E S Pizer

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines
    E S Pizer
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Cancer Res 58:4611-5. 1998
  2. ncbi Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression
    E S Pizer
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Prostate 47:102-10. 2001
  3. ncbi Synthesis and antitumor activity of an inhibitor of fatty acid synthase
    F P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 97:3450-4. 2000
  4. ncbi Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53
    J N Li
    Department of Pathology, Johns Hopkins Medical Institutions, Gerontology Research Center, National Institut on Aging, Baltimore, Maryland 21224, USA
    Cancer Res 61:1493-9. 2001
  5. ncbi Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients
    Y Wang
    Department of Pathology, Johns Hopkins Medical Institutions, 600 N. Wolfe Street/Meyer B-121, Baltimore, MD 21287, USA
    Cancer Lett 167:99-104. 2001

Collaborators

Detail Information

Publications5

  1. ncbi Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines
    E S Pizer
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Cancer Res 58:4611-5. 1998
    ..The data suggest a direct linkage at a regulatory level, between fatty acid synthesis and DNA synthesis in proliferating tumor cells...
  2. ncbi Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression
    E S Pizer
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Prostate 47:102-10. 2001
    ..FAS expression is low in most normal tissues, but is elevated in many human cancers, including androgen-sensitive and androgen-independent prostate cancer...
  3. ncbi Synthesis and antitumor activity of an inhibitor of fatty acid synthase
    F P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 97:3450-4. 2000
    ..This development will enable the in vivo study of FAS inhibition in human cancer and other metabolic diseases...
  4. ncbi Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53
    J N Li
    Department of Pathology, Johns Hopkins Medical Institutions, Gerontology Research Center, National Institut on Aging, Baltimore, Maryland 21224, USA
    Cancer Res 61:1493-9. 2001
    ..Whereas induction of apoptosis appeared related to accumulation of the substrate, malonyl-CoA, after FAS inhibition, the cytostatic effects were independent of malonyl-CoA accumulation and may have resulted from product depletion...
  5. ncbi Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients
    Y Wang
    Department of Pathology, Johns Hopkins Medical Institutions, 600 N. Wolfe Street/Meyer B-121, Baltimore, MD 21287, USA
    Cancer Lett 167:99-104. 2001
    ..39+/-0.35 units/l) compared with healthy subjects (0.27+/-0.02 units/l, P<0.05). Taken together, our data suggest that FAS expression may be a useful tumor marker for breast cancer and play a role in assessing cancer virulence...