Research Topics
| Deborah PersaudSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoirDeborah Persaud
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
AIDS 25:2227-34. 2011..Alternatively, latently infected CD4 T cells maybe killed, while exiting the reservoir upon activation...- Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of ageDeborah Persaud
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
AIDS 26:1483-90. 2012..Identification of HIV infection in exposed infants facilitates early therapy, which may limit viral reservoirs that maintain HIV infection under HAART... - Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loadsDeborah Persaud
Department of Pediatrics, Johns Hopkins University School of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21205, USA
J Virol 78:968-79. 2004..Thus, in most children on HAART with clinically undetectable viremia, there is continued virus production without evolution of resistance in the protease gene... 
Early archiving and predominance of nonnucleoside reverse transcriptase inhibitor-resistant HIV-1 among recently infected infants born in the United StatesDeborah Persaud
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Infect Dis 195:1402-10. 2007....- Slower clearance of nevirapine resistant virus in infants failing extended nevirapine prophylaxis for prevention of mother-to-child HIV transmissionDeborah Persaud
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
AIDS Res Hum Retroviruses 27:823-9. 2011.... - Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapyDeborah Persaud
Department of Pediatrics and Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
AIDS Res Hum Retroviruses 23:381-90. 2007..The effect of early therapy on HIV-1 evolution may have implications for long-term pharmacologic control of HIV-1... - A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patientsDaphne Monie
Johns Hopkins University School of Medicine, Broadway Research Building, Room 879, 733 North Broadway St, Baltimore, MD 21205, USA
J Virol 79:5185-202. 2005..The ability to analyze archival species in viremic patients may have clinical utility in detecting drug-resistant variants not present in the plasma... - Analyses of HIV-1 drug-resistance profiles among infected adolescents experiencing delayed antiretroviral treatment switch after initial nonsuppressive highly active antiretroviral therapyAllison Agwu
Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Medical Institution, Baltimore, Maryland, USA
AIDS Patient Care STDS 22:545-52. 2008..This finding may have implications for initial treatment regimens and transmission risk in HIV-infected youth, a group with rising infection rates... - Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAARTRichard E Nettles
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
JAMA 293:817-29. 2005..CONCLUSION: Most blips in this population appear to represent random biological and statistical variation around mean HIV-1 levels below 50 copies/mL rather than clinically significant elevations in viremia... - Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposureChristian T Ruff
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Virol 76:9481-92. 2002.... - Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loadsTara L Kieffer
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025, USA
J Infect Dis 189:1452-65. 2004..Thus, in some patients, HAART suppresses replication to a level that does not allow the evolution of drug resistance over a time frame of years... - Genotypic resistance in HIV-1-infected patients with persistently detectable low-level viremia while receiving highly active antiretroviral therapyRichard E Nettles
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Clin Infect Dis 39:1030-7. 2004.... - Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cellsJustin R Bailey
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Virol 80:6441-57. 2006..The sequences have been deposited in GenBank. The accession numbers are DQ 391282 to DQ 391351 (for env) and DQ 391352 to DQ 392955 (for RT)... - Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral Carlum Shiu
Johns Hopkins University, Baltimore, MD 21287, USA
J Virol 83:9731-42. 2009..001). These findings suggest that ongoing virus replication contributes to low-level viremia in patients on HAART and that this ongoing replication is subject to CD8(+) T-cell selective pressures... - Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1Haili Zhang
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Virol 78:1718-29. 2004..Thus, the ability to simultaneously analyze residual susceptibility and reduced replication capacity of drug-resistant viruses may provide a basis for rational therapeutic decisions in the setting of treatment failure... - Induction therapy with protease-inhibitors modifies the effect of nevirapine resistance on virologic response to nevirapine-based HAART in childrenAnitha Moorthy
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Clin Infect Dis 52:514-21. 2011..Nevirapine resistance after failed prophylaxis to prevent mother-to-child human immunodeficiency virus (HIV) transmission can compromise subsequent nevirapine-based highly active antiretroviral therapy (HAART)... - A sensitive genotyping assay for detection of drug resistance mutations in reverse transcriptase of HIV-1 subtypes B and C in samples stored as dried blood spots or frozen RNA extractsCarrie Ziemniak
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Virol Methods 136:238-47. 2006..This sensitive and reproducible genotypic assay is feasible for detection of antiretroviral resistance in resource-constrained settings... - Use of dried-blood-spot samples and in-house assays to identify antiretroviral drug resistance in HIV-infected children in resource-constrained settingsCarrie Ziemniak
Department of Pediatrics, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Building, Baltimore, Maryland 21205, USA
J Clin Microbiol 49:4077-82. 2011..DBS genotyping using in-house assays provides an alternative for antiretroviral drug resistance testing in children in resource-constrained regions but may require region-specific optimization before widespread use... - Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infantsAnitha Moorthy
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
PLoS ONE 4:e4096. 2009.... 
Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan AfricaCatherine G Sutcliffe
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Lancet Infect Dis 8:477-89. 2008....- Latency in human immunodeficiency virus type 1 infection: no easy answersDeborah Persaud
Departments of Medicine and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Virol 77:1659-65. 2003 - The challenge of viral reservoirs in HIV-1 infectionJoel N Blankson
Departments of Medicine and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 e mail
Annu Rev Med 53:557-93. 2002..The clinical implications of this and other HIV-1 reservoirs are discussed... - Report from San Francisco: The 11th Conference on Retroviruses and Opportunistic Infections (CROI). The tenacity of NNRTI drug resistanceDeborah Persaud
Hopkins HIV Rep 16:1, 5, 15. 2004
Research Grants
- HIV-1 chemoprophylaxis and archived drug resistance in infantsDeborah Persaud; Fiscal Year: 2010....
- HIV-1 chemoprophylaxis and archived drug resistance in infantsDeborah Persaud; Fiscal Year: 2007....
- HIV Vaccines on Latent Reservoirs in Young Adults on HAARTDeborah Persaud; Fiscal Year: 2007..Clinical specimens and analytic resources from VRC and PACTG provide a unique opportunity to study pathogenesis of viral reservoirs in HIV-1 infected individuals. ..
- HIV Drug Resistance During HAART in AdolescentsDeborah Persaud; Fiscal Year: 2007..The clinical specimens and analytic resources available within the ATN provide a unique opportunity to study HIV pathogenesis in infected adolescents. ..
- HIV Drug Resistance During HAART in AdolescentsDeborah Persaud; Fiscal Year: 2006..The clinical specimens and analytic resources available within the ATN provide a unique opportunity to study HIV pathogenesis in infected adolescents. ..