Alexandru V Olaru

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation
    Alexandru V Olaru
    Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Inflamm Bowel Dis 17:221-31. 2011
  2. pmc The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim
    Takatsugu Kan
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287, USA
    Gastroenterology 136:1689-700. 2009
  3. pmc MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3
    Florin M Selaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hepatology 49:1595-601. 2009
  4. doi MicroRNA-224 negatively regulates p21 expression during late neoplastic progression in inflammatory bowel disease
    Alexandru V Olaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Inflamm Bowel Dis 19:471-80. 2013
  5. pmc Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer
    Tetsuo Ito
    Division of Gastroenterology, Department of Medicine and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 129:2134-46. 2011
  6. pmc Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers
    Alexandru V Olaru
    Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Inflamm Bowel Dis 18:641-8. 2012
  7. pmc Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning
    Yuriko Mori
    Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Endocr Relat Cancer 18:465-78. 2011
  8. pmc MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer
    Sumitaka Yamanaka
    Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dig Liver Dis 44:589-96. 2012
  9. pmc Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells
    Rachana Agarwal
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e8002. 2009
  10. pmc LARP7 is a potential tumor suppressor gene in gastric cancer
    Yulan Cheng
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lab Invest 92:1013-9. 2012

Collaborators

Detail Information

Publications12

  1. pmc Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation
    Alexandru V Olaru
    Department of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Inflamm Bowel Dis 17:221-31. 2011
    ..In the current study we sought to identify specific miR dysregulation along the normal-inflammation-cancer axis...
  2. pmc The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim
    Takatsugu Kan
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287, USA
    Gastroenterology 136:1689-700. 2009
    ..Barrett's esophagus (BE) is a highly premalignant disease that predisposes to the development of esophageal adenocarcinoma (EAC); however, the involvement of microRNAs (miRs) in BE-EAC carcinogenic progression is not known...
  3. pmc MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3
    Florin M Selaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hepatology 49:1595-601. 2009
    ..Conclusions: MiR-21 is overexpressed in human CCAs. Furthermore, miR-21 may be oncogenic, at least in part, by inhibiting PDCD4 and TIMP3. Finally, these data suggest that TIMP3 is a candidate tumor suppressor gene in the biliary tree...
  4. doi MicroRNA-224 negatively regulates p21 expression during late neoplastic progression in inflammatory bowel disease
    Alexandru V Olaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Inflamm Bowel Dis 19:471-80. 2013
    ..In the current study, we sought to identify miR dysregulation specific to progression along the normal-inflammation-cancer axis in colonic specimens from patients with IBD...
  5. pmc Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer
    Tetsuo Ito
    Division of Gastroenterology, Department of Medicine and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 129:2134-46. 2011
    ..8-71.5% of luciferase activity by degrading luciferase mRNA in HSA/c cells. In conclusion, PLK1 is post-transcriptionally regulated by miR-593* and could be a promising molecular target for EC treatment...
  6. pmc Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers
    Alexandru V Olaru
    Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Inflamm Bowel Dis 18:641-8. 2012
    ..We investigated genome-wide CGI methylation in inflammatory bowel disease (IBD)-associated CRCs (IBD-CRCs)...
  7. pmc Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning
    Yuriko Mori
    Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Endocr Relat Cancer 18:465-78. 2011
    ..These potential biomarkers significantly discriminate CRC patients from controls. Thus, they merit further evaluation in stool- and circulating DNA-based CRC detection studies...
  8. pmc MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer
    Sumitaka Yamanaka
    Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dig Liver Dis 44:589-96. 2012
    ..A thorough understanding of gastric cancer at the molecular level is urgently needed. One prominent oncogenic microRNA, miR-21, was previously reported to be upregulated in gastric cancer...
  9. pmc Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells
    Rachana Agarwal
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e8002. 2009
    ..In the present study, we report that claudin-11 (CLDN11) is silenced in gastric cancer via hypermethylation of its promoter region...
  10. pmc LARP7 is a potential tumor suppressor gene in gastric cancer
    Yulan Cheng
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lab Invest 92:1013-9. 2012
    ..001) relative to control siRNA transfection. Taken together, these findings suggest that LARP7 downregulation occurs early during gastric tumorigenesis and may promote gastric tumorigenesis via p-TEFb dysregulation...
  11. pmc MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint
    Alexandru V Olaru
    Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    Hepatology 54:2089-98. 2011
    ..miR-494 emerges as an important regulator of CCA growth and its further study may lead to the development of novel therapeutics...
  12. pmc A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus
    Zhe Jin
    Gastroenterology Division, Johns Hopkins University, Baltimore, MD 21287, USA
    Cancer Res 69:4112-5. 2009
    ..118, respectively) in all 3 models. A methylation biomarker-based panel to predict neoplastic progression in BE has potential clinical value in improving both the efficiency of surveillance endoscopy and the early detection of neoplasia...