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Genomes and Genes | Drew PardollSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Immunology beats cancer: a blueprint for successful translationDrew M Pardoll
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Immunol 13:1129-32. 2012..The successes of antibodies to the immunomodulatory receptor CTLA-4 and blockade of the immunoinhibitory receptor PD-1 in cancer immunotherapy, from gene discovery to patient benefit, have created a paradigm for driving such endeavors...
Immunotherapy earns its spot in the ranks of cancer therapyDrew Pardoll
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Exp Med 209:201-9. 2012..Although tumor-targeted antibodies have certainly cleared this bar, immunotherapies aimed at harnessing antitumor cellular responses have not-until now...- The blockade of immune checkpoints in cancer immunotherapyDrew M Pardoll
Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, CRB1 Room 444, 1650 Orleans Street, Baltimore, Maryland 21287, USA
Nat Rev Cancer 12:252-64. 2012.... - Metastasis-promoting immunity: when T cells turn to the dark sideDrew Pardoll
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Cancer Cell 16:81-2. 2009..In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion... 
A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transferKevin S Gorski
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Mol Immunol 40:35-47. 2003..Endogenous CCL17 and B7-DC mRNAs were increased similarly in IL-4 cultured DCs but only CCL17 was induced by LPS. Additionally, IL-4 increased cell surface expression of B7-DC in both immature and mature DCs...- HLA-DQB1*02-restricted HPV-16 E7 peptide-specific CD4+ T-cell immune responses correlate with regression of HPV-16-associated high-grade squamous intraepithelial lesionsShiwen Peng
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Clin Cancer Res 13:2479-87. 2007..The identification and characterization of endogenously processed HPV antigenic epitopes in closely characterized patient cohorts will provide insight into the reasons for success or failure of therapeutic approaches... - Spatial distribution of tumor vaccine improves efficacyMarion Couch
Department of Otolarynology Head and Neck Surgery, Johns Hopkins Hospital, Johns Hopkins Outpatient Center, Baltimore, Maryland 21287 0901, USA
Laryngoscope 113:1401-5. 2003..Genetically engineered tumor cells were used as a vaccine in a murine model to compare tumor formation after inoculating multiple sites versus a single site. The effect of vaccinating draining lymph node basins was evaluated... - Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINORTianhong Wang
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Blood 113:2906-13. 2009..Our results indicate that blockade of MINOR expression dramatically decreases apoptosis in DCs and suggest that this approach may be a novel means to improve the potency of ex vivo-generated DC vaccines... - IFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacityMaria Pletneva
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 69:6607-14. 2009..Our findings emphasize the unique nature of IKDC as a killer antigen-presenting cell directly linking innate and adaptive immunity... - Immunotherapy of established tumors using bone marrow transplantation with antigen gene--modified hematopoietic stem cellsYan Cui
Immunology and Hematopoiesis Division, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Nat Med 9:952-8. 2003..This tripartite strategy provided potent antigen-specific immunotherapy for an aggressive established tumor... - Lentivirus-mediated gene transfer and expression in established human tumor antigen-specific cytotoxic T cells and primary unstimulated T cellsXianzheng Zhou
Division of Immunology and Hematppoiesis, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Hum Gene Ther 14:1089-105. 2003..These results will have significant implications for the study of T-cell biology and for the improvement of clinical gene therapies of acquired immune deficiency syndrome (AIDS) and cancer... - Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimerasLeo Luznik
Divisions of Hematopoiesis/Immunology and Hematologic Malignancies, Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA
Blood 101:1645-52. 2003.... - Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasionKen Yu Lin
Department of Pathology, Institute of Genetic Medicine, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
Cancer Res 67:1832-41. 2007..These data provide evidence that tumor expression of VCAM-1 represents a new mechanism of immune evasion and has important implications for the development of immunotherapy for human RCC... - Radiotherapy augments the immune response to prostate cancer in a time-dependent mannerTimothy J Harris
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Prostate 68:1319-29. 2008..To address this, we utilized a well-established, autochthonous murine model of prostate cancer to test whether RT could augment (or diminish) the CD4 T cell response to a tumor vaccine... - Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis CAndrea L Cox
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Hepatology 42:104-12. 2005..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html)... - A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myelomaKimberly Noonan
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
Blood 116:3554-63. 2010.... - A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3Cornelia L Trimble
Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Clin Cancer Res 15:361-7. 2009..To evaluate the safety and immunogenicity of a therapeutic human papillomavirus (HPV)16 DNA vaccine administered to women with HPV16+cervical intraepithelial neoplasia (CIN)2/3... - Intratumoral administration of TLR4 agonist absorbed into a cellular vector improves antitumor responsesMeghan B Davis
Departments of Otolaryngology Head and Neck Surgery, Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Clin Cancer Res 17:3984-92. 2011..Because toll-like receptor (TLR) agonists have been well characterized as dendritic cell (DC) activators, we hypothesized that the admixture of TLR4 agonist into a cellular vector could improve the antitumor response in vivo... - Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotypeCornelia L Trimble
Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Clin Cancer Res 11:4717-23. 2005..We carried out a prospective observational cohort study evaluating known, quantifiable prognostic variables of clinical behavior in women with high-grade cervical lesions... - CD4+ T cells pass through an effector phase during the process of in vivo tolerance inductionChing-Tai Huang
Oncology Center and Division of Comparative Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
J Immunol 170:3945-53. 2003..They also suggest that autoimmune pathology can result during the natural process of tolerance induction rather than requiring that tolerance be broken... - Constitutive and inducible expression of b7 family of ligands by human airway epithelial cellsJean Kim
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Rm 3A65A, Baltimore, MD 21224, USA
Am J Respir Cell Mol Biol 33:280-9. 2005..Epithelial B7 homologs could play a role in regulation of lymphocytic activity at mucosal surfaces... - In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responsesTahiro Shin
Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Exp Med 201:1531-41. 2005..These results highlight the contrasting in vivo roles of B7-DC and B7-H1 and indicate that B7-DC functions as a tuning molecule, selectively augmenting T helper 1 and CTL responses... - Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigenCharles G Drake
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Cancer Cell 7:239-49. 2005..These results suggest that immunotherapy for prostate cancer may be most efficacious when administered after androgen ablation... - Interferon-producing killer dendritic cells provide a link between innate and adaptive immunityCamie W Chan
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, CRB 440, 1650 Orleans Street, Baltimore, Maryland 21231, USA
Nat Med 12:207-13. 2006..By virtue of their capacity to kill target cells, followed by antigen presentation, IKDCs provide a link between innate and adaptive immunity... - Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signalingRajani Ravi
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
Cancer Res 66:1730-9. 2006.... - Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune diseaseKatharine A Whartenby
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 102:16741-6. 2005.... - Transduction of donor hematopoietic stem-progenitor cells with Fas ligand enhanced short-term engraftment in a murine model of allogeneic bone marrow transplantationKatharine A Whartenby
Sidney Kimmel Comprehensive Cancer Center at JHU, School of Medicine, Johns Hopkins University, Bunting Blaustein Cancer Research Building, Room 2M44, 1650 Orleans Street, Baltimore, MD 21231, USA
Blood 100:3147-54. 2002..These results suggest potential therapeutic approaches by manipulating lymphohematopoietic stem-progenitor cells to express FasL or other immune-modulating genes in the context of BMT... - Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer modelSatoshi Wada
Department of Oncology, James Buchanan Brady Urological Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Cancer Res 69:4309-18. 2009..Taken together, these data clarify the dose, timing, and mechanism of action by which immunomodulatory cyclophosphamide can be translated to a clinical setting in a combinatorial cancer treatment strategy... - Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergyFumihiko Tsushima
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Blood 110:180-5. 2007..Our results thus reveal previously unappreciated roles of B7-H1 and PD-1 interaction in the control of initiation and reversion of T-cell anergy... - Cellular vaccine approachesDung T Le
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans St, Bunting Blaustein Cancer Research Building, Room 407, Baltimore, MD 21231, USA
Cancer J 16:304-10. 2010.... - Spinning molecular immunology into successful immunotherapyDrew M Pardoll
Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nat Rev Immunol 2:227-38. 2002..These strategies provide a blueprint for the development of successful immunotherapy over the next decade... - T cells take aim at cancerDrew Pardoll
Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 99:15840-2. 2002 - Genetically engineered tumor cell vaccine in a head and neck cancer modelMarion Couch
Department of Otolaryngology Head and Neck Surgery, Outpatient Center, Johns Hopkins Hospital, Room 624, 601 North Caroline Street, Baltimore, MD 21287 0901, USA
Laryngoscope 113:552-6. 2003..Using a murine model, a novel tumor vaccine for head and neck squamous cell carcinoma expressing the granulocyte-macrophage colony stimulating factor (GM-CSF) gene was evaluated for its ability to protect against tumor challenge... - Does the immune system see tumors as foreign or self?Drew Pardoll
Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Annu Rev Immunol 21:807-39. 2003..Elucidation of these mechanisms provides new strategies for cancer immunotherapy... - GM-CSF-based cellular vaccines: a review of the clinical experienceIvan Borrello
Johns Hopkins Oncology Center, Room 453, 1650 Orleans Street, Baltimore, MD 21231, USA
Cytokine Growth Factor Rev 13:185-93. 2002..This review summarizes the results from the clinical trials performed to date and discusses the future directions of GM-CSF-based cellular vaccine strategies aimed at maximizing the therapeutic benefit... - Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAILRajani Ravi
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cancer Res 64:9105-14. 2004.... - Tc17 CD8 T cells: functional plasticity and subset diversityHung Rong Yen
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Immunol 183:7161-8. 2009..Tc17 also accumulated to a greater extent than did Tc1 cells, suggesting that adoptive transfer of CD8 T cells cultured in Tc17 conditions may have therapeutic potential for diseases in which IFN-gamma-producing cells are desired... - Role of LAG-3 in regulatory T cellsChing Tai Huang
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Immunity 21:503-13. 2004..We propose that LAG-3 marks regulatory T cell populations and contributes to their suppressor activity... - Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cellsJoseph F Grosso
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Immunol 182:6659-69. 2009.... - Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenesKiyoshi Yoshimura
Immunology and Hematopoiesis Division, Department of Medical Oncology, Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
Cancer Res 66:1096-104. 2006..These findings show a general approach to focus systemic cancer immunotherapies to specific organs bearing tumor metastases by taking advantage of differential tropisms and the proinflammatory nature of microbes... - LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systemsJoseph F Grosso
Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Clin Invest 117:3383-92. 2007..Taken together, these data demonstrate a direct role for LAG-3 on CD8+ T cells and suggest that LAG-3 blockade may be a potential cancer treatment... - Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringeCornelia Trimble
Department of Obstetrics and Gynecology, The Johns Hopkins Medical Institution, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Vaccine 21:4036-42. 2003..m.) and biojector administrations. Thus, our data suggest that DNA vaccination via gene gun represents the most potent regimen for DNA administration... - Cancer immunotherapy: breaking the barriers to harvest the cropDrew Pardoll
Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Med 10:887-92. 2004..For its promise to be fully realized, both the National Cancer Institute and Food and Drug Administration must take active steps to help academic investigators and companies jointly navigate the pathways from laboratory to clinic... - Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptorTahiro Shin
Sidneu Kimmel Comprehensive Cancer Centre, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
J Exp Med 198:31-8. 2003..Finally, costimulation with B7-DC alone or in conjunction with B7-1 is PD-1 independent, indicating that B7-DC costimulates T cells via a second receptor... - Live attenuated Listeria monocytogenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory T cellsKiyoshi Yoshimura
Department of Surgery and Immunology and Hematopoiesis Division, Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Cancer Res 67:10058-66. 2007..These results show the utility of LM in the treatment of hepatic metastases even in the absence of vaccine administration and further suggest that blockade of Treg cells and NK T cells will enhance antitumor activity... - Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunityTimothy J Harris
Department of Oncology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
J Immunol 179:4313-7. 2007..Thus, STAT3 is a candidate target for T(H)17-dependent autoimmune disease immunotherapy that could selectively inhibit pathogenic immune pathways... - Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastasesAjay Jain
Department of Surgery, Division of Immunology and Hematapoiesis, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann Surg Oncol 10:810-20. 2003..05). CONCLUSIONS: Systemic IL-2 augments tumor vaccine efficacy in the treatment of microscopic murine colorectal hepatic metastases... - Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cellsMonica V Goldberg
Department of Oncology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
Blood 110:186-92. 2007..These findings demonstrate that, in addition to modulating effector functions in the periphery, B7-H1:PD-1 interactions regulate early T-cell-fate decisions... - Integrin alpha2 mediates selective metastasis to the liverKiyoshi Yoshimura
Department of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Blalock 685, Baltimore, MD 21287, USA
Cancer Res 69:7320-8. 2009..These findings define integrin alpha2 as a molecule conferring selective potential for formation of hepatic metastasis, as well as a possible target to prevent their formation... - Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlatesJulie R Brahmer
Johns Hopkins University School of Medicine, and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
J Clin Oncol 28:3167-75. 2010..This phase I study sought to determine the safety and tolerability of anti-PD-1 blockade in patients with treatment-refractory solid tumors and to preliminarily assess antitumor activity, pharmacodynamics, and immunologic correlates... - Tumor immunology--towards a paradigm of reciprocal researchCharles G Drake
Johns Hopkins Department of Medical Oncology, Baltimore, MD 21231, USA
Semin Cancer Biol 12:73-80. 2002..The results of early clinical trials illustrate these points and underscore the critical importance of an interactive dialog between laboratory and clinical research efforts... - Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitisSudarshan Anand
Immunology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Clin Invest 116:1045-51. 2006..Our studies thus identify a what we believe to be a novel function of soluble LIGHT in vivo and offer a potential target for therapeutic interventions in hepatic inflammatory diseases... - Tumor-specific CD4+ T cells from a patient with renal cell carcinoma recognize diverse shared antigensJosef Mautner
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int J Cancer 115:752-9. 2005..These experiments show that a dual Th1/Th2, MHC class II-restricted T-helper-cell response against diverse shared tumor antigens has been elicited in this patient... - Diverse CD8+ T-cell responses to renal cell carcinoma antigens in patients treated with an autologous granulocyte-macrophage colony-stimulating factor gene-transduced renal tumor cell vaccineXianzheng Zhou
Division of Immunology and Hematopoiesis, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
Cancer Res 65:1079-88. 2005.... - Cellular immune selection with hepatitis C virus persistence in humansAndrea L Cox
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
J Exp Med 201:1741-52. 2005..015). These findings reveal two distinct mechanisms of sequence evolution involved in HCV persistence: viral escape from CD8+ T cell responses and optimization of replicative capacity... - Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem/progenitor cellsYan Cui
Division of Immunology and Hematopoiesis, Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, MD 21231, USA
Blood 99:399-408. 2002..This study demonstrated successful targeting of transgene expression to APCs/DCs after stable gene transduction of pluripotent HSCs... - Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cellsFan Pan
Immunology and Hematopoiesis Division, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Science 325:1142-6. 2009..Silencing of Eos in Tregs abrogates their ability to suppress immune responses and endows them with partial effector function, thus demonstrating the critical role that Eos plays in Treg programming... - Gene therapy for experimental brain tumors using a xenogenic cell line engineered to secrete hIL-2Maciej S Lesniak
Department of Neurosurgery, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Neurooncol 64:155-60. 2003..Our findings demonstrate that the use of a xenogenic cell line can provide a potent vehicle for the delivery of gene therapy and may therefore represent a new approach for brain tumor therapy... - Tumor recognition and self-recognition induce distinct transcriptional profiles in antigen-specific CD4 T cellsDerese Getnet
Department of Oncology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
J Immunol 182:4675-85. 2009..Interestingly, this Treg skewing was a property of even early-stage tumors, suggesting Treg induction as an important tolerance mechanism during tumor development... - Immunologic consequences of signal transducers and activators of transcription 3 activation in human squamous cell carcinomaEmilia Albesiano
Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 70:6467-76. 2010..These results show the importance of STAT3 activation in regulating the immunomodulatory mediators by human tumors and further validate STAT3 as a promising target for therapeutic intervention... - Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunologyDan A Laheru
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Bunting-Blaustein Cancer Research Building, Room 4M07, 1650 Orleans Street, Baltimore, MD 21231, USA
Mol Cancer Ther 4:1645-52. 2005..We outline here a paradigm for early-stage clinical development of immunotherapy combinations that use vaccines to drive tumor antigen-specific responses while simultaneously targeting immune regulatory pathways... - Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cellsTianhong Wang
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Med 10:48-54. 2004..We propose that tumor Stat-3 activity can mediate immune evasion by blocking both the production and sensing of inflammatory signals by multiple components of the immune system... - High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infectionAlleluiah Rutebemberwa
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Immunol 181:8215-25. 2008..These results support the idea that PD-1 expression on T cells specific for nonescaped epitopes contributes to viral persistence and suggest that PD-1 blockade may alter the outcome of HCV infection... - Feedback inhibition of calcineurin and Ras by a dual inhibitory protein CarabinFan Pan
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 445:433-6. 2007..Thus, Carabin is a negative feedback inhibitor of the calcineurin signalling pathway that also mediates crosstalk between calcineurin and Ras... - A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cellsDerese Getnet
Department of Oncology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
Mol Immunol 47:1595-600. 2010..Taken together, these data suggest that Helios may play an important role in regulatory T cell function and support the concept that Helios may be a novel target to manipulate Treg activity in a clinical setting... - A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responsesShaoguang Wu
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Med 15:1016-22. 2009..These results show a Stat3- and T(H)17-dependent pathway for inflammation-induced cancer by a common human commensal bacterium, providing new mechanistic insight into human colon carcinogenesis... - Inhibition of vasospasm with lymphocyte function-associated antigen-1 monoclonal antibody in a femoral artery model in ratsRichard E Clatterbuck
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurosurg 97:676-82. 2002..In this report the authors confirm this hypothesis with mAbs directed against lymphocyte function-associated antigen-1 ([LFA-1] CD11a/CD18), the molecule on the surface of leukocytes that interacts with ICAM-1... - Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumorXiang yang Wang
Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Immunol Immunother 51:311-9. 2002..These observations demonstrate that manipulation of hsp110 expression in tumors, specifically when combined with GM-CSF, represents a potentially powerful approach to cancer vaccine formulation... - Tumor-specific CD8+ T lymphocytes derived from the peripheral blood of prostate cancer patients by in vitro stimulation with autologous tumor cell linesFranck Housseau
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int J Cancer 98:57-62. 2002.... - Tumor reactive T cells get a boostDrew M Pardoll
Nat Biotechnol 20:1207-8. 2002 - Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunityKimberly R Jordan
University of Colorado Denver and Health Sciences Center, Denver, CO 80206, USA
J Immunol 180:188-97. 2008..Thus, the mechanism of Ag presentation induced by this vaccine is consistent with cross-priming by dendritic cells. This straightforward approach will facilitate future analyses of T cells elicited by peptide mimotopes... - Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availabilityTsvetelina Pentcheva-Hoang
Howard Hughes Medical Institute, Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:17765-70. 2007..PD-1 and CD28 have similar kinetics of synaptic accumulation, suggesting that the process involves T cell receptor-triggered cytoskeletal reorganization followed by ligand binding... - Expression of programmed death 1 ligands by murine T cells and APCTomohide Yamazaki
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
J Immunol 169:5538-45. 2002..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation... - B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthmaKoichiro Matsumoto
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Biochem Biophys Res Commun 365:170-5. 2008..These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-gamma production during the effector phase of allergic asthma... - Differential binding properties of B7-H1 and B7-DC to programmed death-1Pornpan Youngnak
Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
Biochem Biophys Res Commun 307:672-7. 2003..Our results suggest that the differential binding properties of B7-H1 and B7-DC may be responsible for differential contributions of these two PD-1 ligands to immune responses... - Cutting edge: Expression of functional CD137 receptor by dendritic cellsRyan A Wilcox
Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
J Immunol 168:4262-7. 2002..Our findings implicate CD137 as an important receptor involved in the modulation of DC function... - Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cellsLoc T Nguyen
Department of Immunology, Mayo Medical and Graduate Schools, Mayo Clinic, Rochester, MN 55905, USA
J Exp Med 196:1393-8. 2002..In addition to the established costimulatory and inhibitory functions associated with B7-DC, this molecule can also function as a conduit for extracellular signals to DCs modifying DC functions... - Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cellsSuresh Radhakrishnan
Department of Immunology, Mayo Medical and Graduate Schools, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
J Immunol 170:1830-8. 2003..These findings imply that, in addition to known costimulatory roles, B7-DC can function as a receptor for signals delivered by cells expressing B7-DC ligands... - Dexamethasone mediated inhibition of local IL-2 immunotherapy is dose dependent in experimental brain tumorsMaciej S Lesniak
Division of Neurosurgery, The University of Chicago Hospitals, Chicago, IL 60637, USA
J Neurooncol 70:23-8. 2004..These results suggest that while high doses of dexamethasone can completely inhibit the immune response observed with IL-2, lower and more likely therapeutic doses of dexamethasone do not inhibit local IL-2 immunotherapy... - Immunostimulatory monoclonal antibodies for cancer therapyIgnacio Melero
Centro de Investigación Médica Aplicada CIMA and Clínica Universitaria, Universidad de Navarra, Pamplona, Spain
Nat Rev Cancer 7:95-106. 2007..Importantly, mAbs of this type have now entered clinical trials with encouraging initial results... - Peptide-beta2-microglobulin-MHC fusion molecules bind antigen-specific T cells and can be used for multivalent MHC-Ig complexesTim F Greten
Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, FZ Oststadt, Raum 310, Pasteurallee 5, Germany
J Immunol Methods 271:125-35. 2002..These molecules bind antigen-specific T cells with high specificity and sensitivity, therefore, providing a valuable tool for detection as well as enrichment of antigen-specific T cells... - Advances in gene therapy for malignant melanomaMaria G Sotomayor
Cutaneous Oncology Program, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, USA
Cancer Control 9:39-48. 2002.... - Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 toleranceYiping Yang
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Immunol 5:508-15. 2004..These results demonstrate that virus provides TLR signals required for bypassing regulatory T cell-mediated tolerance and emphasize the importance of persistent TLR signals for immunotherapy in the setting of established tolerance... - Building the bionic T cellDrew M Pardoll
Nat Med 13:1411-3. 2007
Research Grants
- The Role of EOS in Regulatory T-cell Biology.Drew M Pardoll; Fiscal Year: 2010..This proposal explore mechanism of Eos dependent Gene silencing and test the hypothesis that regulation of Eos is an important mechanism to control the regulatory T cell/ effector T cell balance in immunity. ..
- Analysis of the STAT3 Pathway In Tumor Tolerance and Immune EvasionDrew M Pardoll; Fiscal Year: 2010....
- Analysis of New Dendritic Cell Costimulatory MoleculeDrew Pardoll; Fiscal Year: 2006....
- Identification of Novel Immune Cell- the NKDCDrew M Pardoll; Fiscal Year: 2010..Specific Aim #3: Define the capacity of NKDC to process and present antigens to T cells. Specific Aim #4: Define the role of NKDC in response to tumors. ..
- Identification of Novel Immune Cell- the NKDCDrew Pardoll; Fiscal Year: 2007..Specific Aim #3: Define the capacity of NKDC to process and present antigens to T cells. Specific Aim #4: Define the role of NKDC in response to tumors. ..
- Antigen Specific Immunotherapy with Transduced HSCDrew Pardoll; Fiscal Year: 2007....
- Analysis of Lag-3 in Regulatory T cell FunctionDrew Pardoll; Fiscal Year: 2007..2) Elucidate the direct role of LAG-3 in modulating the activity of Treg cells and 3) Analyze the effect of blockade or elimination of LAG-3+ Treg cells in enhancing the activity of immunotherapies for established cancer. ..
- Analysis of the STAT3 Pathway In Tumor Tolerance and Immune EvasionDrew Pardoll; Fiscal Year: 2007....
- RENAL CANCER ANTIGENS RECOGNIZED BY CD4 T CELLSDrew Pardoll; Fiscal Year: 2001....
- ANALYSIS OF E7 SPECIFIC T CELLS USING MHC-1GG MOLECULESDrew Pardoll; Fiscal Year: 2002....