C A Pardo

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence
    Hong Na
    Department of Medicine University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Retrovirology 8:44. 2011
  2. ncbi request reprint Immunity, neuroglia and neuroinflammation in autism
    Carlos A Pardo
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int Rev Psychiatry 17:485-95. 2005
  3. ncbi request reprint HIV neuropathy: insights in the pathology of HIV peripheral nerve disease
    C A Pardo
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Peripher Nerv Syst 6:21-7. 2001
  4. ncbi request reprint The neurobiology of autism
    Carlos A Pardo
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA
    Brain Pathol 17:434-47. 2007
  5. ncbi request reprint Immune reconstitution inflammatory syndrome in the CNS of HIV-infected patients
    A Venkataramana
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Neurology 67:383-8. 2006
  6. ncbi request reprint Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Ann Neurol 54:287-96. 2003
  7. pmc The need for caution in considering the diagnostic utility of antibasal ganglia antibodies in movement disorders
    H S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 N Wolfe Street, Baltimore, MD, USA
    Arch Dis Child 89:595-7. 2004
  8. ncbi request reprint CD4 and chemokine receptors on human brain microvascular endothelial cells, implications for human immunodeficiency virus type 1 pathogenesis
    Monique F Stins
    Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Endothelium 11:275-84. 2004
  9. ncbi request reprint Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statins
    Ashok Chauhan
    Department of Neurology, Richard Johnson Division of Neuro Immunology and Neurological Infections, The Johns Hopkins University, 509 Pathology, 600 N Wolfe St, Baltimore, MD 21287, USA
    FASEB J 21:777-89. 2007
  10. ncbi request reprint Sturge-Weber syndrome: altered blood vessel fibronectin expression and morphology
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Child Neurol 20:572-7. 2005

Research Grants

  1. HIV infection and drugs of abuse in neuroglial function
    Carlos Pardo Villamizar; Fiscal Year: 2007

Detail Information

Publications43

  1. pmc Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence
    Hong Na
    Department of Medicine University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Retrovirology 8:44. 2011
    ....
  2. ncbi request reprint Immunity, neuroglia and neuroinflammation in autism
    Carlos A Pardo
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int Rev Psychiatry 17:485-95. 2005
    ..A better understanding of the role of neuroinflammation in the pathogenesis of autism may have important clinical and therapeutic implications...
  3. ncbi request reprint HIV neuropathy: insights in the pathology of HIV peripheral nerve disease
    C A Pardo
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Peripher Nerv Syst 6:21-7. 2001
    ..Opportunisitic infections, mostly associated with cytomegalovirus or herpes zoster virus infection occur in late stages of AIDS and produce characteristic clinical features such as mononeuritis multiple or radiculopathies...
  4. ncbi request reprint The neurobiology of autism
    Carlos A Pardo
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA
    Brain Pathol 17:434-47. 2007
    ..We also discuss evidence implicating oxidative stress, neuroglial activation and neuroimmunity in autism...
  5. ncbi request reprint Immune reconstitution inflammatory syndrome in the CNS of HIV-infected patients
    A Venkataramana
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Neurology 67:383-8. 2006
    ..To describe challenges in diagnosis and management of patients with clinical syndromes of immune reconstitution inflammatory syndrome (IRIS) involving the CNS...
  6. ncbi request reprint Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Ann Neurol 54:287-96. 2003
    ..This newly described Schwann cell-neuron interaction may be pathogenically relevant not only in HIV-SN but also in other peripheral neuropathies...
  7. pmc The need for caution in considering the diagnostic utility of antibasal ganglia antibodies in movement disorders
    H S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 N Wolfe Street, Baltimore, MD, USA
    Arch Dis Child 89:595-7. 2004
  8. ncbi request reprint CD4 and chemokine receptors on human brain microvascular endothelial cells, implications for human immunodeficiency virus type 1 pathogenesis
    Monique F Stins
    Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Endothelium 11:275-84. 2004
    ....
  9. ncbi request reprint Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statins
    Ashok Chauhan
    Department of Neurology, Richard Johnson Division of Neuro Immunology and Neurological Infections, The Johns Hopkins University, 509 Pathology, 600 N Wolfe St, Baltimore, MD 21287, USA
    FASEB J 21:777-89. 2007
    ..Our findings suggest that ET-1 may be critical in mediating the neuropathogenesis of HIV dementia and that statins may have therapeutic potential in these patients...
  10. ncbi request reprint Sturge-Weber syndrome: altered blood vessel fibronectin expression and morphology
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Child Neurol 20:572-7. 2005
    ..Altered blood vessel fibronectin expression in Sturge-Weber syndrome could contribute to abnormal vascular structure and function in this disorder...
  11. ncbi request reprint Neuroglial activation and neuroinflammation in the brain of patients with autism
    Diana L Vargas
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Ann Neurol 57:67-81. 2005
    ..Our findings indicate that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain...
  12. ncbi request reprint In vitro modeling of the HIV-macrophage reservoir
    Amanda Brown
    Johns Hopkins School of Medicine, Department of Neurology, 600 North Wolfe St, Baltimore, MD 21287, USA
    J Leukoc Biol 80:1127-35. 2006
    ..A subset of these, were replication competent as shown by their ability to express GFP and/or p24 antigen after reactivation with IL-4...
  13. ncbi request reprint Diagnosis and management of acute myelopathies
    Adam I Kaplin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Osler 320, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Neurologist 11:2-18. 2005
    ..TM may exist as part of a multifocal CNS disease (eg, MS), multisystemic disease (eg, systemic lupus erythematosus), or as an isolated, idiopathic entity...
  14. ncbi request reprint The pathology of Rasmussen syndrome: stages of cortical involvement and neuropathological studies in 45 hemispherectomies
    Carlos A Pardo
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Epilepsia 45:516-26. 2004
    ..To characterize the profile of cortical involvement in RS, we studied the pathological changes in the cerebral cortex of 45 hemispherectomies performed at Johns Hopkins Hospital between 1985 and 2002...
  15. ncbi request reprint Matrix metalloproteinase-1 activates a pertussis toxin-sensitive signaling pathway that stimulates the release of matrix metalloproteinase-9
    Katherine Conant
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurochem 82:885-93. 2002
    ..Together, these results suggest that MMP-1 signals through a pertussis toxin-sensitive G protein-coupled receptor...
  16. pmc Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells
    Dennis J Grab
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Negl Trop Dis 3:e479. 2009
    ....
  17. pmc Improving neurological outcomes post-cardiac arrest in a rat model: immediate hypothermia and quantitative EEG monitoring
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Resuscitation 76:431-42. 2008
    ..To enhance the administration of TH, we studied brain electrophysiological monitoring in determining the benefit of early initiation of TH compared to conventional administration in a rat model...
  18. ncbi request reprint Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia
    Norman J Haughey
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Neurol 55:257-67. 2004
    ..These results suggest that HIV-1 infection may promote a lipid imbalance in neural cells, resulting in an overproduction of ceramide and consequent cellular dysfunction and death...
  19. ncbi request reprint Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Pediatr Res 53:762-9. 2003
    ..The reproducible differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the SWS normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS...
  20. ncbi request reprint Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors
    Monique F Stins
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Lab Invest 83:1787-98. 2003
    ..The activation of brain endothelium of children by HIV-1 protein gp120 by way of CD4 and chemokine receptors may have implications for the pathogenesis of HIV-1 encephalopathy in the pediatric population...
  21. ncbi request reprint Transverse Myelitis: pathogenesis, diagnosis and treatment
    Chitra Krishnan
    Department of Neurology, Johns Hopkins Transverse Myelitis Center, 600 N Wolfe Street Pathology 627C, Baltimore MD 21287 6965, USA
    Front Biosci 9:1483-99. 2004
    ..Additionally, we will review current concepts on the natural history, immunopathogenesis and treatment strategies for patients with TM...
  22. pmc Differential effects of HIV infected macrophages on dorsal root ganglia neurons and axons
    Katrin Hahn
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Neurol 210:30-40. 2008
    ..These observations suggest a differential effect on the axon and cell body. Different mechanisms of injury may be operative in these two structures...
  23. ncbi request reprint Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism
    M C Zerrate
    Department of Neurology, Pathology 627, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Pharmacol Exp Ther 322:16-22. 2007
    ..This study provides a useful animal model for understanding the neuropathological processes underlying autism spectrum disorders...
  24. ncbi request reprint Aquaporin 4 is increased in association with human immunodeficiency virus dementia: implications for disease pathogenesis
    Coryse St Hillaire
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurovirol 11:535-43. 2005
    ..Additional studies may be warranted to determine whether altered AQP4 expression represents a protective and/or maladaptive response to central nervous system (CNS) inflammation...
  25. pmc IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis
    Adam I Kaplin
    Department of Psychiatry and Behavioral Sciences, Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Clin Invest 115:2731-41. 2005
    ..The elucidation of this pathway identifies specific therapeutic targets in the management of CNS autoimmune conditions...
  26. ncbi request reprint Amyloid precursor protein expression in circulating monocytes and brain macrophages from patients with HIV-associated cognitive impairment
    Ari Vehmas
    Department of Neurology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Neuroimmunol 157:99-110. 2004
    ..In the brain, APP appeared as axonal immunoreactivity and diffuse plaques, and APP+ perivascular macrophages were seen in cases with severe dementia. APP may facilitate monocyte entry into the brain...
  27. ncbi request reprint Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia
    R G Cutler
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, MD, USA
    Neurology 63:626-30. 2004
    ..Despite these correlative observations, there has been little evidence suggesting a mechanism whereby the expression of ApoE4 renders neurons susceptible to insult...
  28. pmc Associations between retinal nerve fiber layer abnormalities and optic nerve examination
    D Cettomai
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurology 75:1318-25. 2010
    ....
  29. doi request reprint Fatal immune reconstitution inflammatory syndrome with human immunodeficiency virus infection and Candida meningitis: case report and review of the literature
    Jennifer L Berkeley
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurovirol 14:267-76. 2008
    ..Additionally, the authors review the literature regarding CNS IRIS...
  30. pmc The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain
    Horea Rus
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:11094-9. 2005
    ..3(high)/CCR7(-) T(EM), suggesting that a subset of cerebrospinal fluid cells existed in a primed state ready to become T(EM). These studies provide further rationale for the use of specific Kv1.3 antagonists in MS...
  31. ncbi request reprint Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis
    David N Irani
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Neurol 59:237-47. 2006
    ..The diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis...
  32. pmc Accumulation of the adenosine triphosphate synthase subunit C in the mnd mutant mouse. A model for neuronal ceroid lipofuscinosis
    C A Pardo
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196
    Am J Pathol 144:829-35. 1994
    ..The mnd mouse should be of great value for investigations of the genetics of NCL, for studies designed to delineate the mechanism that lead to neuronal degeneration in these disorders, and for testing novel therapeutic approaches...
  33. doi request reprint Hashimoto's encephalopathy
    Nicoline Schiess
    Department of Neurology, Division of Neuroimmunology and Neuroinfectious Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 1142:254-65. 2008
    ..Further controlled studies of the use of steroids, plasmapheresis, or immunosuppressant medications are needed in the future to prove the concept of the pathogenic role of antithyroid antibodies in HE...
  34. ncbi request reprint Editorial comment: CD8+ lymphocytosis and DILS--a tale of split personality
    Carlos A Pardo
    HIV Neurosciences Group, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    AIDS Read 12:410-1. 2002
  35. ncbi request reprint Pathogenesis of simian immunodeficiency virus-induced alterations in macaque trigeminal ganglia
    Victoria A Laast
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neuropathol Exp Neurol 66:26-34. 2007
    ....
  36. ncbi request reprint Therapy Insight: CNS manifestations of HIV-associated immune reconstitution inflammatory syndrome
    David J Riedel
    University of Maryland, Baltimore, MD 21287, USA
    Nat Clin Pract Neurol 2:557-65. 2006
    ..Furthermore, it is possible that more-chronic forms of the syndrome exist but remain unrecognized. Here, we review the various clinical presentations of CNS IRIS, and discuss options for their management...
  37. ncbi request reprint Demyelinating disorders: update on transverse myelitis
    Chitra Krishnan
    Department of Neurology, Johns Hopkins University School of Medicine, Pathology 627, 600 North Wolfe Street, Baltimore, MD 21287 6965, USA
    Curr Neurol Neurosci Rep 6:236-43. 2006
    ..Clinical trials testing the efficacy of promising axonoprotective agents in combination with intravenous steroids in the treatment of TM are currently underway...
  38. ncbi request reprint Peripheral nerve-derived HIV-1 is predominantly CCR5-dependent and causes neuronal degeneration and neuroinflammation
    Gareth Jones
    University of Calgary, Calgary, Canada
    Virology 334:178-93. 2005
    ..Our results suggest that HIV-1 infection of the peripheral nervous system causes axonal degeneration, possibly through the induction of pro-inflammatory cytokines...
  39. ncbi request reprint Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues
    Melissa J Churchill
    The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Neurovirol 12:146-52. 2006
    ..The ability of HIV-1 to integrate in terminally differentiated astrocytes suggests a permanent reservoir of provirus in brain that will impact the development and likely success of strategies aimed at eradicating HIV-1...
  40. pmc CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages
    Corinna Trebst
    Department of Neurosciences, The Lerner Research Institute, Cleveland, Ohio 44195, USA
    Am J Pathol 162:427-38. 2003
    ..CCR8 expression may also indicate a selective program of mononuclear phagocyte gene expression...
  41. ncbi request reprint Characterization of human immunodeficiency virus (HIV)-infected cells in infiltrates associated with CNS opportunistic infections in patients with HIV clade C infection
    Anita Mahadevan
    Departments of Neuropathology, National Institute of Mental Health and Neurological Sciences, Bangalore, India
    J Neuropathol Exp Neurol 66:799-808. 2007
    ..These findings suggest the possibility that patients, even if successfully treated for an opportunistic inflection, may be at high risk of developing HIV encephalitis and subsequent dementia...
  42. ncbi request reprint Recent developments in the HIV neuropathies
    Carlos A Luciano
    Specialized Neuroscience Research Program in NeuroAIDS, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00936, USA
    Curr Opin Neurol 16:403-9. 2003
    ....
  43. ncbi request reprint HIV-associated sensory neuropathies
    Sanjay C Keswani
    AIDS 16:2105-17. 2002

Research Grants1

  1. HIV infection and drugs of abuse in neuroglial function
    Carlos Pardo Villamizar; Fiscal Year: 2007
    ..The results of these studies will facilitate a better understanding of the mechanisms of injury in HIV infection and drug abuse and will provide insight into the design of more effective therapeutics. ..