Duojia Pan

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc The hippo signaling pathway in development and cancer
    Duojia Pan
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 19:491-505. 2010
  2. ncbi request reprint Hippo signaling in organ size control
    Duojia Pan
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 21:886-97. 2007
  3. pmc The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression
    Laura M Koontz
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 25:388-401. 2013
  4. doi request reprint The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway
    Shian Wu
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 14:388-98. 2008
  5. pmc The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
    Chen Ling
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:10532-7. 2010
  6. pmc The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
    Nailing Zhang
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 19:27-38. 2010
  7. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
  8. pmc Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2
    Feng Yin
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 154:1342-55. 2013
  9. doi request reprint The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway
    Dora M Lam-Himlin
    Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
    Int J Gastrointest Cancer 37:103-9. 2006
  10. pmc Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies
    Haibo Bai
    Department of Pathology, Howard Hughes Medical Institute Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Pathol 43:1376-85. 2012

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc The hippo signaling pathway in development and cancer
    Duojia Pan
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 19:491-505. 2010
    ..These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology...
  2. ncbi request reprint Hippo signaling in organ size control
    Duojia Pan
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 21:886-97. 2007
    ..Here, I provide a historical review of this potent growth-regulatory pathway and highlight outstanding questions that will likely be the focus of future investigation...
  3. pmc The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression
    Laura M Koontz
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 25:388-401. 2013
    ..These findings fill a major gap in Hippo-mediated transcriptional regulation and open up possibilities for modulating the YAP oncoprotein in cancer and regenerative medicine...
  4. doi request reprint The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway
    Shian Wu
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 14:388-98. 2008
    ..Our results uncover a heretofore missing link in the Hpo signaling pathway and provide a glimpse of the molecular events on a Hpo-responsive enhancer element...
  5. pmc The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
    Chen Ling
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:10532-7. 2010
    ..Furthermore, our studies implicate Crb as a putative cell surface receptor for Hippo signaling by uncovering a transmembrane protein that directly binds to an apical component of the Hippo pathway...
  6. pmc The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
    Nailing Zhang
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 19:27-38. 2010
    ..Our studies link Merlin/NF2 to mammalian Hippo signaling and implicate YAP activation as a mediator of pathologies relevant to Neurofibromatosis 2...
  7. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
    ..These results uncover a universal size-control mechanism in metazoan...
  8. pmc Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2
    Feng Yin
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 154:1342-55. 2013
    ..Our findings elucidate an important molecular function of Merlin and highlight the plasma membrane as a critical subcellular compartment for Hippo signal transduction...
  9. doi request reprint The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway
    Dora M Lam-Himlin
    Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
    Int J Gastrointest Cancer 37:103-9. 2006
    ..The potential role of YAP in tumorigenesis was also reported in a murine genetic screen which identified a genomic amplification of YAP in hepatocellular carcinoma...
  10. pmc Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies
    Haibo Bai
    Department of Pathology, Howard Hughes Medical Institute Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Pathol 43:1376-85. 2012
    ..Our findings suggested that Yes-associated protein contributes to primary liver tumorigenesis and likely mediates its oncogenic effects through modulating Survivin expression...
  11. pmc The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
    Jing Cai
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 24:2383-8. 2010
    ..Thus, the YAP oncoprotein must be exquisitely controlled in tissue regeneration to allow compensatory proliferation and prevent the intrinsic oncogenic potential of a tissue regeneration program...
  12. pmc Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
    Yi Liu-Chittenden
    Howard Hughes Medical Institute, Maryland, USA
    Genes Dev 26:1300-5. 2012
    ..These findings provide proof of principle that inhibiting TEAD-YAP interactions is a pharmacologically viable strategy against the YAP oncoprotein...
  13. pmc Expression of Yes-associated protein in common solid tumors
    Angela A Steinhardt
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 39:1582-9. 2008
    ....
  14. pmc Yes-associated protein regulates the hepatic response after bile duct ligation
    Haibo Bai
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hepatology 56:1097-107. 2012
    ..Finally, we demonstrated that YAP likely mediates its biological effects through the modulation of Survivin expression...
  15. ncbi request reprint The use of Yes-associated protein expression in the diagnosis of persistent neonatal cholestatic liver disease
    Grzegorz T Gurda
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287
    Hum Pathol 45:1057-64. 2014
    ..In summary, we show that YAP expression modulates both bile duct proliferation and liver damage/fibrosis while acting as a sensitive and specific marker in the differential diagnosis of persistent neonatal cholestasis. ..
  16. ncbi request reprint Fat flies expanded the hippo pathway: a matter of size control
    Feng Yin
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci STKE 2007:pe12. 2007
    ..Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu...
  17. pmc A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis
    Qian Chen
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute
    Genes Dev 28:432-7. 2014
    ..The selective requirement for YAP in oncogenic growth highlights the potential of YAP inhibitors as molecular targeted therapies against breast cancers. ..
  18. ncbi request reprint The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    Jianbin Huang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell 122:421-34. 2005
    ..Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene...
  19. pmc Tsc2 is not a critical target of Akt during normal Drosophila development
    Jixin Dong
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    Genes Dev 18:2479-84. 2004
    ..Strikingly, such mutants completely rescue the lethality and cell growth defects of Tsc2-null mutants. Taken together, our data suggest that Tsc2 is not a critical substrate of Akt in normal Drosophila development...
  20. ncbi request reprint hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    Shian Wu
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 114:445-56. 2003
    ..A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals...

Research Grants18

  1. SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENT
    Duojia Pan; Fiscal Year: 2001
    ..Understanding the molecular mechanisms of dPTEN function will not only provide insights into size control mechanisms in development, but also shed light on how PTEN functions as a tumor suppressor gene in humans. ..
  2. Control of cell number in developing retina
    Duojia Pan; Fiscal Year: 2009
    ..Besides revealing basic mechanisms of eye development, our studies have general implications for the development of other tissues. ..
  3. Control of cell number in developing retina
    Duojia Pan; Fiscal Year: 2009
    ..Besides revealing basic mechanisms of eye development, our studies have general implications for the development of other tissues. ..
  4. Control of cell number in developing retina
    Duojia Pan; Fiscal Year: 2007
    ..Besides revealing basic mechanisms of eye development, our studies have general implications for the development of other tissues. ..
  5. Function of the Small GTPase Rheb in Cell Growth
    Duojia Pan; Fiscal Year: 2007
    ..These studies should not only help us understand basic developmental mechanisms, but also provide insights into human diseases and cancer. ..
  6. Function of the Small GTPase Rheb in Cell Growth
    Duojia Pan; Fiscal Year: 2006
    ..These studies should not only help us understand basic developmental mechanisms, but also provide insights into human diseases and cancer. ..
  7. Control of cell number in developing retina
    Duojia Pan; Fiscal Year: 2004
    ..Besides revealing basic mechanisms of eye development, our studies have general implications for the development of other tissues. ..
  8. Function of the Small GTPase Rheb in Cell Growth
    Duojia Pan; Fiscal Year: 2005
    ..These studies should not only help us understand basic developmental mechanisms, but also provide insights into human diseases and cancer. ..
  9. Control of cell number in developing retina
    Duojia Pan; Fiscal Year: 2006
    ..Besides revealing basic mechanisms of eye development, our studies have general implications for the development of other tissues. ..
  10. SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENT
    Duojia Pan; Fiscal Year: 2005
    ..Understanding the molecular mechanisms of dPTEN function will not only provide insights into size control mechanisms in development, but also shed light on how PTEN functions as a tumor suppressor gene in humans. ..
  11. Control of cell number in developing retina
    Duojia Pan; Fiscal Year: 2004
    ..Besides revealing basic mechanisms of eye development, our studies have general implications for the development of other tissues. ..
  12. SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENT
    Duojia Pan; Fiscal Year: 2004
    ..Understanding the molecular mechanisms of dPTEN function will not only provide insights into size control mechanisms in development, but also shed light on how PTEN functions as a tumor suppressor gene in humans. ..
  13. SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENT
    Duojia Pan; Fiscal Year: 2003
    ..Understanding the molecular mechanisms of dPTEN function will not only provide insights into size control mechanisms in development, but also shed light on how PTEN functions as a tumor suppressor gene in humans. ..
  14. SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENT
    Duojia Pan; Fiscal Year: 2002
    ..Understanding the molecular mechanisms of dPTEN function will not only provide insights into size control mechanisms in development, but also shed light on how PTEN functions as a tumor suppressor gene in humans. ..
  15. SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENT
    Duojia Pan; Fiscal Year: 2001
    ..Understanding the molecular mechanisms of dPTEN function will not only provide insights into size control mechanisms in development, but also shed light on how PTEN functions as a tumor suppressor gene in humans. ..
  16. Control of cell number in developing retina
    Duojia Pan; Fiscal Year: 2010
    ..Such insights may facilitate the therapeutic interventions of relevant human diseases, including diseases of the retina. ..