Research Topics
Genomes and Genes | C A PardoSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulenceHong Na
Department of Medicine University of Alberta, Edmonton, AB, T6G 2S2, Canada
Retrovirology 8:44. 2011....
Immunity, neuroglia and neuroinflammation in autismCarlos A Pardo
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Int Rev Psychiatry 17:485-95. 2005..A better understanding of the role of neuroinflammation in the pathogenesis of autism may have important clinical and therapeutic implications...- HIV neuropathy: insights in the pathology of HIV peripheral nerve diseaseC A Pardo
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Peripher Nerv Syst 6:21-7. 2001..Opportunisitic infections, mostly associated with cytomegalovirus or herpes zoster virus infection occur in late stages of AIDS and produce characteristic clinical features such as mononeuritis multiple or radiculopathies... - The neurobiology of autismCarlos A Pardo
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA
Brain Pathol 17:434-47. 2007..We also discuss evidence implicating oxidative stress, neuroglial activation and neuroimmunity in autism... - Immune reconstitution inflammatory syndrome in the CNS of HIV-infected patientsA Venkataramana
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Neurology 67:383-8. 2006..Some patients may respond to a brief course of treatment with corticosteroids... - Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neuronsSanjay C Keswani
Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
Ann Neurol 54:287-96. 2003..This newly described Schwann cell-neuron interaction may be pathogenically relevant not only in HIV-SN but also in other peripheral neuropathies... - The need for caution in considering the diagnostic utility of antibasal ganglia antibodies in movement disordersH S Singer
Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 N Wolfe Street, Baltimore, MD, USA
Arch Dis Child 89:595-7. 2004 - CD4 and chemokine receptors on human brain microvascular endothelial cells, implications for human immunodeficiency virus type 1 pathogenesisMonique F Stins
Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Endothelium 11:275-84. 2004.... - Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statinsAshok Chauhan
Department of Neurology, Richard Johnson Division of Neuro Immunology and Neurological Infections, The Johns Hopkins University, 509 Pathology, 600 N Wolfe St, Baltimore, MD 21287, USA
FASEB J 21:777-89. 2007..Our findings suggest that ET-1 may be critical in mediating the neuropathogenesis of HIV dementia and that statins may have therapeutic potential in these patients... - Sturge-Weber syndrome: altered blood vessel fibronectin expression and morphologyAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Child Neurol 20:572-7. 2005..Altered blood vessel fibronectin expression in Sturge-Weber syndrome could contribute to abnormal vascular structure and function in this disorder... - Neuroglial activation and neuroinflammation in the brain of patients with autismDiana L Vargas
Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
Ann Neurol 57:67-81. 2005..Our findings indicate that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain... - In vitro modeling of the HIV-macrophage reservoirAmanda Brown
Johns Hopkins School of Medicine, Department of Neurology, 600 North Wolfe St, Baltimore, MD 21287, USA
J Leukoc Biol 80:1127-35. 2006..A subset of these, were replication competent as shown by their ability to express GFP and/or p24 antigen after reactivation with IL-4... - Diagnosis and management of acute myelopathiesAdam I Kaplin
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Osler 320, 600 N Wolfe Street, Baltimore, MD 21287, USA
Neurologist 11:2-18. 2005..TM may exist as part of a multifocal CNS disease (eg, MS), multisystemic disease (eg, systemic lupus erythematosus), or as an isolated, idiopathic entity... - The pathology of Rasmussen syndrome: stages of cortical involvement and neuropathological studies in 45 hemispherectomiesCarlos A Pardo
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Epilepsia 45:516-26. 2004..To characterize the profile of cortical involvement in RS, we studied the pathological changes in the cerebral cortex of 45 hemispherectomies performed at Johns Hopkins Hospital between 1985 and 2002... - Matrix metalloproteinase-1 activates a pertussis toxin-sensitive signaling pathway that stimulates the release of matrix metalloproteinase-9Katherine Conant
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurochem 82:885-93. 2002..Together, these results suggest that MMP-1 signals through a pertussis toxin-sensitive G protein-coupled receptor... - Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cellsDennis J Grab
Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS Negl Trop Dis 3:e479. 2009.... - Improving neurological outcomes post-cardiac arrest in a rat model: immediate hypothermia and quantitative EEG monitoringXiaofeng Jia
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Resuscitation 76:431-42. 2008..To enhance the administration of TH, we studied brain electrophysiological monitoring in determining the benefit of early initiation of TH compared to conventional administration in a rat model... - Perturbation of sphingolipid metabolism and ceramide production in HIV-dementiaNorman J Haughey
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann Neurol 55:257-67. 2004..These results suggest that HIV-1 infection may promote a lipid imbalance in neural cells, resulting in an overproduction of ceramide and consequent cellular dysfunction and death... - Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissueAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Pediatr Res 53:762-9. 2003..The reproducible differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the SWS normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS... - Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptorsMonique F Stins
Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Lab Invest 83:1787-98. 2003..The activation of brain endothelium of children by HIV-1 protein gp120 by way of CD4 and chemokine receptors may have implications for the pathogenesis of HIV-1 encephalopathy in the pediatric population... - Transverse Myelitis: pathogenesis, diagnosis and treatmentChitra Krishnan
Department of Neurology, Johns Hopkins Transverse Myelitis Center, 600 N Wolfe Street Pathology 627C, Baltimore MD 21287 6965, USA
Front Biosci 9:1483-99. 2004..Additionally, we will review current concepts on the natural history, immunopathogenesis and treatment strategies for patients with TM... - Differential effects of HIV infected macrophages on dorsal root ganglia neurons and axonsKatrin Hahn
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Exp Neurol 210:30-40. 2008..These observations suggest a differential effect on the axon and cell body. Different mechanisms of injury may be operative in these two structures... - Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autismM C Zerrate
Department of Neurology, Pathology 627, 600 N Wolfe St, Baltimore, MD 21287, USA
J Pharmacol Exp Ther 322:16-22. 2007..This study provides a useful animal model for understanding the neuropathological processes underlying autism spectrum disorders... - Aquaporin 4 is increased in association with human immunodeficiency virus dementia: implications for disease pathogenesisCoryse St Hillaire
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Neurovirol 11:535-43. 2005..Additional studies may be warranted to determine whether altered AQP4 expression represents a protective and/or maladaptive response to central nervous system (CNS) inflammation... - IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitisAdam I Kaplin
Department of Psychiatry and Behavioral Sciences, Bloomberg School of Public Health, Baltimore, Maryland, USA
J Clin Invest 115:2731-41. 2005..The elucidation of this pathway identifies specific therapeutic targets in the management of CNS autoimmune conditions... - Amyloid precursor protein expression in circulating monocytes and brain macrophages from patients with HIV-associated cognitive impairmentAri Vehmas
Department of Neurology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Neuroimmunol 157:99-110. 2004..In the brain, APP appeared as axonal immunoreactivity and diffuse plaques, and APP+ perivascular macrophages were seen in cases with severe dementia. APP may facilitate monocyte entry into the brain... - Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementiaR G Cutler
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, MD, USA
Neurology 63:626-30. 2004..Despite these correlative observations, there has been little evidence suggesting a mechanism whereby the expression of ApoE4 renders neurons susceptible to insult... - Associations between retinal nerve fiber layer abnormalities and optic nerve examinationD Cettomai
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
Neurology 75:1318-25. 2010.... 
Fatal immune reconstitution inflammatory syndrome with human immunodeficiency virus infection and Candida meningitis: case report and review of the literatureJennifer L Berkeley
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurovirol 14:267-76. 2008..Additionally, the authors review the literature regarding CNS IRIS...- The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brainHorea Rus
Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 102:11094-9. 2005..3(high)/CCR7(-) T(EM), suggesting that a subset of cerebrospinal fluid cells existed in a primed state ready to become T(EM). These studies provide further rationale for the use of specific Kv1.3 antagonists in MS... - Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosisDavid N Irani
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Ann Neurol 59:237-47. 2006..The diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis... - Accumulation of the adenosine triphosphate synthase subunit C in the mnd mutant mouse. A model for neuronal ceroid lipofuscinosisC A Pardo
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196
Am J Pathol 144:829-35. 1994..The mnd mouse should be of great value for investigations of the genetics of NCL, for studies designed to delineate the mechanism that lead to neuronal degeneration in these disorders, and for testing novel therapeutic approaches... - Hashimoto's encephalopathyNicoline Schiess
Department of Neurology, Division of Neuroimmunology and Neuroinfectious Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann N Y Acad Sci 1142:254-65. 2008..Further controlled studies of the use of steroids, plasmapheresis, or immunosuppressant medications are needed in the future to prove the concept of the pathogenic role of antithyroid antibodies in HE... - Editorial comment: CD8+ lymphocytosis and DILS--a tale of split personalityCarlos A Pardo
HIV Neurosciences Group, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
AIDS Read 12:410-1. 2002 - Pathogenesis of simian immunodeficiency virus-induced alterations in macaque trigeminal gangliaVictoria A Laast
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Neuropathol Exp Neurol 66:26-34. 2007.... - Therapy Insight: CNS manifestations of HIV-associated immune reconstitution inflammatory syndromeDavid J Riedel
University of Maryland, Baltimore, MD 21287, USA
Nat Clin Pract Neurol 2:557-65. 2006..Furthermore, it is possible that more-chronic forms of the syndrome exist but remain unrecognized. Here, we review the various clinical presentations of CNS IRIS, and discuss options for their management... - Demyelinating disorders: update on transverse myelitisChitra Krishnan
Department of Neurology, Johns Hopkins University School of Medicine, Pathology 627, 600 North Wolfe Street, Baltimore, MD 21287-6965, USA
Curr Neurol Neurosci Rep 6:236-43. 2006..Clinical trials testing the efficacy of promising axonoprotective agents in combination with intravenous steroids in the treatment of TM are currently underway... - Peripheral nerve-derived HIV-1 is predominantly CCR5-dependent and causes neuronal degeneration and neuroinflammationGareth Jones
University of Calgary, Calgary, Canada
Virology 334:178-93. 2005..Our results suggest that HIV-1 infection of the peripheral nervous system causes axonal degeneration, possibly through the induction of pro-inflammatory cytokines... - Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissuesMelissa J Churchill
The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
J Neurovirol 12:146-52. 2006..The ability of HIV-1 to integrate in terminally differentiated astrocytes suggests a permanent reservoir of provirus in brain that will impact the development and likely success of strategies aimed at eradicating HIV-1... - CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophagesCorinna Trebst
Department of Neurosciences, The Lerner Research Institute, Cleveland, Ohio 44195, USA
Am J Pathol 162:427-38. 2003..CCR8 expression may also indicate a selective program of mononuclear phagocyte gene expression... - Characterization of human immunodeficiency virus (HIV)-infected cells in infiltrates associated with CNS opportunistic infections in patients with HIV clade C infectionAnita Mahadevan
Departments of Neuropathology, National Institute of Mental Health and Neurological Sciences, Bangalore, India
J Neuropathol Exp Neurol 66:799-808. 2007..These findings suggest the possibility that patients, even if successfully treated for an opportunistic inflection, may be at high risk of developing HIV encephalitis and subsequent dementia... - Recent developments in the HIV neuropathiesCarlos A Luciano
Specialized Neuroscience Research Program in NeuroAIDS, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00936, USA
Curr Opin Neurol 16:403-9. 2003..A better understanding of the prevailing mechanisms will allow for more effective interventions... - HIV-associated sensory neuropathiesSanjay C Keswani
AIDS 16:2105-17. 2002
Research Grants
- HIV infection and drugs of abuse in neuroglial functionCarlos Pardo Villamizar; Fiscal Year: 2007..The results of these studies will facilitate a better understanding of the mechanisms of injury in HIV infection and drug abuse and will provide insight into the design of more effective therapeutics. ..