
    ..Thus, we examined the validity of relative risk (RR) estimates of prostate cancer progression using three methods for control sampling from cohorts of men with prostate cancer generated by Monte Carlo simulation...
  57. ncbi request reprint Mismatch repair polymorphisms and the risk of colorectal cancer
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 120:1548-54. 2007
    ..No association was observed with the MSH6 and MLH1 polymorphisms overall. This study suggests that common polymorphisms in the mismatch repair gene, MSH3, may increase the risk of colorectal cancer, especially proximal colon cancer...
  58. ncbi request reprint Plasma antibodies against Trichomonas vaginalis and subsequent risk of prostate cancer
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 15:939-45. 2006
    ..We investigated this infection in relation to incident prostate cancer in a nested case-control study within the Health Professionals Follow-up Study...
  59. ncbi request reprint Association between serum adiponectin, and pathological stage and grade in men undergoing radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    J Urol 174:1266-70. 2005
    ..Obesity has been associated with advanced stage and a higher risk of biochemical progression following radical prostatectomy (RP) in several series. We examined whether serum adiponectin is associated with advanced disease stage at RP...
  60. ncbi request reprint Stronger association between obesity and biochemical progression after radical prostatectomy among men treated in the last 10 years
    Stephen J Freedland
    Departments of Urology, and Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 11:2883-8. 2005
    ..Whether the association between obesity and aggressive disease has changed as a result of these temporal changes is unclear...
  61. pmc Inflammation in prostate carcinogenesis
    Angelo M De Marzo
    Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA
    Nat Rev Cancer 7:256-69. 2007
    ....
  62. pmc A prospective study of the associations between treated diabetes and cancer outcomes
    Hsin Chieh Yeh
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Diabetes Care 35:113-8. 2012
    ....
  63. doi request reprint Sex steroid hormone concentrations and risk of death in US men
    Andy Menke
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 171:583-92. 2010
    ..Future studies should be conducted to fully characterize the association of low free and bioavailable testosterone concentrations and mortality in men and to describe the mechanism underlying the association...
  64. ncbi request reprint Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of Aging
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Urology 60:1118-23. 2002
    ..To investigate the association between prostate cancer and calcium and other nutrients thought to influence the synthesis of 1,25-dihydroxyvitamin D [1,25(OH)2D]...
  65. doi request reprint C-reactive protein and colorectal adenoma in the CLUE II cohort
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Cancer Causes Control 19:559-67. 2008
    ..Thus, we evaluated the association between plasma C-reactive protein concentration and development of colorectal adenoma in a nested case-control study...
  66. ncbi request reprint Sexually transmitted infections, prostatitis, ejaculation frequency, and the odds of lower urinary tract symptoms
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 162:898-906. 2005
    ..These results suggest that early genitourinary infections may contribute to later development of LUTS, although confirmation in additional population settings is warranted...
  67. pmc Endogenous sex steroid hormones and measures of chronic kidney disease (CKD) in a nationally representative sample of men
    Stella Yi
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Clin Endocrinol (Oxf) 71:246-52. 2009
    ..Sex steroid hormones may play a role in the pathogenesis of chronic kidney disease (CKD)...
  68. ncbi request reprint Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men
    Edward Giovannucci
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:84-9. 2003
    ..The age-related decline in plasma IGF-I may be exacerbated by low intakes of protein and minerals. The potential role of these dietary factors on cancer risk through altering IGF-I levels requires study...
  69. ncbi request reprint Associations of obesity with lower urinary tract symptoms and noncancer prostate surgery in the Third National Health and Nutrition Examination Survey
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 159:390-7. 2004
    ..Results suggest that being overweight in young adulthood may be associated with a lower prevalence of LUTS later in life, whereas weight gain and central adiposity in adulthood are possibly associated with a higher prevalence of LUTS...
  70. pmc Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men
    Channing J Paller
    Department of Endocrinology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Endocrinol (Oxf) 70:26-34. 2009
    ..We evaluated the association of serum total and free sex steroid hormones and SHBG with osteopaenia in a nationally representative sample of men aged 20-90 years...
  71. pmc Decreased expression of Cyr61 is associated with prostate cancer recurrence after surgical treatment
    Katherine B D'Antonio
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Clin Cancer Res 16:5908-13. 2010
    ..In this study, we evaluated the association between Cyr61 staining intensity and subsequent recurrence after surgical treatment of clinically localized prostate cancer...
  72. ncbi request reprint ATAAA repeat upstream of glutathione S-transferase P1 and prostate cancer risk
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 59:159-64. 2002
    ..Upstream of its promoter is a polymorphic ATAAA repeat of unknown functional significance. We evaluated whether this polymorphism is associated with prostate cancer...
  73. ncbi request reprint C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort study
    Kathy J Helzlsouer
    Prevention and Research Center, Mercy Medical Center, 6th Floor, 227 St Paul Place, Baltimore, MD 21202, USA
    Eur J Cancer 42:704-7. 2006
    ..However, the potential benefits of anti-inflammatory chemopreventive agents must be weighed against their adverse effects before widespread use is recommended...
  74. ncbi request reprint Dinucleotide repeat in the insulin-like growth factor-I gene is not related to risk of colorectal adenoma
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1509-10. 2002
  75. ncbi request reprint Association of markers of insulin and glucose control with subsequent colorectal cancer risk
    Sharon H Saydah
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 12:412-8. 2003
    ....
  76. ncbi request reprint What can geography tell us about prostate cancer?
    Ann C Klassen
    Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Prev Med 30:S7-15. 2006
    ..A model is presented for geographically integrated research in prostate cancer, with discussion of how spatially referenced data and methods could enhance approaches to answering remaining questions in prostate cancer...
  77. ncbi request reprint RNASEL Arg462Gln polymorphism and prostate cancer in PLCO
    Sarah E Daugherty
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Prostate 67:849-54. 2007
    ..The relationship of this variant to sporadic prostate cancer remains uncertain...
  78. ncbi request reprint Prevalence and risk factors for erectile dysfunction in the US
    Elizabeth Selvin
    Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
    Am J Med 120:151-7. 2007
    ..To assess the prevalence of erectile dysfunction and to quantify associations between putative risk factors and erectile dysfunction in the US adult male population...
  79. doi request reprint C-reactive protein and colorectal cancer risk: a systematic review of prospective studies
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Cancer 123:1133-40. 2008
    ..More work is needed to understand the extent to which circulating high-sensitivity C-reactive protein or other blood inflammatory markers are related to colonic inflammation...
  80. ncbi request reprint Missing stage and grade in Maryland prostate cancer surveillance data, 1992-1997
    Ann C Klassen
    Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Prev Med 30:S77-87. 2006
    ..Two clinical elements often missing in surveillance data are histologic grade and stage of disease. Missing data are either not clinically ascertained or not successfully abstracted...
  81. pmc Acne and risk of prostate cancer
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 121:2688-92. 2007
    ..acnes infection. Therefore, additional biologic and epidemiologic studies are necessary to determine and elucidate the possible role of P. acnes infection in prostate carcinogenesis...
  82. ncbi request reprint Gonorrhea, syphilis, clinical prostatitis, and the risk of prostate cancer
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 15:2160-6. 2006
    ..Therefore, to investigate these associations without concerns of recall and interviewer biases, we conducted a large, prospective investigation in the Health Professionals Follow-up Study...
  83. ncbi request reprint Association of vasectomy and prostate cancer among men in a Maryland cohort
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Room E6138, Baltimore, MD 21205, USA
    Cancer Causes Control 16:1189-94. 2005
    ..To evaluate the association of vasectomy with prostate cancer...
  84. ncbi request reprint Physical activity and benign prostatic hyperplasia
    E A Platz
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA
    Arch Intern Med 158:2349-56. 1998
    ..Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study...
  85. ncbi request reprint No association between the I105V polymorphism of the glutathione S-transferase P1 gene (GSTP1) and prostate cancer risk: a prospective study
    T F Shepard
    The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:1267-8. 2000
  86. ncbi request reprint A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women
    E Giovannucci
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:345-9. 2000
    ..These analyses indicate that high levels of circulating IGF-1 and particularly low levels of IGFBP-3 are associated independently with an elevated risk of large or tubulovillous/villous colorectal adenoma and cancer...
  87. ncbi request reprint Early prostate cancer antigen expression in predicting presence of prostate cancer in men with histologically negative biopsies
    D E Hansel
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Urol 177:1736-40. 2007
    ....
  88. ncbi request reprint Association between markers of the metabolic syndrome and lower urinary tract symptoms in the Third National Health and Nutrition Examination Survey (NHANES III)
    S Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Obes (Lond) 29:310-6. 2005
    ..To examine the association of components of the metabolic syndrome with lower urinary tract symptoms (LUTS), which often result from prostate enlargement and heightened tone of prostate and bladder smooth muscle...
  89. ncbi request reprint Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 29:568-72. 2008
    ....
  90. ncbi request reprint Intakes of energy and macronutrients and the risk of benign prostatic hyperplasia
    Sadao Suzuki
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 75:689-97. 2002
    ..Benign prostatic hyperplasia (BPH) is a common disease of older men. Although the etiology remains unclear, nutritional factors may have an effect on the disease...
  91. ncbi request reprint Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial
    Zhihong Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:1977-83. 2006
    ..Obesity increases the risk of high-grade but decreases the risk of low-grade prostate cancer, and this relationship is independent of the lower risk for prostate cancer among men with diabetes...
  92. ncbi request reprint Obesity, adipokines, and prostate cancer in a prospective population-based study
    Jacques Baillargeon
    Center for Epidemiology and Biostatistics, University of Texas Health Sciences Center at San Antonio, 78284 7802, USA
    Cancer Epidemiol Biomarkers Prev 15:1331-5. 2006
    ..The purpose of this investigation was to examine the association of obesity and the adipokines leptin, adiponectin, and interleukin-6 (IL-6) with prostate cancer risk and aggressiveness...
  93. pmc Metabolic factors associated with benign prostatic hyperplasia
    J Kellogg Parsons
    Division of Urology, University of California San Diego, 200 West Arbor Drive, San Diego, California 21287, USA
    J Clin Endocrinol Metab 91:2562-8. 2006
    ..Obesity and associated abnormalities in glucose homeostasis may play a role in benign prostatic hyperplasia development by influencing prostate growth...
  94. doi request reprint The influence of statin medications on prostate-specific antigen levels
    Robert J Hamilton
    Division of Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    J Natl Cancer Inst 100:1511-8. 2008
    ..However, the influence of statins on prostate-specific antigen (PSA) levels and what effect this could potentially have on prostate cancer diagnosis are unknown...
  95. ncbi request reprint Fiber from fruit and colorectal neoplasia
    Mia A Papas
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6143, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 13:1267-70. 2004
  96. ncbi request reprint Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III)
    Sabine Rohrmann
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Urology 69:708-13. 2007
    ..To evaluate the association of circulating sex steroid hormones and sex hormone binding globulin (SHBG) with lower urinary tract symptoms (LUTS)...
  97. ncbi request reprint Obesity and prostate cancer: making sense out of apparently conflicting data
    Stephen J Freedland
    Department of Surgery, Veterans Affairs Medical Center, Durham, NC 27710, USA
    Epidemiol Rev 29:88-97. 2007
    ..Emerging data suggest a differential effect of obesity by disease aggressiveness: obesity may reduce the risk of nonaggressive disease while it may promote aggressive disease...
  98. ncbi request reprint Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma
    Sarah E Daugherty
    Divison of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, 6120 Executive Boulevard, EPS Rm 8113, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1536-42. 2007
    ..AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis...
  99. ncbi request reprint Assessment of 54 biomarkers for biopsy-detectable prostate cancer
    Dipen J Parekh
    Department of Urology, University of Texas Health Sciences Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7802, USA
    Cancer Epidemiol Biomarkers Prev 16:1966-72. 2007
    ....
  100. ncbi request reprint Epidemiologic musing on statin drugs in the prevention of advanced prostate cancer
    Elizabeth A Platz
    Cancer Epidemiol Biomarkers Prev 16:2175-80. 2007
  101. ncbi request reprint Re: Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasia
    Sabine Rohrmann
    J Urol 172:779. 2004

Research Grants3

  1. INSTITUTIONAL RESEARCH CANCER EPIDEMIOLOGY FELLOWSHIP
    Elizabeth Platz; Fiscal Year: 2007
    ....