Timothy M Pawlik

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Prioritizing strategies for comprehensive liver cancer control in Asia: a conjoint analysis
    John F P Bridges
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 624 N, Broadway, Room 689, Baltimore, MD 21205, USA
    BMC Health Serv Res 12:376. 2012
  2. doi request reprint Disclosure of "nonharmful" medical errors and other events: duty to disclose
    Catherine J Chamberlain
    Department of Surgery, School of Medicine, The Johns Hopkins University, Harvey Room 611, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Surg 147:282-6. 2012
  3. pmc Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension
    David L Joyce
    Departments of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 22187 6681, USA
    World J Surg Oncol 6:80. 2008
  4. doi request reprint Primary sclerosing cholangitis: role of extrahepatic biliary resection
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University Hospital, Baltimore, MD 21287, USA
    J Am Coll Surg 206:822-30; discussion 830-2. 2008
  5. doi request reprint Expanding criteria for resectability of colorectal liver metastases
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 22187 6681, USA
    Oncologist 13:51-64. 2008
  6. ncbi request reprint Incidence of finding residual disease for incidental gallbladder carcinoma: implications for re-resection
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 22187 6681, USA
    J Gastrointest Surg 11:1478-86; discussion 1486-7. 2007
  7. ncbi request reprint Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer
    Timothy M Pawlik
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Surgery 141:610-8. 2007
  8. ncbi request reprint Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysis
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 14:2807-16. 2007
  9. ncbi request reprint The role of radiation in retroperitoneal sarcomas: a surgical perspective
    Timothy M Pawlik
    Department of Surgery, Division of Surgical Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Curr Opin Oncol 19:359-66. 2007
  10. pmc Preoperative assessment of hepatocellular carcinoma tumor grade using needle biopsy: implications for transplant eligibility
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Ann Surg 245:435-42. 2007

Detail Information

Publications141 found, 100 shown here

  1. pmc Prioritizing strategies for comprehensive liver cancer control in Asia: a conjoint analysis
    John F P Bridges
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 624 N, Broadway, Room 689, Baltimore, MD 21205, USA
    BMC Health Serv Res 12:376. 2012
    ..Concordance of priorities was assessed across the region and across respondent roles...
  2. doi request reprint Disclosure of "nonharmful" medical errors and other events: duty to disclose
    Catherine J Chamberlain
    Department of Surgery, School of Medicine, The Johns Hopkins University, Harvey Room 611, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Surg 147:282-6. 2012
    ..Full disclosure of nonharmful errors is advocated, and recommendations on how to discuss errors with patients are provided. An argument that full error disclosure may improve future patient care is also outlined...
  3. pmc Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension
    David L Joyce
    Departments of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 22187 6681, USA
    World J Surg Oncol 6:80. 2008
    ..VIPomas are rare neuroendocrine tumors poorly described in the literature. Aggressive resection of patients with advanced VIPoma neuroendocrine tumors has rarely been reported...
  4. doi request reprint Primary sclerosing cholangitis: role of extrahepatic biliary resection
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University Hospital, Baltimore, MD 21287, USA
    J Am Coll Surg 206:822-30; discussion 830-2. 2008
    ..Management of PSC patients without cirrhosis remains controversial. We examined the results of extrahepatic biliary resection (EHBR) for PSC...
  5. doi request reprint Expanding criteria for resectability of colorectal liver metastases
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 22187 6681, USA
    Oncologist 13:51-64. 2008
    ..A therapeutic approach that includes all aspects of multidisciplinary and multimodality care is required to select and treat this complex group of patients...
  6. ncbi request reprint Incidence of finding residual disease for incidental gallbladder carcinoma: implications for re-resection
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 22187 6681, USA
    J Gastrointest Surg 11:1478-86; discussion 1486-7. 2007
    ....
  7. ncbi request reprint Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer
    Timothy M Pawlik
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Surgery 141:610-8. 2007
    ....
  8. ncbi request reprint Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysis
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 14:2807-16. 2007
    ..The role of hepatic resection for metastatic squamous cell carcinoma (SCC) remains unknown. The current study evaluates the role of hepatic resection in patients with metastatic SCC to the liver...
  9. ncbi request reprint The role of radiation in retroperitoneal sarcomas: a surgical perspective
    Timothy M Pawlik
    Department of Surgery, Division of Surgical Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Curr Opin Oncol 19:359-66. 2007
    ..Radiation therapy for retroperitoneal sarcoma patients is complex because it requires decisions on not only the timing of administration, but also the technique of delivery...
  10. pmc Preoperative assessment of hepatocellular carcinoma tumor grade using needle biopsy: implications for transplant eligibility
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Ann Surg 245:435-42. 2007
    ..To examine the diagnostic agreement of preoperative needle core biopsy (NCB) grading of hepatocellular carcinoma (HCC) compared with the final surgical pathologic tumor grade...
  11. pmc Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding protein
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M, d, Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 6:68. 2006
    ....
  12. doi request reprint Debate: Resection for early hepatocellular carcinoma
    Timothy M Pawlik
    Departments of Surgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
    J Gastrointest Surg 13:1026-8. 2009
    ..The best therapeutic strategies for patients with early HCC and well-compensated cirrhosis should be dependent on the individual clinical situation, not adherence to dogmatic universal adoption of either resection or transplantation...
  13. pmc Patient readmission and mortality after surgery for hepato-pancreato-biliary malignancies
    Eric B Schneider
    Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Am Coll Surg 215:607-15. 2012
    ..The objective of the current study was to compare readmission after pancreatic vs hepatobiliary surgical procedures, as well as to identify potential factors associated with higher readmission within 30 days of discharge...
  14. pmc Influence of patient, physician, and hospital factors on 30-day readmission following pancreatoduodenectomy in the United States
    Omar Hyder
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
    JAMA Surg 148:1095-102. 2013
    ..IMPORTANCE It is not known whether hospital and surgeon volumes have an association with readmission among patients undergoing pancreatoduodenectomy...
  15. doi request reprint Liver-directed therapy for hepatic metastases in patients undergoing pancreaticoduodenectomy: a dual-center analysis
    Mechteld C de Jong
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 252:142-8. 2010
    ..To analyze the perioperative and long-term outcomes of patients undergoing liver-directed therapy after pancreaticoduodenectomy in a large dual-center cohort of patients...
  16. pmc Adjuvant chemoradiotherapy after pancreatic resection for invasive carcinoma associated with intraductal papillary mucinous neoplasm of the pancreas
    Michael J Swartz
    Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
    Int J Radiat Oncol Biol Phys 76:839-44. 2010
    ..Intraductal papillary mucinous neoplasms are mucin-producing cystic neoplasms of the pancreas. One-third are associated with invasive carcinoma. We examined the benefit of adjuvant chemoradiotherapy (CRT) for this cohort...
  17. doi request reprint The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: a multi-institutional analysis of 305 cases
    Mechteld C de Jong
    Division of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer 118:4737-47. 2012
    ..In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival...
  18. ncbi request reprint Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases
    Daria Zorzi
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
    J Gastrointest Surg 10:86-94. 2006
    ..AR is not superior to WR in terms of tumor clearance, pattern of recurrence, or survival. WR should remain an integral component of the surgical treatment of CLM...
  19. doi request reprint Patient readmission and mortality after colorectal surgery for colon cancer: impact of length of stay relative to other clinical factors
    Eric B Schneider
    Department of Surgery and Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Am Coll Surg 214:390-8; discussion 398-9. 2012
    ..The objective of the current study was to evaluate risk factors associated with readmission among a nationwide cohort of patients after colorectal surgery...
  20. pmc Adjuvant chemoradiation for pancreatic adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study
    Charles C Hsu
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Hospital, Baltimore, MD, USA
    Ann Surg Oncol 17:981-90. 2010
    ..Our goal was to examine efficacy of adjuvant CRT in resected pancreatic adenocarcinoma compared with surgery alone...
  21. doi request reprint Trends in nontherapeutic laparotomy rates in patients undergoing surgical therapy for hepatic colorectal metastases
    Timothy M Pawlik
    Department of Surgery, The Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 22187, USA
    Ann Surg Oncol 16:371-8. 2009
    ..The reasons for this trend are probably multifactorial and may include improved preoperative assessment, such as PET imaging, as well as salvage surgical options...
  22. doi request reprint Determining pattern of recurrence following pancreaticoduodenectomy and adjuvant 5-flurouracil-based chemoradiation therapy: effect of number of metastatic lymph nodes and lymph node ratio
    Bolanle Asiyanbola
    Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
    J Gastrointest Surg 13:752-9. 2009
    ..There are limited data on patterns of recurrence and factors associated with local recurrence following pancreaticoduodenectomy for pancreatic adenocarcinoma and adjuvant 5-flurouracil-based chemoradiation therapy...
  23. ncbi request reprint Incidence and management of chyle leaks following pancreatic resection: a high volume single-center institutional experience
    Lia Assumpcao
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 12:1915-23. 2008
    ..We sought to identify possible risk factors associated with chyle leaks following pancreatic resection, as well as determine the natural history of this rare complication...
  24. ncbi request reprint Conditional survival after surgical resection of colorectal liver metastasis: an international multi-institutional analysis of 949 patients
    Hari Nathan
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Coll Surg 210:755-64, 764-6. 2010
    ..We sought to assess the comparative performance of various colorectal liver metastasis prognostic scoring systems, as well as to investigate the CS of patients who underwent resection of colorectal liver metastasis...
  25. pmc Patterns of consultation and treatment of patients with hepatocellular carcinoma presenting to a large academic medical center in the US
    Sylvie Stacy
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 17:1600-8. 2013
    ..This study sought to evaluate referral and treatment patterns among patients with HCC at a large academic medical center...
  26. pmc Unresectable hepatocellular carcinoma: MR imaging after intraarterial therapy. Part I. Identification and validation of volumetric functional response criteria
    Susanne Bonekamp
    Russell H Morgan Department of Radiology and Radiological Science and Department of Surgery and Oncology, The Johns Hopkins Hospital, 600 N Wolfe St, MRI 143, Baltimore, MD 21287, USA
    Radiology 268:420-30. 2013
    ..To identify and validate the optimal thresholds for volumetric functional MR imaging response criteria to predict overall survival after intraarterial treatment (IAT) in patients with unresectable hepatocellular carcinoma (HCC)...
  27. ncbi request reprint Phase 2 study of erlotinib combined with adjuvant chemoradiation and chemotherapy in patients with resectable pancreatic cancer
    Joseph M Herman
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Int J Radiat Oncol Biol Phys 86:678-85. 2013
    ..Gemcitabine-erlotinib therapy has demonstrated a survival benefit for patients with metastatic PDAC. Here we report the first phase 2 study of erlotinib in combination with adjuvant chemoradiation and chemotherapy for resected PDAC...
  28. pmc Early mortality risk score: identification of poor outcomes following upfront surgery for resectable pancreatic cancer
    Charles C Hsu
    The Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 410 North Broadway Suite 1440, Baltimore, MD 21231 2410, USA
    J Gastrointest Surg 16:753-61. 2012
    ..This study examines the preoperative predictors of early mortality following PD and combines these variables into an early mortality risk score (EMRS)...
  29. doi request reprint Therapeutic efficacy of combined intraoperative ablation and resection for colorectal liver metastases: an international, multi-institutional analysis
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Harvey 611, 600N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 15:336-44. 2011
    ..By combining resection and ablation, the number of patients eligible for surgery can be expanded. We sought to determine the efficacy of combined resection and ablation for CRLM...
  30. pmc Impact of sarcopenia on outcomes following intra-arterial therapy of hepatic malignancies
    Rebecca M Dodson
    Department of Surgery, Johns Hopkins University School of Medicine, Blalock 688 600 N Wolfe Street, Baltimore, 21287, MD, USA
    J Gastrointest Surg 17:2123-32. 2013
    ..Assessment of patient performance status is often subjective. Sarcopenia--measurement of muscle wasting--may be a more objective means to assess performance status and therefore mortality risk following intra-arterial therapy (IAT)...
  31. pmc Assessing short- and long-term outcomes among black vs white Medicare patients undergoing resection of colorectal cancer
    Eric B Schneider
    Department of Surgery, Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Blalock 688, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Surg 205:402-8. 2013
    ..We sought to identify differences among black and white Medicare-insured patients with colorectal cancer who underwent resection...
  32. pmc Treating patients with colon cancer liver metastasis: a nationwide analysis of therapeutic decision making
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 19:3668-76. 2012
    ..Criteria for resectability of colon cancer liver metastases (CLM) are evolving, yet little is known about how physicians choose a therapeutic strategy for potentially resectable CLM...
  33. doi request reprint Outcomes of adjuvant chemoradiation after pancreaticoduodenectomy with mesenterico-portal vein resection for adenocarcinoma of the pancreas
    Boris Hristov
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 76:176-80. 2010
    ..The purpose of this study was to compare outcomes between pancreaticoduodenectomy (PD) with and without mesenterico-portal vein resection (VR) in patients receiving adjuvant CRT for pancreatic adenocarcinoma...
  34. ncbi request reprint Impact of obesity on perioperative outcomes and survival following pancreaticoduodenectomy for pancreatic cancer: a large single-institution study
    Susan Tsai
    Department of Surgery, Johns Hopkins Medical Institutions, 600N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 14:1143-50. 2010
    ..To examine the effect of body mass index (BMI) on clinicopathologic factors and long-term survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma...
  35. pmc Two-stage strategy for patients with extensive bilateral colorectal liver metastases
    Susan Tsai
    Department of Surgery, Division of Surgical Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    HPB (Oxford) 12:262-9. 2010
    ..Two-stage hepatectomy has been proposed for patients with bilateral colorectal liver metastases. The present study assesses the feasibility and outcome of two-stage hepatectomy for the treatment of colorectal liver metastases...
  36. ncbi request reprint Timing of multimodality therapy for resectable synchronous colorectal liver metastases: a retrospective multi-institutional analysis
    Srinevas K Reddy
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Surg Oncol 16:1809-19. 2009
    ..However, prospective randomized trials are needed to determine the optimal timing of chemotherapy...
  37. pmc Adjuvant chemoradiation therapy after pancreaticoduodenectomy in elderly patients with pancreatic adenocarcinoma
    David P Horowitz
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 80:1391-7. 2011
    ..To evaluate the efficacy of adjuvant chemoradiation therapy (CRT) for pancreatic adenocarcinoma patients ≥ 75 years of age...
  38. ncbi request reprint Resection of hepatic colorectal metastases involving the caudate lobe: perioperative outcome and survival
    Eddie K Abdalla
    Department of Surgical Oncology Unit 444, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    J Gastrointest Surg 11:66-72. 2007
    ..To examine clinical features and outcome of patients who underwent hepatic resection for colorectal liver metastases (LM) involving the caudate lobe...
  39. pmc Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional series
    Sushanth Reddy
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Am Coll Surg 208:950-7; discussion 957-9. 2009
    ..Solid-pseudopapillary neoplasms (SPNs) are rare pancreatic tumors with malignant potential. Clinicopathologic characteristics and outcomes of patients with SPN were reviewed...
  40. pmc 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades
    Jin He
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    HPB (Oxford) 16:83-90. 2014
    ..This study was carried out to determine relative survival rates and trends in outcomes in patients who underwent resection of periampullary adenocarcinomas (PACs) with curative intent at a single institution over the last three decades...
  41. ncbi request reprint Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma
    Timothy M Pawlik
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Liver Transpl 11:1086-92. 2005
    ....
  42. ncbi request reprint Hepatic resection for metastatic melanoma: distinct patterns of recurrence and prognosis for ocular versus cutaneous disease
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 444, Houston 77030, USA
    Ann Surg Oncol 13:712-20. 2006
    ..Resection of melanoma metastatic to the liver remains controversial. We evaluated the efficacy of hepatic resection in patients with metastatic ocular and cutaneous melanoma and assessed factors that could affect survival after resection...
  43. ncbi request reprint Solitary colorectal liver metastasis: resection determines outcome
    Thomas A Aloia
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77230 1402, USA
    Arch Surg 141:460-6; discussion 466-7. 2006
    ..Hepatic resection (HR) and radiofrequency ablation (RFA) have been proposed as equivalent treatments for colorectal liver metastasis...
  44. pmc Recurrence after operative management of intrahepatic cholangiocarcinoma
    Omar Hyder
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Surgery 153:811-8. 2013
    ..Data on recurrence after operation for intrahepatic cholangiocarcinoma (ICC) are limited. We sought to investigate rates and patterns of recurrence in patients after operative intervention for ICC...
  45. doi request reprint Survival of patients operated for colorectal liver metastases and concomitant extra-hepatic disease: external validation of a prognostic model
    Michael N Mavros
    Departments of Surgery at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Surg Oncol 107:481-5. 2013
    ..A bi-institutional database was used to perform an external validation of this model...
  46. pmc Sequential intra-arterial therapy and portal vein embolization is feasible and safe in patients with advanced hepatic malignancies
    Peter D Peng
    Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA
    HPB (Oxford) 14:523-31. 2012
    ..Portal vein embolization (PVE) with intra-arterial therapy (IAT) may increase future liver remnant (FLR) hypertrophy. As such, the feasibility, safety and efficacy of IAT+PVE were investigated...
  47. ncbi request reprint Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma
    Timothy M Pawlik
    Department of Surgery, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Arch Surg 140:450-7; discussion 457-8. 2005
    ..A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection...
  48. ncbi request reprint Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 250:440-8. 2009
    ..To investigate rates and patterns of recurrence in patients following curative intent surgery for colorectal liver metastasis...
  49. ncbi request reprint Safety and efficacy of curative intent surgery for peri-ampullary liver metastasis
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Surg Oncol 102:256-63. 2010
    ..The management of patients with peri-ampullary liver metastasis remains controversial. We sought to assess the safety and efficacy of curative intent surgery for peri-ampullary liver metastasis...
  50. ncbi request reprint Oncolysis by viral replication and inhibition of angiogenesis by a replication-conditional herpes simplex virus that expresses mouse endostatin
    John T Mullen
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer 101:869-77. 2004
    ..However, complete tumor regression was rarely observed...
  51. doi request reprint Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis
    Jordan M Winter
    Department of Surgery, Johns Hopkins Medical Institutions, Halsted 610, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 14:379-87. 2010
    ..We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms...
  52. ncbi request reprint National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis
    Skye C Mayo
    Department of Surgery, The Johns Hopkins University School of Medicine, Harvey 611, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 14:1578-91. 2010
    ..We sought to evaluate compliance with these recommendations and to assess trends in the management and survival of patients with GBA...
  53. ncbi request reprint Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis
    Srinevas K Reddy
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Surg Oncol 14:3481-91. 2007
    ..This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and hepatic resections...
  54. pmc Variation in lymph node assessment after colon cancer resection: patient, surgeon, pathologist, or hospital?
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 15:471-9. 2011
    ..We sought to quantify relative proportions of the variation in lymph node assessment after colon cancer resection occurring at the patient, surgeon, pathologist, and hospital levels...
  55. pmc The role of liver-directed surgery in patients with hepatic metastasis from a gynecologic primary carcinoma
    Sarah I Kamel
    Department of Surgery, Johns Hopkins University School of Medicine, Harvey 611, 600 N Wolfe Street, Baltimore, MD 21287, USA
    World J Surg 35:1345-54. 2011
    ..We sought to determine the safety and efficacy of liver-directed surgery for hepatic metastasis from gynecologic primaries...
  56. pmc Re-evaluating the impact of tumor size on survival following pancreaticoduodenectomy for pancreatic adenocarcinoma
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Surg Oncol 103:656-62. 2011
    ..We sought to examine the association of size with outcomes following resection of pancreatic adenocarcinoma...
  57. ncbi request reprint Alternative lengthening of telomeres predicts site of origin in neuroendocrine tumor liver metastases
    Epameinondas Dogeas
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD
    J Am Coll Surg 218:628-35. 2014
    ..In this study, we aimed to evaluate the use of ALT as a biomarker in patients with NELM, in particular to predict the site of origin of metastases...
  58. ncbi request reprint Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma: a national perspective
    Skye C Mayo
    Department of Surgery, Johns Hopkins Hospital, Baltimore, MD
    J Am Coll Surg 218:196-205. 2014
    ..We sought to investigate the differences over time in surgically managed FLC compared with conventional HCC using population-based data...
  59. ncbi request reprint Unresectable hepatocellular carcinoma: MR imaging after intraarterial therapy. Part II. Response stratification using volumetric functional criteria after intraarterial therapy
    Susanne Bonekamp
    Department of Radiology, Johns Hopkins School of Medicine, The Johns Hopkins Hospital, 600 N Wolfe St, MRI 143, Baltimore, MD 21287, USA
    Radiology 268:431-9. 2013
    ....
  60. ncbi request reprint Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: results of a multicenter study
    Timothy M Pawlik
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Surgery 137:403-10. 2005
    ..We evaluated the efficacy of hepatic resection and the factors affecting survival after resection in such patients...
  61. pmc Impact of sarcopenia on outcomes following resection of pancreatic adenocarcinoma
    Peter Peng
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 16:1478-86. 2012
    ..Sarcopenia--the measurement of muscle wasting--may be a more objective and comprehensive patient-specific factor associated with long-term survival...
  62. pmc Hepatic resection for metastatic gastrointestinal stromal tumors in the tyrosine kinase inhibitor era
    Ryan S Turley
    Department of Surgery, Duke University Medical Center, Durham, NC 27110, USA
    Cancer 118:3571-8. 2012
    ..The objective of this study was to determine whether combination therapy for hepatic GIST metastases is associated with improved overall survival compared with reported outcomes from surgery or TKI therapy alone...
  63. pmc Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent
    Skye C Mayo
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer 118:2674-81. 2012
    ..Survival estimates, however, are dynamic and may change based on the time already survived. The authors sought to assess conditional survival among a large cohort of patients who underwent resection of PDAC...
  64. doi request reprint National trends in surgical procedures for hepatocellular carcinoma: 1998-2008
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 118:1838-44. 2012
    ..We quantified trends in use, mortality, and patient and hospital characteristics for 3 surgical therapies for HCC (resection, ablation, and transplantation) in the United States from 1998 to 2008...
  65. pmc Palliative surgical management of patients with unresectable pancreatic adenocarcinoma: trends and lessons learned from a large, single institution experience
    Peter J Kneuertz
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 15:1917-27. 2011
    ..We examined trends in the relative use of palliative bypass over time with an emphasis on identifying changes in surgical indications, type of bypass performed, as well as perioperative outcomes associated with surgical palliation...
  66. doi request reprint Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis: results from an international multi-institutional analysis
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Harvey 611 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 13:2141-51. 2009
    ..We sought to determine safety and efficacy of repeat CIS for recurrent colorectal liver metastasis as well as determine factors predictive of survival in a large multicenter cohort of patients...
  67. pmc Predictors of survival after resection of retroperitoneal sarcoma: a population-based analysis and critical appraisal of the AJCC staging system
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 250:970-6. 2009
    ..To identify predictors of survival after resection of retroperitoneal sarcoma (RPS) and to evaluate the performance of the American Joint Committee on Cancer (AJCC) staging system for RPS...
  68. pmc Adjuvant chemoradiation therapy for adenocarcinoma of the distal pancreas
    Kristin J Redmond
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 17:3112-9. 2010
    ..This study was designed to examine the effect of adjuvant 5-FU-based chemoradiation therapy (CRT) after distal pancreatectomy for adenocarcinoma of the distal pancreas...
  69. doi request reprint Peri-operative mortality and long-term survival after total pancreatectomy for pancreatic adenocarcinoma: a population-based perspective
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Surg Oncol 99:87-92. 2009
    ..We sought to analyze peri-operative mortality and long-term survival following TP versus PP for pancreatic adenocarcinoma...
  70. ncbi request reprint Total pancreatectomy for pancreatic adenocarcinoma: evaluation of morbidity and long-term survival
    Sushanth Reddy
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 22187, USA
    Ann Surg 250:282-7. 2009
    ..To analyze relative perioperative and long-term outcomes of patients undergoing total pancreatectomy versus pancreaticoduodenectomy...
  71. ncbi request reprint Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis
    Mark B Slidell
    Department of Surgery, Georgetown University Hospital, Washington, District of Columbia, USA
    Ann Surg Oncol 15:165-74. 2008
    ..LNR has never been investigated in a large population-based study of patients with pancreatic adenocarcinoma...
  72. ncbi request reprint Pancreatic resection of isolated metastases from nonpancreatic primary cancers
    Sushanth Reddy
    Department of Surgery, The Johns Hopkins University, 600 North Wolfe Street, Carnegie 681, Baltimore, Maryland 21287, USA
    Ann Surg Oncol 15:3199-206. 2008
    ..The goal of this study is to report the safety and efficacy of pancreatic resection for isolated metastatic cancers from nonpancreatic primary disease...
  73. ncbi request reprint Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?
    Ana Luiza Gleisner
    Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 22187 6681, USA
    Cancer 110:2484-92. 2007
    ..Specifically, the role of hepatic resection for metastatic periampullary or pancreatic adenocarcinoma remains controversial...
  74. ncbi request reprint Selectivity of an oncolytic herpes simplex virus for cells expressing the DF3/MUC1 antigen
    Hideki Kasuya
    Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 64:2561-7. 2004
    ..DF3gamma34.5 was effective against carcinoma xenografts in nude mice. Regulation of gamma(1)34.5 by the DF3/MUC1 promoter is a promising strategy for development of HSV-1 mutants for viral oncolysis...
  75. pmc Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm?
    Jin He
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Am Coll Surg 216:657-65; discussion 665-7. 2013
    ..Little is known about the risk of subsequently developing a new or progressive intraductal papillary mucinous neoplasm (IPMN) after partial pancreatic resection of a noninvasive IPMN...
  76. pmc Management of patients with pancreatic adenocarcinoma: national trends in patient selection, operative management, and use of adjuvant therapy
    Skye C Mayo
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Am Coll Surg 214:33-45. 2012
    ..Advances in surgical technique and perioperative care have reduced perioperative mortality; however, temporal trends in perioperative morbidity and the use of adjuvant therapy on a population basis remain ill-defined...
  77. pmc Evaluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study
    Amol K Narang
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Radiat Oncol 6:126. 2011
    ..We combined the experience of two institutions to better delineate which patients may benefit from adjuvant chemoradiation...
  78. ncbi request reprint Debunking dogma: surgery for four or more colorectal liver metastases is justified
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Gastrointest Surg 10:240-8. 2006
    ..Certain clinicopathologic factors, including lack of response to neoadjuvant chemotherapy, were associated with a worse prognosis...
  79. ncbi request reprint Intrahepatic cholangiocarcinoma
    George A Poultsides
    Department of Surgery, Division of Surgical Oncology, Stanford University School of Medicine, 300 Pasteur Drive, H3680, Stanford, CA 94305 5641, USA
    Surg Clin North Am 90:817-37. 2010
    ..For those patients with inoperable disease, locoregional therapy with transarterial chemoembolization can be considered...
  80. pmc Shifting trends in liver-directed management of patients with colorectal liver metastasis: a population-based analysis
    Skye C Mayo
    Department of Surgery, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    Surgery 150:204-16. 2011
    ..We sought to evaluate population-based temporal trends in perioperative management, as well as short- and long-term outcomes associated with the operative management of colorectal liver metastasis (CRLM)...
  81. ncbi request reprint Subtotal hepatectomy following neoadjuvant chemotherapy for a previously unresectable hepatocellular carcinoma
    Daria Zorzi
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030 4009, USA
    J Hepatobiliary Pancreat Surg 13:347-50. 2006
    ..This case illustrates that the combination of innovative neoadjuvant chemotherapy and well-planned surgical approaches may benefit a small number of patients previously deemed unresectable...
  82. ncbi request reprint Results of a single-center experience with resection and ablation for sarcoma metastatic to the liver
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Arch Surg 141:537-43; discussion 543-4. 2006
    ..A subset of patients with sarcoma liver metastasis may benefit from hepatic resection and/or ablation...
  83. pmc Hilar cholangiocarcinoma: tumor depth as a predictor of outcome
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Surg 146:697-703. 2011
    ..The American Joint Committee on Cancer staging system for hilar cholangiocarcinoma may be inaccurate because the bile duct lacks discrete tissue boundaries...
  84. pmc Refining the definition of perioperative mortality following hepatectomy using death within 90 days as the standard criterion
    Skye C Mayo
    Department of Surgery, School of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    HPB (Oxford) 13:473-82. 2011
    ..To better define perioperative mortality, trends in the risk for death during the first 90 days after hepatectomy were assessed...
  85. ncbi request reprint A proposed staging system for intrahepatic cholangiocarcinoma
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 16:14-22. 2009
    ..We propose a staging system specifically developed for ICC based on number of tumors, vascular invasion, lymph node status, and presence of metastatic disease...
  86. pmc Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients
    K Ranh Voong
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD 21231 6681, USA
    Hum Pathol 41:113-22. 2010
    ..Treatment with adjuvant chemoradiation therapy is associated with improved survival. The proportion of squamous differentiation in resected pancreatic adenosquamous carcinoma specimens does not appear to impact overall survival...
  87. doi request reprint Surgical management of early-stage hepatocellular carcinoma: resection or transplantation?
    Emily C Bellavance
    Department of Surgery, University of Maryland Medical Center, Baltimore, MD, USA
    J Gastrointest Surg 12:1699-708. 2008
    ..The purpose of the current study was to compare the outcome of patients with well-compensated cirrhosis and early stage hepatocellular carcinoma treated with initial hepatic resection versus transplantation...
  88. pmc Patterns of recurrence following liver resection for colorectal metastases: effect of primary rectal tumor site
    Lia Assumpcao
    Department of Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Arch Surg 143:743-9; discussion 749-50. 2008
    ..This may affect the pattern of recurrence and survival rates following hepatic resection of liver metastases from rectal adenocarcinoma...
  89. ncbi request reprint Colorectal liver metastases: recurrence and survival following hepatic resection, radiofrequency ablation, and combined resection-radiofrequency ablation
    Ana L Gleisner
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 22187 6681, USA
    Arch Surg 143:1204-12. 2008
    ....
  90. ncbi request reprint Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment
    Mechteld C de Jong
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Oncol 29:3140-5. 2011
    ..To identify factors associated with outcome after surgical management of intrahepatic cholangiocarcinoma (ICC) and examine the impact of lymph node (LN) assessment on survival...
  91. ncbi request reprint Risk factors for pancreatic leak after distal pancreatectomy
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Surg 250:277-81. 2009
    ..We sought to evaluate the incidence of and identify risk factors for the development of PL in patients undergoing distal pancreatectomy (DP) at a single high-volume institution...
  92. doi request reprint Surgical management of hepatic neuroendocrine tumor metastasis: results from an international multi-institutional analysis
    Skye C Mayo
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 17:3129-36. 2010
    ..We sought to define the efficacy of the surgical management of NELM in a large multicenter international cohort of patients...
  93. ncbi request reprint Assessment of the role of sentinel lymph node biopsy for primary cutaneous desmoplastic melanoma
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77230, USA
    Cancer 106:900-6. 2006
    ..The role of sentinel lymph node biopsy (SLNB) in the treatment of desmoplastic melanoma (DM) remains undefined. The purpose of this study was to evaluate the use of SLNB for DM...
  94. ncbi request reprint Patient variability in intraoperative ultrasonographic characteristics of colorectal liver metastases
    Michael A Choti
    Department of Surgery, Johns Hopkins Hospital, 600 N Wolfe St, Blalock 665, Baltimore, MD 22187 6681, USA
    Arch Surg 143:29-34; discussion 35. 2008
    ..The interpatient and intrapatient variability of tumor IOUS echogenicity was assessed...
  95. ncbi request reprint The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonography
    Mark G Van Vledder
    Department of Surgery, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Surg 145:661-7. 2010
    ..To investigate the association of relative tumor echogenicity and hepatic steatosis in patients undergoing resection of colorectal liver metastases (CRLM)...
  96. pmc Racial disparity in surgical mortality after major hepatectomy
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Am Coll Surg 207:312-9. 2008
    ..We sought to quantify and explore the nature of racial disparities in surgical mortality after major hepatectomy in a nationally representative cohort of patients...
  97. pmc Regulation of herpes simplex virus 1 replication using tumor-associated promoters
    John T Mullen
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Surg 236:502-12; discussion 512-3. 2002
    ..To investigate use of transcriptional regulatory elements (promoters) for tumor-associated antigens to achieve HSV-1 replication preferentially in cells that overexpress the tumor-associated antigens...
  98. ncbi request reprint Trends in survival after surgery for cholangiocarcinoma: a 30-year population-based SEER database analysis
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Room 442, Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    J Gastrointest Surg 11:1488-96; discussion 1496-7. 2007
    ..We suggest that these trends are largely caused by developments in imaging technology, improvements in patient selection, and advances in surgical techniques...
  99. pmc Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected database at the Johns Hopkins Hospital
    Joseph M Herman
    Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 26:3503-10. 2008
    ..To examine the efficacy of adjuvant chemoradiotherapy after pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PC) in patients undergoing resection at Johns Hopkins Hospital (JHH; Baltimore, MD)...
  100. pmc Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas
    George A Poultsides
    Department of Surgery, Sidney Kimmel Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA
    Ann Surg 251:470-6. 2010
    ....
  101. pmc Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Surg 241:715-22, discussion 722-4. 2005
    ..To evaluate the influence of surgical margin status on survival and site of recurrence in patients treated with hepatic resection for colorectal metastases...