Research Topics
Genomes and Genes | Duojia PanSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
The hippo signaling pathway in development and cancerDuojia Pan
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Cell 19:491-505. 2010..These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology...
Hippo signaling in organ size controlDuojia Pan
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Genes Dev 21:886-97. 2007..Here, I provide a historical review of this potent growth-regulatory pathway and highlight outstanding questions that will likely be the focus of future investigation...
The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathwayShian Wu
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Cell 14:388-98. 2008..Our results uncover a heretofore missing link in the Hpo signaling pathway and provide a glimpse of the molecular events on a Hpo-responsive enhancer element...- The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to ExpandedChen Ling
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 107:10532-7. 2010..Furthermore, our studies implicate Crb as a putative cell surface receptor for Hippo signaling by uncovering a transmembrane protein that directly binds to an apical component of the Hippo pathway... - The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammalsNailing Zhang
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Cell 19:27-38. 2010..Our studies link Merlin/NF2 to mammalian Hippo signaling and implicate YAP activation as a mediator of pathologies relevant to Neurofibromatosis 2... - The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathwayDora M Lam-Himlin
Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
Int J Gastrointest Cancer 37:103-9. 2006..The potential role of YAP in tumorigenesis was also reported in a murine genetic screen which identified a genomic amplification of YAP in hepatocellular carcinoma... - Elucidation of a universal size-control mechanism in Drosophila and mammalsJixin Dong
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 130:1120-33. 2007..These results uncover a universal size-control mechanism in metazoan... - Expression of Yes-associated protein modulates Survivin expression in primary liver malignanciesHaibo Bai
Department of Pathology, Howard Hughes Medical Institute Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Hum Pathol 43:1376-85. 2012..Our findings suggested that Yes-associated protein contributes to primary liver tumorigenesis and likely mediates its oncogenic effects through modulating Survivin expression... - The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration programJing Cai
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Genes Dev 24:2383-8. 2010..Thus, the YAP oncoprotein must be exquisitely controlled in tissue regeneration to allow compensatory proliferation and prevent the intrinsic oncogenic potential of a tissue regeneration program... - Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAPYi Liu-Chittenden
Howard Hughes Medical Institute, Maryland, USA
Genes Dev 26:1300-5. 2012..These findings provide proof of principle that inhibiting TEAD-YAP interactions is a pharmacologically viable strategy against the YAP oncoprotein... - Expression of Yes-associated protein in common solid tumorsAngela A Steinhardt
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Hum Pathol 39:1582-9. 2008.... - Yes-associated protein regulates the hepatic response after bile duct ligationHaibo Bai
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Hepatology 56:1097-107. 2012..CONCLUSION: Our data suggest that YAP promotes cholangiocyte and hepatocyte proliferation and prevents parenchymal damage after cholestatic injury in mice and thus may mediate the response to cholestasis-induced human liver disease... - Fat flies expanded the hippo pathway: a matter of size controlFeng Yin
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Sci STKE 2007:pe12. 2007..Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu... - The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAPJianbin Huang
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Cell 122:421-34. 2005..Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene... - Tsc2 is not a critical target of Akt during normal Drosophila developmentJixin Dong
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
Genes Dev 18:2479-84. 2004..Strikingly, such mutants completely rescue the lethality and cell growth defects of Tsc2-null mutants. Taken together, our data suggest that Tsc2 is not a critical substrate of Akt in normal Drosophila development... - hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and wartsShian Wu
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 114:445-56. 2003..A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals...
Research Grants
- Control of cell number in developing retinaDuojia Pan; Fiscal Year: 2009..Besides revealing basic mechanisms of eye development, our studies have general implications for the development of other tissues. ..
- Function of the Small GTPase Rheb in Cell GrowthDuojia Pan; Fiscal Year: 2007..These studies should not only help us understand basic developmental mechanisms, but also provide insights into human diseases and cancer. ..
- SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENTDuojia Pan; Fiscal Year: 2005..Understanding the molecular mechanisms of dPTEN function will not only provide insights into size control mechanisms in development, but also shed light on how PTEN functions as a tumor suppressor gene in humans. ..
- Control of cell number in developing retinaDuojia Pan; Fiscal Year: 2010..Such insights may facilitate the therapeutic interventions of relevant human diseases, including diseases of the retina. ..