Genomes and Genes
Alexandru V Olaru
Affiliation: Johns Hopkins University
- Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformationAlexandru V Olaru
Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland 21231, USA
Inflamm Bowel Dis 17:221-31. 2011..In the current study we sought to identify specific miR dysregulation along the normal-inflammation-cancer axis...
- The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and BimTakatsugu Kan
Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287, USA
Gastroenterology 136:1689-700. 2009..Barrett's esophagus (BE) is a highly premalignant disease that predisposes to the development of esophageal adenocarcinoma (EAC); however, the involvement of microRNAs (miRs) in BE-EAC carcinogenic progression is not known...
- MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3Florin M Selaru
Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Hepatology 49:1595-601. 2009..Conclusions: MiR-21 is overexpressed in human CCAs. Furthermore, miR-21 may be oncogenic, at least in part, by inhibiting PDCD4 and TIMP3. Finally, these data suggest that TIMP3 is a candidate tumor suppressor gene in the biliary tree...
- MicroRNA-224 negatively regulates p21 expression during late neoplastic progression in inflammatory bowel diseaseAlexandru V Olaru
Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
Inflamm Bowel Dis 19:471-80. 2013..In the current study, we sought to identify miR dysregulation specific to progression along the normal-inflammation-cancer axis in colonic specimens from patients with IBD...
- Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancerTetsuo Ito
Division of Gastroenterology, Department of Medicine and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int J Cancer 129:2134-46. 2011..8-71.5% of luciferase activity by degrading luciferase mRNA in HSA/c cells. In conclusion, PLK1 is post-transcriptionally regulated by miR-593* and could be a promising molecular target for EC treatment...
- Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancersAlexandru V Olaru
Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Inflamm Bowel Dis 18:641-8. 2012..We investigated genome-wide CGI methylation in inflammatory bowel disease (IBD)-associated CRCs (IBD-CRCs)...
- Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanningYuriko Mori
Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Endocr Relat Cancer 18:465-78. 2011..These potential biomarkers significantly discriminate CRC patients from controls. Thus, they merit further evaluation in stool- and circulating DNA-based CRC detection studies...
- MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancerSumitaka Yamanaka
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dig Liver Dis 44:589-96. 2012..A thorough understanding of gastric cancer at the molecular level is urgently needed. One prominent oncogenic microRNA, miR-21, was previously reported to be upregulated in gastric cancer...
- Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cellsRachana Agarwal
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 4:e8002. 2009..In the present study, we report that claudin-11 (CLDN11) is silenced in gastric cancer via hypermethylation of its promoter region...
- LARP7 is a potential tumor suppressor gene in gastric cancerYulan Cheng
Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Lab Invest 92:1013-9. 2012..001) relative to control siRNA transfection. Taken together, these findings suggest that LARP7 downregulation occurs early during gastric tumorigenesis and may promote gastric tumorigenesis via p-TEFb dysregulation...
- MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpointAlexandru V Olaru
Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, MD 21205, USA
Hepatology 54:2089-98. 2011..miR-494 emerges as an important regulator of CCA growth and its further study may lead to the development of novel therapeutics...
- A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagusZhe Jin
Gastroenterology Division, Johns Hopkins University, Baltimore, MD 21287, USA
Cancer Res 69:4112-5. 2009..118, respectively) in all 3 models. A methylation biomarker-based panel to predict neoplastic progression in BE has potential clinical value in improving both the efficiency of surveillance endoscopy and the early detection of neoplasia...