Peter Pedersen

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205 2185, USA
    J Bioenerg Biomembr 39:211-22. 2007
  2. ncbi request reprint Glucose metabolism in cancer: importance of transcription factor-DNA interactions within a short segment of the proximal region og the type II hexokinase promoter
    Min Gyu Lee
    Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Biol Chem 278:41047-58. 2003
  3. ncbi request reprint The cancer cell's "power plants" as promising therapeutic targets: an overview
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 39:1-12. 2007
  4. doi request reprint Mitochondria in relation to cancer metastasis: introduction to a mini-review series
    Peter L Pedersen
    Department of Biological Chemistry and Oncology, Sidney Kimmel Cancer Center, and Center for Metabolism and Obesity Research, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Bioenerg Biomembr 44:615-7. 2012
  5. ncbi request reprint 3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: introduction to a special issue
    Peter L Pedersen
    Department of Biological Chemistry, Center for Cell Metabolism and Obesity Research, and Sidney Kimmel Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205 2185, USA
    J Bioenerg Biomembr 44:1-6. 2012
  6. doi request reprint Mitochondrial matters of the brain: amyloid formation and Alzheimer's disease introduction
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    J Bioenerg Biomembr 41:403-5. 2009
  7. doi request reprint Mitochondrial matters of the heart: a plethora of regulatory modes to maintain function for a long lifetime
    Peter L Pedersen
    Department of Biological Chemistry, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    J Bioenerg Biomembr 41:95-8. 2009
  8. doi request reprint Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, MD 21205 2185, USA
    J Bioenerg Biomembr 40:123-6. 2008
  9. doi request reprint Transport ATPases into the year 2008: a brief overview related to types, structures, functions and roles in health and disease
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MA 21205 2185, USA
    J Bioenerg Biomembr 39:349-55. 2007
  10. ncbi request reprint Transport ATPases: structure, motors, mechanism and medicine: a brief overview
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, Maryland, 21205 2185, USA
    J Bioenerg Biomembr 37:349-57. 2005

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205 2185, USA
    J Bioenerg Biomembr 39:211-22. 2007
    ..e., glycolysis and mitochondria) resulting in tumor destruction without harm to the animals...
  2. ncbi request reprint Glucose metabolism in cancer: importance of transcription factor-DNA interactions within a short segment of the proximal region og the type II hexokinase promoter
    Min Gyu Lee
    Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Biol Chem 278:41047-58. 2003
    ..These findings implicate signaling pathways directed to a short segment of the proximal region of the HKII promoter as major contributors to HKII overexpression in many cancers...
  3. ncbi request reprint The cancer cell's "power plants" as promising therapeutic targets: an overview
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 39:1-12. 2007
    ..Regardless how death is inflicted, every cancer cell must die, be it fast or slow...
  4. doi request reprint Mitochondria in relation to cancer metastasis: introduction to a mini-review series
    Peter L Pedersen
    Department of Biological Chemistry and Oncology, Sidney Kimmel Cancer Center, and Center for Metabolism and Obesity Research, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Bioenerg Biomembr 44:615-7. 2012
    ..Young H. Ko near the turn of the century to be a potent anti-cancer agent [Ko et al.(2001) Can Lett 173:83-91]...
  5. ncbi request reprint 3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: introduction to a special issue
    Peter L Pedersen
    Department of Biological Chemistry, Center for Cell Metabolism and Obesity Research, and Sidney Kimmel Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205 2185, USA
    J Bioenerg Biomembr 44:1-6. 2012
    ..Suffice it to say in this bottom line, "3BP, a small molecule, results in a remarkable therapeutic effect when it comes to treating cancers exhibiting a "Warburg effect". This includes most cancer types...
  6. doi request reprint Mitochondrial matters of the brain: amyloid formation and Alzheimer's disease introduction
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    J Bioenerg Biomembr 41:403-5. 2009
    ..The development of future therapies for this disease is likely to rely heavily on the new knowledge gained...
  7. doi request reprint Mitochondrial matters of the heart: a plethora of regulatory modes to maintain function for a long lifetime
    Peter L Pedersen
    Department of Biological Chemistry, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    J Bioenerg Biomembr 41:95-8. 2009
    ..5-3.0 billion beats, a feat that is energetically feasible only due to the heart cells' (cardiomyocytes) large population of mitochondria with bound HK-2...
  8. doi request reprint Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, MD 21205 2185, USA
    J Bioenerg Biomembr 40:123-6. 2008
    ..However, upon addition of tumor mitochondria containing VDAC bound HK-2, the low glycolytic rate is increased to a high rate near that catalyzed by the tumor cytoplasm from which the tumor mitochondria were derived...
  9. doi request reprint Transport ATPases into the year 2008: a brief overview related to types, structures, functions and roles in health and disease
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MA 21205 2185, USA
    J Bioenerg Biomembr 39:349-55. 2007
    ..In mammalian mitochondria these events occur on a larger complex or "nano-machine" called the "ATP synthasome" that consists of the ATP synthase in complex formation with carriers for P(i) and ADP/ATP...
  10. ncbi request reprint Transport ATPases: structure, motors, mechanism and medicine: a brief overview
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, Maryland, 21205 2185, USA
    J Bioenerg Biomembr 37:349-57. 2005
    ....
  11. ncbi request reprint Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention
    Peter L Pedersen
    Department of Biological Chemistry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2185, USA
    Biochim Biophys Acta 1555:14-20. 2002
    ....
  12. ncbi request reprint Transport ATPases in biological systems and relationship to human disease: a brief overview
    Peter L Pedersen
    Department of Biological Chemistry, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 34:327-32. 2002
    ..Here, the author provides a brief discussion of transport ATPases that are present in biological systems and their relevance or possible relevance to human disease...
  13. ncbi request reprint Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production
    Jean Francois H Geschwind
    Division of Cardiovascular and Interventional Radiology, The Russell H Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Cancer Res 62:3909-13. 2002
    ....
  14. ncbi request reprint Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma
    Jean Francois Geschwind
    Johns Hopkins Hospital, Cardiovascular and Interventional Diagnostic Laboratory, Russell H Morgan Department of Radiology and Radiological Sciences, 600 N Wolfe Street, Baltimore, MD 21231, USA
    Expert Rev Anticancer Ther 4:449-57. 2004
    ....
  15. ncbi request reprint Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
    Young H Ko
    The Russell H Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem Biophys Res Commun 324:269-75. 2004
    ..In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers...
  16. ncbi request reprint Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression
    Ashish Goel
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Biol Chem 278:15333-40. 2003
    ..These novel observations indicate that one of the initial events in activating the HKII gene during either transformation or tumor progression may reside at the epigenetic level...
  17. ncbi request reprint ATP synthases: insights into their motor functions from sequence and structural analyses
    Sangjin Hong
    Department of Biological Chemistry, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, Maryland 21205 2185, USA
    J Bioenerg Biomembr 35:95-120. 2003
    ..It is suggested that the different properties of mitochondrial subunit b may be necessary for interaction with other proteins, e.g., the supernumerary subunits...
  18. ncbi request reprint Expanding the subproteome of the inner mitochondria using protein separation technologies: one- and two-dimensional liquid chromatography and two-dimensional gel electrophoresis
    Todd McDonald
    Department of Medicine, The Technical Implementation and Coordination Core of The Johns Hopkins NHLBI Proteomics Center, The Johns Hopkins University, Baltimore, MD 21224, USA
    Mol Cell Proteomics 5:2392-411. 2006
    ..We also demonstrated that both the one- and two-dimensional LC allowed for the separation of the alpha-subunit of F1F0 ATP synthase that differed due to a change in pI or hydrophobicity...
  19. pmc ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas
    Sangjin Hong
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205 2185, USA
    Microbiol Mol Biol Rev 72:590-641, Table of Contents. 2008
    ....
  20. pmc Cystic fibrosis transmembrane conductance regulator: the NBF1+R (nucleotide-binding fold 1 and regulatory domain) segment acting alone catalyses a Co2+/Mn2+/Mg2+-ATPase activity markedly inhibited by both Cd2+ and the transition-state analogue orthovanada
    Jean Philippe Annereau
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Biochem J 371:451-62. 2003
    ....
  21. ncbi request reprint ATP synthase of yeast: structural insight into the different inhibitory potencies of two regulatory peptides and identification of a new potential regulator
    Sangjin Hong
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205 2185, USA
    Arch Biochem Biophys 405:38-43. 2002
    ..Thus, yeast appears unique in regulating the ATP synthase by involving multiple peptides (IF(1), STF(1), STF(2), and perhaps STF(3))...
  22. ncbi request reprint Mitochondrial ATP synthasome. Cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP/ATP
    Young H Ko
    Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:12305-9. 2003
    ..They also provide evidence that the cristae are a subcompartment of the inner membrane...

Research Grants44

  1. CONTROL OF ENZYMATIC PHOSPHATE TRANSFER IN MITOCHONDRIA
    Peter Pedersen; Fiscal Year: 2009
    ..These studies also have direct relevance to using nanotechnology in medicine as the ATP synthasome is comprised of 2 reversible nanomotors. ..
  2. CANCER-RELATED GLYCOLYTIC GENE--REGULATION/TARGETING
    Peter Pedersen; Fiscal Year: 2003
    ..These studies are fundamental to our understanding at the gene level of one of the most common phenotypes of cancer cells, and are likely to lead to novel approaches for controlling the growth of highly malignant tumors. ..
  3. MOLECULAR AND CHEMICAL DESCRIPTION OF CFTR FUNCTION
    Peter Pedersen; Fiscal Year: 2003
    ..The proposed studies are fundamental to understanding structure/function relationships within CFTR, to understanding the underlying basis of most cases of CF, and to developing new strategies to treat the disease. ..
  4. CONTROL OF ENZYMATIC PHOSPHATE TRANSFER IN MITOCHONDRIA
    Peter Pedersen; Fiscal Year: 2007
    ..These studies also have direct relevance to using nanotechnology in medicine as the ATP synthasome is comprised of 2 reversible nanomotors. ..
  5. Cancer-Related Glycolytic Gene:Regulation and Targeting
    Peter Pedersen; Fiscal Year: 2007
    ..abstract_text> ..
  6. CONTROL OF ENZYMATIC PHOSPHATE TRANSFER IN MITOCHONDRIA
    Peter Pedersen; Fiscal Year: 2004
    ..g., in cancer and aging, where ATP synthesis is down-regulated, and a whole host of pathologies generally categorized as "mitochondrial diseases". ..
  7. CONTROL OF ENZYMATIC PHOSPHATE TRANSFER IN MITOCHONDRIA
    Peter Pedersen; Fiscal Year: 1980
    ..The proposed studies are both necessary and fundamental to elucidating and understanding the complex mechanisms underlying energy metabolism of normal and cancer cells...
  8. MOLECULAR AND CHEMICAL DESCRIPTION OF CFTR FUNCTION
    Peter Pedersen; Fiscal Year: 1993
    ..The proposed studies are fundamental for understanding the molecular and chemical basis of cystic fibrosis, and may encourage future experiments directed at replacing only a small portion of the "wild type" CFTR gene in CF patients...